Vladimir Matchkov

The role of Ca(2+) activated Cl(-) channels in blood pressure control

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The role of Ca(2+) activated Cl(-) channels in blood pressure control. / Matchkov, Vladimir V; Bødtkjer, Donna Marie Briggs; Aalkjaer, Christian.

In: Current Opinion in Pharmacology, Vol. 21, 04.2015, p. 127-37.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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@article{00a0fb1a8d984058a6720c76c9256f14,
title = "The role of Ca(2+) activated Cl(-) channels in blood pressure control",
abstract = "Ca(2+)-activated Cl(-) channels (CaCCs) have numerous functions in the body and are potential players in the control of blood pressure. The CaCCs represent a heterologous group including at least two protein families; TMEM16 and bestrophins. CaCCs expression has been shown in the kidney, the heart and blood vessels. Agonist-stimulated Ca(2+)-activated Cl(-) current is important for secretion in kidney epithelia, generation of a repolarizing current in the heart and amplification of excitation-contraction coupling in vascular smooth muscle cells. Changes in CaCC expression are shown in association with hypertension, kidney cysts, sudden cardiac death and arrhythmias. This review discusses recent advances in studies concerning the role of CaCC for blood pressure control with focus on the kidney, the heart and blood vessels.",
author = "Matchkov, {Vladimir V} and B{\o}dtkjer, {Donna Marie Briggs} and Christian Aalkjaer",
note = "Copyright {\textcopyright} 2015 Elsevier Ltd. All rights reserved.",
year = "2015",
month = apr,
doi = "10.1016/j.coph.2015.02.003",
language = "English",
volume = "21",
pages = "127--37",
journal = "Current Opinion in Pharmacology",
issn = "1471-4892",
publisher = "Elsevier Ltd. * Current Opinion Journals",

}

RIS

TY - JOUR

T1 - The role of Ca(2+) activated Cl(-) channels in blood pressure control

AU - Matchkov, Vladimir V

AU - Bødtkjer, Donna Marie Briggs

AU - Aalkjaer, Christian

N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.

PY - 2015/4

Y1 - 2015/4

N2 - Ca(2+)-activated Cl(-) channels (CaCCs) have numerous functions in the body and are potential players in the control of blood pressure. The CaCCs represent a heterologous group including at least two protein families; TMEM16 and bestrophins. CaCCs expression has been shown in the kidney, the heart and blood vessels. Agonist-stimulated Ca(2+)-activated Cl(-) current is important for secretion in kidney epithelia, generation of a repolarizing current in the heart and amplification of excitation-contraction coupling in vascular smooth muscle cells. Changes in CaCC expression are shown in association with hypertension, kidney cysts, sudden cardiac death and arrhythmias. This review discusses recent advances in studies concerning the role of CaCC for blood pressure control with focus on the kidney, the heart and blood vessels.

AB - Ca(2+)-activated Cl(-) channels (CaCCs) have numerous functions in the body and are potential players in the control of blood pressure. The CaCCs represent a heterologous group including at least two protein families; TMEM16 and bestrophins. CaCCs expression has been shown in the kidney, the heart and blood vessels. Agonist-stimulated Ca(2+)-activated Cl(-) current is important for secretion in kidney epithelia, generation of a repolarizing current in the heart and amplification of excitation-contraction coupling in vascular smooth muscle cells. Changes in CaCC expression are shown in association with hypertension, kidney cysts, sudden cardiac death and arrhythmias. This review discusses recent advances in studies concerning the role of CaCC for blood pressure control with focus on the kidney, the heart and blood vessels.

U2 - 10.1016/j.coph.2015.02.003

DO - 10.1016/j.coph.2015.02.003

M3 - Journal article

C2 - 25727479

VL - 21

SP - 127

EP - 137

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

SN - 1471-4892

ER -