Tomonori Takeuchi

Locus Coeruleus and Dopamine-Dependent Memory Consolidation

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Locus Coeruleus and Dopamine-Dependent Memory Consolidation. / Yamasaki, Miwako; Takeuchi, Tomonori.

In: Neural Plasticity, Vol. 2017, 8602690, 10.2017.

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Yamasaki, Miwako ; Takeuchi, Tomonori. / Locus Coeruleus and Dopamine-Dependent Memory Consolidation. In: Neural Plasticity. 2017 ; Vol. 2017.

Bibtex

@article{244bab33a8d9472c8cfb80b09dce1a87,
title = "Locus Coeruleus and Dopamine-Dependent Memory Consolidation",
abstract = "Most everyday memories including many episodic-like memories that we may form automatically in the hippocampus (HPC) are forgotten, while some of them are retained for a long time by a memory stabilization process, called initial memory consolidation. Specifically, the retention of everyday memory is enhanced, in humans and animals, when something novel happens shortly before or after the time of encoding. Converging evidence has indicated that dopamine (DA) signaling via D1/D5 receptors in HPC is required for persistence of synaptic plasticity and memory, thereby playing an important role in the novelty-associated memory enhancement. In this review paper, we aim to provide an overview of the key findings related to D1/D5 receptor-dependent persistence of synaptic plasticity and memory in HPC, especially focusing on the emerging evidence for a role of the locus coeruleus (LC) in DA-dependent memory consolidation. We then refer to candidate brain areas and circuits that might be responsible for detection and transmission of the environmental novelty signal and molecular and anatomical evidence for the LC-DA system. We also discuss molecular mechanisms that might mediate the environmental novelty-associated memory enhancement, including plasticity-related proteins that are involved in initial memory consolidation processes in HPC.",
keywords = "Animals, Dopamine/physiology, Hippocampus/physiology, Humans, Locus Coeruleus/physiology, Memory Consolidation/physiology, Neural Pathways/physiology, Neuronal Plasticity, Receptors, Dopamine D1/physiology, Receptors, Dopamine D5/physiology, RECEPTOR MESSENGER-RNA, PROTEIN-SYNTHESIS, SYNAPTIC PLASTICITY, RAT HIPPOCAMPAL-FORMATION, VENTRAL TEGMENTAL AREA, CA1 REGION, ADULT-RAT, REGION IN-VITRO, SPATIAL MEMORY, LONG-TERM POTENTIATION",
author = "Miwako Yamasaki and Tomonori Takeuchi",
year = "2017",
month = "10",
doi = "10.1155/2017/8602690",
language = "English",
volume = "2017",
journal = "Neural Plasticity",
issn = "2090-5904",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Locus Coeruleus and Dopamine-Dependent Memory Consolidation

AU - Yamasaki, Miwako

AU - Takeuchi, Tomonori

PY - 2017/10

Y1 - 2017/10

N2 - Most everyday memories including many episodic-like memories that we may form automatically in the hippocampus (HPC) are forgotten, while some of them are retained for a long time by a memory stabilization process, called initial memory consolidation. Specifically, the retention of everyday memory is enhanced, in humans and animals, when something novel happens shortly before or after the time of encoding. Converging evidence has indicated that dopamine (DA) signaling via D1/D5 receptors in HPC is required for persistence of synaptic plasticity and memory, thereby playing an important role in the novelty-associated memory enhancement. In this review paper, we aim to provide an overview of the key findings related to D1/D5 receptor-dependent persistence of synaptic plasticity and memory in HPC, especially focusing on the emerging evidence for a role of the locus coeruleus (LC) in DA-dependent memory consolidation. We then refer to candidate brain areas and circuits that might be responsible for detection and transmission of the environmental novelty signal and molecular and anatomical evidence for the LC-DA system. We also discuss molecular mechanisms that might mediate the environmental novelty-associated memory enhancement, including plasticity-related proteins that are involved in initial memory consolidation processes in HPC.

AB - Most everyday memories including many episodic-like memories that we may form automatically in the hippocampus (HPC) are forgotten, while some of them are retained for a long time by a memory stabilization process, called initial memory consolidation. Specifically, the retention of everyday memory is enhanced, in humans and animals, when something novel happens shortly before or after the time of encoding. Converging evidence has indicated that dopamine (DA) signaling via D1/D5 receptors in HPC is required for persistence of synaptic plasticity and memory, thereby playing an important role in the novelty-associated memory enhancement. In this review paper, we aim to provide an overview of the key findings related to D1/D5 receptor-dependent persistence of synaptic plasticity and memory in HPC, especially focusing on the emerging evidence for a role of the locus coeruleus (LC) in DA-dependent memory consolidation. We then refer to candidate brain areas and circuits that might be responsible for detection and transmission of the environmental novelty signal and molecular and anatomical evidence for the LC-DA system. We also discuss molecular mechanisms that might mediate the environmental novelty-associated memory enhancement, including plasticity-related proteins that are involved in initial memory consolidation processes in HPC.

KW - Animals

KW - Dopamine/physiology

KW - Hippocampus/physiology

KW - Humans

KW - Locus Coeruleus/physiology

KW - Memory Consolidation/physiology

KW - Neural Pathways/physiology

KW - Neuronal Plasticity

KW - Receptors, Dopamine D1/physiology

KW - Receptors, Dopamine D5/physiology

KW - RECEPTOR MESSENGER-RNA

KW - PROTEIN-SYNTHESIS

KW - SYNAPTIC PLASTICITY

KW - RAT HIPPOCAMPAL-FORMATION

KW - VENTRAL TEGMENTAL AREA

KW - CA1 REGION

KW - ADULT-RAT

KW - REGION IN-VITRO

KW - SPATIAL MEMORY

KW - LONG-TERM POTENTIATION

U2 - 10.1155/2017/8602690

DO - 10.1155/2017/8602690

M3 - Review

C2 - 29123927

VL - 2017

JO - Neural Plasticity

JF - Neural Plasticity

SN - 2090-5904

M1 - 8602690

ER -