Thomas Vorup-Jensen

Professor

Profile photo

Thomas Vorup-Jensen

Professor

  • Department of Biomedicine - Forskning og uddannelse, Skou-bygningen
Postal address:
Høegh-Guldbergs Gade 10
1115, 230
8000
Aarhus C
Denmark

Email: vorup-jensen@biomed.au.dk

Mobile: +4521489781

Phone: +4521489781

Recent Activities

European Commission (External organisation)

Thomas Vorup-Jensen (Member)

20 May 2020

JAMA: The Journal of the American Medical Association (Journal)

Thomas Vorup-Jensen (Reviewer)

19 May 2020

University of Southern Denmark (External organisation)

Thomas Vorup-Jensen (Member)

6 May 2020

Frontiers in Immunology (Journal)

Thomas Vorup-Jensen (Reviewer)

20 Mar 2020

Ugeskr for Læger (Journal)

Thomas Vorup-Jensen (Reviewer)

14 Mar 2020

Strategic Research Centre: Personalised Approach to Pseudomonas aeruginosa (PAPA)

Thomas Vorup-Jensen (Participant)

5 Mar 2020

17th iNANO Annual Meeting 2020

Thomas Vorup-Jensen (Participant)

15 Jan 2020

Journal of Immunology (Journal)

Thomas Vorup-Jensen (Reviewer)

12 Dec 2019

Vaccine (Journal)

Thomas Vorup-Jensen (Reviewer)

28 Oct 2019

Aarhus University (Organisational unit)

Thomas Vorup-Jensen (Chairman)

2 Sep 20198 Nov 2019

Press clippings

ASTRID2 åbner nye døre

Thomas Vorup-Jensen

13/09/2012

1 item of Media coverage

AU indvier den ultimative røntgen-kilde

Thomas Vorup-Jensen

10/09/2012

1 item of Media coverage

Aarhus Universitet får ny doktor i immunologi

Thomas Vorup-Jensen

05/09/2014

1 item of Media coverage

Algoritmer og proteinmolekyler

Thomas Vorup-Jensen

31/01/2018

1 Media contribution

Bagklog på P1 m. Esben Kjær & Tobias Dybvad

Thomas Vorup-Jensen

09/12/2017

1 Media contribution

Berlingske Tidende

Thomas Vorup-Jensen

04/12/2017

1 Media contribution

DOKTORFORSVAR OM IMMUNSYSTEMET

Thomas Vorup-Jensen

04/09/2014

1 item of Media coverage

DR2 Dagen

Thomas Vorup-Jensen

05/12/2017

1 Media contribution

Dansk biotekselskab på frierfødder

Thomas Vorup-Jensen

29/06/2016

1 item of Media coverage

Dansk gennembrud giver ny viden om bakterier

Thomas Vorup-Jensen

04/10/2016

1 item of Media coverage

Deadline: Interview m. Thomas Vorup-Jensen

Thomas Vorup-Jensen

13/01/2007

1 Media contribution

Derfor er kolesterolmedicin godt for diabetikere og sklerosepatienter

Thomas Vorup-Jensen

05/07/2016

1 item of Media coverage

Det Sundhedsvidenskabelige Fakultets Ph.D. Dag 2011

Thomas Vorup-Jensen

14/01/2011

1 Media contribution

Er der ukrudtsgift i vores vacciner?

Thomas Vorup-Jensen

07/05/2018

1 Media contribution

Forskere: Universiteternes lave prioritet i genåbningen er stærkt bekymrende

Thomas Vorup-Jensen

20/05/2020

1 Media contribution

Forskernes udstillingsvindue

Thomas Vorup-Jensen

16/01/2010

1 Media contribution

Forskningen kom frem i lyset

Thomas Vorup-Jensen

17/01/2009

1 Media contribution

Frihed falmer uden finanser

Thomas Vorup-Jensen

23/02/2009

1 Media contribution

From MS to AMR

Thomas Vorup-Jensen

08/12/2017

1 Media contribution

Genterapi og et bedre menneske

Thomas Vorup-Jensen

25/09/2018

1 item of Media coverage

Interdisciplinaritet hvad og hvorfor?

Thomas Vorup-Jensen

06/01/2017

1 Media contribution

Interview i Jyllandsposten: "Nye regler for cremer er for slappe"

Thomas Vorup-Jensen

19/02/2013

1 item of Media coverage

Ja tak: Kaffe kan holde flere sygdomme væk

Thomas Vorup-Jensen

18/01/2017

1 Media contribution

KAFFEN ER MED TIL AT HOLDE DIG UNG

Thomas Vorup-Jensen

24/02/2017

1 Media contribution

Kaffe forebygger (måske) alderdom

Thomas Vorup-Jensen

28/01/2017

1 Media contribution

Kan vi få en konstruktiv vaccine debat?

Thomas Vorup-Jensen

28/01/2019

1 Media contribution

Kolesterolmedicin mod sclerose

Thomas Vorup-Jensen

15/08/2016

1 item of Media coverage

Kolesterolmedicins virkning på betændelsessygdomme kortlagt

Thomas Vorup-Jensen

05/07/2016

1 item of Media coverage

Kommentar: Fremryk genåbning af universiteterne

Thomas Vorup-Jensen

18/05/2020

1 Media contribution

Lup på effekten af Copaxone

Thomas Vorup-Jensen & Bettina Winther Grumsen

05/09/2014

1 item of Media coverage

MS-Medikament gegen Multiresistenz

Thomas Vorup-Jensen

07/12/2017

1 Media contribution

NY PROFESSOR MSO: Immunforsvaret under luppen

Thomas Vorup-Jensen

04/04/2013

1 item of Media coverage

NYT JOB

Thomas Vorup-Jensen

09/01/2018

1 Media contribution

Navne i Noter

Thomas Vorup-Jensen

05/09/2014

1 item of Media coverage

Negativt ladede sukkerstoffer på T lymfocytter som mål for terapeutisk behandling med Copaxone

Thomas Vorup-Jensen

03/05/2018

1 Media contribution

Nyt professorat i biomedicin

Thomas Vorup-Jensen

10/01/2018

1 Media contribution

Nyt professorat i biomedicin i Aarhus

Thomas Vorup-Jensen

08/01/2018

1 Media contribution

Nyt våben mod farlige bakterier

Thomas Vorup-Jensen

04/12/2017

1 Media contribution

P1 Morgen

Thomas Vorup-Jensen

06/12/2017

1 Media contribution

P4 Morgen

Thomas Vorup-Jensen

14/01/2010

1 Media contribution

P4 Morgen

Thomas Vorup-Jensen

13/01/2007

1 Media contribution

Regional nyhedsudsendelse

Thomas Vorup-Jensen

28/01/2009

1 Media contribution

Repurposing drugs could be key to fighting antibiotic resistance

Thomas Vorup-Jensen

16/11/2017

1 Media contribution

Repurposing: Gammel medicin kan behandle flere nye sygdomme i fremtiden

Thomas Vorup-Jensen

09/12/2017

1 Media contribution

Sclerosis medicine can fight multi – resistant bacteria

Thomas Vorup-Jensen

07/12/2017

1 Media contribution

Sclerosis medicine can fight multi-resistant bacteria

Thomas Vorup-Jensen

22/11/2017

1 Media contribution

Skarp, nysgerrig og original: 4 forskere mindes nobelprismodtager

Thomas Vorup-Jensen

29/06/2018

1 Media contribution

Sklerosemedicin dræbte bakterier

Thomas Vorup-Jensen

17/12/2017

1 Media contribution

Sklerosemedicin kan også slå multiresistente bakterier ihjel

Thomas Vorup-Jensen

05/12/2017

1 Media contribution

Sklerosemedicin slår på forunderlig vis multiresistente bakterier ihjel

Thomas Vorup-Jensen

04/12/2017

1 Media contribution

Spotlight on Denmark

Thomas Vorup-Jensen

04/11/2015

1 item of Media coverage

Særlige Bindingsmoilekyler i Kroppen skal undersøges

Thomas Vorup-Jensen

07/02/2013

1 item of Media coverage

Ugens podcast: Gammel medicin kan være sand guldgrube

Thomas Vorup-Jensen

07/12/2017

1 Media contribution

Åbent brev fra forskere til politikere: Fremskynd genåbningen af universiteterne

Thomas Vorup-Jensen

18/05/2020

1 Media contribution

Projects

Atomic resolution insight on the principles of ligand recognition by integrin receptor aMb2

Vorup-Jensen, T. & Andersen, G. R.

01/08/201331/07/2016

NEURODIN: Center for study and prevention of the Neurodegenerative Inflammation NEURODIN

Romero-Ramos, M., Vorup-Jensen, T., Sanchez-Guajardo, V. & Brooks, D.

AU IDEAS AUFF

01/01/201431/12/2018

DIREKT: Disarming the intravascular innate immune response to improve treatment modalities for chronic kidney disease

Sutherland, D. S. & Vorup-Jensen, T.

01/12/201330/11/2017

NANOBRAIN: Imaging inflammation in vivo in ischemic stroke: development of a multimodal NANOprobe & BRAIN imaging methods

Vorup-Jensen, T.

01/10/201531/03/2019

Peer-reviewed Publications

Bladt, TM, Vorup-Jensen, T, Sædder, EA & Ebbesen, M 2020, 'Empirical Investigation of Ethical Challenges Related to the Use of Biological Therapies', The Journal of Law, Medicine & Ethics.
Parbo, P, Madsen, LS, Ismail, R, Zetterberg, H, Blennow, K, Eskildsen, SF, Vorup-Jensen, T & Brooks, DJ 2020, 'Low plasma neurofilament light levels associated with raised cortical microglial activation suggest inflammation acts to protect prodromal Alzheimer's disease', Alzheimer's Research & Therapy, vol. 12, no. 1, 3. https://doi.org/10.1186/s13195-019-0574-0
Juul-Madsen, K, Qvist, P, Bendtsen, KL, Langkilde, AE, Vestergaard, B, Howard, K, Dehesa-Etxebeste, M, Paludan, SR, Andersen, GR, Jensen, PH, Otzen, DE, Romero-Ramos, M & Vorup-Jensen, T 2020, 'Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4', Journal of Immunology, vol. 204, no. 5, pp. 1345-1361. https://doi.org/10.4049/jimmunol.1900494
Juul-Madsen, K, Zhao, H, Vorup-Jensen, T & Schuck, P 2019, 'Efficient data acquisition with three-channel centerpieces in sedimentation velocity', Analytical Biochemistry, vol. 586, 113414, pp. 113414. https://doi.org/10.1016/j.ab.2019.113414
Cedzynski, M, Thielens, NM, Mollnes, TE & Vorup-Jensen, T (eds) 2019, The role of complement in health and disease. Frontiers in Immunology, Frontiers Media S.A., Lausanne. https://doi.org/10.3389/978-2-88963-159-9
Murphy, RA, Hill Christiansen, S, Sabnis, A, Schelenz, S, Vorup-Jensen, T, Davies, JC & Edwards, A 2019, 'GLATIRAMER ACETATE IS AN ANTIBIOTIC RESISTANCE BREAKER AGAINST CYSTIC FIBROSIS STRAINS OF PSEUDOMONAS AERUGINOSA VIA DISRUPTION OF THE BACTERIAL OUTER MEMBRANE', pp. S297-298. https://doi.org/10.1002/ppul.22495
Skovdal, SM, Christiansen, SH, Johansen, KS, Viborg, O, Bruun, NH, Jensen-Fangel, S, Holm, IE, Vorup-Jensen, T & Petersen, E 2019, 'Inhaled nebulized glatiramer acetate against Gram-negative bacteria is not associated with adverse pulmonary reactions in healthy, young adult female pigs', PLOS ONE, vol. 14, no. 10, e0223647. https://doi.org/10.1371/journal.pone.0223647
Cedzyński, M, Thielens, NM, Mollnes, TE & Vorup-Jensen, T 2019, 'Editorial: The Role of Complement in Health and Disease', Frontiers in Immunology, vol. 10, 1869. https://doi.org/10.3389/fimmu.2019.01869
Vorup-Jensen, T & Jensen, RK 2018, 'Structural immunology of complement receptors 3 and 4', Frontiers in Immunology, vol. 9, no. NOV, 2716, pp. 1-20. https://doi.org/10.3389/fimmu.2018.02716
Bladt, TM, Vorup-Jensen, T, Sædder, EA & Ebbesen, M 2018, 'Etiske perspektiver på diskussionen om fordeling af ressourcer i det danske sundhedsvæsen', Ugeskrift for Laeger, vol. 22/2018. <http://ugeskriftet.dk/debat/etiske-perspektiver-pa-diskussionen-om-fordeling-af-ressourcer-i-det-danske-sundhedsvaesen>
Støy, S, Sandahl, TD, Hansen, AL, Deleuran, B, Vorup-Jensen, T, Vilstrup, H & Kragstrup, TW 2018, 'Correction: Decreased monocyte shedding of the migration inhibitor soluble CD18 in alcoholic hepatitis', Clinical and Translational Gastroenterology, vol. 9, no. 7, 171, pp. 171. https://doi.org/10.1038/s41424-018-0041-4
Støy, S, Sandahl, TD, Hansen, AL, Deleuran, B, Vorup-Jensen, T, Vilstrup, H & Kragstrup, TW 2018, 'Decreased monocyte shedding of the migration inhibitor soluble CD18 in alcoholic hepatitis', Clinical and Translational Gastroenterology, vol. 9, no. 6, 160, pp. e1-e10. https://doi.org/10.1038/s41424-018-0022-7
Christiansen, SH, Murphy, RA, Juul-Madsen, K, Fredborg, M, Hvam, ML, Axelgaard, E, Skovdal, SM, Meyer, RL, Sorensen, UBS, Moeller, A, Nyengaard, JR, Norskov-Lauritsen, N, Wang, M, Gadjeva, M, Howard, KA, Davies, JC, Petersen, E & Vorup-Jensen, T 2017, 'The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria', Scientific Reports, vol. 7, 15653. https://doi.org/10.1038/s41598-017-15969-3
Kragstrup, TW, Juul-Madsen, K, Christiansen, SH, Zhang, X, Krog, J, Vorup-Jensen, T & Kjaergaard, AG 2017, 'Altered levels of soluble CD18 may associate immune mechanisms with outcome in sepsis', Clinical and Experimental Immunology, vol. 190, no. 2, pp. 258-267. https://doi.org/10.1111/cei.13016
Pakula, MM, Maier, TJ & Vorup-Jensen, T 2017, 'Insight on the impacts of free amino acids and their metabolites on the immune system from a perspective of inborn errors of amino acid metabolism', Expert Opinion On Therapeutic Targets, vol. 21, no. 6, pp. 611-626. https://doi.org/10.1080/14728222.2017.1323879
Christiansen, SH, Zhang, X, Juul-Madsen, K, Hvam, ML, Vad, BS, Behrens, MA, Thygesen, IL, Jalilian, B, Pedersen, JS, Howard, K, Otzen, DE & Vorup-Jensen, T 2017, 'The random co-polymer glatiramer acetate rapidly kills primary human leukocytes through sialic-acid-dependent cell membrane damage', B B A - Biomembranes, vol. 1859, no. 3, pp. 425-437. https://doi.org/10.1016/j.bbamem.2017.01.001
von Euler Chelpin, M & Vorup-Jensen, T 2017, 'Targets and Mechanisms in Prevention of Parkinson's Disease through Immunomodulatory Treatments', Scandinavian Journal of Immunology, vol. 85, no. 5, pp. 321-330. https://doi.org/10.1111/sji.12542
Stoey, S, Sandahl, TD, Hansen, AL, Deleuran, B, Vorup-Jensen, T, Vilstrup, H & Kragstrup, TW 2016, 'Augmented shedding of the leukocyte migration inhibitor soluble CD18 combined with increased plasma levels in human alcoholic hepatitis', Hepatology, vol. 64, no. 1 SUPP, pp. 522A-522A.
Kugadas, A, Christiansen, SH, Sankaranarayanan, S, Surana, NK, Gauguet, S, Kunz, R, Fichorova, R, Vorup-Jensen, T & Gadjeva, M 2016, 'IMPACT OF MICROBIOTA ON RESISTANCE TO OCULAR PSEUDOMONAS AERUGINOSA–INDUCED KERATITIS', PLOS Pathogens.
Jensen, MR, Bajic, G, Zhang, X, Laustsen, AK, Koldsø, H, Skeby, KK, Schiøtt, B, Andersen, GR & Vorup-Jensen, T 2016, 'Structural basis for simvastatin competitive antagonism of complement receptor 3', Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M116.732222
Howard, KA, Vorup-Jensen, T & Peer, D (eds) 2016, Nanomedicine. Advances in Delivery Science and Technology, 1 edn, Springer, New York.
Huang, S-Y, Jensen, MR, Rosenberg, CA, Zhu, X-Q, Petersen, E & Vorup-Jensen, T 2016, 'In silico and in vivo analysis of Toxoplasma gondii epitopes by correlating survival data with peptide-MHC-I binding affinities', International Journal of Infectious Diseases, vol. 48, pp. 14-19. https://doi.org/10.1016/j.ijid.2016.04.014
Kragstrup, TW, Greisen, SR, Nielsen, MA, Rhodes, C, Stengaard-Pedersen, K, Hetland, ML, Hørslev-Petersen, K, Junker, P, Østergaard, M, Hvid, M, Vorup-Jensen, T, Robinson, WH, Sokolove, J & Deleuran, B 2016, 'The interleukin-20 receptor axis in early rheumatoid arthritis: novel links between disease-associated autoantibodies and radiographic progression', Arthritis research & therapy, vol. 18, no. 1, 61. https://doi.org/10.1186/s13075-016-0964-7
Zhang, X, Bajic, G, Andersen, GR, Christiansen, SH & Vorup-Jensen, T 2016, 'The cationic peptide LL-37 binds Mac-1 (CD11b/CD18) with a low dissociation rate and promotes phagocytosis', B B A - Proteins and Proteomics. https://doi.org/10.1016/j.bbapap.2016.02.013
Kragstrup, TW, Jalilian, B, Keller, KK, Zhang, X, Laustsen, JK, Stengaard-Pedersen, K, Hetland, ML, Hørslev-Petersen, K, Junker, P, Østergaard, M, Hauge, E-M, Hvid, M, Vorup-Jensen, T & Deleuran, B 2016, 'Changes in Soluble CD18 in Murine Autoimmune Arthritis and Rheumatoid Arthritis Reflect Disease Establishment and Treatment Response', PLOS ONE, vol. 11, no. 2, pp. e0148486. https://doi.org/10.1371/journal.pone.0148486
Roos, J, Grösch, S, Werz, O, Schröder, P, Ziegler, S, Fulda, S, Paulus, P, Urbschat, A, Kühn, B, Maucher, I, Fettel, J, Vorup-Jensen, T, Piesche, M, Matrone, C, Steinhilber, D, Parnham, MJ & Maier, TJ 2016, 'Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?', Pharmacology & Therapeutics, vol. 157, pp. 43-64. https://doi.org/10.1016/j.pharmthera.2015.11.001
Bech, R, Jalilian, B, Agger, R, Iversen, L, Erlandsen, M, Otkjaer, K, Johansen, C, Paludan, SR, Rosenberg, CA, Kragballe, K & Vorup-Jensen, T 2016, 'Interleukin 20 regulates dendritic cell migration and expression of co-stimulatory molecules', Molecular and Cellular Therapies, vol. 4, no. 1. https://doi.org/10.1186/s40591-016-0046-x
Roos, J, Vorup-Jensen, T, Matrone, C, Maier, TJ & et al. 2016, 'On the role of lipoxygenases in pathogenesis of cancer.', Progress in inflammation research (submitted after invitation), vol. Lipoxygenases in Inflammation, Progress in Inflammation Research, DOI 10.1007/978-3-319-27766-0_7.
Vorup-Jensen, T 2016, The Nanoscience of Polyvalent Binding by Proteins in the Immune Response. in K Howard, T Vorup-Jensen & D Peer (eds), Nanomedicine. Springer-Verlag New York, pp. 53-76.
Brinck-Jensen, NS, Vorup-Jensen, T, Leutscher, PDC, Erikstrup, C & Petersen, E 2015, 'Immunogenicity of twenty peptides representing epitopes of the hepatitis B core and surface antigens by IFN-γ response in chronic and resolved HBV', BMC Immunology, vol. 16, no. 1, 65. https://doi.org/10.1186/s12865-015-0127-7
Kragstrup, TW, Greisen, S, Nielsen, MA, Rhodes, C, Stengaard-Pedersen, K, Hetland, ML, Horslev-Petersen, K, Junker, P, Ostergaard, M, Hvid, M, Vorup-Jensen, T, Robinson, WH, Sokolove, J & Deleuran, B 2015, 'The IL-20 Receptor Axis in Early Rheumatoid Arthritis', Arthritis & Rheumatology, vol. 67.
Kläning, E, Christensen, BS, Bajic, G, Hoffmann, SV, Jones, NC, Callesen, MM, Andersen, GR, Sørensen, ES & Vorup-Jensen, T 2015, 'Multiple low-affinity interactions support binding of human osteopontin to integrin αXβ2', B B A - Proteins and Proteomics, vol. 1854, no. 8, pp. 930-938. https://doi.org/10.1016/j.bbapap.2015.03.008
Stoey, S, Sandahl, TD, Deleuran, B, Vorup-Jensen, T, Vilstrup, H & Kragstrup, TW 2015, 'THE LEUKOCYTE MIGRATION INHIBITOR SOLUBLE CD18 INCREASES WITH SEVERITY OF HUMAN ALCOHOLIC HEPATITIS', Journal of Hepatology, vol. 62, pp. S776-S776.
Papazian, D, Chhoden, T, Arge, M, Vorup-Jensen, T, Nielsen, CH, Lund, K, Würtzen, PA & Hansen, S 2015, 'Polarization Affects Airway Epithelial Conditioning of Monocyte-Derived Dendritic Cells', American Journal of Respiratory Cell and Molecular Biology (Online). https://doi.org/10.1165/rcmb.2014-0183OC
Brinck-Jensen, N-S, Vorup-Jensen, T, Leutscher, PDC, Erikstrup, C & Petersen, E 2015, 'Immunogenicity of twenty peptides representing epitopes of the hepatitis B core and surface antigens by IFN-γ response in chronic and resolved HBV', B M C Immunology, vol. 16, no. 1, pp. 65. https://doi.org/10.1186/s12865-015-0127-7
Kragstrup, TW, Jalilian, B, Keller, KK, Stengaard-Pedersen, K, Hetland, ML, Horslev-Petersen, K, Junker, P, Ostergaard, M, Hauge, EM, Hvid, M, Vorup-Jensen, T & Deleuran, B 2014, 'Changes in Soluble CD18 Reflect Latency in the Immune System and Predict Radiographic Progression in Early Rheumatoid Arthritis', Arthritis & Rheumatology, vol. 66, pp. S863-S864.
Kläning, E, Christensen, B, Sørensen, ES, Vorup-Jensen, T & Jensen, JK 2014, 'Osteopontin binds multiple calcium ions with high affinity and independently of phosphorylation status', Bone, vol. 66, pp. 90-95. https://doi.org/10.1016/j.bone.2014.05.020
Munksgaard, PS, Skals, MG, Reinholdt, J, Poulsen, K, Jensen, MR, Yang, C, Leipziger, J, Vorup-Jensen, T & Praetorius, HA 2014, 'Sialic acid residues are essential for cell lysis mediated by leukotoxin from Aggregatibacter actinomycetemcomitans', Infection and Immunity, vol. 82, no. 6, pp. 2219-28. https://doi.org/10.1128/IAI.01647-14
Bech, R, Otkjaer, K, Birkelund, S, Vorup-Jensen, T, Agger, R, Johansen, C, Iversen, L, Kragballe, K & Rømer, J 2014, 'Interleukin 20 protein locates to distinct mononuclear cells in psoriatic skin', Experimental Dermatology Online. https://doi.org/10.1111/exd.12371
Kragstrup, TW, Jalilian, B, Hvid, M, Kjærgaard, A, Ostgård, R, Schiøttz-Christensen, B, Jurik, AG, Robinson, WH, Vorup-Jensen, T & Deleuran, B 2014, 'Decreased plasma levels of soluble CD18 link leukocyte infiltration with disease activity in spondyloarthritis', Arthritis research & therapy, vol. 16, no. 1, pp. R42. https://doi.org/10.1186/ar4471
Wittenborn, TR, Larsen, EKU, Nielsen, T, Rydtoft, LM, Hansen, L, Nygaard, JV, Vorup-Jensen, T, Kjems, J, Horsman, MR & Nielsen, NC 2014, 'Accumulation of nano-sized particles in a murine model of angiogenesis', Biochemical and Biophysical Research Communications, vol. 443, no. 2, pp. 470-6. https://doi.org/10.1016/j.bbrc.2013.11.127
Vorup-Jensen, T 2014, Challenges and opportunities in fractionation of recombinant human mannan-binding lectin. in The Complement System: Methods and Protocols. The Humana Press Inc., Methods in Molecular Biology, vol. 1100, pp. 109-121. https://doi.org/10.1007/978-1-62703-724-2_9
Nielsen, GK & Vorup-Jensen, T 2014, Detection of soluble CR3 (CD11b/CD18) by time-resolved immunofluorometry. in The Complement System: Methods and Protocols. The Humana Press Inc., Methods in Molecular Biology, vol. 1100, pp. 355-364. https://doi.org/10.1007/978-1-62703-724-2_30
Vorup-Jensen, T 2014, 'Challenges and opportunities in fractionation of recombinant human mannan-binding lectin', Methods in molecular biology (Clifton, N.J.), vol. 1100, pp. 109-21. https://doi.org/10.1007/978-1-62703-724-2_9
Nielsen, GK & Vorup-Jensen, T 2014, Detection of Soluble CR3 (CD11b/CD18) by Time-Resolved Immunofluorometry. in M Gadjeva (ed.), The Complement System: Methods and Protocols. Springer, Methods in Molecular Biology, vol. 1100, pp. 355-64. https://doi.org/10.1007/978-1-62703-724-2_30
Jalilian, B, Hill Christiansen, S, Einarsson, HB, Rasoli, M, Petersen, E & Vorup-Jensen, T 2013, 'Properties and prospects of adjuvants in influenza vaccination - messy precipitates or blessed opportunities?', Molecular and Cellular Therapies, vol. 1, 2.
Bajic, G, Yatime, L, Sim, RB, Vorup-Jensen, T & Andersen, GR 2013, 'Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3', Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 41, pp. 16426–16431. https://doi.org/10.1073/pnas.1311261110
Rosenberg, C, Bovin, NV, Bram, LV, Flyvbjerg, E, Erlandsen, M, Vorup-Jensen, T & Petersen, E 2013, 'Age is an important determinant in humoral and T cell responses to immunization with hepatitis B surface antigen', Human Vaccines & Immunotherapeutics, vol. 9, no. 7, pp. 1466-76. https://doi.org/10.4161/hv.24480
Kragstrup, TW, Vorup-Jensen, T, Deleuran, B & Hvid, M 2013, 'A simple set of validation steps identifies and removes false results in a sandwich enzyme-linked immunosorbent assay caused by anti-animal IgG antibodies in plasma from arthritis patients', SpringerPlus, vol. 2, no. 1, pp. 263. https://doi.org/10.1186/2193-1801-2-263
Reinholdt, J, Poulsen, K, Brinkmann, CR, Hoffmann, SV, Stapulionis, R, Enghild, JJ, Jensen, UB, Boesen, T & Vorup-Jensen, T 2013, 'Monodisperse and LPS-free Aggregatibacter actinomycetemcomitans leukotoxin: Interactions with human β2 integrins and erythrocytes', BBA General Subjects, vol. 1834, no. 2, pp. 546-558. https://doi.org/10.1016/j.bbapap.2012.12.004
Kragstrup, TW, Jalilian, B, Hvid, M, Kjærgaard, AG, Østgård, R, Schiøttz-Christensen, B, Jurik, AG, Vorup-Jensen, T & Deleuran, BW 2013, 'Decreased plasma levels of soluble CD18 link leukocyte migration and disease activity in spondyloarthritis.', Arthritis & Rheumatism, no. 65 (suppl. 10).
Kragstrup, TW, Jalilian, B, Hvid, M, Kjærgaard, AG, Østgård, R, Schiøttz-Christensen, B, Jurik, AG, Vorup-Jensen, T & Deleuran, BW 2013, 'Inadequate CD18 shedding and increased depletion of soluble CD18 contributes to inflammatory acitivity in spondyloarthritis (P5090)', Journal of Immunology, no. 190, 180.28.
Gjelstrup, LC, Kaspersen, JD, Behrens, MA, Pedersen, JS, Thiel, S, Kingshott, P, Oliveira, CLP, Thielens, NM & Vorup-Jensen, T 2012, 'The role of nanometer-scaled ligand patterns in polyvalent binding by large mannan-binding lectin oligomers', Journal of Immunology, vol. 188, no. 3, pp. 1292-306. https://doi.org/10.4049/jimmunol.1103012
Vorup-Jensen, T 2012, Wrong resemblance? Role of the immune system in the biocompatibility of nanostructured materials. in Handbook of Harnessing Biomaterials in Nanomedicine. Pan Stanford Publishing Pte Ltd Singapore , pp. 283-308. https://doi.org/10.4032/9789814364270
Vorup-Jensen, T 2012, 'Surface Plasmon Resonance Biosensing in Studies of the Binding Between β(2) Integrin I Domains and Their Ligands', Methods in Molecular Biology, vol. 757, pp. 55-71. https://doi.org/10.1007/978-1-61779-166-6_5
Jalilian, B, Einarsson, HB & Vorup-Jensen, T 2012, 'Glatiramer Acetate in Treatment of Multiple Sclerosis: A Toolbox of Random Co-Polymers for Targeting Inflammatory Mechanisms of both the Innate and Adaptive Immune System?', International Journal of Molecular Sciences (Online), vol. 13, no. 11, pp. 14579-605. https://doi.org/10.3390/ijms131114579
Munksgaard, PS, Vorup-Jensen, T, Reinholdt, J, Söderström, CM, Poulsen, K, Leipziger, J, Praetorius, HA & Skals, M 2012, 'Leukotoxin from Aggregatibacter actinomycetemcomitans causes shrinkage and P2X receptor-dependent lysis of human erythrocytes', Cellular Microbiology, vol. 14, no. 12, pp. 1904-20. https://doi.org/10.1111/cmi.12021
Vorup-Jensen, T & Peer, D 2012, 'Nanotoxicity and the importance of being earnest', Advanced Drug Delivery Reviews, vol. 64, no. 15, pp. 1661-2. https://doi.org/10.1016/j.addr.2012.09.002
Vorup-Jensen, T 2012, 'On the roles of polyvalent binding in immune recognition: Perspectives in the nanoscience of immunology and the immune response to nanomedicines', Advanced Drug Delivery Reviews, vol. 64, no. 15, pp. 1759-81. https://doi.org/10.1016/j.addr.2012.06.003
Wittenborn, T, Nielsen, T, Nygaard, JV, Larsen, EKU, Thim, T, Rydtoft, LM, Vorup-Jensen, T, Kjems, J, Nielsen, NC, Horsman, MR & Falk, E 2012, 'Ultra-High-Field DCE-MRI of Angiogenesis in a Novel Angiogenesis Mouse Model', Journal of Magnetic Resonance Imaging, vol. 35, no. 3, pp. 703-710. https://doi.org/10.1002/jmri.22855
Vorup-Jensen, T & Boesen, T 2011, 'Protein ultrastructure and the nanoscience of complement activation', Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2011.05.023
Bohn, AB, Nederby, L, Harbo, T, Skovbo, A, Vorup-Jensen, T, Krog, J, Jakobsen, J & Hokland, M 2011, 'The effect of IgG levels on the number of natural killer cells and their Fc receptors in chronic inflammatory demyelinating polyradiculoneuropathy', European Journal of Neurology, vol. 18, no. 6, pp. 919-924.
Gjelstrup, LC, Andersen, SH, Petersen, SV, Enghild, JJ, Blom, AM, Vorup-Jensen, T & Thiel, S 2011, 'The role of higher-order protein structure in supporting binding by heteroclitic monoclonal antibodies: the monoclonal antibody KIM185 to CD18 also binds C4-binding protein', Molecular Immunology, vol. 49, no. 1-2, pp. 38-47. https://doi.org/10.1016/j.molimm.2011.07.018
Dolatshahi-Pirouz, A, Jensen, TB, Vorup-Jensen, T, Riber-Hansen, R, Chevallier, J, Besenbacher, F, Foss, M & Sutherland, DS 2010, 'Synthesis of functional nanomaterials via colloidal mask templating and glancing angle deposition (GLAD)”', Advanced Engineering Materials, vol. 12, no. 9, pp. 899-905.
Vorup-Jensen, T 2010, 'Coping with complexity (in macromolecular interactions)-A comment on Rebecca L. Rich's and David G. Myszka's "Grading the commercial optical biosensor literature-Class of 2008: 'The Mighty Binders"'', Journal of Molecular Recognition, vol. 23, no. 4, pp. 389-391. https://doi.org/10.1002/jmr.1046
Gjelstrup, LC, Boesen, T, Kragstrup, TW, Jørgensen, A, Klein, NJ, Thiel, S, Deleuran, BW & Vorup-Jensen, T 2010, 'Functionally Active CD11/CD18 Integrin Complexes are Shedded From the Leukocyte Membranes in Chronic Inflammation Disorders', Scandinavian Journal of Immunology, vol. 71, no. 6, pp. 515-515.
Pedersen, MB, Zhou, X, Larsen, EKU, Sørensen, US, Kjems, J, Nygaard, JV, Nyengaard, JR, Meyer, RL, Boesen, T & Vorup-Jensen, T 2010, 'Curvature of Synthetic and Natural Surfaces is an Important Target Feature in Classical Pathway Complement Activation', Journal of Immunology, vol. 184, no. 4, pp. 1931-1945. https://doi.org/10.4049/jimmunol.0902214
Gjelstrup, LC, Boesen, T, Kragstrup, TW, Jørgensen, A, Klein, NJ, Thiel, S, Deleuran, B & Vorup-Jensen, T 2010, 'Shedding of Large Functionally Active CD11/CD18 Integrin Complexes from Leukocyte Membranes during Synovial Inflammation Distinguishes Three Types of Arthritis through Differential Epitope Exposure', Journal of Immunology, vol. 185, no. 7, pp. 4154-68. https://doi.org/10.4049/jimmunol.1000952
Rosenberg, C, De Craeye, S, Jongert, E, Gargano, N, Beghetto, E, Del Porto, P, Vorup-Jensen, T, Petersen, E & Rosenberg, CA 2009, 'Induction of partial protection against infection with Toxoplasma gondii genotype II by DNA vaccination with recombinant chimeric tachyzoite antigens', Vaccine, vol. 27, no. 18, pp. 2489-98. https://doi.org/10.1016/j.vaccine.2009.02.058
Wittenborn, T, Nygaard, JV, Horsman, MR, Vorup-Jensen, T, Kjems, J, Thim, T, Nielsen, T, Larsen, EKU & Falk, E 2009, 'A Novel in Vivo Angiogenesis Mouse Model', Arteriosclerosis, Thrombosis, and Vascular Biology, no. 7.
Rosenberg, CA, De Craeye, S, Jongert, E, Gargano, N, Beghetto, E, Del Porto, P, Vorup-Jensen, T & Petersen, JE 2009, 'Induction of partial protection against infection with Toxoplasma gondii genotype II by DNA vaccination with recombinant chimeric tachyzoite antigens', Vaccine, vol. 27, pp. 2489-98.
Schack, L, Stapulionis, R, Christensen, B, Kofod-Olsen, E, Sørensen, UBS, Vorup-Jensen, T, Sørensen, ES & Höllsberg, P 2009, 'Osteopontin enhances phagocytosis through a novel osteopontin receptor, the alphaXbeta2 integrin', Journal of Immunology, vol. 182, no. 11, pp. 6943-50. https://doi.org/10.4049/jimmunol.0900065
Larsen, EKU, Nielsen, T, Wittenborn, T, Birkedal, H, Vorup-Jensen, T, Jakobsen, MH, Østergaard, L, Horsman, MR, Besenbacher, F, Howard, KA & Kjems, J 2009, 'Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors', A C S Nano, vol. 3, no. 7, pp. 1947-51. https://doi.org/10.1021/nn900330m
Kingshott, P, Arpanaei, A, Stapulionis, R & Vorup-Jensen, T 2008, Reduced attachment of blood mononuclear and αMβ2-expressing cells to surfaces coated with fish proteins. in 8th World Biomaterials Congress 2008. 8th World Biomaterials Congress 2008, vol. 3, 8th World Biomaterials Congress 2008, WBC 2008, Amsterdam, Netherlands, 28/05/2008.
Stapulionis, R, Oliveira, CLP, Gjelstrup, MC, Pedersen, JS, Hokland, ME, Hoffmann, SV, Poulsen, K, Jacobsen, C & Vorup-Jensen, T 2008, 'Structural insight into the function of myelin basic protein as a ligand for integrin αMβ2', Journal of Immunology, vol. 180, no. 6, pp. 3946-3956.
Kingshott, P, Arpanaei, A, Stapulionis, R & Vorup-Jensen, T 2008, 'Reduced attachment of blood mononuclear and alphaM-Beta2-expressing cells to surfaces coated with fish proteins.', Paper presented at 8th World Biomaterials Congress, Amsterdam, Netherlands, 17/12/2010.
Stapulionis, R, Oliveira, C, Gjelstrup, MC, Pedersen, JS, Hokland, M, Hoffmann, SV, Poulsen, K, Jacobsen, C & Vorup-Jensen, T 2008, 'Structural insight into the function of myelin basic protein as a ligand for integrin αMβ2', Journal of Immunology, vol. 180, pp. 3946-3956.
Vorup-Jensen, T, Chi, L, Gjelstrup, LC, Jensen, UB, Jewett, CA, Xie, C, Shimaoka, M, Linhardt, RJ & Springer, TA 2007, 'Binding between the integrin alphaXbeta2 (CD11c/CD18) and heparin', Journal of Biological Chemistry, vol. 282, no. 42, pp. 30869-77. https://doi.org/10.1074/jbc.M706114200
Dong, M, Xu, S, Oliveira, C, Pedersen, JS, Thiel, S, Besenbacher, F & Vorup-Jensen, T 2007, 'Conformational changes in mannan-binding lectin bound to ligand surfaces', The Journal of Immunology, vol. 178, pp. 3016-3022.
Dong, M, Xu, S, Oliveira, CLP, Pedersen, JS, Thiel, S, Besenbacher, F & Vorup-Jensen, T 2007, 'Conformational changes in mannan-binding lectin bound to ligand surfaces', Journal of Immunology, vol. 178, no. 5, pp. 3016-22.
Vorup-Jensen, T, Waldron, TT, Astrof, N, Shimaoka, M & Springer, TA 2007, 'The connection between metal ion affinity and ligand affinity in integrin I domains.', Biochim. Biophys. Acta., vol. 1774, pp. 1148-1155.
Zhang, M, Takahashi, K, Alicot, EM, Vorup-Jensen, T, Kessler, B, Thiel, S, Jensenius, JC, Ezekowitz, RAB, Moore, FD & Carroll, MC 2006, 'Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury', Journal of Immunology, vol. 177, no. 7, pp. 4727-34.
Zhang, M, Takahashi, K, Alicot, EM, Vorup-Jensen, T, Kessler, B, Thiel, S, Jensenius, JC, Ezekowitz, RA, Moore, FD & Carroll, MC 2006, 'Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury', J. Immunol., vol. 177, pp. 4727-34.
Zhang, M, Alicot, EM, Chiu, I, Li, J, Verna, N, Vorup-Jensen, T, Kessler, B, Shimaoka, M, Chan, R, Friend, D, Mahmood, U, Weissleder, R, Moore, FD & Carroll, MC 2006, 'Identification of the target self-antigens in reperfusion injury', J. Exp. Med., vol. 203, pp. 141-52.
Vorup-Jensen, T, Carman, CV, Shimaoka, M, Schuck, P, Svitel, J & Springer, TA 2005, 'Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin αXβ 2', Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 5, pp. 1614-1619. https://doi.org/10.1073/pnas.0409057102
Vorup-Jensen, T, Carman, CV, Shimaoka, M, Schuck, P, Svitel, J & Springer, TA 2005, 'Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin αΧβ', Proc. Natl. Acad. Science USA, vol. 102, pp. 1614-9.
Vorup-Jensen, T, Ostermeier, C, Shimaoka, M, Hommel, U & Springer, TA 2003, 'Structure and allosteric regulation of the αXβ2 integrin I domain', Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 4, pp. 1873-1878. https://doi.org/10.1073/pnas.0237387100
Vorup-Jensen, T, Ostermeier, C, Shimaoka, M, Hommel, U & Springer, TA 2003, 'Structure and allosteric regulation of the αΧβ2 integrin I domain', Proc. Natl. Acad. Science USA, vol. 100, pp. 1873-8.
Dagnaes-Hansen, F, Holst, HU, Jensen, MS, Vorup-Jensen, T, Flyvbjerg, A, Jensen, UB & Jensen, TG 2002, 'Physiological effects of human growth hormone produced after hydrodynamic gene transfer of a plasmid vector containing the human ubiquitin promotor', Journal of Molecular Medicine, vol. 80, no. 10, pp. 665-70. https://doi.org/10.1007/s00109-002-0371-1
Vorup-Jensen, T, Jensen, UB, Liu, H, Kawasaki, T, Uemura, K, Thiel, S, Dagnaes-Hansen, F & Jensen, TG 2001, 'Tail-vein injection of mannan-binding lectin DNA leads to high expression levels of multimeric protein in liver', Molecular Therapy, vol. 3, no. 6, pp. 867-74. https://doi.org/10.1006/mthe.2001.0335
Vorup-Jensen, T, Sørensen, ES, Jensen, UB, Schwaeble, W, Kawasaki, T, Ma, Y, Uemura, K, Wakamiya, N, Suzuki, Y, Jensen, TG, Takahashi, K, Ezekowitz, RA, Thiel, S & Jensenius, JC 2001, 'Recombinant expression of human mannan-binding lectin', International Immunopharmacology, vol. 1, no. 4, pp. 677-87.
Thielens, NM, Cseh, S, Thiel, S, Vorup-Jensen, T, Rossi, V, Jensenius, JC & Arlaud, GJ 2001, 'Interaction properties of human mannan-binding lectin (MBL)-associated serine proteases-1 and -2, MBL-associated protein 19, and MBL', Journal of Immunology, vol. 166, no. 8, pp. 5068-77.
Dahl, MR, Thiel, S, Matsushita, M, Fujita, T, Willis, AC, Christensen, T, Vorup-Jensen, T & Jensenius, JC 2001, 'MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway', Immunity, vol. 15, pp. 127-135.
Dahl, MR, Thiel, S, Matsushita, M, Fujita, T, Willis, AC, Christensen, T, Vorup-Jensen, T & Jensenius, JC 2001, 'MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway', Immunity, vol. 15, no. 1, pp. 127-35.
Stover, C, Endo, Y, Takahashi, M, Lynch, NJ, Constantinescu, C, Vorup-Jensen, T, Thiel, S, Friedl, H, Hankeln, T, Hall, R, Gregory, S, Fujita, T & Schwaeble, W 2001, 'The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3', Genes and Immunity, vol. 2, no. 3, pp. 119-27. https://doi.org/10.1038/sj.gene.6363745
Petersen, SV, Thiel, S, Jensen, L, Vorup-Jensen, T, Koch, C & Jensenius, JC 2000, 'Control of the classical and the MBL pathway of complement activation', Mol. Immunol, vol. 37, pp. 803-11.
Petersen, SV, Thiel, S, Jensen, L, Vorup-Jensen, T, Koch, C & Jensenius, JC 2000, 'Control of the classical and the MBL pathway of complement activation.', Molecular Immunology, vol. 37, no. 14, pp. 803-11.
Vorup-Jensen, T, Petersen, SV, Hansen, AG, Poulsen, K, Schwaeble, W, Sim, RB, Reid, KB, Davis, SJ, Thiel, S & Jensenius, JC 2000, 'Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2.', Journal of Immunology, vol. 165, no. 4, pp. 2093-100.
Thiel, S, Petersen, SV, Vorup-Jensen, T, Matsushita, M, Fujita, T, Stover, CM, Schwaeble, WJ & Jensenius, JC 2000, 'Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine proteases 1 and 2, and the MBL-associated protein MAp19.', Journal of Immunology, vol. 165, no. 2, pp. 878-87.
Vorup-Jensen, T, Hjort, T, Abraham-Peskir, JV, Guttmann, P, Jensenius, JC, Uggerhøj, E & Medenwaldt, R 1999, 'Outstanding contribution: X-ray microscopy of human spermatozoa shows change of mitochondrial morphology after capacitation', Hum. Reprod., vol. 14, pp. 880-884.
Stover, CM, Thiel, S, Thelen, M, Lynch, NJ, Vorup-Jensen, T, Jensenius, JC & Schwaeble, WJ 1999, 'Two constituents of the initiation complex of the mannan-binding elctin activation pathway of complement are encoded by a single structural gene', J. Immunol., vol. 162, pp. 3481-90.
Stover, CM, Thiel, S, Thelen, M, Lynch, NJ, Vorup-Jensen, T, Jensenius, JC & Schwaeble, WJ 1999, 'Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene', Journal of Immunology, vol. 162, no. 6, pp. 3481-90.
Vorup-Jensen, T, Hjort, T, Abraham-Peskir, JV, Guttmann, P, Jensenius, JC, Uggerhøj, E & Medenwaldt, R 1999, 'X-ray microscopy of human spermatozoa shows change of mitochondrial morphology after capacitation', Human Reproduction, vol. 14, no. 4, pp. 880-4.
Laursen, SB, Dalgaard, TS, Thiel, S, Lim, BL, Vorup-Jensen, T, Juul-Madsen, HR, Takahashi, A, Hamana, T, Kawakami, M & Jensenius, JC 1998, 'Cloning and sequencing of a cDNA encoding chicken mannan-binding lectin (MBL) and comparison with mammalian analogues', Immunology, vol. 93, pp. 421-30.
Vorup-Jensen, T, Jensenius, JC & Thiel, S 1998, 'MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway', Immunobiology, vol. 199, pp. 348-57.
Vorup-Jensen, T, Jensenius, JC & Thiel, S 1998, 'MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway', Immunobiology, vol. 199, no. 2, pp. 348-57.
Thiel, S, Vorup-Jensen, T, Stover, CM, Schwaeble, W, Laursen, SB, Poulsen, K, Willis, AC, Eggleton, P, Hansen, S, Holmskov, U, Reid, KB & Jensenius, JC 1997, 'A second serine protease associated with mannan-binding lectin that activates complement', Nature, vol. 386, pp. 506-10.
Thiel, S, Vorup-Jensen, T, Stover, CM, Schwaeble, W, Laursen, S, Poulsen, K, Willis, AC, Eggleton, P, Hansen, S, Holmskov, UL, Reid, KB & Jensenius, JC 1997, 'A second serine protease associated with mannan-binding lectin that activates complement', Nature, vol. 386, no. 6624, pp. 506-10. https://doi.org/10.1038/386506a0