Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Bestrophin is important for the rhythmic but not the tonic contraction in rat mesenteric small arteries. / Broegger, Torbjoern; Jacobsen, Jens Christian Brings; Dam, Vibeke Secher et al.
In: Advances in Cardiovascular Research, Vol. 91, No. 4, 2011, p. 685-93.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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TY - JOUR
T1 - Bestrophin is important for the rhythmic but not the tonic contraction in rat mesenteric small arteries
AU - Broegger, Torbjoern
AU - Jacobsen, Jens Christian Brings
AU - Dam, Vibeke Secher
AU - Boedtkjer, Donna M Briggs
AU - Kold-Petersen, Henrik
AU - Pedersen, Finn Skou
AU - Aalkjaer, Christian
AU - Matchkov, Vladimir V
PY - 2011
Y1 - 2011
N2 - We have previously characterized a cGMP-dependent Ca(2+)-activated Cl(-) current in vascular smooth muscle cells (SMCs) and have shown its dependence on bestrophin-3 expression. We hypothesize that this current is important for synchronization of SMCs in the vascular wall. In the present study, we aimed to test this hypothesis by transfecting rat mesenteric small arteries in vivo with siRNA specifically targeting bestrophin-3.
AB - We have previously characterized a cGMP-dependent Ca(2+)-activated Cl(-) current in vascular smooth muscle cells (SMCs) and have shown its dependence on bestrophin-3 expression. We hypothesize that this current is important for synchronization of SMCs in the vascular wall. In the present study, we aimed to test this hypothesis by transfecting rat mesenteric small arteries in vivo with siRNA specifically targeting bestrophin-3.
KW - Animals
KW - Arginine Vasopressin
KW - Calcium
KW - Chloride Channels
KW - Male
KW - Mesenteric Arteries
KW - Norepinephrine
KW - RNA, Messenger
KW - RNA, Small Interfering
KW - Rats
KW - Rats, Wistar
KW - Transfection
KW - Vasoconstriction
U2 - 10.1093/cvr/cvr111
DO - 10.1093/cvr/cvr111
M3 - Journal article
C2 - 21498420
VL - 91
SP - 685
EP - 693
JO - Advances in Cardiovascular Research
JF - Advances in Cardiovascular Research
SN - 2159-1717
IS - 4
ER -