Thomas Damgaard Sandahl

Blood culture-positive infections in patients with alcoholic hepatitis

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Blood culture-positive infections in patients with alcoholic hepatitis. / Wernlund, Pernille Glahn ; Støy, Sidsel; Lemming, Lars; Vilstrup, Hendrik; Sandahl, Thomas Damgaard.

In: Scandinavian Journal of Infectious Diseases, Vol. 46, No. 12, 12.2014, p. 902-5.

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Wernlund, Pernille Glahn ; Støy, Sidsel ; Lemming, Lars ; Vilstrup, Hendrik ; Sandahl, Thomas Damgaard. / Blood culture-positive infections in patients with alcoholic hepatitis. In: Scandinavian Journal of Infectious Diseases. 2014 ; Vol. 46, No. 12. pp. 902-5.

Bibtex

@article{d13e8e387ede4b01899af9b87ba715f7,
title = "Blood culture-positive infections in patients with alcoholic hepatitis",
abstract = "Acute alcoholic hepatitis (AH) is a life-threatening disease and its course is often determined by infections. However, the pattern of pathogens has not been studied. We examined the microbiological pathogens that caused blood-borne infection in patients with AH. We included 32 AH patients without infection at inclusion. Patients were followed for 1 month and their infection status was recorded based on clinical records, radiologic exams and cultures of different secreta. Nine patients (28%) developed blood culture-positive infections. The agents were of heterogeneous aetiology and came from various sites of infection. Candida species accounted for three of these infections (33%). Five patients (16%) died, two of which had positive blood cultures. A high fraction was invasively infected by a heterogeneous spectrum of microbes including yeasts and commensal bacteria. This may reflect the severe immune impairment of AH and suggests thorough infection screening and an immediate broad-spectrum antibiotic approach if infection is suspected.",
author = "Wernlund, {Pernille Glahn} and Sidsel St{\o}y and Lars Lemming and Hendrik Vilstrup and Sandahl, {Thomas Damgaard}",
year = "2014",
month = dec,
doi = "10.3109/00365548.2014.951682",
language = "English",
volume = "46",
pages = "902--5",
journal = "Scandinavian Journal of Infectious Diseases",
issn = "0036-5548",
publisher = "Taylor & Francis ",
number = "12",

}

RIS

TY - JOUR

T1 - Blood culture-positive infections in patients with alcoholic hepatitis

AU - Wernlund, Pernille Glahn

AU - Støy, Sidsel

AU - Lemming, Lars

AU - Vilstrup, Hendrik

AU - Sandahl, Thomas Damgaard

PY - 2014/12

Y1 - 2014/12

N2 - Acute alcoholic hepatitis (AH) is a life-threatening disease and its course is often determined by infections. However, the pattern of pathogens has not been studied. We examined the microbiological pathogens that caused blood-borne infection in patients with AH. We included 32 AH patients without infection at inclusion. Patients were followed for 1 month and their infection status was recorded based on clinical records, radiologic exams and cultures of different secreta. Nine patients (28%) developed blood culture-positive infections. The agents were of heterogeneous aetiology and came from various sites of infection. Candida species accounted for three of these infections (33%). Five patients (16%) died, two of which had positive blood cultures. A high fraction was invasively infected by a heterogeneous spectrum of microbes including yeasts and commensal bacteria. This may reflect the severe immune impairment of AH and suggests thorough infection screening and an immediate broad-spectrum antibiotic approach if infection is suspected.

AB - Acute alcoholic hepatitis (AH) is a life-threatening disease and its course is often determined by infections. However, the pattern of pathogens has not been studied. We examined the microbiological pathogens that caused blood-borne infection in patients with AH. We included 32 AH patients without infection at inclusion. Patients were followed for 1 month and their infection status was recorded based on clinical records, radiologic exams and cultures of different secreta. Nine patients (28%) developed blood culture-positive infections. The agents were of heterogeneous aetiology and came from various sites of infection. Candida species accounted for three of these infections (33%). Five patients (16%) died, two of which had positive blood cultures. A high fraction was invasively infected by a heterogeneous spectrum of microbes including yeasts and commensal bacteria. This may reflect the severe immune impairment of AH and suggests thorough infection screening and an immediate broad-spectrum antibiotic approach if infection is suspected.

U2 - 10.3109/00365548.2014.951682

DO - 10.3109/00365548.2014.951682

M3 - Journal article

C2 - 25290580

VL - 46

SP - 902

EP - 905

JO - Scandinavian Journal of Infectious Diseases

JF - Scandinavian Journal of Infectious Diseases

SN - 0036-5548

IS - 12

ER -