Thomas Franz Erich Willnow

VPS10P Domain Receptors: Sorting Out Brain Health and Disease

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VPS10P Domain Receptors : Sorting Out Brain Health and Disease. / Malik, Anna R; Willnow, Thomas E.

In: Trends in Neurosciences, Vol. 43, No. 11, 11.2020, p. 870-885.

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Malik, Anna R ; Willnow, Thomas E. / VPS10P Domain Receptors : Sorting Out Brain Health and Disease. In: Trends in Neurosciences. 2020 ; Vol. 43, No. 11. pp. 870-885.

Bibtex

@article{deb919b5516f4d359c7581cfe1e7d903,
title = "VPS10P Domain Receptors: Sorting Out Brain Health and Disease",
abstract = "VPS10P (vacuolar protein sorting 10 protein) domain receptors are neuronal sorting receptors that direct cargo proteins to their destined location in subcellular compartments of the soma, dendrites, and the axon. Protein sorting by receptors such as SORLA, sortilin, and SorCS2 controls functional integrity and viability of neurons, whereas sorting receptor dysfunctions are linked to acute, psychiatric, and neurodegenerative diseases. Here, we discuss molecular mechanisms that define ligand repertoire and sorting path and that control plasticity of VPS10P domain receptor expression in the healthy brain and in response to injury. These findings highlight important concepts in neuronal protein sorting and why aberrant sorting contributes to the progression of devastating diseases of the human brain, including epilepsy, Alzheimer's disease, and frontotemporal dementia.",
keywords = "SORLA, SorCS, neurodegenerative disease, neurotrophin signaling, protein sorting, sortilin",
author = "Malik, {Anna R} and Willnow, {Thomas E}",
note = "Copyright {\textcopyright} 2020 Elsevier Ltd. All rights reserved.",
year = "2020",
month = nov,
doi = "10.1016/j.tins.2020.08.003",
language = "English",
volume = "43",
pages = "870--885",
journal = "Trends in Neurosciences",
issn = "0166-2236",
publisher = "Elsevier Ltd. * Trends Journals",
number = "11",

}

RIS

TY - JOUR

T1 - VPS10P Domain Receptors

T2 - Sorting Out Brain Health and Disease

AU - Malik, Anna R

AU - Willnow, Thomas E

N1 - Copyright © 2020 Elsevier Ltd. All rights reserved.

PY - 2020/11

Y1 - 2020/11

N2 - VPS10P (vacuolar protein sorting 10 protein) domain receptors are neuronal sorting receptors that direct cargo proteins to their destined location in subcellular compartments of the soma, dendrites, and the axon. Protein sorting by receptors such as SORLA, sortilin, and SorCS2 controls functional integrity and viability of neurons, whereas sorting receptor dysfunctions are linked to acute, psychiatric, and neurodegenerative diseases. Here, we discuss molecular mechanisms that define ligand repertoire and sorting path and that control plasticity of VPS10P domain receptor expression in the healthy brain and in response to injury. These findings highlight important concepts in neuronal protein sorting and why aberrant sorting contributes to the progression of devastating diseases of the human brain, including epilepsy, Alzheimer's disease, and frontotemporal dementia.

AB - VPS10P (vacuolar protein sorting 10 protein) domain receptors are neuronal sorting receptors that direct cargo proteins to their destined location in subcellular compartments of the soma, dendrites, and the axon. Protein sorting by receptors such as SORLA, sortilin, and SorCS2 controls functional integrity and viability of neurons, whereas sorting receptor dysfunctions are linked to acute, psychiatric, and neurodegenerative diseases. Here, we discuss molecular mechanisms that define ligand repertoire and sorting path and that control plasticity of VPS10P domain receptor expression in the healthy brain and in response to injury. These findings highlight important concepts in neuronal protein sorting and why aberrant sorting contributes to the progression of devastating diseases of the human brain, including epilepsy, Alzheimer's disease, and frontotemporal dementia.

KW - SORLA

KW - SorCS

KW - neurodegenerative disease

KW - neurotrophin signaling

KW - protein sorting

KW - sortilin

UR - http://www.scopus.com/inward/record.url?scp=85090478619&partnerID=8YFLogxK

U2 - 10.1016/j.tins.2020.08.003

DO - 10.1016/j.tins.2020.08.003

M3 - Review

C2 - 32896433

VL - 43

SP - 870

EP - 885

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0166-2236

IS - 11

ER -