Thomas Damgaard Sandahl

Highest frequencies of interleukin-22-producing T helper cells in alcoholic hepatitis patients with a favourable short-term course

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Alcoholic hepatitis (AH) has a severe prognosis due to hepatic inflammatory injury. The cytokine interleukin-22 (IL-22) is reported to exert anti-apoptotic and proliferative effects, but IL-22 has not been studied during the course of AH. IL-22 is mainly produced by CD4(+) (helper) T cells, including Th17 cells. In addition, Th17 cells produce the proinflammatory cytokine IL-17A, which has been implicated in AH.
Original languageEnglish
JournalPLOS ONE
Volume8
Issue1
Pages (from-to)e55101
ISSN1932-6203
DOIs
Publication statusPublished - 2013

    Research areas

  • Adult, Aged, Antigens, CD4, Antigens, CD45, Female, Hepatitis, Alcoholic, Humans, Interleukin-17, Interleukin-23, Interleukins, Male, Middle Aged, T-Lymphocytes, Helper-Inducer

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