Projects per year
Personal profile
Profile
As a professor in the cardiovascular physiology, I combine teaching activities in a broad spectrum of medical physiology and research within microcirculatory abnormalities. Specifically, I am interested in control of cerebral microcirculation and its changes in various neurological disorders and metabolic comorbidities. I have a background within electrophysiology, ion transport biophysics, microcirculation and intracellular signaling.
Job responsibilities
I am primary involved in research and supervision of bachelor, master, PhD students and postdocs in their cardiovascular research projects within a focus to comorbidities with neurological and metabolic abnormalities. As a university teacher, I am responsible for cardiovascular lectures, seminars and classroom teaching of medical students as well as handle their exams. I also lead the Department’s Phenotyping Core Facility that provides a broad range of phenotyping services and expertise.
Research
I am conducting research on microcirculation, particularly brain microcirculation in health and its changes in neurological diseases, e.g., stroke, depression and familial migraine. My research contributes to better understanding how adjacent tissue ensures local blood supply sufficient for normal function and how this balance is disturbed in disease. My goal is to integrate genetics and molecular biology of disease with functional abnormalities to propose an efficient therapeutic strategy.
Keywords
- Biophysics
- Ion channels
- Electrophysiology
- membrane potention
- Ion transport
- Physiology
- chloride channel
- Na,K-ATPase
- Resistance arteries
- blood prefusion
- Heart and circulation
- cerebral circulation
- heart failure
- metabolic syndrome
- Resistance arteries
- esistance artery myography
- animal models
- Neuroscience and learning
- migraine
- ischemic stroke
- depression
- Neurovascular coupling
- Comorbidity
- metabolic syndrome
- Neurobiology
- Cerebral blood flow
- Na,K-ATPase
- Neurovascular coupling
Areas of expertise
- Subject area
- Neuroscience
- Physiology
- Biophysics
- Biomedicine
- pre-clinical research
- Cardiovascular research
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
Projects
- 1 Finished
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The NA,K-ATPase dependent signaling pathway is associated with vascular abnormalities
Bouzinova, E. (Participant) & Matchkov, V. (Participant)
01/01/2015 → 31/12/2017
Project: Research
Research output
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Chloride fluxes and GABA release sustain inhibition in the CNS: The role for Bestrophin 1 anion channels
Verkhratsky, A., Untiet, V. & Matchkov, V. V., Jan 2025, In: Acta Physiologica (Print). 241, 1, p. e14254 e14254.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Editorial › peer-review
1 Citation (Scopus) -
Exploring the association between familial hemiplegic migraine genes (CACNA1A, ATP1A2 and SCN1A) with migraine and epilepsy: A UK Biobank exome-wide association study
Staehr, C., Nyegaard, M., Bach, F. W., Rohde, P. D. & Matchkov, V. V., Jan 2025, In: Cephalalgia : an international journal of headache. 45, 1, p. 3331024241306103Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Spatial Transcriptomics and Proteomics Profiling After Ischemic Stroke Reperfusion: Insights Into Vascular Alterations
Hansen, L. M. B., Dam, V. S., Guldbrandsen, H. Ø., Staehr, C., Pedersen, T. M., Kalucka, J. M., Beck, H. C., Postnov, D., Lin, L. & Matchkov, V., 7 Mar 2025, In: Stroke.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Spinal cord blood flow elevation with systemic vasopressor noradrenaline is partly mediated by vasodilation of spinal arteries due to reduced expression of alpha adrenoreceptors
Entezari, S., Thygesen, M. M., Staehr, C., Melnikova, E., Skov, M., Rajanathan, R., Rasmussen, M., Rasmussen, M. M. & Matchkov, V. V., Mar 2025, In: The spine journal : official journal of the North American Spine Society. 25, 3, p. 609-619 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Targeting Na,K-ATPase-Src signaling to normalize cerebral blood flow in a murine model of familial hemiplegic migraine
Staehr, C., Guldbrandsen, H. Ø., Homilius, C., Johnsen, L. Ø., Postnov, D., Pedersen, T. M., Pierre, S., Sandow, S. L. & Matchkov, V. V., 4 Dec 2024, (E-pub / Early view) In: Journal of Cerebral Blood Flow and Metabolism. p. 271678X241305562Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Activities
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Swedish Research Council
Matchkov, V. (Member)
2023 → …Activity: Presentations, memberships, ownership and other activities › Member of committee, council or board
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Lund University
Matchkov, V. (Member)
2023Activity: Presentations, memberships, ownership and other activities › Member of review committee
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The Scandinavian Physiological Society
Matchkov, V. (Member)
Oct 2022 → Oct 2026Activity: Presentations, memberships, ownership and other activities › Member of board or management of company or organisation
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Censorkorpset for de farmaceutiske uddannelser
Matchkov, V. (Examiner)
2015 → …Activity: External lectures and Examination › Examination
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annual meeting of the Physiological Society
Matchkov, V. (Organizer)
1 Jul 2014Activity: Participating in or organising an event types › Participation in or organisation af a conference