Stine Linding Andersen

Long-term Iodine nutrition is associated with longevity in older adults: a 20 years' follow-up of the Randers-Skagen study

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Standard

Long-term Iodine nutrition is associated with longevity in older adults : a 20 years' follow-up of the Randers-Skagen study. / Riis, Johannes; Pedersen, Klaus M.; Danielsen, Mathias B. et al.

In: British Journal of Nutrition, Vol. 125, No. 3, 02.2021, p. 260-265.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Riis, J, Pedersen, KM, Danielsen, MB, Sørensen, GVB, Jørgensen, MG, Andersen, SL, Carlé, A, Pedersen, IB, Torp-Pedersen, C & Andersen, S 2021, 'Long-term Iodine nutrition is associated with longevity in older adults: a 20 years' follow-up of the Randers-Skagen study', British Journal of Nutrition, vol. 125, no. 3, pp. 260-265. https://doi.org/10.1017/S0007114520001592

APA

Riis, J., Pedersen, K. M., Danielsen, M. B., Sørensen, G. V. B., Jørgensen, M. G., Andersen, S. L., Carlé, A., Pedersen, I. B., Torp-Pedersen, C., & Andersen, S. (2021). Long-term Iodine nutrition is associated with longevity in older adults: a 20 years' follow-up of the Randers-Skagen study. British Journal of Nutrition, 125(3), 260-265. https://doi.org/10.1017/S0007114520001592

CBE

Riis J, Pedersen KM, Danielsen MB, Sørensen GVB, Jørgensen MG, Andersen SL, Carlé A, Pedersen IB, Torp-Pedersen C, Andersen S. 2021. Long-term Iodine nutrition is associated with longevity in older adults: a 20 years' follow-up of the Randers-Skagen study. British Journal of Nutrition. 125(3):260-265. https://doi.org/10.1017/S0007114520001592

MLA

Vancouver

Riis J, Pedersen KM, Danielsen MB, Sørensen GVB, Jørgensen MG, Andersen SL et al. Long-term Iodine nutrition is associated with longevity in older adults: a 20 years' follow-up of the Randers-Skagen study. British Journal of Nutrition. 2021 Feb;125(3):260-265. doi: 10.1017/S0007114520001592

Author

Riis, Johannes ; Pedersen, Klaus M. ; Danielsen, Mathias B. et al. / Long-term Iodine nutrition is associated with longevity in older adults : a 20 years' follow-up of the Randers-Skagen study. In: British Journal of Nutrition. 2021 ; Vol. 125, No. 3. pp. 260-265.

Bibtex

@article{85474de44e6c45718b4b778c8312a2ee,
title = "Long-term Iodine nutrition is associated with longevity in older adults: a 20 years' follow-up of the Randers-Skagen study",
abstract = "Iodine intake affects the occurrence of thyroid disorders. However, the association of iodine intake with longevity remains to be described. This led us to perform a 20-year follow-up on participants from the Randers-Skagen (RaSk) study. Residents in Randers born in 1920 (n=210) and Skagen born in 1918-1923 (n=218) were included in a clinical study in 1997-1998. Mean iodine content in drinking water was 2 μg/L in Randers and 139 μg/L in Skagen. We collected baseline data through questionnaires, performed physical examinations, and measured iodine concentrations in spot urine samples. Income data were retrieved from Danish registries. We performed follow-up on mortality until 12-12-2017 using Danish registries. Complete follow-up data were available on 428 out of 430 of participants (99.5%). At baseline, the median urinary iodine concentration was 55 μg/L in Randers and 160 μg/L in Skagen residents. Participants were long-term residents with 72.8% and 92.7% residing for more than 25 years in Randers and Skagen, respectively. Cox regression showed that living in Skagen compared to Randers was associated with lower hazard ratio (HR) of death in both age- and sex-adjusted analysis (HR 0.60, 95% CI: 0.41-0.87, P = 0.006), but also after adjustment for age, sex, number of drugs, Charlson Comorbidity Index, smoking, alcohol, and income (HR 0.60, 95% CI: 0.41-0.87, P = 0.008). Residing in iodine replete Skagen was associated with increased longevity. This indicates, that long-term residency in an iodine replete environment may be associated with increased longevity compared to residency in an iodine deficient environment.",
keywords = "Iodine nutrition, longevity, older adults, tap water, thyroid function",
author = "Johannes Riis and Pedersen, {Klaus M.} and Danielsen, {Mathias B.} and S{\o}rensen, {Gustav V.B.} and J{\o}rgensen, {Martin G.} and Andersen, {Stine L.} and Allan Carl{\'e} and Pedersen, {Inge B.} and Christian Torp-Pedersen and Stig Andersen",
year = "2021",
month = feb,
doi = "10.1017/S0007114520001592",
language = "English",
volume = "125",
pages = "260--265",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Long-term Iodine nutrition is associated with longevity in older adults

T2 - a 20 years' follow-up of the Randers-Skagen study

AU - Riis, Johannes

AU - Pedersen, Klaus M.

AU - Danielsen, Mathias B.

AU - Sørensen, Gustav V.B.

AU - Jørgensen, Martin G.

AU - Andersen, Stine L.

AU - Carlé, Allan

AU - Pedersen, Inge B.

AU - Torp-Pedersen, Christian

AU - Andersen, Stig

PY - 2021/2

Y1 - 2021/2

N2 - Iodine intake affects the occurrence of thyroid disorders. However, the association of iodine intake with longevity remains to be described. This led us to perform a 20-year follow-up on participants from the Randers-Skagen (RaSk) study. Residents in Randers born in 1920 (n=210) and Skagen born in 1918-1923 (n=218) were included in a clinical study in 1997-1998. Mean iodine content in drinking water was 2 μg/L in Randers and 139 μg/L in Skagen. We collected baseline data through questionnaires, performed physical examinations, and measured iodine concentrations in spot urine samples. Income data were retrieved from Danish registries. We performed follow-up on mortality until 12-12-2017 using Danish registries. Complete follow-up data were available on 428 out of 430 of participants (99.5%). At baseline, the median urinary iodine concentration was 55 μg/L in Randers and 160 μg/L in Skagen residents. Participants were long-term residents with 72.8% and 92.7% residing for more than 25 years in Randers and Skagen, respectively. Cox regression showed that living in Skagen compared to Randers was associated with lower hazard ratio (HR) of death in both age- and sex-adjusted analysis (HR 0.60, 95% CI: 0.41-0.87, P = 0.006), but also after adjustment for age, sex, number of drugs, Charlson Comorbidity Index, smoking, alcohol, and income (HR 0.60, 95% CI: 0.41-0.87, P = 0.008). Residing in iodine replete Skagen was associated with increased longevity. This indicates, that long-term residency in an iodine replete environment may be associated with increased longevity compared to residency in an iodine deficient environment.

AB - Iodine intake affects the occurrence of thyroid disorders. However, the association of iodine intake with longevity remains to be described. This led us to perform a 20-year follow-up on participants from the Randers-Skagen (RaSk) study. Residents in Randers born in 1920 (n=210) and Skagen born in 1918-1923 (n=218) were included in a clinical study in 1997-1998. Mean iodine content in drinking water was 2 μg/L in Randers and 139 μg/L in Skagen. We collected baseline data through questionnaires, performed physical examinations, and measured iodine concentrations in spot urine samples. Income data were retrieved from Danish registries. We performed follow-up on mortality until 12-12-2017 using Danish registries. Complete follow-up data were available on 428 out of 430 of participants (99.5%). At baseline, the median urinary iodine concentration was 55 μg/L in Randers and 160 μg/L in Skagen residents. Participants were long-term residents with 72.8% and 92.7% residing for more than 25 years in Randers and Skagen, respectively. Cox regression showed that living in Skagen compared to Randers was associated with lower hazard ratio (HR) of death in both age- and sex-adjusted analysis (HR 0.60, 95% CI: 0.41-0.87, P = 0.006), but also after adjustment for age, sex, number of drugs, Charlson Comorbidity Index, smoking, alcohol, and income (HR 0.60, 95% CI: 0.41-0.87, P = 0.008). Residing in iodine replete Skagen was associated with increased longevity. This indicates, that long-term residency in an iodine replete environment may be associated with increased longevity compared to residency in an iodine deficient environment.

KW - Iodine nutrition

KW - longevity

KW - older adults

KW - tap water

KW - thyroid function

UR - http://www.scopus.com/inward/record.url?scp=85085324021&partnerID=8YFLogxK

U2 - 10.1017/S0007114520001592

DO - 10.1017/S0007114520001592

M3 - Journal article

C2 - 32378500

AN - SCOPUS:85085324021

VL - 125

SP - 260

EP - 265

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 3

ER -