Thomas Franz Erich Willnow

Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity. / Seo, Ji A; Kang, Min-Cheol; Yang, Won-Mo; Hwang, Won Min; Kim, Sang Soo; Hong, Soo Hyun; Heo, Jee-In; Vijyakumar, Achana; Pereira de Moura, Leandro; Uner, Aykut; Huang, Hu; Lee, Seung Hwan; Lima, Inês S; Park, Kyong Soo; Kim, Min Seon; Dagon, Yossi; Willnow, Thomas E; Aroda, Vanita; Ciaraldi, Theodore P; Henry, Robert R; Kim, Young-Bum.

In: Nature Communications, Vol. 11, No. 1, 24.04.2020, p. 2024.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Seo, JA, Kang, M-C, Yang, W-M, Hwang, WM, Kim, SS, Hong, SH, Heo, J-I, Vijyakumar, A, Pereira de Moura, L, Uner, A, Huang, H, Lee, SH, Lima, IS, Park, KS, Kim, MS, Dagon, Y, Willnow, TE, Aroda, V, Ciaraldi, TP, Henry, RR & Kim, Y-B 2020, 'Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity', Nature Communications, vol. 11, no. 1, pp. 2024. https://doi.org/10.1038/s41467-020-15963-w

APA

Seo, J. A., Kang, M-C., Yang, W-M., Hwang, W. M., Kim, S. S., Hong, S. H., Heo, J-I., Vijyakumar, A., Pereira de Moura, L., Uner, A., Huang, H., Lee, S. H., Lima, I. S., Park, K. S., Kim, M. S., Dagon, Y., Willnow, T. E., Aroda, V., Ciaraldi, T. P., ... Kim, Y-B. (2020). Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity. Nature Communications, 11(1), 2024. https://doi.org/10.1038/s41467-020-15963-w

CBE

Seo JA, Kang M-C, Yang W-M, Hwang WM, Kim SS, Hong SH, Heo J-I, Vijyakumar A, Pereira de Moura L, Uner A, Huang H, Lee SH, Lima IS, Park KS, Kim MS, Dagon Y, Willnow TE, Aroda V, Ciaraldi TP, Henry RR, Kim Y-B. 2020. Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity. Nature Communications. 11(1):2024. https://doi.org/10.1038/s41467-020-15963-w

MLA

Vancouver

Seo JA, Kang M-C, Yang W-M, Hwang WM, Kim SS, Hong SH et al. Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity. Nature Communications. 2020 Apr 24;11(1):2024. https://doi.org/10.1038/s41467-020-15963-w

Author

Seo, Ji A ; Kang, Min-Cheol ; Yang, Won-Mo ; Hwang, Won Min ; Kim, Sang Soo ; Hong, Soo Hyun ; Heo, Jee-In ; Vijyakumar, Achana ; Pereira de Moura, Leandro ; Uner, Aykut ; Huang, Hu ; Lee, Seung Hwan ; Lima, Inês S ; Park, Kyong Soo ; Kim, Min Seon ; Dagon, Yossi ; Willnow, Thomas E ; Aroda, Vanita ; Ciaraldi, Theodore P ; Henry, Robert R ; Kim, Young-Bum. / Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity. In: Nature Communications. 2020 ; Vol. 11, No. 1. pp. 2024.

Bibtex

@article{051eae6307b540868cc15c4e6a689a18,
title = "Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity",
abstract = "Crosstalk between liver and skeletal muscle is vital for glucose homeostasis. Hepatokines, liver-derived proteins that play an important role in regulating muscle metabolism, are important to this communication. Here we identify apolipoprotein J (ApoJ) as a novel hepatokine targeting muscle glucose metabolism and insulin sensitivity through a low-density lipoprotein receptor-related protein-2 (LRP2)-dependent mechanism, coupled with the insulin receptor (IR) signaling cascade. In muscle, LRP2 is necessary for insulin-dependent IR internalization, an initial trigger for insulin signaling, that is crucial in regulating downstream signaling and glucose uptake. Of physiologic significance, deletion of hepatic ApoJ or muscle LRP2 causes insulin resistance and glucose intolerance. In patients with polycystic ovary syndrome and insulin resistance, pioglitazone-induced improvement of insulin action is associated with an increase in muscle ApoJ and LRP2 expression. Thus, the ApoJ-LRP2 axis is a novel endocrine circuit that is central to the maintenance of normal glucose homeostasis and insulin sensitivity.",
keywords = "Adult, Animals, Cell Line, Clusterin/blood, Disease Models, Animal, Female, Glucose/metabolism, Glucose Clamp Technique, Humans, Hypoglycemic Agents/pharmacology, Insulin/metabolism, Insulin Resistance, Liver/metabolism, Low Density Lipoprotein Receptor-Related Protein-2/genetics, Male, Mice, Mice, Knockout, Muscle, Skeletal/metabolism, Pioglitazone/pharmacology, Polycystic Ovary Syndrome/blood, Receptor, Insulin/metabolism, Signal Transduction/drug effects",
author = "Seo, {Ji A} and Min-Cheol Kang and Won-Mo Yang and Hwang, {Won Min} and Kim, {Sang Soo} and Hong, {Soo Hyun} and Jee-In Heo and Achana Vijyakumar and {Pereira de Moura}, Leandro and Aykut Uner and Hu Huang and Lee, {Seung Hwan} and Lima, {In{\^e}s S} and Park, {Kyong Soo} and Kim, {Min Seon} and Yossi Dagon and Willnow, {Thomas E} and Vanita Aroda and Ciaraldi, {Theodore P} and Henry, {Robert R} and Young-Bum Kim",
year = "2020",
month = apr,
day = "24",
doi = "10.1038/s41467-020-15963-w",
language = "English",
volume = "11",
pages = "2024",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity

AU - Seo, Ji A

AU - Kang, Min-Cheol

AU - Yang, Won-Mo

AU - Hwang, Won Min

AU - Kim, Sang Soo

AU - Hong, Soo Hyun

AU - Heo, Jee-In

AU - Vijyakumar, Achana

AU - Pereira de Moura, Leandro

AU - Uner, Aykut

AU - Huang, Hu

AU - Lee, Seung Hwan

AU - Lima, Inês S

AU - Park, Kyong Soo

AU - Kim, Min Seon

AU - Dagon, Yossi

AU - Willnow, Thomas E

AU - Aroda, Vanita

AU - Ciaraldi, Theodore P

AU - Henry, Robert R

AU - Kim, Young-Bum

PY - 2020/4/24

Y1 - 2020/4/24

N2 - Crosstalk between liver and skeletal muscle is vital for glucose homeostasis. Hepatokines, liver-derived proteins that play an important role in regulating muscle metabolism, are important to this communication. Here we identify apolipoprotein J (ApoJ) as a novel hepatokine targeting muscle glucose metabolism and insulin sensitivity through a low-density lipoprotein receptor-related protein-2 (LRP2)-dependent mechanism, coupled with the insulin receptor (IR) signaling cascade. In muscle, LRP2 is necessary for insulin-dependent IR internalization, an initial trigger for insulin signaling, that is crucial in regulating downstream signaling and glucose uptake. Of physiologic significance, deletion of hepatic ApoJ or muscle LRP2 causes insulin resistance and glucose intolerance. In patients with polycystic ovary syndrome and insulin resistance, pioglitazone-induced improvement of insulin action is associated with an increase in muscle ApoJ and LRP2 expression. Thus, the ApoJ-LRP2 axis is a novel endocrine circuit that is central to the maintenance of normal glucose homeostasis and insulin sensitivity.

AB - Crosstalk between liver and skeletal muscle is vital for glucose homeostasis. Hepatokines, liver-derived proteins that play an important role in regulating muscle metabolism, are important to this communication. Here we identify apolipoprotein J (ApoJ) as a novel hepatokine targeting muscle glucose metabolism and insulin sensitivity through a low-density lipoprotein receptor-related protein-2 (LRP2)-dependent mechanism, coupled with the insulin receptor (IR) signaling cascade. In muscle, LRP2 is necessary for insulin-dependent IR internalization, an initial trigger for insulin signaling, that is crucial in regulating downstream signaling and glucose uptake. Of physiologic significance, deletion of hepatic ApoJ or muscle LRP2 causes insulin resistance and glucose intolerance. In patients with polycystic ovary syndrome and insulin resistance, pioglitazone-induced improvement of insulin action is associated with an increase in muscle ApoJ and LRP2 expression. Thus, the ApoJ-LRP2 axis is a novel endocrine circuit that is central to the maintenance of normal glucose homeostasis and insulin sensitivity.

KW - Adult

KW - Animals

KW - Cell Line

KW - Clusterin/blood

KW - Disease Models, Animal

KW - Female

KW - Glucose/metabolism

KW - Glucose Clamp Technique

KW - Humans

KW - Hypoglycemic Agents/pharmacology

KW - Insulin/metabolism

KW - Insulin Resistance

KW - Liver/metabolism

KW - Low Density Lipoprotein Receptor-Related Protein-2/genetics

KW - Male

KW - Mice

KW - Mice, Knockout

KW - Muscle, Skeletal/metabolism

KW - Pioglitazone/pharmacology

KW - Polycystic Ovary Syndrome/blood

KW - Receptor, Insulin/metabolism

KW - Signal Transduction/drug effects

U2 - 10.1038/s41467-020-15963-w

DO - 10.1038/s41467-020-15963-w

M3 - Journal article

C2 - 32332780

VL - 11

SP - 2024

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

ER -