Tomonori Takeuchi

Locus Coeruleus and Dopamine-Dependent Memory Consolidation

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review


  • Miwako Yamasaki, Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, 060-8638, Japan.
  • ,
  • Tomonori Takeuchi

Most everyday memories including many episodic-like memories that we may form automatically in the hippocampus (HPC) are forgotten, while some of them are retained for a long time by a memory stabilization process, called initial memory consolidation. Specifically, the retention of everyday memory is enhanced, in humans and animals, when something novel happens shortly before or after the time of encoding. Converging evidence has indicated that dopamine (DA) signaling via D1/D5 receptors in HPC is required for persistence of synaptic plasticity and memory, thereby playing an important role in the novelty-associated memory enhancement. In this review paper, we aim to provide an overview of the key findings related to D1/D5 receptor-dependent persistence of synaptic plasticity and memory in HPC, especially focusing on the emerging evidence for a role of the locus coeruleus (LC) in DA-dependent memory consolidation. We then refer to candidate brain areas and circuits that might be responsible for detection and transmission of the environmental novelty signal and molecular and anatomical evidence for the LC-DA system. We also discuss molecular mechanisms that might mediate the environmental novelty-associated memory enhancement, including plasticity-related proteins that are involved in initial memory consolidation processes in HPC.

Original languageEnglish
Article number8602690
JournalNeural Plasticity
Number of pages15
Publication statusPublished - Oct 2017
Externally publishedYes

    Research areas

  • Animals, Dopamine/physiology, Hippocampus/physiology, Humans, Locus Coeruleus/physiology, Memory Consolidation/physiology, Neural Pathways/physiology, Neuronal Plasticity, Receptors, Dopamine D1/physiology, Receptors, Dopamine D5/physiology, RECEPTOR MESSENGER-RNA, PROTEIN-SYNTHESIS, SYNAPTIC PLASTICITY, RAT HIPPOCAMPAL-FORMATION, VENTRAL TEGMENTAL AREA, CA1 REGION, ADULT-RAT, REGION IN-VITRO, SPATIAL MEMORY, LONG-TERM POTENTIATION

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