Sia Viborg Lindskrog

2025

Circulating tumour DNA and circulating tumour cells in bladder cancer — from discovery to clinical implementation

Lindskrog, S. V., Strandgaard, T., Nordentoft, I., Galsky, M. D., Powles, T., Agerbæk, M., Jensen, J. B., Alix-Panabières, C. & Dyrskjøt, L., 2025, (E-pub / Early view) In: Nature Reviews Urology. 5068.

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Comprehensive genomic characterization of early-stage bladder cancer

Prip, F., Lamy, P., Lindskrog, S. V., Strandgaard, T., Nordentoft, I., Birkenkamp-Demtröder, K., Birkbak, N. J., Kristjánsdóttir, N., Kjær, A., Andreasen, T. G., Ahrenfeldt, J., Pedersen, J. S., Rasmussen, A. M., Hermann, G. G., Mogensen, K., Petersen, A. C., Hartmann, A., Grimm, M. O., Horstmann, M. & Nawroth, R. & 12 others, Segersten, U., Sikic, D., van Kessel, K. E. M., Zwarthoff, E. C., Maurer, T., Simic, T., Malmström, P. U., Malats, N., Jensen, J. B., Real, F. X., Dyrskjøt, L. & UROMOL Consortium, Jan 2025, In: Nature Genetics. 57, 1, p. 115-125 11 p., 2301.

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1 Citation (Scopus)

2024

Association of Age with Non-muscle-invasive Bladder Cancer: Unearthing a Biological Basis for Epidemiological Disparities?

Lobo, N., Duan, Z., Sood, A., Tan, W. S., Grajales, V., Contieri, R., Lindskrog, S. V., Dyrskjøt, L., Zhao, H., Giordano, S. H., Williams, S. B., Bree, K. K. & Kamat, A. M., 1 Oct 2024, In: European Urology Oncology. 7, 5, p. 1069-1079 11 p.

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5 Citations (Scopus)

Detection of circulating tumor DNA by tumor-informed whole-genome sequencing enables prediction of recurrence in stage III colorectal cancer patients

Frydendahl, A., Nors, J., Rasmussen, M. H., Henriksen, T. V., Nesic, M., Reinert, T., Afterman, D., Lauterman, T., Kuzman, M., Gonzalez, S., Glavas, D., Smadback, J., Maloney, D., Levativ, J., Yahalom, M., Ptashkin, R., Tavassoly, I., Donenhirsh, Z., White, E. & Kandasamy, R. & 13 others, Alon, U., Nordentoft, I., Lindskrog, S. V., Dyrskjøt, L., Jaensch, C., Løve, U. S., Andersen, P. V., Thorlacius-Ussing, O., Iversen, L. H., Gotschalck, K. A., Zviran, A., Oklander, B. & Andersen, C. L., Nov 2024, In: European Journal of Cancer. 211, 114314.

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2 Citations (Scopus)

Field Cancerization Is Associated with Tumor Development, T-cell Exhaustion, and Clinical Outcomes in Bladder Cancer

Strandgaard, T., Nordentoft, I., Birkenkamp-Demtröder, K., Salminen, L., Prip, F., Rasmussen, J., Andreasen, T. G., Lindskrog, S. V., Christensen, E., Lamy, P., Knudsen, M., Steiniche, T., Jensen, J. B. & Dyrskjøt, L., Jan 2024, In: European Urology. 85, 1, p. 82-92 11 p.

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19 Citations (Scopus)

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Towards circulating tumor DNA-guided treatment of muscle-invasive bladder cancer

Lindskrog, S. V. & Dyrskjøt, L., 30 Jun 2024, In: Translational andrology and urology. 13, 6, p. 1056-1060 5 p.

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Whole-genome Mutational Analysis for Tumor-informed Detection of Circulating Tumor DNA in Patients with Urothelial Carcinoma

Nordentoft, I., Lindskrog, S. V., Birkenkamp-Demtröder, K., Gonzalez, S., Kuzman, M., Levatic, J., Glavas, D., Ptashkin, R., Smadbeck, J., Afterman, D., Lauterman, T., Cohen, Y., Donenhirsh, Z., Tavassoly, I., Alon, U., Frydendahl, A., Rasmussen, M. H., Andersen, C. L., Lamy, P. & Knudsen, M. & 6 others, Polak, P., Zviran, A., Oklander, B., Agerbæk, M., Jensen, J. B. & Dyrskjøt, L., Oct 2024, In: European Urology. 86, 4, p. 301-311 11 p.

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10 Citations (Scopus)

2023

5600 / 24: Utility of circulating tumor DNA and transcriptomic profiling in predicting outcome in muscle invasive bladder cancer patients

Lindskrog, S. V., Laliotis, G., Birkenkamp-Demtröder, K., Nordentoft, I. K., Lamy, P., Z. White, E., Pajak, N., Andreasen, T. G., Dutta, P., Malhotra, M., Sharma, S., Calhoun, M., ElNaggar, A. C., Liu, M. C., Agerbæk, M. O., Jensen, J. B. & Dyrskjøt, L., Apr 2023.

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Cell-free urine- and plasma DNA mutational analysis predicts neoadjuvant chemotherapy response and outcome in patients with muscle invasive bladder cancer

Christensen, E., Nordentoft, I., Birkenkamp-Demtroder, K., Elbæk, S. K., Lindskrog, S. V., Taber, A., Andreasen, T. G., Strandgaard, T., Knudsen, M., Lamy, P., Agerbæk, M., Jensen, J. B. & Dyrskjøt, L., 15 Apr 2023, In: Clinical Cancer Research. 29, 8, p. 1582–1591 10 p.

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34 Citations (Scopus)

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Circulating Tumor DNA Analysis in Advanced Urothelial Carcinoma: Insights from Biological Analysis and Extended Clinical Follow-up

Lindskrog, S. V., Birkenkamp-Demtröder, K., Nordentoft, I. K., Laliotis, G., Lamy, P., Christensen, E., Renner, D., Andreasen, T. G., Lange, N., Sharma, S., ElNaggar, A. C., Liu, M. C., Sethi, H., Aleshin, A., Agerbæk, M., Jensen, J. B. & Dyrskjøt, L., Dec 2023, In: Clinical Cancer Research. 29, 23, p. 4797-4807 11 p.

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19 Citations (Scopus)

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FGFR3 Mutational Activation Can Induce Luminal-like Papillary Bladder Tumor Formation and Favors a Male Sex Bias

Shi, M. J., Fontugne, J., Moreno-Vega, A., Meng, X. Y., Groeneveld, C., Dufour, F., Kamoun, A., Viborg Lindskrog, S., Cabel, L., Krucker, C., Rapinat, A., Dunois-Larde, C., Lepage, M. L., Chapeaublanc, E., Levrel, O., Dixon, V., Lebret, T., Almeida, A., De Reynies, A. & Rochel, N. & 4 others, Dyrskjøt, L., Allory, Y., Radvanyi, F. & Bernard-Pierrot, I., Jan 2023, In: European Urology. 83, 1, p. 70-81 12 p.

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15 Citations (Scopus)

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Improved protocol for single-nucleus RNA-sequencing of frozen human bladder tumor biopsies

Schmøkel, S. S., Nordentoft, I., Lindskrog, S. V., Lamy, P., Knudsen, M., Jensen, J. B. & Dyrskjøt, L., Dec 2023, In: Nucleus. 14, 1, 2186686.

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2 Citations (Scopus)

Single-nucleus and Spatially Resolved Intratumor Subtype Heterogeneity in Bladder Cancer

Lindskrog, S. V., Schmøkel, S. S., Nordentoft, I., Lamy, P., Knudsen, M., Prip, F., Strandgaard, T., Jensen, J. B. & Dyrskjøt, L., May 2023, In: European Urology Open Science. 51, p. 78-88 11 p.

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Open Access

10 Citations (Scopus)

Utility of circulating tumor DNA and transcriptomic profiling in predicting outcome in muscle invasive bladder cancer patients

Birkenkamp-Demtröder, K., Lindskrog, S. V., Laliotis, G., Nordentoft, I. K., Lamy, P., Agerbæk, M., Jensen, J. B. & Dyrskjøt, L., 2 May 2023.

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2022

Abstract 540: Genome-wide circulating tumor DNA for monitoring treatment response and metastatic relapse in bladder cancer

Nordentoft, I. K., Birkenkamp-Demtröder, K., Christensen, E., Deochand, S., Maloney, D., Danielle, A., Lindskrog, S. V., Agerbæk, M., Jensen, J. B., Oklander, B., Zviran, A. & Dyrskjøt, L., 2022.

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Author Correction: Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis

Taber, A., Christensen, E., Lamy, P., Nordentoft, I., Prip, F., Lindskrog, S. V., Birkenkamp-Demtröder, K., Okholm, T. L. H., Knudsen, M., Pedersen, J. S., Steiniche, T., Agerbæk, M., Jensen, J. B. & Dyrskjøt, L., Apr 2022, In: Nature Communications. 13, 1, 1 p., 1916.

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Elevated T-cell Exhaustion and Urinary Tumor DNA Levels Are Associated with Bacillus Calmette-Guérin Failure in Patients with Non-muscle-invasive Bladder Cancer

Strandgaard, T., Lindskrog, S. V., Nordentoft, I., Christensen, E., Birkenkamp-Demtröder, K., Andreasen, T. G., Lamy, P., Kjær, A., Ranti, D., Wang, Y. A., Bieber, C., Prip, F., Rasmussen, J., Steiniche, T., Birkbak, N., Sfakianos, J., Horowitz, A., Jensen, J. B. & Dyrskjøt, L., Dec 2022, In: European Urology. 82, 6, p. 646-656 11 p.

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33 Citations (Scopus)

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Genome-wide Meta-analysis Identifies Novel Genes Associated with Recurrence and Progression in Non-muscle-invasive Bladder Cancer

Galesloot, T. E., Grotenhuis, A. J., Kolev, D., Aben, K. K., Bryan, R. T., Catto, J. W. F., Cheng, K. K., Conroy, S., Dyrskjøt, L., Fleshner, N. E., James, N. D., Lamy, P., Lindskrog, S. V., Malats, N., Mengual, L., Verhaegh, G., Zeegers, M. P., Kiemeney, L. A. L. M. & Vermeulen, S. H., Feb 2022, In: European Urology Oncology. 5, 1, p. 70-83 14 p.

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8 Citations (Scopus)

11 Downloads (Pure)

2021

An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer

Lindskrog, S. V., Prip, F., Lamy, P., Taber, A., Groeneveld, C. S., Birkenkamp-Demtröder, K., Jensen, J. B., Strandgaard, T., Nordentoft, I., Christensen, E., Sokac, M., Birkbak, N. J., Maretty, L., Hermann, G. G., Petersen, A. C., Weyerer, V., Grimm, M. O., Horstmann, M., Sjödahl, G. & Höglund, M. & 27 others, Steiniche, T., Mogensen, K., de Reyniès, A., Nawroth, R., Jordan, B., Lin, X., Dragicevic, D., Ward, D. G., Goel, A., Hurst, C. D., Raman, J. D., Warrick, J. I., Segersten, U., Sikic, D., van Kessel, K. E. M., Maurer, T., Meeks, J. J., DeGraff, D. J., Bryan, R. T., Knowles, M. A., Simic, T., Hartmann, A., Zwarthoff, E. C., Malmström, P. U., Malats, N., Real, F. X. & Dyrskjøt, L., 1 Dec 2021, In: Nature Communications. 12, 1, 18 p., 2301.

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212 Citations (Scopus)

SPTAN1, APC, and FGFR3 Mutation Status and APOBEC Mutation Signatures are Predictive of Mitomycin C Response in Non-muscle-invasive Bladder Cancer

Skydt Lindgren, M., Lamy, P., Lindskrog, S. V., Christensen, E., Nordentoft, I. K., Birkenkamp-Demtröder, K., Ulhøi, B. P., Jensen, J. B. & Dyrskjøt, L., Dec 2021, In: European Urology Open Science. 34, p. 59-67 9 p.

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2 Citations (Scopus)

Stage-stratified molecular profiling of non-muscle-invasive bladder cancer enhances biological, clinical, and therapeutic insight

Hurst, C. D., Cheng, G., Platt, F. M., Castro, M. A. A., Marzouka, N. A. D. S., Eriksson, P., Black, E. V. I., Alder, O., Lawson, A. R. J., Lindskrog, S. V., Burns, J. E., Jain, S., Roulson, J. A., Brown, J. C., Koster, J., Robertson, A. G., Martincorena, I., Dyrskjøt, L., Höglund, M. & Knowles, M. A., Dec 2021, In: Cell Reports Medicine. 2, 12, 100472.

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37 Citations (Scopus)

2020

Identification of Differential Tumor Subtypes of T1 Bladder Cancer

Robertson, A. G., Groeneveld, C. S., Jordan, B., Lin, X., McLaughlin, K. A., Das, A., Fall, L. A., Fantini, D., Taxter, T. J., Mogil, L. S., Lindskrog, S. V., Dyrskjøt, L., McConkey, D. J., Svatek, R. S., de Reyniès, A., Castro, M. A. A. & Meeks, J. J., Oct 2020, In: European Urology. 78, 4, p. 533-537 5 p.

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100 Citations (Scopus)

Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis

Taber, A., Christensen, E., Lamy, P., Nordentoft, I., Prip, F., Lindskrog, S. V., Birkenkamp-Demtröder, K., Okholm, T. L. H., Knudsen, M., Pedersen, J. S., Steiniche, T., Agerbæk, M., Jensen, J. B. & Dyrskjøt, L., Sept 2020, In: Nature Communications. 11, 1, 15 p., 4858.

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Open Access

145 Citations (Scopus)

2019

Early Detection of Metastatic Relapse and Monitoring of Therapeutic Efficacy by Ultra-Deep Sequencing of Plasma Cell-Free DNA in Patients With Urothelial Bladder Carcinoma

Christensen, E., Birkenkamp-Demtröder, K., Sethi, H., Shchegrova, S., Salari, R., Nordentoft, I., Wu, H.-T., Knudsen, M., Lamy, P., Lindskrog, S. V., Taber, A., Balcioglu, M., Vang, S., Assaf, Z., Sharma, S., Tin, A. S., Srinivasan, R., Hafez, D., Reinert, T. & Navarro, S. & 14 others, Olson, A., Ram, R., Dashner, S., Rabinowitz, M., Billings, P., Sigurjonsson, S., Andersen, C. L., Swenerton, R., Aleshin, A., Zimmermann, B., Agerbæk, M., Lin, C.-H. J., Jensen, J. B. & Dyrskjøt, L., Jun 2019, In: Journal of Clinical Oncology. 37, 18, p. 1547-1557 12 p.

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359 Citations (Scopus)

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Sia Viborg Lindskrog

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