Steen Jakobsen

Behavioral response to novelty correlates with dopamine receptor availability in striatum of Göttingen minipigs.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Behavioral response to novelty correlates with dopamine receptor availability in striatum of Göttingen minipigs. / Lind, Nanna Marie; Gjedde, Albert; Moustgaard, Anette; Olsen, Aage K.; Jensen, Svend Borup; Jakobsen, Steen; Arnfred, Sidse Marie; Hansen, Axel Kornerup; Hemmingsen, Ralf Peter; Cumming, Paul.

In: Behavioural Brain Research, Vol. 164, No. 2, 2005, p. 172-7.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Lind, NM, Gjedde, A, Moustgaard, A, Olsen, AK, Jensen, SB, Jakobsen, S, Arnfred, SM, Hansen, AK, Hemmingsen, RP & Cumming, P 2005, 'Behavioral response to novelty correlates with dopamine receptor availability in striatum of Göttingen minipigs.', Behavioural Brain Research, vol. 164, no. 2, pp. 172-7. https://doi.org/10.1016/j.bbr.2005.06.008

APA

Lind, N. M., Gjedde, A., Moustgaard, A., Olsen, A. K., Jensen, S. B., Jakobsen, S., ... Cumming, P. (2005). Behavioral response to novelty correlates with dopamine receptor availability in striatum of Göttingen minipigs. Behavioural Brain Research, 164(2), 172-7. https://doi.org/10.1016/j.bbr.2005.06.008

CBE

Lind NM, Gjedde A, Moustgaard A, Olsen AK, Jensen SB, Jakobsen S, Arnfred SM, Hansen AK, Hemmingsen RP, Cumming P. 2005. Behavioral response to novelty correlates with dopamine receptor availability in striatum of Göttingen minipigs. Behavioural Brain Research. 164(2):172-7. https://doi.org/10.1016/j.bbr.2005.06.008

MLA

Vancouver

Author

Lind, Nanna Marie ; Gjedde, Albert ; Moustgaard, Anette ; Olsen, Aage K. ; Jensen, Svend Borup ; Jakobsen, Steen ; Arnfred, Sidse Marie ; Hansen, Axel Kornerup ; Hemmingsen, Ralf Peter ; Cumming, Paul. / Behavioral response to novelty correlates with dopamine receptor availability in striatum of Göttingen minipigs. In: Behavioural Brain Research. 2005 ; Vol. 164, No. 2. pp. 172-7.

Bibtex

@article{a47d3be018de11ddafca000ea68e967b,
title = "Behavioral response to novelty correlates with dopamine receptor availability in striatum of G{\"o}ttingen minipigs.",
abstract = "Behavioral response to novelty in rats has been linked both to dopamine transmission in the ventral striatum, and to propensity to self-administer psychostimulant drugs. In order to probe the relationship between behavioral response to novelty and dopamine systems we have developed a behavioral model for correlation with positron emission tomography (PET) of dopamine transmission in brain of G{\"o}ttingen minipigs. In the present study, we measured exploration of a novel object by recording the number of contacts, and duration of contact with a novel object, in groups of six male and six female adult minipigs. We hypothesized that these novelty scores would correlate with the amphetamine-evoked dopamine release in ventral striatum, measured 2 weeks later in a PET study of the availability of binding sites for the dopamine D2/3 antagonist [11C]raclopride. There were significant correlations between duration of contact with a novel object and the amphetamine-evoked reductions in binding potential (DeltapB) in the left ventral striatum of the 12 animals; Comparison of results by gender revealed that the correlation was driven mainly by the male group, and was not present in the female group. We interpret these results to show that propensity to explore an unfamiliar object is relatively elevated in pigs with low basal occupancy of dopamine D2/3 receptors by endogenous dopamine, and with high amphetamine-induced occupancy of released dopamine in the male pigs.",
keywords = "Adaptation, Psychological, Animals, Carbon Radioisotopes, Corpus Striatum, Exploratory Behavior, Female, Male, Personality, Positron-Emission Tomography, Raclopride, Receptors, Dopamine, Sex Factors, Swine, Swine, Miniature, Tissue Distribution",
author = "Lind, {Nanna Marie} and Albert Gjedde and Anette Moustgaard and Olsen, {Aage K.} and Jensen, {Svend Borup} and Steen Jakobsen and Arnfred, {Sidse Marie} and Hansen, {Axel Kornerup} and Hemmingsen, {Ralf Peter} and Paul Cumming",
year = "2005",
doi = "10.1016/j.bbr.2005.06.008",
language = "English",
volume = "164",
pages = "172--7",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier BV",
number = "2",

}

RIS

TY - JOUR

T1 - Behavioral response to novelty correlates with dopamine receptor availability in striatum of Göttingen minipigs.

AU - Lind, Nanna Marie

AU - Gjedde, Albert

AU - Moustgaard, Anette

AU - Olsen, Aage K.

AU - Jensen, Svend Borup

AU - Jakobsen, Steen

AU - Arnfred, Sidse Marie

AU - Hansen, Axel Kornerup

AU - Hemmingsen, Ralf Peter

AU - Cumming, Paul

PY - 2005

Y1 - 2005

N2 - Behavioral response to novelty in rats has been linked both to dopamine transmission in the ventral striatum, and to propensity to self-administer psychostimulant drugs. In order to probe the relationship between behavioral response to novelty and dopamine systems we have developed a behavioral model for correlation with positron emission tomography (PET) of dopamine transmission in brain of Göttingen minipigs. In the present study, we measured exploration of a novel object by recording the number of contacts, and duration of contact with a novel object, in groups of six male and six female adult minipigs. We hypothesized that these novelty scores would correlate with the amphetamine-evoked dopamine release in ventral striatum, measured 2 weeks later in a PET study of the availability of binding sites for the dopamine D2/3 antagonist [11C]raclopride. There were significant correlations between duration of contact with a novel object and the amphetamine-evoked reductions in binding potential (DeltapB) in the left ventral striatum of the 12 animals; Comparison of results by gender revealed that the correlation was driven mainly by the male group, and was not present in the female group. We interpret these results to show that propensity to explore an unfamiliar object is relatively elevated in pigs with low basal occupancy of dopamine D2/3 receptors by endogenous dopamine, and with high amphetamine-induced occupancy of released dopamine in the male pigs.

AB - Behavioral response to novelty in rats has been linked both to dopamine transmission in the ventral striatum, and to propensity to self-administer psychostimulant drugs. In order to probe the relationship between behavioral response to novelty and dopamine systems we have developed a behavioral model for correlation with positron emission tomography (PET) of dopamine transmission in brain of Göttingen minipigs. In the present study, we measured exploration of a novel object by recording the number of contacts, and duration of contact with a novel object, in groups of six male and six female adult minipigs. We hypothesized that these novelty scores would correlate with the amphetamine-evoked dopamine release in ventral striatum, measured 2 weeks later in a PET study of the availability of binding sites for the dopamine D2/3 antagonist [11C]raclopride. There were significant correlations between duration of contact with a novel object and the amphetamine-evoked reductions in binding potential (DeltapB) in the left ventral striatum of the 12 animals; Comparison of results by gender revealed that the correlation was driven mainly by the male group, and was not present in the female group. We interpret these results to show that propensity to explore an unfamiliar object is relatively elevated in pigs with low basal occupancy of dopamine D2/3 receptors by endogenous dopamine, and with high amphetamine-induced occupancy of released dopamine in the male pigs.

KW - Adaptation, Psychological

KW - Animals

KW - Carbon Radioisotopes

KW - Corpus Striatum

KW - Exploratory Behavior

KW - Female

KW - Male

KW - Personality

KW - Positron-Emission Tomography

KW - Raclopride

KW - Receptors, Dopamine

KW - Sex Factors

KW - Swine

KW - Swine, Miniature

KW - Tissue Distribution

U2 - 10.1016/j.bbr.2005.06.008

DO - 10.1016/j.bbr.2005.06.008

M3 - Journal article

C2 - 16043240

VL - 164

SP - 172

EP - 177

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 2

ER -