Steen Jakobsen

Inhibition of tumor lactate oxidation: consequences for the tumor microenvironment

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Inhibition of tumor lactate oxidation: consequences for the tumor microenvironment. / Busk, Morten; Walenta, Stefan; Mueller-Klieser, Wolfgang; Steiniche, Torben; Jakobsen, Steen; Horsman, Michael Robert; Overgaard, Jens.

In: Radiotherapy & Oncology, 2011, p. 404-11.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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@article{567121d12bd0414382a205311c7442a4,
title = "Inhibition of tumor lactate oxidation: consequences for the tumor microenvironment",
abstract = "Tumor cells are recognized as being highly glycolytic. However, recently it was suggested that lactate produced in hypoxic tumor areas may be taken up by the monocarboxylate transporter MCT1 and oxidized in well-oxygenated tumor parts. Furthermore, it was shown that inhibition of lactate oxidation using the MCT1 inhibitor α-cyano-hydroxycinnamate (CHC) can radio-sensitize tumors possibly by forcing a switch from lactate oxidization to glycolysis in oxygenated cells, which in turn improves tumor oxygenation and indirectly kills radio-resistant hypoxic tumor cells from glucose starvation.",
keywords = "Animals, Autoradiography, Carcinoma, Squamous Cell, Cell Hypoxia, Cell Line, Tumor, Cinnamates, Female, Fluorodeoxyglucose F18, Glucose, Glycolysis, Head and Neck Neoplasms, Immunoenzyme Techniques, Lactates, Linear Models, Luminescent Measurements, Mice, Mice, Nude, Monocarboxylic Acid Transporters, Nitroimidazoles, Oxidation-Reduction, Symporters, Tumor Microenvironment, Uterine Cervical Neoplasms",
author = "Morten Busk and Stefan Walenta and Wolfgang Mueller-Klieser and Torben Steiniche and Steen Jakobsen and Horsman, {Michael Robert} and Jens Overgaard",
note = "Copyright {\circledC} 2011 Elsevier Ireland Ltd. All rights reserved.",
year = "2011",
doi = "10.1016/j.radonc.2011.05.053",
language = "English",
pages = "404--11",
journal = "Radiotherapy & Oncology",
issn = "0167-8140",
publisher = "Elsevier Ireland Ltd.",

}

RIS

TY - JOUR

T1 - Inhibition of tumor lactate oxidation: consequences for the tumor microenvironment

AU - Busk, Morten

AU - Walenta, Stefan

AU - Mueller-Klieser, Wolfgang

AU - Steiniche, Torben

AU - Jakobsen, Steen

AU - Horsman, Michael Robert

AU - Overgaard, Jens

N1 - Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

PY - 2011

Y1 - 2011

N2 - Tumor cells are recognized as being highly glycolytic. However, recently it was suggested that lactate produced in hypoxic tumor areas may be taken up by the monocarboxylate transporter MCT1 and oxidized in well-oxygenated tumor parts. Furthermore, it was shown that inhibition of lactate oxidation using the MCT1 inhibitor α-cyano-hydroxycinnamate (CHC) can radio-sensitize tumors possibly by forcing a switch from lactate oxidization to glycolysis in oxygenated cells, which in turn improves tumor oxygenation and indirectly kills radio-resistant hypoxic tumor cells from glucose starvation.

AB - Tumor cells are recognized as being highly glycolytic. However, recently it was suggested that lactate produced in hypoxic tumor areas may be taken up by the monocarboxylate transporter MCT1 and oxidized in well-oxygenated tumor parts. Furthermore, it was shown that inhibition of lactate oxidation using the MCT1 inhibitor α-cyano-hydroxycinnamate (CHC) can radio-sensitize tumors possibly by forcing a switch from lactate oxidization to glycolysis in oxygenated cells, which in turn improves tumor oxygenation and indirectly kills radio-resistant hypoxic tumor cells from glucose starvation.

KW - Animals

KW - Autoradiography

KW - Carcinoma, Squamous Cell

KW - Cell Hypoxia

KW - Cell Line, Tumor

KW - Cinnamates

KW - Female

KW - Fluorodeoxyglucose F18

KW - Glucose

KW - Glycolysis

KW - Head and Neck Neoplasms

KW - Immunoenzyme Techniques

KW - Lactates

KW - Linear Models

KW - Luminescent Measurements

KW - Mice

KW - Mice, Nude

KW - Monocarboxylic Acid Transporters

KW - Nitroimidazoles

KW - Oxidation-Reduction

KW - Symporters

KW - Tumor Microenvironment

KW - Uterine Cervical Neoplasms

U2 - 10.1016/j.radonc.2011.05.053

DO - 10.1016/j.radonc.2011.05.053

M3 - Journal article

SP - 404

EP - 411

JO - Radiotherapy & Oncology

JF - Radiotherapy & Oncology

SN - 0167-8140

ER -