Thomas Damgaard Sandahl

The lectin pathway of the complement system is downregulated in Crohn's disease patients who respond to anti-TNF-α therapy

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The lectin pathway of the complement system is initiated through the recognition of pathogens or altered self-structures by mannan-binding lectin (MBL) or ficolins and subsequent activation of MBL-associated serine proteases (MASPs). Altered ficolin levels may contribute to a dysregulated immune response in Crohn's disease (CD). A complete analysis of the lectin pathway has not been performed in patients with CD. We hypothesised that the lectin pathway proteins exacerbate inflammation in CD.
Original languageEnglish
JournalJournal of Crohn's & colitis
Volume8
Issue6
Pages (from-to)521-8
Number of pages9
ISSN1873-9946
DOIs
Publication statusPublished - 2 Feb 2014

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