Tomonori Takeuchi

Schema-dependent gene activation and memory encoding in neocortex

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Schema-dependent gene activation and memory encoding in neocortex. / Tse, Dorothy; Takeuchi, Tomonori; Kakeyama, Masaki; Kajii, Yasushi; Okuno, Hiroyuki; Tohyama, Chiharu; Bito, Haruhiko; Morris, Richard G M.

In: Science, Vol. 333, No. 6044, 12.08.2011, p. 891-5.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Tse, D, Takeuchi, T, Kakeyama, M, Kajii, Y, Okuno, H, Tohyama, C, Bito, H & Morris, RGM 2011, 'Schema-dependent gene activation and memory encoding in neocortex', Science, vol. 333, no. 6044, pp. 891-5. https://doi.org/10.1126/science.1205274

APA

Tse, D., Takeuchi, T., Kakeyama, M., Kajii, Y., Okuno, H., Tohyama, C., Bito, H., & Morris, R. G. M. (2011). Schema-dependent gene activation and memory encoding in neocortex. Science, 333(6044), 891-5. https://doi.org/10.1126/science.1205274

CBE

Tse D, Takeuchi T, Kakeyama M, Kajii Y, Okuno H, Tohyama C, Bito H, Morris RGM. 2011. Schema-dependent gene activation and memory encoding in neocortex. Science. 333(6044):891-5. https://doi.org/10.1126/science.1205274

MLA

Vancouver

Tse D, Takeuchi T, Kakeyama M, Kajii Y, Okuno H, Tohyama C et al. Schema-dependent gene activation and memory encoding in neocortex. Science. 2011 Aug 12;333(6044):891-5. https://doi.org/10.1126/science.1205274

Author

Tse, Dorothy ; Takeuchi, Tomonori ; Kakeyama, Masaki ; Kajii, Yasushi ; Okuno, Hiroyuki ; Tohyama, Chiharu ; Bito, Haruhiko ; Morris, Richard G M. / Schema-dependent gene activation and memory encoding in neocortex. In: Science. 2011 ; Vol. 333, No. 6044. pp. 891-5.

Bibtex

@article{3abeccac507941c699edea769ef42178,
title = "Schema-dependent gene activation and memory encoding in neocortex",
abstract = "When new learning occurs against the background of established prior knowledge, relevant new information can be assimilated into a schema and thereby expand the knowledge base. An animal model of this important component of memory consolidation reveals that systems memory consolidation can be very fast. In experiments with rats, we found that the hippocampal-dependent learning of new paired associates is associated with a striking up-regulation of immediate early genes in the prelimbic region of the medial prefrontal cortex, and that pharmacological interventions targeted at that area can prevent both new learning and the recall of remotely and even recently consolidated information. These findings challenge the concept of distinct fast (hippocampal) and slow (cortical) learning systems, and shed new light on the neural mechanisms of memory assimilation into schemas.",
keywords = "6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology, Animals, Cues, Cytoskeletal Proteins/genetics, Early Growth Response Protein 1/genetics, Genes, Immediate-Early, Hippocampus/physiology, Learning, Male, Memory, Mental Recall, Neocortex/physiology, Nerve Tissue Proteins/genetics, Prefrontal Cortex/physiology, Rats, Receptors, AMPA/antagonists & inhibitors, Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors, Synaptic Transmission/drug effects, Transcriptional Activation, Up-Regulation",
author = "Dorothy Tse and Tomonori Takeuchi and Masaki Kakeyama and Yasushi Kajii and Hiroyuki Okuno and Chiharu Tohyama and Haruhiko Bito and Morris, {Richard G M}",
year = "2011",
month = aug,
day = "12",
doi = "10.1126/science.1205274",
language = "English",
volume = "333",
pages = "891--5",
journal = "Science",
issn = "0036-8075",
publisher = "AMER ASSOC ADVANCEMENT SCIENCE",
number = "6044",

}

RIS

TY - JOUR

T1 - Schema-dependent gene activation and memory encoding in neocortex

AU - Tse, Dorothy

AU - Takeuchi, Tomonori

AU - Kakeyama, Masaki

AU - Kajii, Yasushi

AU - Okuno, Hiroyuki

AU - Tohyama, Chiharu

AU - Bito, Haruhiko

AU - Morris, Richard G M

PY - 2011/8/12

Y1 - 2011/8/12

N2 - When new learning occurs against the background of established prior knowledge, relevant new information can be assimilated into a schema and thereby expand the knowledge base. An animal model of this important component of memory consolidation reveals that systems memory consolidation can be very fast. In experiments with rats, we found that the hippocampal-dependent learning of new paired associates is associated with a striking up-regulation of immediate early genes in the prelimbic region of the medial prefrontal cortex, and that pharmacological interventions targeted at that area can prevent both new learning and the recall of remotely and even recently consolidated information. These findings challenge the concept of distinct fast (hippocampal) and slow (cortical) learning systems, and shed new light on the neural mechanisms of memory assimilation into schemas.

AB - When new learning occurs against the background of established prior knowledge, relevant new information can be assimilated into a schema and thereby expand the knowledge base. An animal model of this important component of memory consolidation reveals that systems memory consolidation can be very fast. In experiments with rats, we found that the hippocampal-dependent learning of new paired associates is associated with a striking up-regulation of immediate early genes in the prelimbic region of the medial prefrontal cortex, and that pharmacological interventions targeted at that area can prevent both new learning and the recall of remotely and even recently consolidated information. These findings challenge the concept of distinct fast (hippocampal) and slow (cortical) learning systems, and shed new light on the neural mechanisms of memory assimilation into schemas.

KW - 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology

KW - Animals

KW - Cues

KW - Cytoskeletal Proteins/genetics

KW - Early Growth Response Protein 1/genetics

KW - Genes, Immediate-Early

KW - Hippocampus/physiology

KW - Learning

KW - Male

KW - Memory

KW - Mental Recall

KW - Neocortex/physiology

KW - Nerve Tissue Proteins/genetics

KW - Prefrontal Cortex/physiology

KW - Rats

KW - Receptors, AMPA/antagonists & inhibitors

KW - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors

KW - Synaptic Transmission/drug effects

KW - Transcriptional Activation

KW - Up-Regulation

U2 - 10.1126/science.1205274

DO - 10.1126/science.1205274

M3 - Journal article

C2 - 21737703

VL - 333

SP - 891

EP - 895

JO - Science

JF - Science

SN - 0036-8075

IS - 6044

ER -