Steen Jakobsen

Radiosynthesis and in vivo evaluation of [(11)C]MP-10 as a positron emission tomography radioligand for phosphodiesterase 10A

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Christophe Plisson
  • ,
  • Cristian Salinas
  • ,
  • David Weinzimmer
  • ,
  • David Labaree
  • ,
  • Shu-Fei Lin
  • ,
  • Yu-Shin Ding
  • ,
  • Steen Jakobsen
  • Paul W Smith
  • ,
  • Kawanishi Eiji
  • ,
  • Richard E Carson
  • ,
  • Roger N Gunn
  • ,
  • Eugenii A Rabiner
The aim of this study was to evaluate a newly reported positron emission tomography (PET) radioligand [(11)C]MP-10, a potent and selective inhibitor of the central phosphodiesterase 10A enzyme (PDE10A) in vivo, using PET.
Original languageEnglish
JournalNuclear Medicine and Biology
Volume38
Issue6
Pages (from-to)875-84
Number of pages10
ISSN0969-8051
DOIs
Publication statusPublished - 2011

    Research areas

  • Animals, Carbon Radioisotopes, Enzyme Inhibitors, Female, Humans, Kinetics, Ligands, Papio, Phosphoric Diester Hydrolases, Positron-Emission Tomography, Pyrazoles, Quinolines, Radiochemistry, Substrate Specificity, Swine

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