Tomonori Takeuchi

Locus coeruleus and dopaminergic consolidation of everyday memory

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Tomonori Takeuchi
  • Adrian J Duszkiewicz, Centre for Cognitive and Neural Systems, Edinburgh Neuroscience, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK.
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  • Alex Sonneborn, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
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  • Patrick A Spooner, Centre for Cognitive and Neural Systems, Edinburgh Neuroscience, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK.
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  • Miwako Yamasaki, Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, 060-8638, Japan.
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  • Masahiko Watanabe, Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, 060-8638, Japan.
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  • Caroline C Smith, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
  • ,
  • Guillén Fernández, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, 6525 EZ, The Netherlands.
  • ,
  • Karl Deisseroth, Departments of Psychiatry and Behavioral Sciences and of Bioengineering, Stanford University, Stanford, California 94305, USA.
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  • Robert W Greene, International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, 305-8575, Japan.
  • ,
  • Richard G M Morris, Instituto de Neurociencias, CSIC-UMH, Alicante, 03550, Spain.

The retention of episodic-like memory is enhanced, in humans and animals, when something novel happens shortly before or after encoding. Using an everyday memory task in mice, we sought the neurons mediating this dopamine-dependent novelty effect, previously thought to originate exclusively from the tyrosine-hydroxylase-expressing (TH+) neurons in the ventral tegmental area. Here we report that neuronal firing in the locus coeruleus is especially sensitive to environmental novelty, locus coeruleus TH+ neurons project more profusely than ventral tegmental area TH+ neurons to the hippocampus, optogenetic activation of locus coeruleus TH+ neurons mimics the novelty effect, and this novelty-associated memory enhancement is unaffected by ventral tegmental area inactivation. Surprisingly, two effects of locus coeruleus TH+ photoactivation are sensitive to hippocampal D1/D5 receptor blockade and resistant to adrenoceptor blockade: memory enhancement and long-lasting potentiation of synaptic transmission in CA1 ex vivo. Thus, locus coeruleus TH+ neurons can mediate post-encoding memory enhancement in a manner consistent with possible co-release of dopamine in the hippocampus.

Original languageEnglish
JournalNature
Volume537
Issue7620
Pages (from-to)357-362
Number of pages18
ISSN0028-0836
DOIs
Publication statusPublished - 15 Sep 2016
Externally publishedYes

    Research areas

  • Animals, CA1 Region, Hippocampal/cytology, Dopamine/metabolism, In Vitro Techniques, Locus Coeruleus/cytology, Male, Memory Consolidation/drug effects, Mice, Mice, Inbred C57BL, Neurons/metabolism, Optogenetics, Receptors, Adrenergic/metabolism, Receptors, Dopamine D1/antagonists & inhibitors, Receptors, Dopamine D5/antagonists & inhibitors, Synaptic Transmission/drug effects, Ventral Tegmental Area/cytology, RAT, LONG-TERM POTENTIATION, PROTEIN-SYNTHESIS, SUBSTANTIA-NIGRA, VENTRAL TEGMENTAL AREA, NOVELTY, CA1 REGION, SPATIAL MEMORY, NORADRENERGIC NEURONS, RECEPTORS

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