Research

We investigate muscle development, signaling and maintenance, by studying the biological role of sarcomeric and muscle associated proteins. We are particularly interested to decipher molecular mechanisms that play a role in the development of cardiac and skeletal muscle myopathies.

Profile

Hailing from Germany, Dr. Lange obtained a Dipl.biol. from Humboldt University Berlin in 2001 and a PhD from the Swiss Federal Institute of Technology Zurich (ETHZ) in 2005. During his postdoctoral work at King's College London and UC San Diego, he made seminal contributions to the mechanistic understanding of the role that sarcomeric and muscle associated proteins play for cardiomyopathy and neuromuscular disease development. He continues his research at Aarhus University and UC San Diego.

Cooperation and dissemination

My lab has established many international collaborations, including with research groups in Germany (Prof. Olga Mayans, Konstanz U), Sweden (Prof. Borgeson, Gothenburg U), the USA (Profs. Farah Sheikh & Yoshitake Cho, UCSD), the UK (Profs. Elisabeth Ehler & Katja Gehmlich, KCL & Birmingham U) and Italy (Prof. Vincenzo Sorrentino, U of Siena). These collaborations have led to several peer-reviewed manuscripts, which have been published in internationally renowned journals, like the Journal of General Physiology, iScience, the Journal of Clinical Investigations (JCI) or the Journal of Molecular Biology.

Teaching

Dr. Lange contributes to teaching in the Department of Biomedicine at Aarhus University. His teaching portolio includes the following activities: 

• Course on Molecular Principles of Cell and Organ Functions
• Course on Integration of Cell and Organ Function
• Bachelors projects for medical students
• PhD student supervisor

Dr. Lange is also a member of the PhD Committee at the Graduate School of Health, Aarhus University, and one of the organizers for the newly established Cardiovascular PhD program at AU.

Health focuses on more interdisciplinarity with new PhD programs.

To support PhD students in achieving a sharper professional profile and promote interdisciplinary collaboration, AU Health is now introducing three new PhD programs, one of which is the Cardiovascular PhD programme.

The program focuses on diseases of the heart and circulatory system and gives PhD students the opportunity to delve into advanced research methods and techniques in cardiovascular medicine.

"We aim to create a dynamic learning environment where students can develop their research and access the latest techniques. The program allows us to train the next generation of researchers in the most advanced methods in cardiovascular medicine."

Job responsibilities

The main responsibilities of my position as Associatre Professor in the Department of Biomedicine are research (including a requirement to publish/disseminate research results) and research-based teaching in the areas of medical physiology (Integration of cell and organ function) and medical biomedicine (molecular principles of cell and organ function). 

Additionally, I am the co-director of the Cardiovascular PhD programme at Aarhus University, and supervise students.