A PET Tracer for Renal Organic Cation Transporters, 11C-metformin: Radiosynthesis and Preclinical Proof-of-Concept Studies. / Jakobsen, Steen; Busk, Morten; Jensen, Jonas Brorson; Munk, Ole Lajord; Zois, Nora Elisabeth; Alstrup, Aage Kristian Olsen; Jessen, Niels; Frøkiær, Jørgen.
In: Journal of Nuclear Medicine, Vol. 57(4), 01.04.2016, p. 615-621.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
A PET study of effects of chronic 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") on serotonin markers in Göttingen minipig brain. / Cumming, Paul; Møller, Mette; Benda, Kjeld; Minuzzi, Luciano; Jakobsen, Steen; Jensen, Svend B; Pakkenberg, Bente; Stark, Anette K; Gramsbergen, Jan Bert; Andreasen, Mette F; Olsen, Aage K.
In: Synapse, Vol. 61, No. 7, 2007, p. 478-87.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
A dose-response study of ecstasy (MDMA) on the porcine serotonin system. / Olsen, Aage Kristian; Jakobsen, Steen; Jensen, Svend Borup; Minuzzi, Luciano; Cumming, Paul.
2005. Abstract from ScandLAS Symposium, Uppsala, Sweden.Research output: Contribution to conference › Conference abstract for conference › Research
A model of Parkinson’s Disease in pig and primate by repeated intraventricular administration of an inhibitor of the ubiquitin proteasome system (UPS). / Doudet, Doris; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Møller, Arne; Sørensen, Jens Christian Hedemann; Landau, Anne M.
2013. Abstract from XX World Congress on Parkinson´s Disease and related disorders, Geneva, Switzerland.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
A model of Parkinson’s disease (PD) in pig and primate by repeated ICV administration of an inhibitor of the ubiquitin proteasome system (UPS). / Doudet, Doris; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Møller, Arne; Sørensen, Jens Christian Hedemann; Landau, Anne M.
2013. Poster session presented at XX World Congress on Parkinson´s Disease and related disorders, Geneva, Switzerland.Research output: Contribution to conference › Poster › Research › peer-review
Accessing radiation response using hypoxia PET imaging and oxygen sensitive electrodes: a preclinical study. / Mortensen, Lise Saksø; Busk, Morten; Nordsmark, Marianne; Jakobsen, Steen; Theil, Jørn; Overgaard, Jens; Horsman, Michael R.
In: Radiotherapy & Oncology, Vol. 99, No. 3, 2011, p. 418-23.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Acute Vagal Nerve Stimulation Lowers α2 Adrenoceptor Availability : Possible Mechanism of Therapeutic Action. / Landau, Anne M.; Dyve, Suzan; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Gjedde, Albert; Doudet, Doris.
In: Brain Stimulation, Vol. 8, No. 4, 2015, p. 702-707.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Acute vagal nerve stimulation promotes noradrenaline release in minipig brain. / Landau, Anne M.; Dyve, Suzan; Alstrup, Aage Kristian Olsen; Jakobsen, Steen; Rodell, Anders; Gjedde, Albert; Doudet, Doris.
2010. Abstract from 16th World Congress of Basic and Clinical Pharmacology, København, Denmark.Research output: Contribution to conference › Conference abstract for conference › Research
Amphetamine challenge decreases yohimbine binding to α2 adrenoceptors in Landrace pig brain. / Landau, Anne M; Doudet, Doris J; Jakobsen, Steen.
In: Psychopharmacology, Vol. 222, No. 1, 2012, p. 155-163.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Amphetamine-induced inhibition of [C-11]yohimbine binding in rat brain. / Phan, Jenny-Ann; Jakobsen, Steen; Landau, Anne M.; Doudet, Doris; Gjedde, Albert.
2012. Poster session presented at The Ninth International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM2012), Baltimore, United States.Research output: Contribution to conference › Poster › Research › peer-review
Anesthesia in animal imaging : Differing effects of propofol versus isoflurane on dopamine 1 receptor binding in Göttingen minipig brain. / Alstrup, Aage Kristian Olsen; Jakobsen, Steen; Wegener, Gregers; Hansen, Axel Kornerup; Doudet, Doris; Landau, Anne M.
In: NeuroImage, No. 1, 2010, p. 181.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Conference abstract in journal › Research
Assessing hypoxia in animal tumor models based on pharmocokinetic analysis of dynamic FAZA PET. / Busk, Morten; Munk, Ole Lajord; Jakobsen, Steen; Wang, Tobias; Skals, Marianne; Steiniche, Torben; Horsman, Michael Robert; Overgaard, Jens.
In: Acta Oncologica, Vol. 49, No. 7, 2010, p. 922-33.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Automatic extraction of myocardial mass and volumes using parametric images from dynamic nongated PET. / Harms, Hendrik Johannes; Hansson, Nils Henrik Stubkjær; Tolbod, Lars Poulsen; Kim, Won Yong; Jakobsen, Steen; Bouchelouche, Kirsten; Wiggers, Henrik; Frøkiaer, Jørgen; Sörensen, Jens.
In: Journal of Nuclear Medicine, Vol. 57, No. 9, 28.04.2016, p. 1382-87.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Behavioral response to novelty correlates with dopamine receptor availability in striatum of Göttingen minipigs. / Lind, Nanna Marie; Gjedde, Albert; Moustgaard, Anette; Olsen, Aage K.; Jensen, Svend Borup; Jakobsen, Steen; Arnfred, Sidse Marie; Hansen, Axel Kornerup; Hemmingsen, Ralf Peter; Cumming, Paul.
In: Behavioural Brain Research, Vol. 164, No. 2, 2005, p. 172-7.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Behaviour of [11C]R(-)- and [11C]S(+)-rolipram in vitro and in vivo, and their use as PET radiotracers for the quantificative assay of PDE4. / Parker, Christine A; Matthews, Julian C; Gunn, Roger N; Martarello, Laurent; Cunningham, Vincent J; Dommett, David; Knibb, Stephen T; Bender, Dirk; Jakobsen, Steen; Brown, John; Gee, Antony D.
In: Synapse, Vol. 55, No. 4, 2005, p. 270-9.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Binding of the hallucinogen 5-[11C] Meo-DMT in brain of living pigs. / Pedersen, Kasper; Gjedde, Albert; Olsen, Aage Kristian; Jakobsen, Steen; Cumming, Paul; Jensen, Svend Borup.
2006. Abstract from NRM Meeting, København, Denmark.Research output: Contribution to conference › Conference abstract for conference › Research
Binding of the hallucinogen MeO-DMT in the brain of domestic pig. / Olsen, Aage Kristian; Jensen, Svend Borup; Pedersen, Kasper; Jakobsen, Steen; Cumming, Paul.
2006. Abstract from ScandLAS Symposium, Helsingør, Denmark.Research output: Contribution to conference › Conference abstract for conference › Research
Biodistribution and radiation dosimetry of [N-methyl-11C]mirtazapine, an antidepressant affecting adrenoceptors. / Marthi, Katalin; Hansen, Søren B; Jakobsen, Steen; Bender, Dirk; Smith, Stefan Bo; Smith, Donald F.
In: Applied Radiation and Isotopes, Vol. 59, No. 2-3, 2012, p. 175-9.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Biodistribution of [ 11C]-metformin and mRNA expression of placentae metformin transporters in the pregnant chinchilla. / Dahl Andersen, Maria; Duvald, Christina Søndergaard; Vendelbo, Mikkel; Pedersen, Steen Bønløkke; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Mikkelsen, Emmeli; Ovesen, Per Glud; Pedersen, Michael.
In: Contrast Media & Molecular Imaging, Vol. 2019, 9787340, 30.04.2019.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Brain Serotonin Transporter Binding In a Minipig Model of Parkinson's Disease. / Lillethorup, Thea Pinholt; Glud, Andreas Nørgaard; Sørensen, Jens Christian Hedemann; Landau, Anne M.; Jakobsen, Steen; Jakobsen, Steen.
2015. Poster session presented at Brain & Brain PET 2015, Vancouver, Canada.Research output: Contribution to conference › Poster › Research
Can hypoxia-PET map hypoxic cell density heterogeneity accurately in an animal tumor model at a clinically obtainable image contrast? / Busk, Morten; Horsman, Michael Robert; Jakobsen, Steen; Hansen, Kim V; Bussink, Johan; van der Kogel, Albert; Overgaard, Jens.
In: Radiotherapy & Oncology, Vol. 92, No. 3, 09.2009, p. 429-436.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Carbon-11 labelled cholylsarcosine: a PET-tracer for conjugated bile acids. / Frisch, Kim; Jakobsen, Steen; Sørensen, Michael; Munk, Ole Lajord; Alstrup, Aage Kristian Olsen; Ott, Peter; Hofmann, Alan F. ; Keiding, Susanne.
2012. Poster session presented at Falk Symposium 184, XXII International Bile Acid Meeting, Wien, Austria.Research output: Contribution to conference › Poster › Research › peer-review
Carbon-11 labelling of cholylsarcosine and in vivo imaging of conjugated bile acids by positron emission tomography. / Frisch, Kim; Jakobsen, Steen; Sørensen, Michael; Munk, Ole Lajord; Alstrup, Aage Kristian Olsen; Ott, Peter; Hofmann, Alan F.; Keiding, Susanne.
2012. Poster session presented at Danish Chemical Society, Odense, Denmark.Research output: Contribution to conference › Poster › Research › peer-review
Cellular uptake of PET tracers of glucose metabolism and hypoxia and their linkage. / Busk, Morten; Horsman, Michael R; Jakobsen, Steen; Bussink, Johan; van der Kogel, Albert; Overgaard, Jens.
In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 35, No. 12, 12.2008, p. 2294-303.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Characterisation of the binding of the hallucinogen 11C-MEO-DMT in brain of living pigs. / Jensen, Svend Borup; Olsen, Aage Kristian; Pedersen, Kasper; Jakobsen, Steen; Cumming, Paul.
In: Journal of Nuclear Medicine, 2006, p. 278P.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Conference abstract in journal › Research
Cholinergic PET imaging in infections and inflammation using 11C-donepezil and 18F-FEOBV. / Jørgensen, Nis Pedersen; Alstrup, Aage Kristian Olsen; Mortensen, Frank Viborg; Knudsen, Karoline; Jakobsen, Steen; Madsen, Line Bille; Bender, Dirk; Breining, Peter; Petersen, Mikkel Steen; Schleimann, Mariane Høgsbjerg; Dagnæs-Hansen, Frederik; Gormsen, Lars Christian; Borghammer, Per.
In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 44, No. 3, 03.2017, p. 449–458.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Chronic L-DOPA treatment prevents increased binding of [11C] MDL100907 to 5-HT2A receptors in a rat model of Parkinson’s disease. / Nahimi, Adjmal; Landau, Annie; Høltzermann, Mette; Simonsen, Mette; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Gjedde, Albert; Doudet, Doris.
2012. Poster session presented at The 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain, Baltimore, United States.Research output: Contribution to conference › Poster › Research › peer-review
Combined PET/microdialysis studies in minipig for PET tracer validation. / Landau, Anne M.; Alstrup, Aage Kristian Olsen; Wegener, Gregers; Jakobsen, Steen; Schacht, Anna C.; Jacobsen, Jan; Mørk, Arne; Sørensen, Jens Christian Hedemann; Doudet, Doris.
2013. Abstract from Minipig Research Forum, Rom, Italy.Research output: Contribution to conference › Conference abstract for conference › Research
Combined in vivo PET-microdialysis studies of NA release in minipig. / Doudet, Doris; Landau, Annie; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Mørk, Arne; Sørensen, Jens Christian H.; Wegener, Gregers.
2012. Poster session presented at 28th World CINP, Stockholm, Sweden.Research output: Contribution to conference › Poster › Research › peer-review
Decreased in vivo α2 adrenoceptor binding in the Flinders Sensitive Line rat model of depression. / Landau, Anne M.; Phan, Jenny-Ann; Iversen, Peter; Lillethorup, Thea P; Simonsen, Mette; Wegener, Gregers; Jakobsen, Steen; Doudet, Doris J.
In: Neuropharmacology, Vol. 91, 04.2015, p. 97-102.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Detection of alpha2-adrenergic receptors in brain of living pig with 11C-yohimbine. / Jakobsen, Steen; Pedersen, K.; Smith, Donald F.; Jensen, S. B.; Munk, Ole Lajord; Cumming, Paul.
In: J. Nucl. Med., No. 47, 2006, p. 2008-2015.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Detection of alphe-2 adrenergic receptora in brain of living pig with [11C]yohimbine. / Jakobsen, Steen; Pedersen, Kasper; Smith, Donald F.; Jensen, Svend Borup; Olsen, Aage Kristian; Cumming, Paul.
In: NeuroImage, 2006, p. T123-T124.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Conference abstract in journal › Research
Detection of {alpha}2-Adrenergic Receptors in Brain of Living Pig with 11C-Yohimbine. / Jakobsen, Steen; Pedersen, Kasper; Smith, Donald F.; Jensen, Svend Borup; Munk, Ole Lajord; Cumming, Paul.
In: The Journal of Nuclear Medicine, Vol. 47, No. 12, 2006, p. 2008-2015.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Differential Amphetamine and Ligand Concentration Inhibition of 11C-Yohimbine binding in Brain: Effect of Plasma Protein Binding Displacement. / Phan, Jenny-Ann; Landau, Anne M.; Jakobsen, Steen; Doudet, Doris; Gjedde, Albert.
2013.Research output: Contribution to conference › Poster › Research › peer-review
Diffusion Kurtosis Imaging of Fibrotic Mouse Kidneys. / Kjølby, Birgitte Fuglsang; Jakobsen, Steen; Jensen, Jonas; Pedersen, Lea Hougaard; Rydtoft, Louise Munk; Jespersen, Sune Nørhøj; Hansen, Brian.
2015. Abstract from ISMRM 2015 23rd Annual Meeting, Toronto, Canada.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Displacement of [11C]yohimbine binding in brain reveals noradrenaline release by vagal nerve stimulation. / Landau, Annie; Dyve, Suzan; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Møller, Arne; Doudet, Doris; Gjedde, Albert.
2012. Abstract from Mind Lab Symposium, Aarhus, Denmark.Research output: Contribution to conference › Conference abstract for conference › Research
Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies. / Bennacef, Idriss; Salinas, Cristian A; Bonasera, Thomas A; Gunn, Roger N; Audrain, Hélène; Jakobsen, Steen; Nabulsi, Nabeel; Weinzimmer, David; Carson, Richard E; Huang, Yiyun; Holmes, Ian; Micheli, Fabrizio; Heidbreder, Christian; Gentile, Gabriella; Rossi, Tino; Laruelle, Marc.
In: Bioorganic & Medicinal Chemistry Letters, Vol. 19, No. 17, 2009, p. 5056-9.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Dose response in the binding of 11C-Yohimbine to alpha 2 adrenergic receptors in response to increasing doses of amphetamine. / Doudet, Doris; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Landau, Anne M.
2013. Poster session presented at The XXVIth International Symposium on Cerebral Blood Flow, Metabolism and Function & XIth International Conference on Quantification of Brain Function with PET, Shanghai, China.Research output: Contribution to conference › Poster › Research › peer-review
Dual-tracer PET of viable tumor volume and hypoxia for identification of necrosis-containing radio-resistant Sub-volumes. / Busk, Morten; Horsman, Michael R.; Overgaard, Jens; Jakobsen, Steen.
In: Acta Oncologica, Vol. 58, No. 10, 2019, p. 1476-1482.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson's disease. / Phan, Jenny-Ann; Stokholm, Kathrine; Zareba-Paslawska, Justyna; Jakobsen, Steen; Vang, Kim; Gjedde, Albert; Landau, Anne M; Romero-Ramos, Marina.
In: Scientific Reports, Vol. 7, No. 1, 6363, 25.07.2017.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Effects of anesthesia and species on the uptake or binding of radioligands in vivo in the Göttingen minipig. / Alstrup, Aage Kristian Olsen; Landau, Anne M.; Holden, James E; Jakobsen, Steen; Schacht, Anna C Schacht; Audrain, Hélène; Wegener, Gregers; Hansen, Axel K; Gjedde, Albert; Doudet, Doris.
In: BioMed Research International, Vol. 2013, No. 808713, 15.07.2013, p. 1-9.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Effects of vagal nerve stimulation on noradrenaline receptor binding in minipigs by positron emission tomography. / Landau, Anne M.; Doudet, Doris; Alstrup, Aage Kristian Olsen; Jakobsen, Steen; Gjedde, Albert; Dyve, Suzan.
2011. Abstract from Danish Epilepsy Meeting, Vejle, Denmark.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Electroconvulsive therapy alters dopamine and noradrenaline receptor binding in the göttingen minipig brain. / Landau, Anne M.; Alstrup, Aage Kristian Olsen; Møller, Arne; Simonsen, Mette; Jakobsen, Steen; Videbech, Poul; Wegener, Gregers; Gjedde, Albert; Doudet, Doris.
2011. Abstract from World Molecular Imaging Congress (WMIC) , San Diego, United States.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Electroconvulsive therapy alters monoamine receptor binding in the brain of Göttingen minipigs : mechanistic clues into antidepressant action. / Landau, Anne M.; Alstrup, Aage Kristian Olsen; Møller, Arne; Simonsen, Mette; Jakobsen, Steen; Videbech, Poul; Wegener, Gregers; Gjedde, Albert; Doudet, Doris.
2010. Abstract from Society for Neuroscience, .Research output: Contribution to conference › Conference abstract for conference › Research
Electroconvulsive therapy induces alterations in monoaminergic receptor binding in the striatum and frontal cortex of healthy minipigs. / Landau, Anne M.; Alstrup, Aage Kristian Olsen; Møller, Arne; Jakobsen, Steen; Wegener, Gregers; Videbech, Poul; Vang, Kim; Gjedde, Albert; Doudet, Doris.
2009. Abstract from OAK Meeting, Århus, Denmark.Research output: Contribution to conference › Conference abstract for conference › Research
Elektrochok påvirker hjernens dopamin- og noradrenalin receptor-binding hos Göttingen minigrise. / Alstrup, Aage Kristian Olsen; Landau, Anne M.; Møller, Arne; Simonsen, Mette; Jakobsen, Steen; Audrain, Hélène; Videbech, Poul; Wegener, Gregers; Gjedde, Albert; Doudet, Doris.
2011. Poster session presented at Psykiatriens Forskningsdag, .Research output: Contribution to conference › Poster › Research
Elevated dopamine D1 receptor availability in striatum of Göttingen minipigs after electroconvulsive therapy. / Landau, Anne M.; Alstrup, Aage Kristian Olsen; Audrain, Héléne; Jakobsen, Steen; Simonsen, Mette; Møller, Arne; Videbech, Poul B; Wegener, Gregers; Gjedde, Albert; Doudet, Doris J.
In: Journal of Cerebral Blood Flow and Metabolism, Vol. 38, No. 5, 05.2018, p. 881-887.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Erratum to : Evaluation of ECG-gated [(11)C]acetate PET for measuring left ventricular volumes, mass, and myocardial external efficiency. / Stubkjær Hansson, Nils Henrik; Tolbod, Lars; Harms, Hendrik Johannes; Wiggers, Henrik; Kim, Won Yong; Hansen, Esben; Zaremba, Tomas; Frøkiær, Jørgen; Jakobsen, Steen; Sørensen, Jens.
In: Journal of Nuclear Cardiology, Vol. 23, No. 5, 11.05.2016, p. 1232-1232.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Evaluating NA release with C-11 yohimbine: combined in vivo PET-microdialysis studies. / Doudet, Doris; Wegener, Gregers; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Mørk, Arne; Sørensen, Jens Christian Hedemann; Landau, Anne M.
2012. Abstract from The 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain, Baltimore, United States.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Evaluation of ECG-gated [(11)C]acetate PET for measuring left ventricular volumes, mass, and myocardial external efficiency. / Hansson, Nils Henrik; Tolbod, Lars; Harms, Hans; Wiggers, Henrik; Kim, Won Yong; Søvsø Szocska Hansen, Esben; Zaremba, Tomas; Frøkiær, Jørgen; Jakobsen, Steen; Sørensen, Jens.
In: Journal of Nuclear Cardiology, 19.04.2016.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review