Vladimir Matchkov

A model of smooth muscle cell synchronization in the arterial wall.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

A model of smooth muscle cell synchronization in the arterial wall. / Jacobsen, Jens Christian; Aalkjær, Christian; Nilsson, Holger et al.

In: American Journal of Physiology: Heart and Circulatory Physiology, Vol. 293, No. 1, 2007, p. H229-H237.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Jacobsen, JC, Aalkjær, C, Nilsson, H, Matchkov, V, Freiberg, J & Holstein-Rathlou, N-H 2007, 'A model of smooth muscle cell synchronization in the arterial wall.', American Journal of Physiology: Heart and Circulatory Physiology, vol. 293, no. 1, pp. H229-H237.

APA

Jacobsen, J. C., Aalkjær, C., Nilsson, H., Matchkov, V., Freiberg, J., & Holstein-Rathlou, N-H. (2007). A model of smooth muscle cell synchronization in the arterial wall. American Journal of Physiology: Heart and Circulatory Physiology, 293(1), H229-H237.

CBE

Jacobsen JC, Aalkjær C, Nilsson H, Matchkov V, Freiberg J, Holstein-Rathlou N-H. 2007. A model of smooth muscle cell synchronization in the arterial wall. American Journal of Physiology: Heart and Circulatory Physiology. 293(1):H229-H237.

MLA

Jacobsen, Jens Christian et al. "A model of smooth muscle cell synchronization in the arterial wall.". American Journal of Physiology: Heart and Circulatory Physiology. 2007, 293(1). H229-H237.

Vancouver

Jacobsen JC, Aalkjær C, Nilsson H, Matchkov V, Freiberg J, Holstein-Rathlou N-H. A model of smooth muscle cell synchronization in the arterial wall. American Journal of Physiology: Heart and Circulatory Physiology. 2007;293(1):H229-H237.

Author

Jacobsen, Jens Christian ; Aalkjær, Christian ; Nilsson, Holger et al. / A model of smooth muscle cell synchronization in the arterial wall. In: American Journal of Physiology: Heart and Circulatory Physiology. 2007 ; Vol. 293, No. 1. pp. H229-H237.

Bibtex

@article{a76a60001d8311dcbee902004c4f4f50,
title = "A model of smooth muscle cell synchronization in the arterial wall.",
abstract = "Vasomotion is a rhythmic variation in microvascular diameter. Although known for more than 150 years, the cellular processes underlying initiation of vasomotion are not fully understood. In the present study a model of a single cell is extended by coupling a number of cells into a tube. The simulated results point to a permissive role of cyclic guanosine monophosphate (cGMP) in establishing intercellular synchronization. In sufficient concentration, cGMP may activate a cGMP-sensitive calcium-dependent chloride channel causing a tight spatio-temporal coupling between release of sarcoplasmic reticulum (SR) calcium, membrane depolarization and influx of extra-cellular calcium. Low [cGMP] is associated only with unsynchronized waves. At intermediate concentrations, cells display either waves or whole-cell oscillations, but these remain unsynchronized between cells. Whole-cell oscillations are associated with rhythmic variation in membrane potential and flow of current through gap junctions. The amplitude of these oscillations in potential grows with increasing [cGMP], and, past a certain threshold, they become strong enough to entrain all cells in the vascular wall, thereby initiating sustained vasomotion. In this state there is a rhythmic flow of calcium through voltage-sensitive calcium channels into the cytoplasm, making the frequency of established vasomotion sensitive to membrane potential. It is concluded that electrical coupling through gap junctions is likely to be responsible for the rapid synchronization across a large number of cells. Gap-junctional current between cells is due to the appearance of oscillations in the membrane potential which again depend on the entrainment of SR and plasma membrane within the individual cell. Key words: Vasomotion, Mathematical model, Chloride channel, Gap-junctions, Synchronization.",
author = "Jacobsen, {Jens Christian} and Christian Aalkj{\ae}r and Holger Nilsson and Vladimir Matchkov and Jacob Freiberg and Niels-Henrik Holstein-Rathlou",
year = "2007",
language = "English",
volume = "293",
pages = "H229--H237",
journal = "American Journal of Physiology: Heart and Circulatory Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "1",

}

RIS

TY - JOUR

T1 - A model of smooth muscle cell synchronization in the arterial wall.

AU - Jacobsen, Jens Christian

AU - Aalkjær, Christian

AU - Nilsson, Holger

AU - Matchkov, Vladimir

AU - Freiberg, Jacob

AU - Holstein-Rathlou, Niels-Henrik

PY - 2007

Y1 - 2007

N2 - Vasomotion is a rhythmic variation in microvascular diameter. Although known for more than 150 years, the cellular processes underlying initiation of vasomotion are not fully understood. In the present study a model of a single cell is extended by coupling a number of cells into a tube. The simulated results point to a permissive role of cyclic guanosine monophosphate (cGMP) in establishing intercellular synchronization. In sufficient concentration, cGMP may activate a cGMP-sensitive calcium-dependent chloride channel causing a tight spatio-temporal coupling between release of sarcoplasmic reticulum (SR) calcium, membrane depolarization and influx of extra-cellular calcium. Low [cGMP] is associated only with unsynchronized waves. At intermediate concentrations, cells display either waves or whole-cell oscillations, but these remain unsynchronized between cells. Whole-cell oscillations are associated with rhythmic variation in membrane potential and flow of current through gap junctions. The amplitude of these oscillations in potential grows with increasing [cGMP], and, past a certain threshold, they become strong enough to entrain all cells in the vascular wall, thereby initiating sustained vasomotion. In this state there is a rhythmic flow of calcium through voltage-sensitive calcium channels into the cytoplasm, making the frequency of established vasomotion sensitive to membrane potential. It is concluded that electrical coupling through gap junctions is likely to be responsible for the rapid synchronization across a large number of cells. Gap-junctional current between cells is due to the appearance of oscillations in the membrane potential which again depend on the entrainment of SR and plasma membrane within the individual cell. Key words: Vasomotion, Mathematical model, Chloride channel, Gap-junctions, Synchronization.

AB - Vasomotion is a rhythmic variation in microvascular diameter. Although known for more than 150 years, the cellular processes underlying initiation of vasomotion are not fully understood. In the present study a model of a single cell is extended by coupling a number of cells into a tube. The simulated results point to a permissive role of cyclic guanosine monophosphate (cGMP) in establishing intercellular synchronization. In sufficient concentration, cGMP may activate a cGMP-sensitive calcium-dependent chloride channel causing a tight spatio-temporal coupling between release of sarcoplasmic reticulum (SR) calcium, membrane depolarization and influx of extra-cellular calcium. Low [cGMP] is associated only with unsynchronized waves. At intermediate concentrations, cells display either waves or whole-cell oscillations, but these remain unsynchronized between cells. Whole-cell oscillations are associated with rhythmic variation in membrane potential and flow of current through gap junctions. The amplitude of these oscillations in potential grows with increasing [cGMP], and, past a certain threshold, they become strong enough to entrain all cells in the vascular wall, thereby initiating sustained vasomotion. In this state there is a rhythmic flow of calcium through voltage-sensitive calcium channels into the cytoplasm, making the frequency of established vasomotion sensitive to membrane potential. It is concluded that electrical coupling through gap junctions is likely to be responsible for the rapid synchronization across a large number of cells. Gap-junctional current between cells is due to the appearance of oscillations in the membrane potential which again depend on the entrainment of SR and plasma membrane within the individual cell. Key words: Vasomotion, Mathematical model, Chloride channel, Gap-junctions, Synchronization.

M3 - Journal article

VL - 293

SP - H229-H237

JO - American Journal of Physiology: Heart and Circulatory Physiology

JF - American Journal of Physiology: Heart and Circulatory Physiology

SN - 0363-6135

IS - 1

ER -