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Thomas Poulsen

The amido-pentadienoate-functionality of the rakicidins is a thiol reactive electrophile: development of a general synthetic strategy

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We demonstrate that a unique class-defining functionality (mc-APD) found in macrocyclic natural products with potent anti-cancer activity, imparts these compounds with electrophilic reactivity. The mc-APD group represents an interesting structural hybrid between canonical biologically relevant Michael-acceptors. Further, a novel thiol-elimination method for preparation of the mc-APD group is outlined.

Original languageEnglish
JournalChemical Communications
Volume51
Issue62
Pages (from-to)12427-12430
Number of pages4
ISSN1359-7345
DOIs
Publication statusPublished - 21 Jul 2015

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