Research output per year
Research output per year
- 44 results
Search results
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2025
Abstract B024: Advancing precision medicine: A prospective feasibility study integrating ex vivo drug testing and genomic profiling to improve outcomes in children and adults with advanced cancers
Ipsen, M. B., Skjøtt, M. E., Arshadi, A., Poulsen, S. B., Carstensen, R. T., Elbæk, K. J., Korshoej, A. R., B., E. L., Sædder, E. A., Larsen, O. H., Mikkelsen, T. S., Thorsen, K., Thomsen, M. K. & Rusan, M., 1 Mar 2025, In: Cancer Research. 85, 5 supplement, B024.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
An overview of the European standard clinical practice recommendations for choroid plexus tumours
King, D., Bison, B., Cruz, O., Faria, C. C., Filipek, I., Finlay, J. L., Garami, M., Kordes, U. R., Löbel, U., Maclean, J., Mikkelsen, T. S., Obrecht-Sturm, D., Solanki, G., Thomas, C., Timmerman, B., Zapotocky, M. & Adamski, J., Jun 2025, In: EJC Paediatric Oncology. 5, 100226.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open Access -
Hemophilia B Leyden: characteristics and natural history in the International Pediatric Network of Hemophilia Management Registry
Pediatric Network on Hemophilia Management (PedNet) Study Group, Mar 2025, In: Journal of Thrombosis and Haemostasis. 23, 3, p. 921-927 7 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Relapse and survival after relapse among children with cancer in Denmark: 2001–2021
Andersen, M. M., Sørensen, M. C. L., Schmiegelow, K., Sehested, A. M., Rostgaard, K., Olsen, M., Mikkelsen, T. S., Wehner, P. S., Hjalgrim, L. L. & Søegaard, S. H., Jan 2025, In: Pediatric Blood and Cancer. 72, 1, e31384.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
2024
A case of platelet δ-granule defect identified by decreased CD63 expression and decreased serotonin release measured by flow cytometry and liquid chromatography tandem mass spectrometry
Nissen, P. H., Mikkelsen, T. S., Højskov, C. S. & Højbjerg, J. A., Feb 2024, In: Scandinavian Journal of Clinical and Laboratory Investigation. 84, 1, p. 68-70 3 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Letter › peer-review
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Access to Methotrexate Monitoring in Latin America: A Multicountry Survey of Supportive Care Capacity
Villanueva, G., Lowe, J., Tentoni, N., Taluja, A., Villarroel, M., Narváez, C. E., León, S. A., Valencia Libreros, D. L., Gonzalez Suárez, N., Mikkelsen, T. S. & Howard, S. C., 2024, In: Pediatric Hematology and Oncology. 41, 2, p. 135-149 15 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access3 Citations (Scopus) -
Bleeding phenotype according to factor level in 825 children with nonsevere hemophilia: data from the PedNet cohort
de Kovel, M. S., Escuriola-Ettingshausen, C., Königs, C., Ranta, S., Fischer, K. & PedNet study group, Sept 2024, In: Journal of Thrombosis and Haemostasis. 22, 9, p. 2460-2469 10 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
3 Citations (Scopus) -
Determinants of bleeding before and during immune tolerance in 222 boys with severe hemophilia A and inhibitors >5 BU
Fischer, K., Kenet, G., Kurnik, K., Carcao, M., Oldenburg, J., Stamm-Mikkelsen, T., Haro, A. R. C., Koskenvuo, M., Blatny, J., Königs, C. & PedNet study group, Jan 2024, In: Blood Advances. 8, 2, p. 369-377 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
2 Citations (Scopus) -
Factor VIII genotype and the risk of developing high-responding or low-responding inhibitors in severe hemophilia A: data from the PedNet Hemophilia Cohort of 1,202 children
Andersson, N. G., Labarque, V., Kartal-Kaess, M., Pinto, F., Mikkelsen, T. S. & Ljung, R., Apr 2024, In: Haematologica. 109, 4, p. 1293-1296 4 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Letter › peer-review
Open Access2 Citations (Scopus) -
Novel germline TP53 variant (p.(Phe109Ile)) confers high risk of cancer
Byrjalsen, A., Stoltze, U. K., Lautrup, C., Christensen, L. L., Mikkelsen, T., Hjalgrim, L., Brok, J. S., Dahl, C., Schmiegelow, K., Borgwardt, L., Diness, B. R., Van Overeem Hansen, T. & Wadt, K. A. W., 23 Oct 2024, In: Journal of Medical Genetics. 61, 11, p. 1023-1025 3 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Treatment-related mortality among children with cancer in Denmark during 2001-2021
Sørensen, M. C. L., Andersen, M. M., Rostgaard, K., Schmiegelow, K., Mikkelsen, T. S., Wehner, P. S., Olsen, M., Søegaard, S. H. & Hjalgrim, L. L., May 2024, In: Acta Oncologica. 63, p. 294-302 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access3 Citations (Scopus) -
2023
Early clinical indicators of acute kidney injury caused by administering high-dose methotrexate therapy to juvenile pigs
Buddington, R. K., Wong, T., Buddington, K. K., Mikkelsen, T. S., Cao, X. & Howard, S. C., 2023, In: Frontiers in nephrology. 3, p. 1193494 1193494.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
2 Citations (Scopus) -
F8/F9 variants in the population-based PedNet Registry cohort compared with locus-specific genetic databases of the European Association for Haemophilia and Allied Disorders and the Centers for Disease Control and Prevention Hemophilia A or Hemophilia B Mutation Project
Labarque, V., Mancuso, M. E., Kartal-Kaess, M., Ljung, R., Mikkelsen, T. S. & Andersson, N. G., Jan 2023, In: Research and Practice in Thrombosis and Haemostasis. 7, 1, 9 p., 100036.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access2 Citations (Scopus) -
Genetic predisposition and evolutionary traces of pediatric cancer risk: A prospective 5-year population-based genome sequencing study of children with CNS tumors
Stoltze, U. K., Foss-Skiftesvik, J., van Overeem Hansen, T., Byrjalsen, A., Sehested, A., Scheie, D., Mikkelsen, T. S., Rasmussen, S., Bak, M., Okkels, H., Callesen, M. T., Skjøth-Rasmussen, J., Gerdes, A.-M., Schmiegelow, K., Mathiasen, R. & Wadt, K., 1 Apr 2023, In: Neuro-Oncology. 25, 4, p. 761-773 13 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access13 Citations (Scopus) -
Growth hormone deficiency in adult survivors of childhood brain tumors treated with radiation
Baunsgaard, M. M., Helligsoe, A. S. L., Henriksen, L. T., Mikkelsen, T. S., Callesen, M., Weber, B., Hasle, H. & Birkebæk, N., Feb 2023, In: Endocrine Connections. 12, 2, 11 p., e220365 .Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
Insights from a pharmacometric analysis of HDMTX in adults with cancer: Clinically relevant covariates for application in precision dosing
Ibarra, M., Combs, R., Taylor, Z. L., Ramsey, L. B., Mikkelsen, T., Buddington, R. K., Heldrup, J., Barreto, J. N., Guscott, M., Lowe, J., Hurmiz, C., Marada, S., Howard, S. C. & Schaiquevich, P., Feb 2023, In: British Journal of Clinical Pharmacology. 89, 2, p. 660-671 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
7 Citations (Scopus) -
Kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon in an infant girl
Helligsø, L., Mikkelsen, T. S. & Hvas, A.-M., Sept 2023, In: Clinical Case Reports. 11, 9, p. e7859Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
2022
Catheter-directed thrombolysis for massive deep vein thrombosis in an adolescent with severe antithrombin deficiency
Bønløkke, S. T., Serifi, M. A., Mikkelsen, T. S. & Hvas, A.-M., Apr 2022, In: Clinical Case Reports. 10, 4, 5 p., e05681.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
2021
PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum
Alhalabi, K. T., Stichel, D., Sievers, P., Peterziel, H., Sommerkamp, A. C., Sturm, D., Wittmann, A., Sill, M., Jäger, N., Beck, P., Pajtler, K. W., Snuderl, M., Jour, G., Delorenzo, M., Martin, A. M., Levy, A., Dalvi, N., Hansford, J. R., Gottardo, N. G. & Uro-Coste, E. & 42 others, , Nov 2021, In: Acta Neuropathologica. 142, 5, p. 841-857 17 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile49 Citations (Scopus)40 Downloads (Pure) -
Single nucleotide polymorphisms associated with methotrexate-induced nausea in juvenile idiopathic arthritis
Kyvsgaard, N., Mikkelsen, T. S., Als, T. D., Christensen, A. E., Corydon, T. J. & Herlin, T., Apr 2021, In: Pediatric Rheumatology . 19, 1, 13 p., 51.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access7 Citations (Scopus) -
Systematic review of pharmacogenetic factors that influence high-dose methotrexate pharmacokinetics in pediatric malignancies
Taylor, Z. L., Vang, J., Lopez-Lopez, E., Oosterom, N., Mikkelsen, T. & Ramsey, L. B., Jun 2021, In: Cancers. 13, 11, 2837.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open Access41 Citations (Scopus) -
2020
Coping strategies and anxiety in association with methotrexate-induced nausea in juvenile idiopathic arthritis
Kyvsgaard, N., Thastum, M., Mikkelsen, T. S., Christensen, A. E. & Herlin, T., 1 Apr 2020, In: Rheumatology International. 40, 4, p. 591-598 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
11 Citations (Scopus) -
Disseminated intravascular coagulation in children with cancer: A systematic review
Kongstad, C., Mikkelsen, T. S. & Hvas, A. M., 3 Jul 2020, In: Pediatric Hematology and Oncology. 37, 5, p. 390-411 22 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
14 Citations (Scopus) -
ITI Treatment is not First-Choice Treatment in Children with Hemophilia A and Low-Responding Inhibitors: Evidence from a PedNet Study
Van Den Berg, H. M., Mancuso, M. E., Königs, C., D'Oiron, R., Platokouki, H., Mikkelsen, T. S., Motwani, J., Nolan, B., Santagostino, E. & European Pediatric Network for Haemophilia Management (PedNet) , 1 Aug 2020, In: Thrombosis and Haemostasis. 120, 8, p. 1166-1172 7 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
8 Citations (Scopus) -
Novel F8 and F9 gene variants from the PedNet hemophilia registry classified according to ACMG/AMP guidelines
Andersson, N. G., Labarque, V., Letelier, A., Mancuso, M. E., Bührlen, M., Fischer, K., Kartal-Kaess, M., Koskenvuo, M., Mikkelsen, T., Ljung, R. & PedNet study group, Dec 2020, In: Human Mutation. 41, 12, p. 2058-2072Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open AccessFile5 Citations (Scopus)15 Downloads (Pure) -
2019
Increased methotrexate intolerance in juvenile idiopathic arthritis compared to acute lymphoblastic leukaemia in children
Kyvsgaard, N., Mikkelsen, T. S., Thastum, M., Christensen, A. E., Wehner, P. S., Nysom, K. & Herlin, T., Jul 2019, In: PLOS ONE. 14, 7, e0219539.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access7 Citations (Scopus) -
Plasma creatinine as predictor of delayed elimination of high-dose methotrexate in childhood acute lymphoblastic leukemia: A Danish population-based study
Schmidt, D., Kristensen, K., Schroeder, H., Wehner, P. S., Rosthøj, S., Heldrup, J., Damsgaard, L., Schmiegelow, K. & Mikkelsen, T. S., Jun 2019, In: Pediatric Blood and Cancer. 66, 6, 6 p., e27637.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
15 Citations (Scopus) -
2017
Delayed elimination of high-dose methotrexate and use of carboxypeptidase G2 in pediatric patients during treatment for acute lymphoblastic leukemia
Svahn, T., Mellgren, K., Harila-Saari, A., Asberg, A., Kanerva, J., Jonsson, O., Vaitkeviciene, G., Mikkelssen, T. S., Schmiegelow, K. & Heldrup, J., Jul 2017, In: Pediatric Blood & Cancer. 64, 7, 7 p., 26395.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
39 Citations (Scopus) -
2015
Atypical Presentation of Malignant Melanoma in a 16 Months Old Child.
Schoellhammer, L., Mikkelsen, T. S., Schmidt, H. & Birk-Soerensen, L., 2015, In: AMJCR. 3(3), p. 79-81Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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2014
Extended duration of prehydration does not prevent nephrotoxicity or delayed drug elimination in high-dose methotrexate infusions: a prospectively randomized cross-over study
Mikkelsen, T. S., Mamoudou, A. D., Tuckuviene, R., Wehner, P. S. & Schroeder, H., Feb 2014, In: Pediatric Blood & Cancer. 61, 2, p. 297-301 5 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
28 Citations (Scopus) -
2012
Contribution of tumoral and host solute carriers to clinical drug response
Sprowl, J. A., Mikkelsen, T. S., Giovinazzo, H. & Sparreboom, A., 2012, In: Drug Resistance Updates. 15, 1-2, p. 5-20 16 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
23 Citations (Scopus) -
Influence of Polymorphic OATP1B-Type Carriers on the Disposition of Docetaxel
de Graan, A.-J. M., Lancaster, C. S., Obaidat, A., Hagenbuch, B., Elens, L., Friberg, L. E., de Bruijn, P., Hu, S., Gibson, A. A., Bruun, G. H., Corydon, T. J., Mikkelsen, T. S., Walker, A. L., Du, G., Loos, W. J., van Schaik, R. H. N., Baker, S. D., Mathijssen, R. H. J. & Sparreboom, A., 2012, In: Clinical Cancer Research.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
83 Citations (Scopus) -
OATP1B1 polymorphism as a determinant of erythromycin disposition
Lancaster, C. S., Bruun, G. H., Peer, C. J., Mikkelsen, T. S., Corydon, T. J., Gibson, A. A., Hu, S., Orwick, S. J., Mathijssen, R. H. J., Figg, W. D., Baker, S. D. & Sparreboom, A., Nov 2012, In: Clinical Pharmacology and Therapeutics. 92, 5, p. 642-50 9 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
30 Citations (Scopus) -
Periodic fever associated with aphthous stomatitis, pharyngitis and cervical adenitis
Kyvsgaard, N., Mikkelsen, T., Nielsen, J. N. K., Veirum, J. E. & Herlin, T., 2012, In: Danish Medical Bulletin (Online). 59, 7, p. A4452Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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Periodic fever associated with aphthous stomatitis, pharyngitis and cervical adenitis
Kyvsgaard, N., Mikkelsen, T., Korsholm, J., Veirum, J. E. & Herlin, T., 2012, In: Danish Medical Journal. 59, 7Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
16 Citations (Scopus) -
Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition
Ramsey, L. B., Bruun, G. H., Yang, W., Treviño, L. R., Vattathil, S., Scheet, P., Cheng, C., Rosner, G. L., Giacomini, K. M., Fan, Y., Sparreboom, A., Mikkelsen, T. S., Corydon, T. J., Pui, C.-H., Evans, W. E. & Relling, M. V., 2012, In: Genome Research. 22, 1, p. 1-8 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
227 Citations (Scopus) -
2011
PharmGKB summary: methotrexate pathway
Mikkelsen, T. S., Thorn, C. F., Yang, J. J., Ulrich, C. M., French, D., Zaza, G., Dunnenberger, H. M., Marsh, S., McLeod, H. L., Giacomini, K., Becker, M. L., Gaedigk, R., Leeder, J. S., Kager, L., Relling, M. V., Evans, W., Klein, T. E. & Altman, R. B., 2011, In: Pharmacogenetics and Genomics. 21, 10, p. 679-86 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
129 Citations (Scopus) -
Shortening infusion time for high-dose methotrexate alters antileukemic effects: a randomized prospective clinical trial
Mikkelsen, T. S., Sparreboom, A., Cheng, C., Zhou, Y., Boyett, J. M., Raimondi, S. C., Panetta, J. C., Bowman, W. P., Sandlund, J. T., Pui, C.-H., Relling, M. V. & Evans, W. E., 2011, In: Journal of Clinical Oncology. 29, 13, p. 1771-8 8 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
44 Citations (Scopus) -
2010
Clinical characteristics and treatment outcome in Danish PFAPA patients.
Sørensen, N. K., Mikkelsen, T., Korsholm, J., Veirum, J. & Herlin, T., 9 Sept 2010, 17th Pediatric Rheumatology European Society Congress, Valencia : abstract book.Research output: Contribution to book/anthology/report/proceeding › Conference abstract in proceedings › Research › peer-review
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The pharmacokinetics and pharmacodynamics of high-dose methotrexate in the treatment of childhood acute lymphoblastic leukemia
Mikkelsen, T., 2010, Århus Universitet.Research output: Book/anthology/dissertation/report › Ph.D. thesis
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2009
Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity
Filipski, K. K., Mathijssen, R. H., Mikkelsen, T., Schinkel, A. H. & Sparreboom, A., Oct 2009, In: Clinical Pharmacology and Therapeutics. 86, 4, p. 396-402 7 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
359 Citations (Scopus) -
2008
Periodisk feber--to børn med periodisk feber, aftøs stomatitis, faryngitis, adenitis-syndrom
Translated title of the contribution :Periodic fever--two children with periodic fever, aphthous stomatitis pharyngitis, adenitis syndrome Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
1 Citation (Scopus) -
2005
Prognostic value, kinetics and effect of CVVHDF on serum of the myoglobin and creatine kinase in critically ill patients with rhabdomyolysis
Mikkelsen, T. & Toft, P., Jul 2005, In: Acta Anaesthesiologica Scandinavica. 49, 6, p. 859-64 6 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
85 Citations (Scopus) -
2004
The correlation between creatine kinase and myoglobin in critical ill patients with rhabdomyolysis
Mikkelsen, T. S. & Toft, P., 15 Mar 2004, (E-pub / Early view) In: Crit Care Med. 8, 1, p. 155 PMCID: PMC4099742.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review