Steen Jakobsen

  1. 2010
  2. Published

    Noradrenaline release: a potential antidepressant mechanism of brain stimulation therapies. / Landau, Anne M.; Dyve, Suzan; Alstrup, Aage Kristian Olsen; Møller, Arne; Simonsen, Mette; Jakobsen, Steen; Videbech, Poul; Wegener, Gregers; Doudet, Doris.

    2010. Abstract from OAK Meeting, København, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  3. Published

    Noradrenaline release: potential antidepressant mechanism of brain stimulation. / Doudet, Doris; Dyve, Suzan; Alstrup, Aage Kristian Olsen; Jakobsen, Steen; Simonsen, Mette; Møller, Arne; Videbech, Poul; Wegener, Gregers; Gjedde, Albert; Landau, Anne M.

    In: NeuroImage, No. 1, 2010, p. 47.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearch

  4. Published

    Noradrenaline release: potential antidepressant mechanism of brain stimulation? / Doudet, Doris; Dyve, Suzan; Olsen Alstrup, Aage Kristian; Jakobsen, Steen; Simonsen, Mette; Møller, Arne; Videbech, Poul; Wegener, Gregers; Gjedde, Albert; Landau, Anne M.

    In: NeuroImage, 2010.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearch

  5. Published

    Synthesis and in vivo evaluation of [11C]BU99008 as a ligand for the imidazoline I2 binding site. / Kealey, Steven; Husbands, Stephen; Casey, Emma M.; Salinas, Cristian A.; Parker, Christine A.; Jakobsen, Steen; Tyacke, Robin J.; Nutt, David J.; Gee, Antony D.

    In: NeuroImage, Vol. 52, Supplement 1, No. 0, 2010, p. S127 - S128.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference articleResearchpeer-review

  6. 2009
  7. Published

    Can hypoxia-PET map hypoxic cell density heterogeneity accurately in an animal tumor model at a clinically obtainable image contrast? / Busk, Morten; Horsman, Michael Robert; Jakobsen, Steen; Hansen, Kim V; Bussink, Johan; van der Kogel, Albert; Overgaard, Jens.

    In: Radiotherapy & Oncology, Vol. 92, No. 3, 09.2009, p. 429-436.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  8. Published

    Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies. / Bennacef, Idriss; Salinas, Cristian A; Bonasera, Thomas A; Gunn, Roger N; Audrain, Hélène; Jakobsen, Steen; Nabulsi, Nabeel; Weinzimmer, David; Carson, Richard E; Huang, Yiyun; Holmes, Ian; Micheli, Fabrizio; Heidbreder, Christian; Gentile, Gabriella; Rossi, Tino; Laruelle, Marc.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 19, No. 17, 2009, p. 5056-9.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  9. Published

    Electroconvulsive therapy induces alterations in monoaminergic receptor binding in the striatum and frontal cortex of healthy minipigs. / Landau, Anne M.; Alstrup, Aage Kristian Olsen; Møller, Arne; Jakobsen, Steen; Wegener, Gregers; Videbech, Poul; Vang, Kim; Gjedde, Albert; Doudet, Doris.

    2009. Abstract from OAK Meeting, Århus, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  10. Published

    Molecular tools for assessing human depression by positron emission tomography. / Smith, Donald F; Jakobsen, Steen.

    In: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, Vol. 19, No. 9, 2009, p. 611-28.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  11. Published

    Positron emission tomography (PET) imaging with [11C]-labeled erlotinib: a micro-PET study on mice with lung tumor xenografts. / Memon, Ashfaque A; Jakobsen, Steen; Dagnaes-Hansen, Frederik; Sørensen, Boe Sandahl; Keiding, Susanne; Nexø, Ebba.

    In: Cancer research, Vol. 69, No. 3, 2009, p. 873-8.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  12. Published

    [(11)C]Mirtazapine binding in depressed antidepressant nonresponders studied by PET neuroimaging. / Smith, Donald; Stork, Bo; Wegener, Gregers; Ashkanian, Mahmoud; Jakobsen, Steen; Bender, Dirk; Audrain, Hélène; Vase, Karina; Videbech, Poul; Rosenberg, Raben.

    In: Psychopharmacology, Vol. 206, 2009, p. 133-140.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  13. Published

    [11C] labeled erlotinib as a new radiotracer for identification of patients responding to erlotinib treatment : A preliminary study on lung cancer patients. / Memon, Ashfaque Ahmed; Weber, Britta; Jakobsen, Steen; Winterdahl, Michael; Dagnæs-Hansen, Frederik; Madsen, Hans Henrik Torp; Meldgaard, Peter; Sørensen, Boe Sandahl; Keiding, Susanne; Nexø, Ebba.

    In: Journal of Thoracic Oncology, No. 9, 2009, p. S698.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearch

  14. 2008
  15. Published

    Cellular uptake of PET tracers of glucose metabolism and hypoxia and their linkage. / Busk, Morten; Horsman, Michael R; Jakobsen, Steen; Bussink, Johan; van der Kogel, Albert; Overgaard, Jens.

    In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 35, No. 12, 12.2008, p. 2294-303.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  16. Published

    Imaging Hypoxia in Xenografted and Murine Tumors with 18F-Fluoroazomycin Arabinoside: A Comparative Study Involving microPET, Autoradiography, pO2-Polarography, and Fluorescence Microscopy. / Busk, Morten; Horsman, Michael R; Jakobsen, Steen; Keiding, Susanne; van der Kogel, Albert J; Bussink, Johan; Overgaard, Jens.

    In: International Journal of Radiation Oncology, Biology, Physics, Vol. 70, No. 4, 15.03.2008, p. 1202-12.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  17. Published

    Neuroimaging of mirtazapine enantiomers in humans. / Smith, Donald; Hansen, Søren; Jakobsen, Steen; Bender, Dirk; Audrain, Hélène; Ashkanian, Mahmoud; Stork, Bo; Minuzzi, Luciano; Hall, Håkan; Rosenberg, Raben.

    In: Psychopharmacology, Vol. 200, 2008, p. 273-279.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  18. Published

    Novel synthesis and evaluation of 11C Corynanthine as alpha-1 adrenergic tracer. / Jakobsen, Steen; Olsen, Aage Kristian; Nahimi, Adjmal.

    2008. Abstract from Turku PET Symposium, Turku, Finland.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  19. Published

    Regional binding potentials of [11C]mirtazapine enantiomers in human brain. / Smith, Donald F.; Hansen, Søren Baarsgaard; Jakobsen, Steen; Bender, Dirk; Audrain, Héléne; Ashkanian, Mahmoud; Stork, B.S.; Rosenberg, Raben.

    In: European Neuropsychopharmacology, Vol. 18, No. S4, 2008, p. S260-S261.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearch

  20. 2007
  21. Published

    Receptor occupancy of mirtazapine determined by PET in healthy volunteers. / Smith, Donald F.; Stork, Bo S.; Wegener, Gregers; Jakobsen, Steen; Bender, Dirk; Audrain, Hélène; Jensen, Svend B.; Hansen, Søren B.; Rodell, Anders; Rosenberg, Raben.

    In: Psychopharmacology, Vol. 195, No. 1, 01.11.2007, p. 131-138.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  22. Published

    A PET study of effects of chronic 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") on serotonin markers in Göttingen minipig brain. / Cumming, Paul; Møller, Mette; Benda, Kjeld; Minuzzi, Luciano; Jakobsen, Steen; Jensen, Svend B; Pakkenberg, Bente; Stark, Anette K; Gramsbergen, Jan Bert; Andreasen, Mette F; Olsen, Aage K.

    In: Synapse, Vol. 61, No. 7, 2007, p. 478-87.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  23. Published

    Parametric and regional maps of free serotonin 5HT1A receptor sites in human brain as function of age in healthy humans. / Møller, Mette; Jakobsen, Steen; Gjedde, Albert.

    In: Neuropsychopharmacology, Vol. 32, No. 8, 2007, p. 1707-14.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  24. Published

    Receptor occupancy of mirtazapine determined by PET in healty volunteers. / Smith, Donald F.; Stork, Bo S.; Wegener, Gregers; Jakobsen, Steen; Bender, Dirk; Audrain, Héléne; Jensen, Svend B.; Hansen, Søren Baarsgaard; Rodell, Anders; Rosenberg, Raben.

    In: Psychopharmacology, 2007.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  25. Published

    Role of monoaminergic innervation in 6-hydroxydopamine unilateral lesioned animal model of Parkinsons Disease and L-DOPA induced dyskinesia. / Nahimi, Adjmal; Olsen, Aage Kristian; Møller, Arne; Jakobsen, Steen; Østergaard, Søren Dinesen; Doudet, Doris.

    2007. Abstract from OAK Meeting, København, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  26. Published

    Stereoselective neuroimaging in vivo. / Smith, Donald F.; Jakobsen, Steen.

    In: European Neuropsychopharmacology, 2007.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  27. 2006
  28. Published

    Inhibition of [11C]mirtazapine binding by alpha2-adrenoceptor antagonists studied by positron emission tomography in living porcine brain. / Smith, Donald F; Dyve, Suzan; Minuzzi, Luciano; Jakobsen, Steen; Munk, Ole L; Marthi, Katalin; Cumming, Paul.

    In: Synapse, Vol. 59, No. 8, 15.06.2006, p. 463-71.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  29. Published

    Binding of the hallucinogen 5-[11C] Meo-DMT in brain of living pigs. / Pedersen, Kasper; Gjedde, Albert; Olsen, Aage Kristian; Jakobsen, Steen; Cumming, Paul; Jensen, Svend Borup.

    2006. Abstract from NRM Meeting, København, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  30. Published

    Binding of the hallucinogen MeO-DMT in the brain of domestic pig. / Olsen, Aage Kristian; Jensen, Svend Borup; Pedersen, Kasper; Jakobsen, Steen; Cumming, Paul.

    2006. Abstract from ScandLAS Symposium, Helsingør, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  31. Published

    Characterisation of the binding of the hallucinogen 11C-MEO-DMT in brain of living pigs. / Jensen, Svend Borup; Olsen, Aage Kristian; Pedersen, Kasper; Jakobsen, Steen; Cumming, Paul.

    In: Journal of Nuclear Medicine, 2006, p. 278P.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearch

  32. Published

    Detection of alpha2-adrenergic receptors in brain of living pig with 11C-yohimbine. / Jakobsen, Steen; Pedersen, K.; Smith, Donald F.; Jensen, S. B.; Munk, Ole Lajord; Cumming, Paul.

    In: J. Nucl. Med., No. 47, 2006, p. 2008-2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  33. Published

    Detection of alphe-2 adrenergic receptora in brain of living pig with [11C]yohimbine. / Jakobsen, Steen; Pedersen, Kasper; Smith, Donald F.; Jensen, Svend Borup; Olsen, Aage Kristian; Cumming, Paul.

    In: NeuroImage, 2006, p. T123-T124.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearch

  34. Published

    Detection of {alpha}2-Adrenergic Receptors in Brain of Living Pig with 11C-Yohimbine. / Jakobsen, Steen; Pedersen, Kasper; Smith, Donald F.; Jensen, Svend Borup; Munk, Ole Lajord; Cumming, Paul.

    In: The Journal of Nuclear Medicine, Vol. 47, No. 12, 2006, p. 2008-2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  35. Published

    Inhibition of [(11)C]mirtazapine binding by alpha(2)-adrenoceptor antagonists studied by positron emission tomography in living porcine brain. / Smith, Donald F.; Dyve, Suzan; Minuzzi, Luciano; Jakobsen, Steen; Munk, Ole Lajord; Marthi, K; Cumming, Paul.

    In: Synapse, Vol. 59, No. 8, 2006, p. 463-471.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  36. Published

    Mapping of the hallucinogen 5-Meo-DMT in living pig brain. / Pedersen, Kasper; Olsen, Aage Kristian; Jakobsen, Steen; Gjedde, Albert; Cumming, Paul; Jensen, Svend Borup.

    2006. Abstract from Århus Sygehus - Forskningens Dag, Århus, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  37. Published

    Mapping of the hallucinogen 5-Meo-DMT in living porcine brain. / Pedersen, Kasper; olsen, Aage Kristian; Jakobsen, Steen; Gjedde, Albert; Cumming, Paul; Jensen, Svend Borup.

    2006. Abstract from OAK Meeting, Odense, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  38. Published

    PET neuroimaging of [11C]mirtazapine enantiomers in pigs. / Smith, Donald F; Marthi, Katalin; Munk, Ole L; Cumming, Paul; Hansen, Søren B; Jakobsen, Steen.

    In: European Neuropsychopharmacology, Vol. 16, No. 5, 2006, p. 350-7.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  39. Published

    Synthesis, radiolabeling and in vivo evaluation of [11C]RAL-01, a potential phosphodiesterase 5 radioligand. / Jakobsen, Steen; Kodahl, G.M.; Olsen, Aage K.; Cumming, Paul.

    In: Nucl. Med. Biol., No. 33, 2006, p. 593-597.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  40. Published

    [11C]Yohimbine as a PET radioligand for visualising the adrenergic receptors at work. / Jakobsen, Steen; Smith, Donald F.; Jensen, Svend Borup; Olsen, Aage Kristian; Pedersen, Kasper; Cumming, Paul.

    In: European Journal of Nuclear Medicine and Molecular Imaging, 2006, p. S212.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearch

  41. 2005
  42. Published

    A dose-response study of ecstasy (MDMA) on the porcine serotonin system. / Olsen, Aage Kristian; Jakobsen, Steen; Jensen, Svend Borup; Minuzzi, Luciano; Cumming, Paul.

    2005. Abstract from ScandLAS Symposium, Uppsala, Sweden.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  43. Published

    Behavioral response to novelty correlates with dopamine receptor availability in striatum of Göttingen minipigs. / Lind, Nanna Marie; Gjedde, Albert; Moustgaard, Anette; Olsen, Aage K.; Jensen, Svend Borup; Jakobsen, Steen; Arnfred, Sidse Marie; Hansen, Axel Kornerup; Hemmingsen, Ralf Peter; Cumming, Paul.

    In: Behavioural Brain Research, Vol. 164, No. 2, 2005, p. 172-7.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  44. Published

    Behaviour of [11C]R(-)- and [11C]S(+)-rolipram in vitro and in vivo, and their use as PET radiotracers for the quantificative assay of PDE4. / Parker, Christine A; Matthews, Julian C; Gunn, Roger N; Martarello, Laurent; Cunningham, Vincent J; Dommett, David; Knibb, Stephen T; Bender, Dirk; Jakobsen, Steen; Brown, John; Gee, Antony D.

    In: Synapse, Vol. 55, No. 4, 2005, p. 270-9.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  45. Published

    Mapping the amphetamine-evoked dopamine release in the brain of the Göttingen minipig. / Lind, Nanna Marie; Olsen, Aage K.; Moustgaard, Anette; Jensen, Svend Borup; Jakobsen, Steen; Hansen, Axel Kornerup; Arnfred, Sidse Marie; Hemmingsen, Ralf Peter; Gjedde, Albert; Cumming, Paul.

    In: Brain Research Bulletin, Vol. 65, No. 1, 2005, p. 1-9.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  46. Published

    Response to novel correlates with dopamine receptor availability in striatum of living pigs. / Lind, Nanna M.; Moustgaard, Anette; Olsen, Aage Kristian; Jensen, Svend Borup; Jakobsen, Steen; Hansen, Axel Kornerup; Arnfred, Sidse M.; Hemmingsen, Ralf P.; Gjedde, Albert; Cumming, Paul.

    In: Schizophrenia Bulletin, 2005, p. 304.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearch

  47. Published

    Response to novel correlates with dopamine receptor availability in striatum of living pigs. / Lind, Nanna M.; Moustgaard, Anette; Olsen, Aage Kristian; Jensen, Svend Borup; Jakobsen, Steen; Hansen, Axel K.; Arnfred, S. M.; Hemmingsen, Ralf Peter; Gjedde, Albert; Cumming, Paul.

    In: Molecular Imaging and Biology, 2005, p. 142.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperConference abstract in journalResearch

  48. Published

    Synthesis, radiolabeling and in vivo evaluation of [11C]RAL-01 as potential phospordiesterase PET radioligand in the pig. / Jakobsen, Steen; Kodahl, Gitte; Cumming, Paul; Olsen, Aage Kristian.

    2005. Abstract from Turku PET Symposium, Turku, Finland.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  49. Published

    The dose-response effect of MDMA ("Ecstasy") treatment on the serotonin system in the porcine brain. / Olsen, Aage Kristian; Jakobsen, Steen; Jensen, Svend Borup; Minuzzi, Luciano; Cumming, Paul.

    2005. Abstract from ScandLAS Symposium, Uppsala, Sweden.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  50. 2004
  51. Published

    [N-methyl-11C]Mirtazapine for positron emission tomography neuroimaging of antidepressant actions in humans. / Marthi, Katalin; Jakobsen, Steen; Bender, Dirk; Hansen, Søren B; Smith, Stefan Bo; Hermansen, Flemming; Rosenberg, Raben; Smith, Donald F.

    In: Psychopharmacology, Vol. 174, No. 2, 2004, p. 260-5.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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