Vladimir Matchkov

Abnormal Membrane Localization of α2 Isoform of Na,K-ATPase in m. soleus of Dysferlin-Deficient Mice

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  • V V Kravtsova, Department of General Physiology, St. Petersburg State University, St. Petersburg, Russia.
  • ,
  • E V Bouzinova
  • V V Machkov
  • N A Timonina, Department of General Physiology, St. Petersburg State University, St. Petersburg, Russia.
  • ,
  • G F Zakyrjanova, Department of Normal Physiology, Kazan State Medical University, Kazan, Tatarstan Republic, Russia.
  • ,
  • A L Zefirov, Department of Normal Physiology, Kazan State Medical University, Kazan, Tatarstan Republic, Russia.
  • ,
  • I I Krivoi, Department of General Physiology, St. Petersburg State University, St. Petersburg, Russia. iikrivoi@gmail.com.

Dysferlin protein plays a key role in the multimolecular complex responsible for the maintenance of sarcolemma integrity and skeletal muscle cell functioning. We studied the membrane distribution of nicotinic acetylcholine receptors and α2 isoform of Na,K-ATPase in motor endplates of m. soleus in dysferlin-deficient Bla/J mice (a dysferlinopathy model). Endplates of Bla/J mice were characterized by increased area (without changes in fragmentation degree) and reduced density of the membrane distribution of nicotinic acetylcholine receptors in comparison with the corresponding parameters in control С57Bl/6 mice. The density of the membrane distribution of α2 isoform of Na,K-ATPase was also reduced, but the level of the corresponding mRNA remained unchanged. It can be hypothesized that abnormal membrane localization of α2 isoform of Na,K-ATPase results from adaptive skeletal muscle remodeling under conditions of chronic motor dysfunction.

Original languageEnglish
JournalBulletin of Experimental Biology and Medicine
Volume166
Issue5
Pages (from-to)593-597
Number of pages5
ISSN0007-4888
DOIs
Publication statusPublished - 2019

    Research areas

  • Na,K-ATPase isoforms, acetylcholine receptors, dysferlin, dysferlinopathy, nicotinic, skeletal muscle

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