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Vladimir Matchkov

Myogenic response of rat femoral small arteries in relation to wall structure and [Ca2+]i

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Myogenic response of rat femoral small arteries in relation to wall structure and [Ca2+]i. / Matchkov, Vladimir V.; Tarasova, Olga S.; Mulvany, Michael J. et al.
In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 283, No. 1 52-1, 10.07.2002.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Matchkov, VV, Tarasova, OS, Mulvany, MJ & Nilsson, H 2002, 'Myogenic response of rat femoral small arteries in relation to wall structure and [Ca2+]i', American Journal of Physiology - Heart and Circulatory Physiology, vol. 283, no. 1 52-1.

APA

Matchkov, V. V., Tarasova, O. S., Mulvany, M. J., & Nilsson, H. (2002). Myogenic response of rat femoral small arteries in relation to wall structure and [Ca2+]i. American Journal of Physiology - Heart and Circulatory Physiology, 283(1 52-1).

CBE

Matchkov VV, Tarasova OS, Mulvany MJ, Nilsson H. 2002. Myogenic response of rat femoral small arteries in relation to wall structure and [Ca2+]i. American Journal of Physiology - Heart and Circulatory Physiology. 283(1 52-1).

MLA

Matchkov, Vladimir V. et al. "Myogenic response of rat femoral small arteries in relation to wall structure and [Ca2+]i". American Journal of Physiology - Heart and Circulatory Physiology. 2002. 283(1 52-1).

Vancouver

Matchkov VV, Tarasova OS, Mulvany MJ, Nilsson H. Myogenic response of rat femoral small arteries in relation to wall structure and [Ca2+]i. American Journal of Physiology - Heart and Circulatory Physiology. 2002 Jul 10;283(1 52-1).

Author

Matchkov, Vladimir V. ; Tarasova, Olga S. ; Mulvany, Michael J. et al. / Myogenic response of rat femoral small arteries in relation to wall structure and [Ca2+]i. In: American Journal of Physiology - Heart and Circulatory Physiology. 2002 ; Vol. 283, No. 1 52-1.

Bibtex

@article{5e2e5b9453de4b7fabd7ced9e9abe955,
title = "Myogenic response of rat femoral small arteries in relation to wall structure and [Ca2+]i",
abstract = "The present study investigated the influence of media thickness on myogenic tone and intracellular calcium concentration ([Ca2+]i) in rat skeletal muscle small arteries. A ligature was loosely tied around one external iliac artery of 5-wk-old spontaneously hypertensive rats. At 18 wk of age, femoral artery blood pressure was 102 ± 11 mmHg (n = 15) on the ligated side and 164 ± 6 mmHg (n = 15) on the contralateral side. Small arteries feeding the gracilis muscle had a reduced media cross-sectional area and a reduced media-to-lumen ratio on the ligated side, where also the range of myogenic constriction was shifted to lower pressures. However, when expressed as a function of wall stress, diameter responses were nearly identical. [Ca2+]i was higher in vessels from the ligated hindlimb at pressures above 10 mmHg, but vasoconstriction was not accompanied by changes in [Ca2+]i. Thus the myogenic constriction here seems due primarily to changes in intracellular calcium sensitivity, which are determined mainly by the force per cross-sectional area of the wall and therefore altered by changes in vascular structure.",
keywords = "Ca-channel antagonists, Endothelium, Fura 2, Intracellular calcium concentration",
author = "Matchkov, {Vladimir V.} and Tarasova, {Olga S.} and Mulvany, {Michael J.} and Holger Nilsson",
year = "2002",
month = jul,
day = "10",
language = "English",
volume = "283",
journal = "American Journal of Physiology - Heart and Circulatory Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "1 52-1",

}

RIS

TY - JOUR

T1 - Myogenic response of rat femoral small arteries in relation to wall structure and [Ca2+]i

AU - Matchkov, Vladimir V.

AU - Tarasova, Olga S.

AU - Mulvany, Michael J.

AU - Nilsson, Holger

PY - 2002/7/10

Y1 - 2002/7/10

N2 - The present study investigated the influence of media thickness on myogenic tone and intracellular calcium concentration ([Ca2+]i) in rat skeletal muscle small arteries. A ligature was loosely tied around one external iliac artery of 5-wk-old spontaneously hypertensive rats. At 18 wk of age, femoral artery blood pressure was 102 ± 11 mmHg (n = 15) on the ligated side and 164 ± 6 mmHg (n = 15) on the contralateral side. Small arteries feeding the gracilis muscle had a reduced media cross-sectional area and a reduced media-to-lumen ratio on the ligated side, where also the range of myogenic constriction was shifted to lower pressures. However, when expressed as a function of wall stress, diameter responses were nearly identical. [Ca2+]i was higher in vessels from the ligated hindlimb at pressures above 10 mmHg, but vasoconstriction was not accompanied by changes in [Ca2+]i. Thus the myogenic constriction here seems due primarily to changes in intracellular calcium sensitivity, which are determined mainly by the force per cross-sectional area of the wall and therefore altered by changes in vascular structure.

AB - The present study investigated the influence of media thickness on myogenic tone and intracellular calcium concentration ([Ca2+]i) in rat skeletal muscle small arteries. A ligature was loosely tied around one external iliac artery of 5-wk-old spontaneously hypertensive rats. At 18 wk of age, femoral artery blood pressure was 102 ± 11 mmHg (n = 15) on the ligated side and 164 ± 6 mmHg (n = 15) on the contralateral side. Small arteries feeding the gracilis muscle had a reduced media cross-sectional area and a reduced media-to-lumen ratio on the ligated side, where also the range of myogenic constriction was shifted to lower pressures. However, when expressed as a function of wall stress, diameter responses were nearly identical. [Ca2+]i was higher in vessels from the ligated hindlimb at pressures above 10 mmHg, but vasoconstriction was not accompanied by changes in [Ca2+]i. Thus the myogenic constriction here seems due primarily to changes in intracellular calcium sensitivity, which are determined mainly by the force per cross-sectional area of the wall and therefore altered by changes in vascular structure.

KW - Ca-channel antagonists

KW - Endothelium

KW - Fura 2

KW - Intracellular calcium concentration

UR - http://www.scopus.com/inward/record.url?scp=0036299636&partnerID=8YFLogxK

M3 - Journal article

C2 - 12063282

AN - SCOPUS:0036299636

VL - 283

JO - American Journal of Physiology - Heart and Circulatory Physiology

JF - American Journal of Physiology - Heart and Circulatory Physiology

SN - 0363-6135

IS - 1 52-1

ER -