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Sussie Antonsen

Therapeutic delay reduces survival of rectal cancer but not of colonic cancer

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Therapeutic delay reduces survival of rectal cancer but not of colonic cancer. / Iversen, Lene Hjerrild; Antonsen, Sussie; Laurberg, S; Lautrup, M D.

In: British Journal of Surgery, Vol. 96, No. 10, 2009, p. 1183-9.

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Iversen, Lene Hjerrild ; Antonsen, Sussie ; Laurberg, S ; Lautrup, M D. / Therapeutic delay reduces survival of rectal cancer but not of colonic cancer. In: British Journal of Surgery. 2009 ; Vol. 96, No. 10. pp. 1183-9.

Bibtex

@article{a3868e9014a811dfb95d000ea68e967b,
title = "Therapeutic delay reduces survival of rectal cancer but not of colonic cancer",
abstract = "BACKGROUND: The relationship between therapeutic delay and long-term survival from colorectal cancer is unclear. This association was examined prospectively among patients with colorectal cancer in Denmark. METHODS: A total of 740 patients with colorectal cancer were included in a prospective, population-based study in three Danish counties from 1 January 2001 to 31 July 2002. Delay was determined by self-report during a standardized interview. Cox proportional hazards regression was used to compute the hazard ratio (HR) associated with delay, while adjusting for age, sex and co-morbidity, and also for urgency of surgery in patients with colonic cancer. RESULTS: For rectal cancer only, a time span of at least 60 days from the onset of symptoms until treatment (total therapeutic delay) was associated with a 69 per cent higher risk of mortality compared with a total therapeutic delay of less than 60 days (HR 1.69 (95 per cent confidence interval 1.01 to 2.83)). Provider delay (interval from first physician contact until treatment) and hospital delay (interval from referral to a hospital until treatment) of at least 60 days had no impact on survival from colorectal cancer. CONCLUSION: A total therapeutic delay of at least 60 days was a negative prognostic factor for long-term survival from rectal cancer.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Colonic Neoplasms, Denmark, Early Detection of Cancer, Female, Hospitalization, Humans, Infant, Male, Middle Aged, Prospective Studies, Rectal Neoplasms, Survival Analysis, Time Factors, Treatment Outcome, Young Adult",
author = "Iversen, {Lene Hjerrild} and Sussie Antonsen and S Laurberg and Lautrup, {M D}",
year = "2009",
doi = "10.1002/bjs.6700",
language = "English",
volume = "96",
pages = "1183--9",
journal = "British Journal of Surgery",
issn = "0007-1323",
publisher = "JohnWiley & Sons Ltd.",
number = "10",

}

RIS

TY - JOUR

T1 - Therapeutic delay reduces survival of rectal cancer but not of colonic cancer

AU - Iversen, Lene Hjerrild

AU - Antonsen, Sussie

AU - Laurberg, S

AU - Lautrup, M D

PY - 2009

Y1 - 2009

N2 - BACKGROUND: The relationship between therapeutic delay and long-term survival from colorectal cancer is unclear. This association was examined prospectively among patients with colorectal cancer in Denmark. METHODS: A total of 740 patients with colorectal cancer were included in a prospective, population-based study in three Danish counties from 1 January 2001 to 31 July 2002. Delay was determined by self-report during a standardized interview. Cox proportional hazards regression was used to compute the hazard ratio (HR) associated with delay, while adjusting for age, sex and co-morbidity, and also for urgency of surgery in patients with colonic cancer. RESULTS: For rectal cancer only, a time span of at least 60 days from the onset of symptoms until treatment (total therapeutic delay) was associated with a 69 per cent higher risk of mortality compared with a total therapeutic delay of less than 60 days (HR 1.69 (95 per cent confidence interval 1.01 to 2.83)). Provider delay (interval from first physician contact until treatment) and hospital delay (interval from referral to a hospital until treatment) of at least 60 days had no impact on survival from colorectal cancer. CONCLUSION: A total therapeutic delay of at least 60 days was a negative prognostic factor for long-term survival from rectal cancer.

AB - BACKGROUND: The relationship between therapeutic delay and long-term survival from colorectal cancer is unclear. This association was examined prospectively among patients with colorectal cancer in Denmark. METHODS: A total of 740 patients with colorectal cancer were included in a prospective, population-based study in three Danish counties from 1 January 2001 to 31 July 2002. Delay was determined by self-report during a standardized interview. Cox proportional hazards regression was used to compute the hazard ratio (HR) associated with delay, while adjusting for age, sex and co-morbidity, and also for urgency of surgery in patients with colonic cancer. RESULTS: For rectal cancer only, a time span of at least 60 days from the onset of symptoms until treatment (total therapeutic delay) was associated with a 69 per cent higher risk of mortality compared with a total therapeutic delay of less than 60 days (HR 1.69 (95 per cent confidence interval 1.01 to 2.83)). Provider delay (interval from first physician contact until treatment) and hospital delay (interval from referral to a hospital until treatment) of at least 60 days had no impact on survival from colorectal cancer. CONCLUSION: A total therapeutic delay of at least 60 days was a negative prognostic factor for long-term survival from rectal cancer.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Child

KW - Child, Preschool

KW - Colonic Neoplasms

KW - Denmark

KW - Early Detection of Cancer

KW - Female

KW - Hospitalization

KW - Humans

KW - Infant

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Rectal Neoplasms

KW - Survival Analysis

KW - Time Factors

KW - Treatment Outcome

KW - Young Adult

U2 - 10.1002/bjs.6700

DO - 10.1002/bjs.6700

M3 - Journal article

C2 - 19787765

VL - 96

SP - 1183

EP - 1189

JO - British Journal of Surgery

JF - British Journal of Surgery

SN - 0007-1323

IS - 10

ER -