Projects per year
Personal profile
Research
Aarhus University hosts a worldwide unique exposure facility equipped and staffed for human exposures. I’m heading this core facility, where we study environmental exposures to gases O3 CO2 and PM from indoor and outdoor air pollution with and without O3. and different organic compounds like house dust farm. These studies have included front-line methods for exposures as well as effect-outcomes and encompassed monitoring the heart, lungs incl exhaled breath, nasal volume and inflammatory markers, blood, urine, eyes, and skin. The outcomes span molecular-, cellular-, metabolomic- and inflammatory markers.
Since the outset, my studies have been focusing on individual susceptibility with a focus on atopy and gender as risk factors. My group found a lower risk of atopic sensitization in Danish farming students in the SUS-study. Later we were able to show, that this protective effect was mediated through farm upbringing. In a follow up study, we could show that the effect of farm upbringing lasts into adulthood.
My interest in gene environmental interaction (G*E) was sparked with the finding, that heterozygotes for rare Z-allele of -1-antitrypsin (A1A) had a higher risk of byssinosis among cotton workers and for bronchial responsiveness (BHR) in the SUS study of young farmers where we, as the first group, were able to demonstrate a G*E interaction between A1A and farm-exposure for BHR.
Since late nineties, I started to study bigger cohorts within the Danish twin registry and the ECRHS. Here the focus broadened from respiratory diseases to NCDs and negative birth outcomes. This was truly the consequences of moving to effects of drinking water green space, and air pollution working with the CIRRAU center, the Danish Blood donor study The ELAPSE study, and the entire population in the BERTHA Project.
Profile
I study respiratory diseases, other non-communicable diseases and negative birth outcomes in several Danish cohorts. These cohorts includes collaboration with the Glostrup cohorts, the Danish twin registry, the European Lung study (ECRHS) the Danish Blood donor study and the Cancer Registry. I am studying the health effects of environmental exposures including drinking water, air pollution, green- blue space, allergens, thr microbiome Indoor and outdoor, pesticides and noise on the entire population via CIRRAU in the BERTHA Project. In the cohort studies I also investigate gene environmental interaction (G*E).
I’m heading the core facility for human exposure studies, where we study the effects of environmental exposures to gases O3, CO2 and PM from indoor and outdoor air pollution together with colleagues from the aerosol network at AU. These studies include front-line methods for exposures as well as effect-outcomes and encompassed monitoring of the heart, lungs and inflammatory markers. The outcomes span molecular-, cellular-, metabolome- and inflammatory markers.
Cooperation and dissemination
I have a very broad field of collaboration within AU, Denmark as well as internationally.
My main collaboration partners are CIRRAU iClimate and the Departments of: Psychology, Microbiology, Chemistry, Construction and Building Design as well as Bio- and Chemical Technology. At AUH these are the Immunological, Cardiological, Neurological, Pediatric & Occupational Medicine departments
In addition, I have collaboration with DTU, KU, SDU, in connection with collaboration on larger cohorts
Internationally, I am in contact via international collaboration projects such as ECRHS, Nordic Welfair, ELAPSE as well as several EU studies, either directly or in an advisory function.
Teaching
I teach Public Health at the Medical School, and Environment and Health at the Public Health School.
I am the program director for the PhD program in Public Health
Keywords
- Work-related illnesses
- Allergy
- Asthma
- Indoor air
- Respiratory diseases
- Lungs
- Microorganisms
- Extrinsic allergic alveolitis
- Toxic pneumonitis
- Working environment
- Immune system
- Allergy
- Air pollution
- asthma
- Lungs
- Allergy
- Asthma
- Gene environment interaction
- Microorganisms
- TOLL like receptors
- Human exposure (human vulnerability)
- Climate and health
- Pollen forecasts
- Astma
- Environmental toxicology
- Risk and health
Areas of expertise
- Environmental medicine
- Climate and pollution interaction
- Environmental epidemiology
- Gene- environmental interaction
- Toxicology
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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LowAs: LowAs: Health effects of long-term low-level drinking water arsenic exposure
Schullehner, J. (PI) & Sigsgaard, T. (PI)
Independent Research Fund Denmark
01/09/2023 → 31/08/2026
Project: Research
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MARCHES: Methodologies for Assessing the Real Costs to Health of Environmental Stressors
Andersen, M. S. (PI), Geels, C. (Participant), Jensen, S. S. (Participant), Schullehner, J. (Participant), Frohn, L. (Participant), Panduro, T. E. (Participant), Brandt, J. (Participant), Christensen, J. H. (Participant), Massenberg, J. R. (Participant) & Sigsgaard, T. (Participant)
01/01/2023 → 31/12/2026
Project: Research
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Central Processing of Odour Stimuli in Patients With Functional Somatic Disorder or MCS Compared to Healthy Controls
Gormsen, L. K. (PI), Haghshenas Bilehsavar, S. (Project manager), Sigsgaard, T. (Participant), Ovesen, T. (Participant), Møller, A. (Participant) & Fink, P. (Participant)
01/09/2020 → 31/07/2025
Project: Research
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BERTHA: BERTHA - Big Data Centre for Environment and Health
Sigsgaard, T. (PI), Schlünssen, V. (Participant), Sabel, C. E. (PI), Pedersen, C. B. (PI), Erikstrup, C. (PI) & Hertel, O. (PI)
01/03/2018 → …
Project: Research
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BE-READY
Elholm, G. (Project manager), Gabel, C. (Collaborator), Sigsgaard, T. (Award holder), Petersen, S. (Collaborator) & Rasmussen, M. K. (Collaborator)
05/01/2015 → …
Project: Research
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Artificial Intelligence in Asthma Health Literacy: A Comparative Analysis of ChatGPT versus Gemini
Høj, S., Backer, V., Ulrik, C. S., Sigsgaard, T. & Meteran, H., 21 Apr 2025, (E-pub / Early view) In: Journal of Asthma. p. 1-10 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Assessment of information quality in the largest Danish Facebook group on atopic diseases: a mixed bag of help and harm
Høj, S., Thomsen, S. F., Meteran, H., Sigsgaard, T. & Meteran, H., Jan 2025, In: Frontiers in Allergy. 5, 4 p., 1378383.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Associations of parental air pollution and greenness exposures with offspring asthma outcomes
Sinsamala, R. M., Marcon, A., Bertelsen, R. J., Accordini, S., Brandt, J., Frohn, L. M., Geels, C., Gislason, T., Holm, M., Janson, C., Malinovschi, A., Markevych, I., Orru, H., Oudin, A., Real, F. G., Sigsgaard, T., Skulstad, S. M., Svanes, C. & Johannessen, A., 1 Jun 2025, In: Environmental Research. 274, 11 p., 121328.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
A systematic review of the relation between ten potential occupational sensitizing exposures and asthma
Dalbøge, A., Kolstad, H. A., Jahn, A., Ulrik, C. S., Sherson, D. L., Meyer, H. W., Ebbehøj, N., Sigsgaard, T., Baur, X. & Schlünssen, V., 10 Mar 2025, (E-pub / Early view) In: Scandinavian Journal of Work, Environment & Health.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
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Long-term exposure to air pollution and greenness in association with respiratory emergency room visits and hospitalizations: The Life-GAP project
Xu, S., Marcon, A., Bertelsen, R. J., Benediktsdottir, B., Brandt, J., Frohn, L. M., Geels, C., Gislason, T., Heinrich, J., Holm, M., Janson, C., Markevych, I., Modig, L., Orru, H., Schlünssen, V., Sigsgaard, T. & Johannessen, A., 1 Apr 2025, In: Environmental Research. 270, 120938.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access1 Citation (Scopus)
Activities
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Modelling health impacts and external costs of air pollution – the EVA model system
Jensen, S. S. (Lecturer), Brandt, J. (Other), Geels, C. (Other), Frohn, L. M. (Other), Christensen, J. H. (Other), Im, U. (Other), Ketzel, M. (Other), Hansen, K. M. (Other), Hertel, O. (Other), Ellermann, T. (Other), Nielsen, O.-K. (Other), Plejdrup, M. S. (Other), Bønløkke, J. H. (Other), Sigsgaard, T. (Other) & Andersen, M. S. (Other)
17 Dec 2018Activity: Presentations, memberships, employment, ownership and other activities › Lecture and oral contribution
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The first high resolution integrated assessment of air pollution and related health impacts across the Nordic region
Geels, C. (Lecturer), Andersen, M. S. (Lecturer), Christensen, J. H. (Lecturer), Im, U. (Lecturer), Jensen, A. (Lecturer), Nielsen, O.-K. (Lecturer), Plejdrup, M. S. (Lecturer), Pedersen, C. B. (Lecturer), Sigsgaard, T. (Lecturer) & Brandt, J. (Lecturer)
14 May 2018Activity: Presentations, memberships, employment, ownership and other activities › Lecture and oral contribution
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Helbredsomkostninger af luftforurening fra brænderøg og dens geografi
Jensen, S. S. (Lecturer), Brandt, J. (Other), Christensen, J. H. (Other), Geels, C. (Other), Nielsen, O.-K. (Other), Plejdrup, M. S. (Other), Ellermann, T. (Other), Andersen, M. S. (Other) & Sigsgaard, T. (Other)
2018Activity: Presentations, memberships, employment, ownership and other activities › Lecture and oral contribution
File -
FARMING AND HEALTH -25 YEARS OF RESEARCH
Jensen, S. S. (Participant), Brandt, J. (Participant), Bønløkke, J. H. (Participant), Christensen, J. H. (Participant), Ellermann, T. (Participant), Hansen, K. M. (Participant), Nielsen, O.-K. (Participant), Plejdrup, M. S. (Participant), Sigsgaard, T. (Participant) & Geels, C. (Participant)
26 Nov 2017 → 28 Nov 2017Activity: Participating in or organising an event types › Participation in or organisation af a conference
File -
Atmospheric Ammonia, ammonium and incident of asthma – A nationwide case-control study in Danish preschool children
Holst, G. (Lecturer), Thygesen, M. (Other), Pedersen, C. B. (Other), Peel, R. G. (Other), Brandt, J. (Other), Christensen, J. H. (Other), Bønløkke, J. (Other), Hertel, O. (Other) & Sigsgaard, T. (Other)
2017Activity: Presentations, memberships, employment, ownership and other activities › Lecture and oral contribution
Prizes
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Best Environmental Epidemiology Paper (co) 2022
Sigsgaard, T. (Recipient), Sept 2023
Prize: Prizes, scholarships, distinctions
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Danmarks Lungeforening Best Paper 2019
Timm, S. (Recipient), Sigsgaard, T. (Recipient) & Schlünssen, V. (Recipient), 2019
Prize: Prizes, scholarships, distinctions
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European Respiratory Society, Setvice Award
Sigsgaard, T. (Recipient), Sept 2011
Prize: Prizes, scholarships, distinctions
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Press/Media
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Tændte stearinlys og os fra madlavning er skadeligt ved selv mild astma
Rosenkilde Laursen, K. & Sigsgaard, T.
31/08/2023
1 Media contribution
Press/Media: Press / Media
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Passive Vape Exposure From E-Cigarettes Linked to Acute Health Effects in COPD
Rosenkilde Laursen, K., Bønløkke, J. H., Bendstrup, E., Bilde, M., Glasius, M., Gutzke, V. H., Puthukkadan Moosakutty, S., Olin, A.-C., Ravn, P., Østergaard, K. & Sigsgaard, T.
24/02/2021
1 item of Media coverage
Press/Media: Press / Media
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Forsøg med stegt flæsk og stearinlys skal gøre os klogere på partikelforurening i hjemmet
Rosenkilde Laursen, K. & Sigsgaard, T.
04/11/2019
1 item of Media coverage
Press/Media: Press / Media