Tomonori Takeuchi

Regulation of acute nociceptive responses by the NMDA receptor GluRepsilon2 subunit

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Regulation of acute nociceptive responses by the NMDA receptor GluRepsilon2 subunit. / Wainai, T; Takeuchi, T; Seo, N; Mishina, M.

In: NeuroReport, Vol. 12, No. 15, 29.10.2001, p. 3169-72.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Wainai, T, Takeuchi, T, Seo, N & Mishina, M 2001, 'Regulation of acute nociceptive responses by the NMDA receptor GluRepsilon2 subunit', NeuroReport, vol. 12, no. 15, pp. 3169-72.

APA

Wainai, T., Takeuchi, T., Seo, N., & Mishina, M. (2001). Regulation of acute nociceptive responses by the NMDA receptor GluRepsilon2 subunit. NeuroReport, 12(15), 3169-72.

CBE

Wainai T, Takeuchi T, Seo N, Mishina M. 2001. Regulation of acute nociceptive responses by the NMDA receptor GluRepsilon2 subunit. NeuroReport. 12(15):3169-72.

MLA

Vancouver

Wainai T, Takeuchi T, Seo N, Mishina M. Regulation of acute nociceptive responses by the NMDA receptor GluRepsilon2 subunit. NeuroReport. 2001 Oct 29;12(15):3169-72.

Author

Wainai, T ; Takeuchi, T ; Seo, N ; Mishina, M. / Regulation of acute nociceptive responses by the NMDA receptor GluRepsilon2 subunit. In: NeuroReport. 2001 ; Vol. 12, No. 15. pp. 3169-72.

Bibtex

@article{9f55e5adb6244540a8fe9a25af5e4037,
title = "Regulation of acute nociceptive responses by the NMDA receptor GluRepsilon2 subunit",
abstract = "Heterozygous mice mutant for the NMDA-type glutamate receptor (GluR) epsilon2 subunit with a highly homogeneous genetic background showed exaggerated responses to various acute noxious stimuli in the footshock, tail-flick, hot-plate and tail-pinch tests. Because the noxious stimuli in these behavioral tests were electrical, thermal and mechanical, the reduction of GluRepsilon2 proteins exerted stimulatory effects on acute nociceptive responses across modalities. Previous studies showed that GluRepsilon1 and GluRepsilon4 subunit mutant mice exhibited no alteration in the responses to acute noxious stimuli. Thus, among NMDA receptor subunits, the GluRepsilon2 subunit specifically plays an important role in the regulation of the acute nociceptive responses.",
keywords = "Acute Disease, Animals, Central Nervous System/metabolism, Electric Stimulation, Female, Glutamic Acid/metabolism, Heterozygote, Hyperalgesia/genetics, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Nociceptors/metabolism, Pain/genetics, Pain Measurement, Pain Threshold/physiology, Physical Stimulation, Reaction Time/genetics, Receptors, N-Methyl-D-Aspartate/deficiency, Reflex/genetics, Synaptic Transmission/genetics",
author = "T Wainai and T Takeuchi and N Seo and M Mishina",
year = "2001",
month = "10",
day = "29",
language = "English",
volume = "12",
pages = "3169--72",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams & Wilkins",
number = "15",

}

RIS

TY - JOUR

T1 - Regulation of acute nociceptive responses by the NMDA receptor GluRepsilon2 subunit

AU - Wainai, T

AU - Takeuchi, T

AU - Seo, N

AU - Mishina, M

PY - 2001/10/29

Y1 - 2001/10/29

N2 - Heterozygous mice mutant for the NMDA-type glutamate receptor (GluR) epsilon2 subunit with a highly homogeneous genetic background showed exaggerated responses to various acute noxious stimuli in the footshock, tail-flick, hot-plate and tail-pinch tests. Because the noxious stimuli in these behavioral tests were electrical, thermal and mechanical, the reduction of GluRepsilon2 proteins exerted stimulatory effects on acute nociceptive responses across modalities. Previous studies showed that GluRepsilon1 and GluRepsilon4 subunit mutant mice exhibited no alteration in the responses to acute noxious stimuli. Thus, among NMDA receptor subunits, the GluRepsilon2 subunit specifically plays an important role in the regulation of the acute nociceptive responses.

AB - Heterozygous mice mutant for the NMDA-type glutamate receptor (GluR) epsilon2 subunit with a highly homogeneous genetic background showed exaggerated responses to various acute noxious stimuli in the footshock, tail-flick, hot-plate and tail-pinch tests. Because the noxious stimuli in these behavioral tests were electrical, thermal and mechanical, the reduction of GluRepsilon2 proteins exerted stimulatory effects on acute nociceptive responses across modalities. Previous studies showed that GluRepsilon1 and GluRepsilon4 subunit mutant mice exhibited no alteration in the responses to acute noxious stimuli. Thus, among NMDA receptor subunits, the GluRepsilon2 subunit specifically plays an important role in the regulation of the acute nociceptive responses.

KW - Acute Disease

KW - Animals

KW - Central Nervous System/metabolism

KW - Electric Stimulation

KW - Female

KW - Glutamic Acid/metabolism

KW - Heterozygote

KW - Hyperalgesia/genetics

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Nociceptors/metabolism

KW - Pain/genetics

KW - Pain Measurement

KW - Pain Threshold/physiology

KW - Physical Stimulation

KW - Reaction Time/genetics

KW - Receptors, N-Methyl-D-Aspartate/deficiency

KW - Reflex/genetics

KW - Synaptic Transmission/genetics

M3 - Journal article

C2 - 11711849

VL - 12

SP - 3169

EP - 3172

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 15

ER -