Vladimir Matchkov

Heterogeneity and weak coupling may explain the synchronization characteristics of cells in the arterial wall.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Heterogeneity and weak coupling may explain the synchronization characteristics of cells in the arterial wall. / Jacobsen, Jens Christian Brings; Aalkjær, Christian; Matchkov, Vladimir et al.

In: Royal Society of London. Philosophical Transactions. Mathematical, Physical and Engineering Sciences, Vol. 366, No. 1880, 16.07.2008, p. 3483-3502.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Jacobsen, JCB, Aalkjær, C, Matchkov, V, Nilsson, H, Freiberg, JJ & Holstein-Rathlou, N-H 2008, 'Heterogeneity and weak coupling may explain the synchronization characteristics of cells in the arterial wall.', Royal Society of London. Philosophical Transactions. Mathematical, Physical and Engineering Sciences, vol. 366, no. 1880, pp. 3483-3502.

APA

Jacobsen, J. C. B., Aalkjær, C., Matchkov, V., Nilsson, H., Freiberg, J. J., & Holstein-Rathlou, N-H. (2008). Heterogeneity and weak coupling may explain the synchronization characteristics of cells in the arterial wall. Royal Society of London. Philosophical Transactions. Mathematical, Physical and Engineering Sciences, 366(1880), 3483-3502.

CBE

Jacobsen JCB, Aalkjær C, Matchkov V, Nilsson H, Freiberg JJ, Holstein-Rathlou N-H. 2008. Heterogeneity and weak coupling may explain the synchronization characteristics of cells in the arterial wall. Royal Society of London. Philosophical Transactions. Mathematical, Physical and Engineering Sciences. 366(1880):3483-3502.

MLA

Jacobsen, Jens Christian Brings et al. "Heterogeneity and weak coupling may explain the synchronization characteristics of cells in the arterial wall.". Royal Society of London. Philosophical Transactions. Mathematical, Physical and Engineering Sciences. 2008, 366(1880). 3483-3502.

Vancouver

Jacobsen JCB, Aalkjær C, Matchkov V, Nilsson H, Freiberg JJ, Holstein-Rathlou N-H. Heterogeneity and weak coupling may explain the synchronization characteristics of cells in the arterial wall. Royal Society of London. Philosophical Transactions. Mathematical, Physical and Engineering Sciences. 2008 Jul 16;366(1880):3483-3502.

Author

Jacobsen, Jens Christian Brings ; Aalkjær, Christian ; Matchkov, Vladimir et al. / Heterogeneity and weak coupling may explain the synchronization characteristics of cells in the arterial wall. In: Royal Society of London. Philosophical Transactions. Mathematical, Physical and Engineering Sciences. 2008 ; Vol. 366, No. 1880. pp. 3483-3502.

Bibtex

@article{18b1f320694811dd9251000ea68e967b,
title = "Heterogeneity and weak coupling may explain the synchronization characteristics of cells in the arterial wall.",
abstract = "Vascular smooth muscle cells (SMCs) exhibit different types of calcium dynamics. Static vascular tone is associated with unsynchronized calcium waves and the developed force depends on the number of recruited cells. Global calcium transients synchronized among a large number of cells cause rhythmic development of force known as vasomotion. We present experimental data showing a considerable heterogeneity in cellular calcium dynamics in the vascular wall. In stimulated vessels, some SMCs remain quiescent, whereas others display waves of variable frequency. At the onset of vasomotion, all SMCs are enrolled into synchronized oscillation.Simulations of coupled SMCs show that the experimentally observed cellular recruitment, the presence of quiescent cells and the variation in oscillation frequency may arise if the cell population is phenotypically heterogeneous. In this case, quiescent cells can be entrained at the onset of vasomotion by the collective driving force from the synchronized oscillations in the membrane potential of the surrounding cells. Partial synchronization arises with an increase in the concentration of cyclic guanosine monophosphate, but in a heterogeneous cell population complete synchronization also requires a high-conductance pathway that provides strong coupling between the cells.",
keywords = "arterial, vasomotion, synchronization, gap junctions",
author = "Jacobsen, {Jens Christian Brings} and Christian Aalkj{\ae}r and Vladimir Matchkov and Holger Nilsson and Freiberg, {Jacob J} and Niels-Henrik Holstein-Rathlou",
year = "2008",
month = jul,
day = "16",
language = "English",
volume = "366",
pages = "3483--3502",
journal = "Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences",
issn = "1364-503X",
publisher = "Royal Society Publishing",
number = "1880",

}

RIS

TY - JOUR

T1 - Heterogeneity and weak coupling may explain the synchronization characteristics of cells in the arterial wall.

AU - Jacobsen, Jens Christian Brings

AU - Aalkjær, Christian

AU - Matchkov, Vladimir

AU - Nilsson, Holger

AU - Freiberg, Jacob J

AU - Holstein-Rathlou, Niels-Henrik

PY - 2008/7/16

Y1 - 2008/7/16

N2 - Vascular smooth muscle cells (SMCs) exhibit different types of calcium dynamics. Static vascular tone is associated with unsynchronized calcium waves and the developed force depends on the number of recruited cells. Global calcium transients synchronized among a large number of cells cause rhythmic development of force known as vasomotion. We present experimental data showing a considerable heterogeneity in cellular calcium dynamics in the vascular wall. In stimulated vessels, some SMCs remain quiescent, whereas others display waves of variable frequency. At the onset of vasomotion, all SMCs are enrolled into synchronized oscillation.Simulations of coupled SMCs show that the experimentally observed cellular recruitment, the presence of quiescent cells and the variation in oscillation frequency may arise if the cell population is phenotypically heterogeneous. In this case, quiescent cells can be entrained at the onset of vasomotion by the collective driving force from the synchronized oscillations in the membrane potential of the surrounding cells. Partial synchronization arises with an increase in the concentration of cyclic guanosine monophosphate, but in a heterogeneous cell population complete synchronization also requires a high-conductance pathway that provides strong coupling between the cells.

AB - Vascular smooth muscle cells (SMCs) exhibit different types of calcium dynamics. Static vascular tone is associated with unsynchronized calcium waves and the developed force depends on the number of recruited cells. Global calcium transients synchronized among a large number of cells cause rhythmic development of force known as vasomotion. We present experimental data showing a considerable heterogeneity in cellular calcium dynamics in the vascular wall. In stimulated vessels, some SMCs remain quiescent, whereas others display waves of variable frequency. At the onset of vasomotion, all SMCs are enrolled into synchronized oscillation.Simulations of coupled SMCs show that the experimentally observed cellular recruitment, the presence of quiescent cells and the variation in oscillation frequency may arise if the cell population is phenotypically heterogeneous. In this case, quiescent cells can be entrained at the onset of vasomotion by the collective driving force from the synchronized oscillations in the membrane potential of the surrounding cells. Partial synchronization arises with an increase in the concentration of cyclic guanosine monophosphate, but in a heterogeneous cell population complete synchronization also requires a high-conductance pathway that provides strong coupling between the cells.

KW - arterial, vasomotion, synchronization, gap junctions

M3 - Journal article

VL - 366

SP - 3483

EP - 3502

JO - Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

JF - Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

SN - 1364-503X

IS - 1880

ER -