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Hyperthyroidism incidence fluctuates widely in and around pregnancy and is at variance with some other autoimmune diseases : a Danish population-based study. / Andersen, Stine Linding; Olsen, Jørn; Carlé, Allan et al.
In: Journal of Clinical Endocrinology and Metabolism, 08.12.2014, p. jc20143588.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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TY - JOUR
T1 - Hyperthyroidism incidence fluctuates widely in and around pregnancy and is at variance with some other autoimmune diseases
T2 - a Danish population-based study
AU - Andersen, Stine Linding
AU - Olsen, Jørn
AU - Carlé, Allan
AU - Laurberg, Peter
PY - 2014/12/8
Y1 - 2014/12/8
N2 - Context: Hyperthyroidism in women of reproductive age is predominantly caused by Graves' disease. Pregnancy associated changes in the immune system may influence the onset of disease, but population-based incidence rates in and around pregnancy have not been reported. Objective: To estimate the incidence of maternal hyperthyroidism (defined by redeemed prescription of antithyroid drugs) in and around pregnancy and to compare this with the incidence of other autoimmune diseases such as rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). Design: Population-based cohort study. Setting: Danish nationwide registers. Participants: Women giving birth to singleton liveborn children in Denmark from 1999-2008 (n=403,958). Main outcome measure(s): Incidence rates (IR) of maternal hyperthyroidism during a four-year period beginning two years before and ending two years after the date when the mother was giving birth first time in the study period. Results: Altogether 3,673 women (0.9%) were identified with onset of hyperthyroidism from 1997-2010, and the overall IR of maternal hyperthyroidism was 65.0/100,000/year. The IR of hyperthyroidism in and around pregnancy varied widely and was high in the first three months of pregnancy (incidence rate ratio (IRR) versus the remaining study period: 1.50 (95% CI 1.09-2.06)), very low in the last three months of pregnancy (0.26 (0.15-0.44)), and reached the highest level 7-9 months postpartum (3.80 (2.88-5.02)). The incidence variation in and around pregnancy was different for RA and IBD. Conclusion: These are the first population-based data on the incidence of hyperthyroidism in and around pregnancy. The incidence of hyperthyroidism was high in early pregnancy and postpartum whereas such particular pattern was not observed for other diseases of autoimmune origin.
AB - Context: Hyperthyroidism in women of reproductive age is predominantly caused by Graves' disease. Pregnancy associated changes in the immune system may influence the onset of disease, but population-based incidence rates in and around pregnancy have not been reported. Objective: To estimate the incidence of maternal hyperthyroidism (defined by redeemed prescription of antithyroid drugs) in and around pregnancy and to compare this with the incidence of other autoimmune diseases such as rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). Design: Population-based cohort study. Setting: Danish nationwide registers. Participants: Women giving birth to singleton liveborn children in Denmark from 1999-2008 (n=403,958). Main outcome measure(s): Incidence rates (IR) of maternal hyperthyroidism during a four-year period beginning two years before and ending two years after the date when the mother was giving birth first time in the study period. Results: Altogether 3,673 women (0.9%) were identified with onset of hyperthyroidism from 1997-2010, and the overall IR of maternal hyperthyroidism was 65.0/100,000/year. The IR of hyperthyroidism in and around pregnancy varied widely and was high in the first three months of pregnancy (incidence rate ratio (IRR) versus the remaining study period: 1.50 (95% CI 1.09-2.06)), very low in the last three months of pregnancy (0.26 (0.15-0.44)), and reached the highest level 7-9 months postpartum (3.80 (2.88-5.02)). The incidence variation in and around pregnancy was different for RA and IBD. Conclusion: These are the first population-based data on the incidence of hyperthyroidism in and around pregnancy. The incidence of hyperthyroidism was high in early pregnancy and postpartum whereas such particular pattern was not observed for other diseases of autoimmune origin.
U2 - 10.1210/jc.2014-3588
DO - 10.1210/jc.2014-3588
M3 - Journal article
C2 - 25485728
SP - jc20143588
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
ER -