Won Yong Kim

Influence of pre-infarction angina, collateral flow, and pre-procedural TIMI flow on myocardial salvage index by cardiac magnetic resonance in patients with ST-segment elevation myocardial infarction

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Jacob Thomsen Lønborg
  • ,
  • Henning Skov Kelbæk
  • ,
  • Niels Grove Vejlstrup
  • ,
  • Hans Erik Bøtker
  • Won Yong Kim
  • Lene Holmvang
  • ,
  • Erik Jørgensen, Denmark
  • Steffen Helqvist
  • ,
  • Kari Saunamäki
  • ,
  • Leif Thuesen, Denmark
  • Lars Romer Krusell, Denmark
  • Peter Clemmensen
  • ,
  • Thomas Engstrøm
BACKGROUND: In patients with ST-segment elevation myocardial infarction (STEMI) pre-infarction angina, pre-procedural TIMI flow and collateral flow to the myocardium supplied by the infarct related artery are suggested to be cardioprotective. We evaluated the effect of these factors on myocardial salvage index (MSI) and infarct size adjusting for area at risk in patients with STEMI treated with primary percutaneous coronary intervention. METHODS AND RESULTS: Cardiac magnetic resonance (CMR) was used to measure myocardial area at risk within 1-7 days and final infarct size 90±21 days after the STEMI in 200 patients. MSI was calculated as (area-at-risk infarct size) / area-at-risk. Patients with pre-infarction angina had a median MSI of 0.80 (IQR 0.67 to 0.86) versus 0.72 (0.61 to 0.80) in those without pre-infarction angina, P = 0.004). In a regression analysis of the infarct size plotted against the area-at-risk there was a strong trend that the line for the pre-infarction angina group was below the one for the non-angina group (P = 0.05). Patients with pre-procedural TIMI flow 0/1, 2 and 3 had a median MSI of (0.69 (IQR 0.59 to 0.76), 0.78 (0.68 to 0.86) and 0.85 (0.77 to 0.91), respectively (P
Original languageEnglish
JournalEuropean Heart Journal Cardiovascular Imaging
Volume13
Issue5
Pages (from-to)433-443
ISSN1525-2167
DOIs
Publication statusPublished - 2012

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