TY - JOUR

T1 - Maternal thyroid disease in the Danish National Birth Cohort

T2 - prevalence and risk factors

AU - Andersen, Stine Linding

AU - Olsen, Jørn

AU - Laurberg, Peter

N1 - © 2016 European Society of Endocrinology.

PY - 2016/2

Y1 - 2016/2

N2 - OBJECTIVE: Thyroid disorders are common in women of reproductive age, but the exact burden of disease before, during and after a pregnancy is not clear. We describe the prevalence of thyroid disease in women enrolled in the Danish National Birth Cohort (DNBC) and investigate some of its risk factors.DESIGN: Population-based study within the DNBC, which included 101,032 pregnancies (1997-2003).METHODS: We studied women enrolled in the DNBC who gave birth to a live-born child. Information on maternal thyroid disease (hyperthyroidism, hypothyroidism, benign goiter/nodules, thyroid cancer, and other) before, during and up to 5 years after the woman's first pregnancy in the cohort was obtained from self-report (telephone interview in median gestational week 17) and from nationwide registers on hospital diagnosis of thyroid disease/thyroid surgery (from 1977) and prescriptions of thyroid drugs (from 1995).RESULTS: Of the 77,445 women studied, 3018 (3.9%) were identified with an onset of thyroid disease before (2.0%), during (0.1%) or in the 5-year period after the pregnancy (1.8%). During the pregnancy, 153 (0.2%) women received antithyroid drugs and 365 (0.5%) received thyroid hormone for hypothyroidism (83 after previous hyperthyroidism, 42 after previous surgery for benign goiter/nodules or thyroid cancer). Significant risk factors for maternal thyroid disease were age, parity, origin, iodine intake, smoking, alcohol, and BMI.CONCLUSIONS: Around 4% of Danish pregnant women had either a history of thyroid disease or thyroid disease during pregnancy or were diagnosed with thyroid disease for the first-time in the years following a pregnancy. The spectrum of thyroid disease was influenced by demographic and environmental factors.

AB - OBJECTIVE: Thyroid disorders are common in women of reproductive age, but the exact burden of disease before, during and after a pregnancy is not clear. We describe the prevalence of thyroid disease in women enrolled in the Danish National Birth Cohort (DNBC) and investigate some of its risk factors.DESIGN: Population-based study within the DNBC, which included 101,032 pregnancies (1997-2003).METHODS: We studied women enrolled in the DNBC who gave birth to a live-born child. Information on maternal thyroid disease (hyperthyroidism, hypothyroidism, benign goiter/nodules, thyroid cancer, and other) before, during and up to 5 years after the woman's first pregnancy in the cohort was obtained from self-report (telephone interview in median gestational week 17) and from nationwide registers on hospital diagnosis of thyroid disease/thyroid surgery (from 1977) and prescriptions of thyroid drugs (from 1995).RESULTS: Of the 77,445 women studied, 3018 (3.9%) were identified with an onset of thyroid disease before (2.0%), during (0.1%) or in the 5-year period after the pregnancy (1.8%). During the pregnancy, 153 (0.2%) women received antithyroid drugs and 365 (0.5%) received thyroid hormone for hypothyroidism (83 after previous hyperthyroidism, 42 after previous surgery for benign goiter/nodules or thyroid cancer). Significant risk factors for maternal thyroid disease were age, parity, origin, iodine intake, smoking, alcohol, and BMI.CONCLUSIONS: Around 4% of Danish pregnant women had either a history of thyroid disease or thyroid disease during pregnancy or were diagnosed with thyroid disease for the first-time in the years following a pregnancy. The spectrum of thyroid disease was influenced by demographic and environmental factors.

KW - Adult

KW - Cohort Studies

KW - Denmark

KW - Female

KW - Humans

KW - Pregnancy

KW - Pregnancy Complications

KW - Prevalence

KW - Registries

KW - Risk Factors

KW - Thyroid Diseases

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1530/EJE-15-0816

DO - 10.1530/EJE-15-0816

M3 - Journal article

C2 - 26582484

VL - 174

SP - 203

EP - 212

JO - European Journal of Endocrinology. Supplement

JF - European Journal of Endocrinology. Supplement

SN - 0804-4635

IS - 2

ER -