Projects per year
Personal profile
Research
We investigate muscle development, signaling and maintenance, by studying the biological role of sarcomeric and muscle associated proteins. We are particularly interested to decipher molecular mechanisms that play a role in the development of cardiac and skeletal muscle myopathies.
Profile
Hailing from Germany, Dr. Lange obtained a Dipl.biol. from Humboldt University Berlin in 2001 and a PhD from the Swiss Federal Institute of Technology Zurich (ETHZ) in 2005. During his postdoctoral work at King's College London and UC San Diego, he made seminal contributions to the mechanistic understanding of the role that sarcomeric and muscle associated proteins play for cardiomyopathy and neuromuscular disease development. He continues his research at Aarhus University and UC San Diego.
Teaching
Dr. Lange contributes to teaching in the Department of Biomedicine at Aarhus University. His teaching portolio includes the following activities:
- Course on Molecular Principles of Cell and Organ Functions
- Course on Integration of Cell and Organ Function
- Bachelors projects for medical students
- PhD student supervisor
Dr. Lange is also a member of the PhD Committee at the Graduate School of Health, Aarhus University, and one of the organizers for the newly established Cardiovascular PhD program at AU.
Teaching
Health focuses on more interdisciplinarity with new PhD programs.
To support PhD students in achieving a sharper professional profile and promote interdisciplinary collaboration, AU Health is now introducing three new PhD programs, one of which is the Cardiovascular PhD programme.
The program focuses on diseases of the heart and circulatory system and gives PhD students the opportunity to delve into advanced research methods and techniques in cardiovascular medicine.
"We aim to create a dynamic learning environment where students can develop their research and access the latest techniques. The program allows us to train the next generation of researchers in the most advanced methods in cardiovascular medicine."
External positions
Lecturer, Steno Diabetes Center Aarhus, Forskningsudvalget
1 Oct 2022 → …
Affiliated Researcher, University of Gothenburg
2018 → 2022
Associate Professor, UC San Diego
2007 → …
Keywords
- Muscle biology
- Cardiovascular Physiology
- Cell signaling
- Cell biology
- Bones, muscles, joints
Areas of expertise
- Cardiovascular Research
- Cardiomyopathy
- Neuromuscular disease
- Ubiquitin Proteasome System
- Protein Turnover
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Collaborations and top research areas from the last five years
Projects
- 2 Active
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Revealing roles for cullin-linked protein degradation for the development of neuromuscular disorders
Lange, S. (PI)
01/01/2023 → 31/12/2026
Project: Research
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Ankrd1: a novel biomarker and therapeutic target for dilated cardiomyopathy
Lange, S. (PI)
01/06/2024 → 31/05/2027
Project: Research
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The challenges of assessing adiposity in a clinical setting
Börgeson, E., Tavajoh, S., Lange, S. & Jessen, N., 15 Jul 2024, (E-pub ahead of print) In: Nature Reviews. Endocrinology.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
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Metabolic Flexibility of the Heart: The Role of Fatty Acid Metabolism in Health, Heart Failure, and Cardiometabolic Diseases
Actis Dato, V., Lange, S. & Cho, Y., Jan 2024, In: International Journal of Molecular Sciences . 25, 2, 1211.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open Access -
Students at a crossroad: A cross-sectional survey gauging the impact of COVID-19 on medical and biomedical graduates in the United States and Sweden
Lange, S., Soták, M., Hagberg, C. E., Bagunu, G., Vigmo, S. & Börgeson, E., 2023, In: Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology. 51, 5, p. 508-519 12 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Open Access -
The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles
van der Pijl, R. J., Domenighetti, A. A., Sheikh, F., Ehler, E., Ottenheijm, C. A. C. & Lange, S., Oct 2021, In: Biophysical Reviews. 13, 5, p. 653-677 25 p.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
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The role of cullin-RING ligases in striated muscle development, function, and disease
Blondelle, J., Biju, A. & Lange, S., 1 Nov 2020, In: International Journal of Molecular Sciences . 21, 21, p. 1-58 58 p., 7936.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Open Access7 Citations (Scopus)
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UC San Diego
Lange, S. (Visiting researcher)
2023 → 2025Activity: Visiting an external institution types › Visiting an external academic institution
Press/Media
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Five researchers from Health receive DKK 25 million for neurological research
23/11/2022
1 Media contribution
Press/Media: Press / Media
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Notable Alumni - Randall Centre for Cell and Molecular Biophysics, King's College London
02/01/2023
1 item of Media coverage
Press/Media: Press / Media
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Accurate adiposity measurements key to tackling obesity-related diseases, study finds
15/07/2024
1 Media contribution
Press/Media: Press / Media
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AU Health establishes three new interdisciplinary PhD programs
13/06/2024
1 Media contribution
Press/Media: Press / Media
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19 researchers from Health receive grants from Independent Research Fund Denmark
12/10/2023
1 Media contribution
Press/Media: Press / Media