Thomas Damgaard Sandahl

Highest frequencies of interleukin-22-producing T helper cells in alcoholic hepatitis patients with a favourable short-term course

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Highest frequencies of interleukin-22-producing T helper cells in alcoholic hepatitis patients with a favourable short-term course. / Støy, Sidsel; Sandahl, Thomas Damgaard; Dige, Anders Kirch; Agnholt, Jørgen; Rasmussen, Tue Kruse; Grønbæk, Henning; Deleuran, Bent; Vilstrup, Hendrik.

In: PLOS ONE, Vol. 8, No. 1, 2013, p. e55101.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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@article{3576f902cf4d4961bedc3350256d864a,
title = "Highest frequencies of interleukin-22-producing T helper cells in alcoholic hepatitis patients with a favourable short-term course",
abstract = "Alcoholic hepatitis (AH) has a severe prognosis due to hepatic inflammatory injury. The cytokine interleukin-22 (IL-22) is reported to exert anti-apoptotic and proliferative effects, but IL-22 has not been studied during the course of AH. IL-22 is mainly produced by CD4(+) (helper) T cells, including Th17 cells. In addition, Th17 cells produce the proinflammatory cytokine IL-17A, which has been implicated in AH.",
keywords = "Adult, Aged, Antigens, CD4, Antigens, CD45, Female, Hepatitis, Alcoholic, Humans, Interleukin-17, Interleukin-23, Interleukins, Male, Middle Aged, T-Lymphocytes, Helper-Inducer",
author = "Sidsel St{\o}y and Sandahl, {Thomas Damgaard} and Dige, {Anders Kirch} and J{\o}rgen Agnholt and Rasmussen, {Tue Kruse} and Henning Gr{\o}nb{\ae}k and Bent Deleuran and Hendrik Vilstrup",
year = "2013",
doi = "10.1371/journal.pone.0055101",
language = "English",
volume = "8",
pages = "e55101",
journal = "P L o S One",
issn = "1932-6203",
publisher = "public library of science",
number = "1",

}

RIS

TY - JOUR

T1 - Highest frequencies of interleukin-22-producing T helper cells in alcoholic hepatitis patients with a favourable short-term course

AU - Støy, Sidsel

AU - Sandahl, Thomas Damgaard

AU - Dige, Anders Kirch

AU - Agnholt, Jørgen

AU - Rasmussen, Tue Kruse

AU - Grønbæk, Henning

AU - Deleuran, Bent

AU - Vilstrup, Hendrik

PY - 2013

Y1 - 2013

N2 - Alcoholic hepatitis (AH) has a severe prognosis due to hepatic inflammatory injury. The cytokine interleukin-22 (IL-22) is reported to exert anti-apoptotic and proliferative effects, but IL-22 has not been studied during the course of AH. IL-22 is mainly produced by CD4(+) (helper) T cells, including Th17 cells. In addition, Th17 cells produce the proinflammatory cytokine IL-17A, which has been implicated in AH.

AB - Alcoholic hepatitis (AH) has a severe prognosis due to hepatic inflammatory injury. The cytokine interleukin-22 (IL-22) is reported to exert anti-apoptotic and proliferative effects, but IL-22 has not been studied during the course of AH. IL-22 is mainly produced by CD4(+) (helper) T cells, including Th17 cells. In addition, Th17 cells produce the proinflammatory cytokine IL-17A, which has been implicated in AH.

KW - Adult

KW - Aged

KW - Antigens, CD4

KW - Antigens, CD45

KW - Female

KW - Hepatitis, Alcoholic

KW - Humans

KW - Interleukin-17

KW - Interleukin-23

KW - Interleukins

KW - Male

KW - Middle Aged

KW - T-Lymphocytes, Helper-Inducer

U2 - 10.1371/journal.pone.0055101

DO - 10.1371/journal.pone.0055101

M3 - Journal article

C2 - 23372820

VL - 8

SP - e55101

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 1

ER -