Steen Jakobsen

[N-methyl-11C]cholylsarcosine, a novel bile acid tracer for PET/CT of hepatic excretory function: Radiosynthesis and proof-of-concept studies in pigs

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Excretion of conjugated bile acids into bile is an essential function of the liver, and impairment of canalicular bile acid secretion leads to cholestatic liver injury. However, hepatic excretory function cannot be quantified in vivo because of the lack of suitable methods. Cholylsarcosine is an analog of the endogenous bile acid conjugate cholylglycine and exhibits characteristics in vivo that led us to hypothesize that the (11)C-labeled form, that is, [N-methyl-(11)C]cholylsarcosine ((11)C-cholylsarcosine), would be a suitable PET tracer for quantification of hepatic excretory function.
Original languageEnglish
JournalJournal of Nuclear Medicine
Volume53
Issue5
Pages (from-to)772-8
Number of pages7
ISSN0161-5505
DOIs
Publication statusPublished - 2012

    Research areas

  • Animals, Bile Acids and Salts, Cholic Acids, Female, Liver, Liver Function Tests, Positron-Emission Tomography and Computed Tomography, Radioactive Tracers, Radiochemistry, Sarcosine, Swine

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