Steen Jakobsen

Amphetamine challenge decreases yohimbine binding to α2 adrenoceptors in Landrace pig brain

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Amphetamine challenge decreases yohimbine binding to α2 adrenoceptors in Landrace pig brain. / Landau, Anne M; Doudet, Doris J; Jakobsen, Steen.

In: Psychopharmacology, Vol. 222, No. 1, 2012, p. 155-163.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Landau, Anne M ; Doudet, Doris J ; Jakobsen, Steen. / Amphetamine challenge decreases yohimbine binding to α2 adrenoceptors in Landrace pig brain. In: Psychopharmacology. 2012 ; Vol. 222, No. 1. pp. 155-163.

Bibtex

@article{1960907818434498a11354c25b331881,
title = "Amphetamine challenge decreases yohimbine binding to α2 adrenoceptors in Landrace pig brain",
abstract = "RATIONALE: The noradrenaline (NA) system is implicated in neurodegenerative and psychiatric disorders; however, our understanding is impaired by the lack of well-validated radioligands to assess NA function and release. Yohimbine, an α2 adrenoceptor antagonist, has recently been developed as a carbon-11 [11C]-labeled radioligand for positron emission tomography (PET) imaging studies. OBJECTIVES: Here we explore the hypothesis that yohimbine can be used as an in vivo tracer of NA receptor binding and release during amphetamine challenges in Landrace pigs. METHODS: Pigs underwent baseline PET scans with [11C]yohimbine and were then challenged with 10 mg/kg d-amphetamine 20 min prior to a second [11C]yohimbine scan. Using the Logan analysis model, volumes of distribution were calculated from fits of the kinetic data 25-90 min post-yohimbine injection. RESULTS: Amphetamine decreased [11C]yohimbine volume of distribution in the brain regions under investigation, including the thalamus, caudate nucleus, and cortical regions. CONCLUSION: These data suggest that the binding of [11C]yohimbine to α2 adrenoceptors may be displaceable by increases in synaptic concentrations of the endogenous ligand, NA, and possibly dopamine, suggesting the possibility that [11C]yohimbine may be used as a surrogate marker of NA release in vivo.",
author = "Landau, {Anne M} and Doudet, {Doris J} and Steen Jakobsen",
year = "2012",
doi = "10.1007/s00213-011-2632-6",
language = "English",
volume = "222",
pages = "155--163",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Amphetamine challenge decreases yohimbine binding to α2 adrenoceptors in Landrace pig brain

AU - Landau, Anne M

AU - Doudet, Doris J

AU - Jakobsen, Steen

PY - 2012

Y1 - 2012

N2 - RATIONALE: The noradrenaline (NA) system is implicated in neurodegenerative and psychiatric disorders; however, our understanding is impaired by the lack of well-validated radioligands to assess NA function and release. Yohimbine, an α2 adrenoceptor antagonist, has recently been developed as a carbon-11 [11C]-labeled radioligand for positron emission tomography (PET) imaging studies. OBJECTIVES: Here we explore the hypothesis that yohimbine can be used as an in vivo tracer of NA receptor binding and release during amphetamine challenges in Landrace pigs. METHODS: Pigs underwent baseline PET scans with [11C]yohimbine and were then challenged with 10 mg/kg d-amphetamine 20 min prior to a second [11C]yohimbine scan. Using the Logan analysis model, volumes of distribution were calculated from fits of the kinetic data 25-90 min post-yohimbine injection. RESULTS: Amphetamine decreased [11C]yohimbine volume of distribution in the brain regions under investigation, including the thalamus, caudate nucleus, and cortical regions. CONCLUSION: These data suggest that the binding of [11C]yohimbine to α2 adrenoceptors may be displaceable by increases in synaptic concentrations of the endogenous ligand, NA, and possibly dopamine, suggesting the possibility that [11C]yohimbine may be used as a surrogate marker of NA release in vivo.

AB - RATIONALE: The noradrenaline (NA) system is implicated in neurodegenerative and psychiatric disorders; however, our understanding is impaired by the lack of well-validated radioligands to assess NA function and release. Yohimbine, an α2 adrenoceptor antagonist, has recently been developed as a carbon-11 [11C]-labeled radioligand for positron emission tomography (PET) imaging studies. OBJECTIVES: Here we explore the hypothesis that yohimbine can be used as an in vivo tracer of NA receptor binding and release during amphetamine challenges in Landrace pigs. METHODS: Pigs underwent baseline PET scans with [11C]yohimbine and were then challenged with 10 mg/kg d-amphetamine 20 min prior to a second [11C]yohimbine scan. Using the Logan analysis model, volumes of distribution were calculated from fits of the kinetic data 25-90 min post-yohimbine injection. RESULTS: Amphetamine decreased [11C]yohimbine volume of distribution in the brain regions under investigation, including the thalamus, caudate nucleus, and cortical regions. CONCLUSION: These data suggest that the binding of [11C]yohimbine to α2 adrenoceptors may be displaceable by increases in synaptic concentrations of the endogenous ligand, NA, and possibly dopamine, suggesting the possibility that [11C]yohimbine may be used as a surrogate marker of NA release in vivo.

U2 - 10.1007/s00213-011-2632-6

DO - 10.1007/s00213-011-2632-6

M3 - Journal article

VL - 222

SP - 155

EP - 163

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 1

ER -