Won Yong Kim

Relation of left ventricular function, mass, and volume to NT-proBNP in type 1 diabetic patients

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Anne Sofie Astrup, Denmark
  • Won Yong Kim
  • Lise Tarnow, Denmark
  • René M Botnar, Denmark
  • Cheryl Simonsen, Denmark
  • Lau Brix
  • Lotte Pietraszek, Denmark
  • Peter Riis Hansen, Denmark
  • Warren J Manning, Denmark
  • Hans-Henrik Parving, Denmark
  • The Department of Cardiological Medicine B
  • Center of Magnetic Resonance
OBJECTIVES: To measure left ventricular mass (LVM), left ventricular volumes, and left ventricular function (LVF) in a cohort of type 1 diabetic patients and to correlate measures of imaging to NH(2)-terminal pro-brain natriuretic peptide (NT-proBNP). RESEARCH DESIGN AND METHODS: In a cross-sectional study, all patients with type 1 diabetes underwent cardiovascular magnetic resonance imaging. We included 63 patients with diabetic nephropathy and 73 patients with normoalbuminuria. RESULTS: All patients had normal global LVF. LVM was increased in patients with diabetic nephropathy compared with patients with persistent normoalbuminuria. Patients with nephropathy had smaller left ventricular volumes and increased levels of NT-proBNP. Linear regression analysis in patients with diabetic nephropathy showed that NT-proBNP and creatinine were associated with LVM. CONCLUSIONS: Increased LVM is identified in asymptomatic type 1 diabetic patients with nephropathy compared with normoalbuminuric patients. Elevated levels of NT-proBNP were associated with increased LVM, which are both markers of increased cardiovascular risk.
Original languageEnglish
JournalDiabetes Care
Pages (from-to)968-70
Number of pages2
Publication statusPublished - 2008

    Research areas

  • Adult, Age of Onset, Albuminuria, Body Mass Index, Creatinine, Diabetes Mellitus, Type 1, Diabetic Nephropathies, Female, Glomerular Filtration Rate, Heart Ventricles, Hemoglobin A, Glycosylated, Humans, Male, Middle Aged, Natriuretic Peptide, Brain, Peptide Fragments, Ventricular Function, Left

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