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Torben Ellegaard Lund

Modelling large motion events in fMRI studies of patients with epilepsy

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Standard

Modelling large motion events in fMRI studies of patients with epilepsy. / Lemieux, Louis; Salek-Haddadi, Afraim; Lund, Torben E; Laufs, Helmut; Carmichael, David.

In: Magnetic Resonance Imaging, Vol. 25, No. 6, 2007, p. 894-901.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Lemieux, L, Salek-Haddadi, A, Lund, TE, Laufs, H & Carmichael, D 2007, 'Modelling large motion events in fMRI studies of patients with epilepsy', Magnetic Resonance Imaging, vol. 25, no. 6, pp. 894-901. https://doi.org/10.1016/j.mri.2007.03.009

APA

Lemieux, L., Salek-Haddadi, A., Lund, T. E., Laufs, H., & Carmichael, D. (2007). Modelling large motion events in fMRI studies of patients with epilepsy. Magnetic Resonance Imaging, 25(6), 894-901. https://doi.org/10.1016/j.mri.2007.03.009

CBE

Lemieux L, Salek-Haddadi A, Lund TE, Laufs H, Carmichael D. 2007. Modelling large motion events in fMRI studies of patients with epilepsy. Magnetic Resonance Imaging. 25(6):894-901. https://doi.org/10.1016/j.mri.2007.03.009

MLA

Vancouver

Lemieux L, Salek-Haddadi A, Lund TE, Laufs H, Carmichael D. Modelling large motion events in fMRI studies of patients with epilepsy. Magnetic Resonance Imaging. 2007;25(6):894-901. https://doi.org/10.1016/j.mri.2007.03.009

Author

Lemieux, Louis ; Salek-Haddadi, Afraim ; Lund, Torben E ; Laufs, Helmut ; Carmichael, David. / Modelling large motion events in fMRI studies of patients with epilepsy. In: Magnetic Resonance Imaging. 2007 ; Vol. 25, No. 6. pp. 894-901.

Bibtex

@article{5eec8890cc2c11dd9710000ea68e967b,
title = "Modelling large motion events in fMRI studies of patients with epilepsy",
abstract = "EEG-correlated fMRI can provide localisation information on the generators of epileptiform discharges in patients with focal epilepsy. To increase the technique's clinical potential, it is important to consider ways of optimising the yield of each experiment while minimizing the risk of false-positive activation. Head motion can lead to severe image degradation and result in false-positive activation and is usually worse in patients than in healthy subjects. We performed general linear model fMRI data analysis on simultaneous EEG-fMRI data acquired in 34 cases with focal epilepsy. Signal changes associated with large inter-scan motion events (head jerks) were modelled using modified design matrices that include 'scan nulling' regressors. We evaluated the efficacy of this approach by mapping the proportion of the brain for which F-tests across the additional regressors were significant. In 95% of cases, there was a significant effect of motion in 50% of the brain or greater; for the scan nulling effect, the proportion was 36%; this effect was predominantly in the neocortex. We conclude that careful consideration of the motion-related effects in fMRI studies of patients with epilepsy is essential and that the proposed approach can be effective.",
author = "Louis Lemieux and Afraim Salek-Haddadi and Lund, {Torben E} and Helmut Laufs and David Carmichael",
year = "2007",
doi = "10.1016/j.mri.2007.03.009",
language = "English",
volume = "25",
pages = "894--901",
journal = "Magnetic Resonance Imaging",
issn = "0730-725X",
publisher = "Elsevier Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Modelling large motion events in fMRI studies of patients with epilepsy

AU - Lemieux, Louis

AU - Salek-Haddadi, Afraim

AU - Lund, Torben E

AU - Laufs, Helmut

AU - Carmichael, David

PY - 2007

Y1 - 2007

N2 - EEG-correlated fMRI can provide localisation information on the generators of epileptiform discharges in patients with focal epilepsy. To increase the technique's clinical potential, it is important to consider ways of optimising the yield of each experiment while minimizing the risk of false-positive activation. Head motion can lead to severe image degradation and result in false-positive activation and is usually worse in patients than in healthy subjects. We performed general linear model fMRI data analysis on simultaneous EEG-fMRI data acquired in 34 cases with focal epilepsy. Signal changes associated with large inter-scan motion events (head jerks) were modelled using modified design matrices that include 'scan nulling' regressors. We evaluated the efficacy of this approach by mapping the proportion of the brain for which F-tests across the additional regressors were significant. In 95% of cases, there was a significant effect of motion in 50% of the brain or greater; for the scan nulling effect, the proportion was 36%; this effect was predominantly in the neocortex. We conclude that careful consideration of the motion-related effects in fMRI studies of patients with epilepsy is essential and that the proposed approach can be effective.

AB - EEG-correlated fMRI can provide localisation information on the generators of epileptiform discharges in patients with focal epilepsy. To increase the technique's clinical potential, it is important to consider ways of optimising the yield of each experiment while minimizing the risk of false-positive activation. Head motion can lead to severe image degradation and result in false-positive activation and is usually worse in patients than in healthy subjects. We performed general linear model fMRI data analysis on simultaneous EEG-fMRI data acquired in 34 cases with focal epilepsy. Signal changes associated with large inter-scan motion events (head jerks) were modelled using modified design matrices that include 'scan nulling' regressors. We evaluated the efficacy of this approach by mapping the proportion of the brain for which F-tests across the additional regressors were significant. In 95% of cases, there was a significant effect of motion in 50% of the brain or greater; for the scan nulling effect, the proportion was 36%; this effect was predominantly in the neocortex. We conclude that careful consideration of the motion-related effects in fMRI studies of patients with epilepsy is essential and that the proposed approach can be effective.

U2 - 10.1016/j.mri.2007.03.009

DO - 10.1016/j.mri.2007.03.009

M3 - Journal article

C2 - 17490845

VL - 25

SP - 894

EP - 901

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

SN - 0730-725X

IS - 6

ER -