Research output per year
Research output per year
- 1 - 50 out of 101 results
Search results
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2024
Markers of Mitochondrial Function and DNA Repair Associated with Physical Function in Centenarians
Sanchez-Roman, I., Ferrando, B., Myrup Holst, C., Mengel-From, J., Hoei Rasmussen, S., Thinggaard, M., Bohr, V. A., Christensen, K. & Stevnsner, T., Aug 2024, In: Biomolecules. 14, 8, 909.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
2023
Bowhead NEIL1: molecular cloning, characterization, and enzymatic properties
Holm, S., Larsen, R. M., Holst, C. M., Heide-Jørgensen, M. P., Steffensen, J. F., Stevnsner, T. & Larsen, K., Mar 2023, In: Biochimie. 206, p. 136-149 14 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access2 Citations (Scopus) -
Phosphorylation of the Human DNA Glycosylase NEIL2 Is Affected by Oxidative Stress and Modulates Its Activity
Myrup Holst, C., Brøndum Andersen, N., Thinggaard, V., Tilken, M., Lautrup, S., Tesauro, C. & Stevnsner, T., Feb 2023, In: Antioxidants. 12, 2, 20 p., 355.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access1 Citation (Scopus) -
The role of aging and brain-derived neurotrophic factor signaling in expression of base excision repair genes in the human brain
Lautrup, S., Myrup Holst, C., Yde, A., Asmussen, S., Thinggaard, V., Larsen, K., Laursen, L. S., Richner, M., Vaegter, C. B., Prieto, G. A., Berchtold, N., Cotman, C. W. & Stevnsner, T., Sept 2023, In: Aging Cell. 22, 9, 20 p., e13905.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access2 Citations (Scopus) -
2022
Measuring the Activity of DNA Repair Enzymes in Isolated Mitochondria
Ferrando, B., Møller, I. M. & Stevnsner, T., 2022, Plant Mitochondria. New York: Humana Press, p. 321-334 (Methods in Molecular Biology, Vol. 2363).Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
2 Citations (Scopus) -
Molecular markers associated with cognitive impairment in centenarians
Stevnsner, T. & Sanchez-Roman, I., May 2022, In: Aging. 14, 10, p. 4191-4192 2 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Editorial › peer-review
Open Access1 Citation (Scopus) -
Molecular markers of DNA repair and brain metabolism correlate with cognition in centenarians
Sanchez-Roman, I., Ferrando, B., Holst, C. M., Mengel-From, J., Rasmussen, S. H., Thinggaard, M., Bohr, V. A., Christensen, K. & Stevnsner, T., 2022, In: GeroScience. 44, 1, p. 103-125 23 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access13 Citations (Scopus) -
New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary
Schmauck-Medina, T., Molière, A., Lautrup, S., Zhang, J., Chlopicki, S., Madsen, H. B., Cao, S., Soendenbroe, C., Mansell, E., Vestergaard, M. B., Li, Z., Shiloh, Y., Opresko, P. L., Egly, J. M., Kirkwood, T., Verdin, E., Bohr, V. A., Cox, L. S., Stevnsner, T. & Rasmussen, L. J. & 1 others, , Aug 2022, In: Aging. 14, 16, p. 6829-6839 11 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile169 Citations (Scopus)31 Downloads (Pure) -
2021
Epigenetik: Hvordan små metylgrupper kan påvirke vores aldring
Asmussen, S. E., Sørensen, M. & Stevnsner, T. V., Dec 2021, In: Aktuel Naturvidenskab. 6, p. 18-22Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients
Farup, J., Just, J., de Paoli, F., Lin, L., Jensen, J. B., Billeskov, T., Roman, I. S., Cömert, C., Møller, A. B., Madaro, L., Groppa, E., Fred, R. G., Kampmann, U., Gormsen, L. C., Pedersen, S. B., Bross, P., Stevnsner, T., Eldrup, N., Pers, T. H. & Rossi, F. M. V. & 2 others, , Nov 2021, In: Cell Metabolism. 33, 11, p. 2201-2214.e10 25 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access58 Citations (Scopus) -
2020
Endothelin-1 induces a strong pressor effect in ball pythons (Python regius)
Jensen, M. F., Nedergaard, S., Nielsen, H. N., Skovgaard, N., Stevnsner, T. V. & Wang, T., Mar 2020, In: Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology. 241, 110620.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
1 Citation (Scopus) -
2019
DNA repair in plant mitochondria - a complete base excision repair pathway in potato tuber mitochondria
Ferrando, B., Furlanetto, A. L. D. M., Gredilla, R., Havelund, J. F., Hebelstrup, K. H., Møller, I. M. & Stevnsner, T., Jun 2019, In: Physiologia Plantarum. 166, 2, p. 494-512 19 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
18 Citations (Scopus) -
Short-term high temperature treatment reduces viability and inhibits respiration and DNA repair enzymes in Araucaria angustifolia cells
Furlanetto, A. L. D. M., Cadena, S. M. S. C., Martinez, G. R., Ferrando, B., Stevnsner, T. & Møller, I. M., Jun 2019, In: Physiologia Plantarum. 166, 2, p. 513-524 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
7 Citations (Scopus) -
Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases
Lautrup, S., Caponio, D., Cheung, H. H., Piccoli, C., Stevnsner, T., Chan, W. Y. & Fang, E. F., Jun 2019, In: Biogerontology. 20, 3, p. 255-269 15 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
23 Citations (Scopus) -
2018
NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
Hou, Y., Lautrup, S., Cordonnier, S., Wang, Y., Croteau, D. L., Zavala, E., Zhang, Y., Moritoh, K., O'Connell, J. F., Baptiste, B. A., Stevnsner, T. V., Mattson, M. P. & Bohr, V. A., 20 Feb 2018, In: Proceedings of the National Academy of Sciences (PNAS). 115, 8, p. E1876-E1885 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile329 Citations (Scopus)316 Downloads (Pure) -
Two Cockayne Syndrome patients with a novel splice site mutation – clinical and metabolic analyses
Sanchez-Roman, I., Lautrup, S., Aamann, M. D., Neilan, E. G., Østergaard, J. R. & Stevnsner, T., Oct 2018, In: Mechanisms of Ageing and Development. 175, p. 7-16 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
7 Citations (Scopus) -
2017
Base Excision Repair in Aging
Gredilla, R., Bohr, V. A. & Stevnsner, T. V., Jan 2017, The Base Excision Repair Pathway: Molecular Mechanisms and Role in Disease Development and Therapeutic Design. Wilson III, D. M. (ed.). World Scientific, p. 773-803 31 p.Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
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Isolation of functional mitochondria by inertial microfluidics - a new method to sort intracellular organelles from a small scale biological sample
Tesauro, C., Ferrando, B., Ma, X., Jepsen, M. L., Ivarsen, A. K., Frohlich, R., Stevnsner, T., Knudsen, B. R. & Ho, Y. P., 3 May 2017, In: R S C Advances. 7, 38, p. 23735-23741 7 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile10 Citations (Scopus)226 Downloads (Pure) -
Mitophagy in neurodegeneration and aging
Fivenson, E. M., Lautrup, S., Sun, N., Scheibye-Knudsen, M., Stevnsner, T., Nilsen, H., Bohr, V. A. & Fang, E. F., Oct 2017, In: Neurochemistry International. 109, p. 202-209 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
290 Citations (Scopus) -
Role of Estrogen and Other Sex Hormones i Brain Aging. Neuroprotection and DNA Repair
Zárate, S., Stevnsner, T. V. & Gredilla, R., 22 Dec 2017, In: Frontiers in Aging Neuroscience. 9, DEC, 22 p., 430.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open AccessFile198 Citations (Scopus)309 Downloads (Pure) -
2016
Aldring og død
Stevnsner, T. V., 2016, Evolutionsbiologiske milepæle. Finster, K., Wang, T., Borchsenius, F. & Christiansen, F. B. (eds.). 1 ed. Aarhus Universitetsforlag, p. 199-211 13 p.Research output: Contribution to book/anthology/report/proceeding › Book chapter › Education
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The Caenorhabditis elegans Werner syndrome protein participates in DNA damage checkpoint and DNA repair in response to CPT-induced double-strand breaks
Hyun, M., Choi, S., Stevnsner, T. & Ahn, B., 2016, In: Cellular Signalling. 28, 3, p. 214-223 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
8 Citations (Scopus) -
Unilateral ureteral obstruction induces DNA repair by APE1
Aamann, M. D., Norregaard, R., Kristensen, M. L. V., Stevnsner, T. & Frøkiær, J., 2016, In: American Journal of Physiology: Renal Physiology. 310, 8, p. F763-F776 14 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
4 Citations (Scopus) -
2015
Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance
Maynard, S., Keijzers, G., Hansen, A.-M., Osler, M., Molbo, D., Bendix, L., Møller, P., Loft, S., Moreno-Villanueva, M., Bürkle, A., Hvitby, C. P., Schurman, S. H., Stevnsner, T., Rasmussen, L. J., Avlund, K. & Bohr, V. A., Jan 2015, In: Acta Physiologica (Print). 213, 1, p. 156-170 15 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
27 Citations (Scopus) -
Association study of FOXO3A SNPs and aging phenotypes in Danish oldest-old individuals
Soerensen, M., Nygaard, M., Dato, S., Stevnsner, T., Bohr, V., Christensen, K. & Christiansen, L., Feb 2015, In: Aging Cell. 14, 1, p. 60-66 7 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
39 Citations (Scopus) -
Nobelprisen i kemi 2015: Når Kroppen reparerer DNA
Lautrup, S. H., Stevnsner, T. V., Dahlgaard, J. (Editor) & Kjaer, C. R. (Editor), Dec 2015, In: Aktuel Naturvidenskab. 6, p. 28-33 6 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Communication
Open Access -
Regulation of the human Suv3 helicase on DNA by inorganic cofactors
Venø, S. T., Witt, M. B., Kulikowicz, T., Bohr, V. A. & Stevnsner, T., Jan 2015, In: Biochimie. 108, p. 160-168 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
1 Citation (Scopus) -
Werner syndrome: Association of premature aging and cancer predisposition
Ahn, B., Stevnsner, T. & Bohr, V. A., 2015, Molecular Oncology: Causes of Cancer and Targets for Treatment. Gelmann, E. P., Sawyers , C. L. & Rauscher, III , F. J. (eds.). Cambridge University Press, p. 423-433 11 p.Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
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2014
Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity
Aamann, M. D., Hvitby, C. P., Popuri, V., Muftuoglu, M., Lemminger, L. P. B., K. Skeby , C., Keijzers, G., Ahn, B., Bjørås , M., Bohr, V. & Stevnsner, T. V., Jan 2014, In: Mechanisms of Ageing and Development. 135, p. 1-14 14 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
39 Citations (Scopus) -
Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis
Debrabant, B., Soerensen, M., Flachsbart, F., Dato, S., Mengel-From, J., Stevnsner, T., Bohr, V. A., Kruse, T. A., Schreiber, S., Nebel, A., Christensen, K., Tan, Q. & Christiansen, L., 12 Feb 2014, In: European Journal of Human Genetics. 22, p. 1131-1136 6 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
26 Citations (Scopus) -
Hvorfor ældes vi? -når vores molekyler gør os gamle
Stevnsner, T. V., 28 Apr 2014, 25 søforklaringer : naturvidenskabelige fortællinger fra Søauditorierne. Rabæk Kjaer, C. (ed.). Aarhus Universitetsforlag, p. 336-347Research output: Contribution to book/anthology/report/proceeding › Book chapter › Communication
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2013
Age and gender effects on DNA strand break repair in peripheral blood mononuclear cells
Garm, C., Moreno-Villanueva, M., Bürkle, A., Petersen, I., Bohr, V. A., Christensen, K. & Stevnsner, T. V., Feb 2013, In: Aging Cell. 12, 1, p. 56-66 16 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
81 Citations (Scopus) -
Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity
Soerensen, M., Dato, S., Tan, Q., Thinggaard, M., Kleindorp, R., Beekman, M., Suchiman, H. E. D., Jacobsen, R., McGue, M., Stevnsner, T., Bohr, V. A., de Craen, A. J. M., Westendorp, R. G. J., Schreiber, S., Slagboom, P. E., Nebel, A., Vaupel, J. W., Christensen, K. & Christiansen, L., 2013, In: Age (Omaha). 35, 2, p. 487-500 13 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
69 Citations (Scopus) -
Genetic and environmental influence on DNA strand break repair: a twin study
Garm, C., Moreno-Villanueva, M., Bürkle, A., Larsen, L. A., Bohr, V. A., Christensen, K. & Stevnsner, T. V., Jul 2013, In: Environmental and Molecular Mutagenesis. 54, 6, p. 414-420 6 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
16 Citations (Scopus) -
Multiple interaction partners for Cockayne syndrome proteins: Implications for genome and transcriptome maintenance
Aamann, M. D., Muftuoglu, M., Bohr, V. A. & Stevnsner, T., May 2013, In: Mechanisms of Ageing and Development. 134, 5-6, p. 212-224 13 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
30 Citations (Scopus) -
Regulatory interplay of Cockayne syndrome B ATPase and stress-response gene ATF3 following genotoxic stress
Kristensen, H.-U. S., Epanchintsev, A., Rauschendorf, M.-A., Laugel, V., Stevnsner, T., Bohr, V. A., Coin, F. & Egly, J.-M., 18 Jun 2013, In: Proceedings of the National Academy of Sciences (PNAS). 110, 25, p. 2261-2270 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
46 Citations (Scopus) -
Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells
Maynard, S., Keijzers, G., Gram, M., Desler, C., Bendix, L., Budtz-Jørgensen, E., Molbo, D., Croteau, D. L., Osler, M., Stevnsner, T., Rasmussen, L. J., Dela, F., Avlund, K. & Bohr, V., 11 Nov 2013, In: Nature Communications. 5, 11, p. 850-864 15 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
39 Citations (Scopus) -
2012
Cancer and Longevity-Is There a Trade-off? A Study of Cooccurrence in Danish Twin Pairs Born 1900-1918
Christensen, K., Pedersen, J. K., Hjelmborg, J. V. B., Vaupel, J. W., Stevnsner, T. V., Holm, N. V. & Skytthe, A., May 2012, In: The Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 67A, 5, p. 489-494 6 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
11 Citations (Scopus) -
Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis
Sørensen, M., Thinggaard, M., Nygaard, M., Dato, S., Tan, Q., Hjelmborg, J., Andersen-Ranberg, K., Stevnsner, T. V., Bohr, V., Kimura, M., Aviv, A., Christensen, K. & Christiansen, L., Apr 2012, In: Aging Cell. 11, 2Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
98 Citations (Scopus) -
Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies
Soerensen, M., Dato, S., Tan, Q., Thinggaard, M., Kleindorp, R., Beekman, M., Jacobsen, R., Suchiman, H. E. D., de Craen, A. J. M., Westendorp, R. G. J., Schreiber, S., Stevnsner, T., Bohr, V. A., Slagboom, P. E., Nebel, A., Vaupel, J. W., Christensen, K., McGue, M. & Christiansen, L., May 2012, In: Experimental Gerontology. 47, 5, p. 379-387 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
65 Citations (Scopus) -
Mitochondrial base excision repair assays
Gredilla, R. & Stevnsner, T., 2012, Methods in Molecular Biology : DNA Repair Protocols. Bjergbæk, L. (ed.). Humana Press, Vol. 920. p. 289-304 16 p. (Methods in Molecular Biology).Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
10 Citations (Scopus) -
Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer's disease
Diaz, R. G., Weissman, L., Yang, J., Bohr, V. & Stevnsner, T. V., 2012, In: Neurobiology of Aging. 33, 4, p. 694-707Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
32 Citations (Scopus) -
Nuclear and mitochondrial DNA repair in selected eukaryotic aging model systems
Gredilla, R., Garm, C. & Stevnsner, T., 2012, In: Oxidative Medicine and Cellular Longevity. 2012, 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
32 Citations (Scopus) -
2011
DNA repair deficiency in neurodegeneration
Jeppesen, D. K., Bohr, V. & Stevnsner, T. V., Apr 2011, In: Progress in Neurobiology. 30, 94, p. 166-200Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
272 Citations (Scopus) -
The Human Suv3 Helicase Interacts with Replication Protein A and Flap Endonuclease 1 in the Nucleus.
Venø, S. T., Kulikowicz, T., Pestana, C., Stepien, P., Stevnsner, T. V. & Bohr, V., 2011, In: Biochemical Journal.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
18 Citations (Scopus) -
WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-IDNA covalent complexes
Patro, B. S., Hougaard, R. F., Bohr, V. & Stevnsner, T. V., 2011, In: Journal of Cell Science. 124, p. 3967-3979Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
42 Citations (Scopus) -
WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes
Patro, B. S., Frøhlich, R., Bohr, V. A. & Stevnsner, T., 1 Dec 2011, In: Journal of Cell Science. 124, 23, p. 3967-3979 13 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
42 Citations (Scopus) -
2010
Cockayne Syndrome group B protein promotes mtDNA stability by maintaining the BER association with the mitochondrial membrane
Aamann, M. A. D., Sørensen, M., Hvitby, C. P., Bergquist, B., Muftuoglu, M., Tian, J., de Souza-Pinto, N. C., Scheibye-Knudsen, M., Wilson III, D. M., Stevnsner, T. V. & Bohr, V., 2010, In: F A S E B Journal. 24, 7, p. 2334-46Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
122 Citations (Scopus) -
Differential age-related changes in mitochondrial DNA repair activities in mouse brain regions
Gredilla, R., Garm, C., Holm, R., Bohr, V. A. & Stevnsner, T., 2010, In: Neurobiology of Aging. 31, 6, p. 993-1002 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
51 Citations (Scopus) -
Mitochondrial DNA repair and association with aging- an update
Diaz, R. G., Bohr, V. & Stevnsner, T. V., Aug 2010, In: Experimental Gerontology. 45, 7-8Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
123 Citations (Scopus)