Tomonori Takeuchi

Silent Learning

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Silent Learning. / Rossato, Janine I.; Moreno, Andrea; Genzel, Lisa; Yamasaki, Miwako; Takeuchi, Tomonori; Canals, Santiago; Morris, Richard G.M.

In: Current Biology, Vol. 28, No. 21, 2018, p. 3508-3515.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Rossato, JI, Moreno, A, Genzel, L, Yamasaki, M, Takeuchi, T, Canals, S & Morris, RGM 2018, 'Silent Learning', Current Biology, vol. 28, no. 21, pp. 3508-3515. https://doi.org/10.1016/j.cub.2018.09.012

APA

Rossato, J. I., Moreno, A., Genzel, L., Yamasaki, M., Takeuchi, T., Canals, S., & Morris, R. G. M. (2018). Silent Learning. Current Biology, 28(21), 3508-3515. https://doi.org/10.1016/j.cub.2018.09.012

CBE

Rossato JI, Moreno A, Genzel L, Yamasaki M, Takeuchi T, Canals S, Morris RGM. 2018. Silent Learning. Current Biology. 28(21):3508-3515. https://doi.org/10.1016/j.cub.2018.09.012

MLA

Rossato, Janine I. et al. "Silent Learning". Current Biology. 2018, 28(21). 3508-3515. https://doi.org/10.1016/j.cub.2018.09.012

Vancouver

Rossato JI, Moreno A, Genzel L, Yamasaki M, Takeuchi T, Canals S et al. Silent Learning. Current Biology. 2018;28(21):3508-3515. https://doi.org/10.1016/j.cub.2018.09.012

Author

Rossato, Janine I. ; Moreno, Andrea ; Genzel, Lisa ; Yamasaki, Miwako ; Takeuchi, Tomonori ; Canals, Santiago ; Morris, Richard G.M. / Silent Learning. In: Current Biology. 2018 ; Vol. 28, No. 21. pp. 3508-3515.

Bibtex

@article{310b0e1619cd4ed4be0c7b3883ba2a6c,
title = "Silent Learning",
abstract = "We introduce the concept of “silent learning”—the capacity to learn despite neuronal cell-firing being largely absent. This idea emerged from thinking about dendritic computation [1, 2] and examining whether the encoding, expression, and retrieval of hippocampal-dependent memory could be dissociated using the intrahippocampal infusion of pharmacological compounds. We observed that very modest enhancement of GABAergic inhibition with low-dose muscimol blocked both cell-firing and the retrieval of an already-formed memory but left induction of long-term potentiation (LTP) and new spatial memory encoding intact (silent learning). In contrast, blockade of hippocampal NMDA receptors by intrahippocampal D-AP5 impaired both the induction of LTP and encoding but had no effect on memory retrieval. Blockade of AMPA receptors by CNQX impaired excitatory synaptic transmission and cell-firing and both memory encoding and retrieval. Thus, in keeping with the synaptic plasticity and memory hypothesis [3], the hippocampal network can mediate new memory encoding when LTP induction is intact even under conditions in which somatic cell-firing is blocked. It is widely believed that induction of long-term potentiation (LTP) and associated cell-firing is required for new memory formation. Rossato et al. show that memory formation can still occur provided LTP induction is intact even though cell-firing has been prevented using modest GABAergic activation. We refer to this as “silent learning.”",
keywords = "AMPA receptors, GABA receptors, NMDA receptors, learning, long-term potentiation, memory encoding, memory retrieval, synaptic plasticity, watermaze, NMDA RECEPTORS, ON-DEMAND PLATFORM, ASPARTATE RECEPTOR ANTAGONIST, SYNAPTIC PLASTICITY, WATER-MAZE PROCEDURE, DORSAL HIPPOCAMPUS, SELECTIVE IMPAIRMENT, PLACE FIELDS, SPATIAL MEMORY, LONG-TERM POTENTIATION",
author = "Rossato, {Janine I.} and Andrea Moreno and Lisa Genzel and Miwako Yamasaki and Tomonori Takeuchi and Santiago Canals and Morris, {Richard G.M.}",
note = "doi: 10.1016/j.cub.2018.09.012",
year = "2018",
doi = "10.1016/j.cub.2018.09.012",
language = "English",
volume = "28",
pages = "3508--3515",
journal = "Current Biology",
issn = "0960-9822",
publisher = "Cell Press",
number = "21",

}

RIS

TY - JOUR

T1 - Silent Learning

AU - Rossato, Janine I.

AU - Moreno, Andrea

AU - Genzel, Lisa

AU - Yamasaki, Miwako

AU - Takeuchi, Tomonori

AU - Canals, Santiago

AU - Morris, Richard G.M.

N1 - doi: 10.1016/j.cub.2018.09.012

PY - 2018

Y1 - 2018

N2 - We introduce the concept of “silent learning”—the capacity to learn despite neuronal cell-firing being largely absent. This idea emerged from thinking about dendritic computation [1, 2] and examining whether the encoding, expression, and retrieval of hippocampal-dependent memory could be dissociated using the intrahippocampal infusion of pharmacological compounds. We observed that very modest enhancement of GABAergic inhibition with low-dose muscimol blocked both cell-firing and the retrieval of an already-formed memory but left induction of long-term potentiation (LTP) and new spatial memory encoding intact (silent learning). In contrast, blockade of hippocampal NMDA receptors by intrahippocampal D-AP5 impaired both the induction of LTP and encoding but had no effect on memory retrieval. Blockade of AMPA receptors by CNQX impaired excitatory synaptic transmission and cell-firing and both memory encoding and retrieval. Thus, in keeping with the synaptic plasticity and memory hypothesis [3], the hippocampal network can mediate new memory encoding when LTP induction is intact even under conditions in which somatic cell-firing is blocked. It is widely believed that induction of long-term potentiation (LTP) and associated cell-firing is required for new memory formation. Rossato et al. show that memory formation can still occur provided LTP induction is intact even though cell-firing has been prevented using modest GABAergic activation. We refer to this as “silent learning.”

AB - We introduce the concept of “silent learning”—the capacity to learn despite neuronal cell-firing being largely absent. This idea emerged from thinking about dendritic computation [1, 2] and examining whether the encoding, expression, and retrieval of hippocampal-dependent memory could be dissociated using the intrahippocampal infusion of pharmacological compounds. We observed that very modest enhancement of GABAergic inhibition with low-dose muscimol blocked both cell-firing and the retrieval of an already-formed memory but left induction of long-term potentiation (LTP) and new spatial memory encoding intact (silent learning). In contrast, blockade of hippocampal NMDA receptors by intrahippocampal D-AP5 impaired both the induction of LTP and encoding but had no effect on memory retrieval. Blockade of AMPA receptors by CNQX impaired excitatory synaptic transmission and cell-firing and both memory encoding and retrieval. Thus, in keeping with the synaptic plasticity and memory hypothesis [3], the hippocampal network can mediate new memory encoding when LTP induction is intact even under conditions in which somatic cell-firing is blocked. It is widely believed that induction of long-term potentiation (LTP) and associated cell-firing is required for new memory formation. Rossato et al. show that memory formation can still occur provided LTP induction is intact even though cell-firing has been prevented using modest GABAergic activation. We refer to this as “silent learning.”

KW - AMPA receptors

KW - GABA receptors

KW - NMDA receptors

KW - learning

KW - long-term potentiation

KW - memory encoding

KW - memory retrieval

KW - synaptic plasticity

KW - watermaze

KW - NMDA RECEPTORS

KW - ON-DEMAND PLATFORM

KW - ASPARTATE RECEPTOR ANTAGONIST

KW - SYNAPTIC PLASTICITY

KW - WATER-MAZE PROCEDURE

KW - DORSAL HIPPOCAMPUS

KW - SELECTIVE IMPAIRMENT

KW - PLACE FIELDS

KW - SPATIAL MEMORY

KW - LONG-TERM POTENTIATION

UR - http://www.scopus.com/inward/record.url?scp=85055756479&partnerID=8YFLogxK

U2 - 10.1016/j.cub.2018.09.012

DO - 10.1016/j.cub.2018.09.012

M3 - Journal article

C2 - 30415706

VL - 28

SP - 3508

EP - 3515

JO - Current Biology

JF - Current Biology

SN - 0960-9822

IS - 21

ER -