Vladimir Matchkov

Pro-contractile role of chloride in arterial smooth muscle: Postnatal decline potentially governed by sympathetic nerves

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Daria S. Kostyunina, Faculty of Biology, Lomonosov Moscow State University, Russian Academy of Sciences, School of Medicine
  • ,
  • Dina K. Gaynullina, Lomonosov Moscow State University, Russian National Research Medical University
  • ,
  • Vladimir V. Matchkov
  • Olga S. Tarasova, Faculty of Biology, Lomonosov Moscow State University, Russian Academy of Sciences

New Findings: What is the topic of this review? This symposium report discusses the previously unrecognized pro-contractile role of chloride ions in rat arteries at early stages of postnatal development. What advances does it highlight? It highlights the postnatal decline in the contribution of chloride ions to regulation of arterial contractile responses and potential trophic role of sympathetic nerves in these developmental alterations. Abstract: Chloride ions are important for smooth muscle contraction in adult vasculature. Arterial smooth muscle undergoes structural and functional remodelling during early postnatal development, including changes in K + currents, Ca 2+ handling and sensitivity. However, developmental change in the contribution of Cl to regulation of arterial contraction has not yet been explored. Here, we provide the first evidence that the role of Cl in α 1 -adrenergic arterial contraction prominently decreases during early postnatal ontogenesis. The trophic influence of sympathetic nerves is a potential mechanism for postnatal decline of the contribution of Cl to the vascular contraction.

Original languageEnglish
JournalExperimental Physiology
Volume104
Issue7
Pages (from-to)1018-1022
Number of pages5
ISSN0958-0670
DOIs
Publication statusPublished - 1 Jul 2019

    Research areas

  • chloride, ontogenesis, smooth muscle, sympathetic nervous system

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