Vladimir Matchkov

The bestrophin- and TMEM16A-associated Ca 2+ -activated Cl - channels in vascular smooth muscles

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The presence of Ca 2+ -activated Cl - currents (I Cl(Ca) ) in vascular smooth muscle cells (VSMCs) is well established. I Cl(Ca) are supposedly important for arterial contraction by linking changes in [Ca 2+ ]i and membrane depolarization. Bestrophins and some members of the TMEM16 protein family were recently associated with I Cl(Ca) . Two distinct I Cl(Ca) are characterized in VSMCs; the cGMP-dependent I Cl(Ca) dependent upon bestrophin expression and the 'classical' Ca 2+ -activated Cl - current, which is bestrophin-independent. Interestingly, TMEM16A is essential for both the cGMP-dependent and the classical I Cl(Ca) . Furthermore, TMEM16A has a role in arterial contraction while bestrophins do not. TMEM16A's role in the contractile response cannot be explained however only by a simple suppression of the depolarization by Cl - channels. It is suggested that TMEM16A expression modulates voltage-gated Ca 2+ influx in a voltage-independent manner and recent studies also demonstrate a complex role of TMEM16A in modulating other membrane proteins.

Original languageEnglish
Pages (from-to)361-369
Number of pages9
Publication statusPublished - 1 Jan 2014

    Research areas

  • Membrane potential, siRNA, Smooth muscle cells

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