Steen Jakobsen

  1. Conference abstract for conference › Research › Peer-reviewed
  2. Published

    A model of Parkinson’s Disease in pig and primate by repeated intraventricular administration of an inhibitor of the ubiquitin proteasome system (UPS). / Doudet, Doris; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Møller, Arne; Sørensen, Jens Christian Hedemann; Landau, Anne M.

    2013. Abstract from XX World Congress on Parkinson´s Disease and related disorders, Geneva, Switzerland.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  3. Published

    Diffusion Kurtosis Imaging of Fibrotic Mouse Kidneys. / Kjølby, Birgitte Fuglsang; Jakobsen, Steen; Jensen, Jonas; Pedersen, Lea Hougaard; Rydtoft, Louise Munk; Jespersen, Sune Nørhøj; Hansen, Brian.

    2015. Abstract from ISMRM 2015 23rd Annual Meeting, Toronto, Canada.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  4. Published

    Effects of vagal nerve stimulation on noradrenaline receptor binding in minipigs by positron emission tomography. / Landau, Anne M.; Doudet, Doris; Alstrup, Aage Kristian Olsen; Jakobsen, Steen; Gjedde, Albert; Dyve, Suzan.

    2011. Abstract from Danish Epilepsy Meeting, Vejle, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  5. Published

    Electroconvulsive therapy alters dopamine and noradrenaline receptor binding in the göttingen minipig brain. / Landau, Anne M.; Alstrup, Aage Kristian Olsen; Møller, Arne; Simonsen, Mette; Jakobsen, Steen; Videbech, Poul; Wegener, Gregers; Gjedde, Albert; Doudet, Doris.

    2011. Abstract from World Molecular Imaging Congress (WMIC) , San Diego, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  6. Published

    Evaluating NA release with C-11 yohimbine: combined in vivo PET-microdialysis studies. / Doudet, Doris; Wegener, Gregers; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Mørk, Arne; Sørensen, Jens Christian Hedemann; Landau, Anne M.

    2012. Abstract from The 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain, Baltimore, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  7. Published

    In vivo alpha2-adrenoceptor-binding viser en forlænget effekt af elektrochok-behandling på den noradrenerge funktion i Göttingen minigrise. / Landau, Annie; Wegener, Gregers; Alstrup, Aage Kristian Olsen; Jakobsen, Steen; Audrain, Hélène; Møller, Arne; Simonsen, Mette; Gjedde, Albert; Videbech, Poul; Doudet, Doris.

    2012. Abstract from Psykiatriens 7. Forskningsdag, Risskov, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  8. Published

    Inhibition plots of [11C]yohimbine binding reveal consistent non-displaceable volumes of distribution in multiple studies. / Landau, Annie; Dyve, Suzan; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Doudet, Doris; Gjedde, Albert.

    2012.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  9. Published

    Of Pig and Man: Analogy of response to electroconvulsive therapy (ECT): most do, a few don’t. / Doudet, Doris J; Clark, C; Alstrup, Aage Kristian Olsen; Jakobsen, Steen; Gjedde, Albert; Wegener, Gregers; Videbech, Poul; Landau, Anne M.

    2014. Abstract from CINP World Congress, Vancouver, Canada.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  10. Published

    On the interpretation of PET binding data in brain: Effects of anesthesia and consideration of species differences. / Alstrup, Aage Kristian Olsen; Landau, Anne M.; Holden, James E.; Simonsen, Mette; Schacht, Anna C.; Jakobsen, Steen; Wegener, Gregers; Hansen, Axel K.; Gjedde, Albert; Doudet, Doris.

    2011. Abstract from World Molecular Imaging Congress (WMIC), San Diego, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  11. Published

    Preclinical validation of 11C-Metformin: A novel PET tracer targeting organic cation transporters. / Jakobsen, Steen; Busk, Morten; Munk, Ole Lajord; Alstrup, Aage Kristian Olsen; Gormsen, Lars Christian; Jessen, Niels; Frøkiær, Jørgen.

    2014. Abstract from 61th Society of Nuclear Medicine Annual Meeting, Saint Louis, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  12. Published

    Proteasome inhibition model of Parkinson’s disease in Gottingen minipig: Combined dopaminergic and noradrenergic effects. / Landau, Anne M; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Schacht, Anna C.; Møller, Arne; Sørensen, Jens Christian Hedemann; Doudet, Doris.

    2013. Abstract from The XXVIth International Symposium on Cerebral Blood Flow, Metabolism and Function & XIth International Conference on Quantification of Brain Function with PET, Shanghai, China.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  13. Published

    The minipig as an animal model to study antidepressant pharmacology by PET. / Landau, Anne M.; Dyve, Suzan; Alstrup, Aage Kristian Olsen; Jakobsen, Steen; Simonsen, Mette; Møller, Arne; Videbech, Poul; Wegener, Gregers; Gjedde, Albert; Doudet, Doris.

    2011. Abstract from NIDA, Florida, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  14. Published

    Update: inhibition plots of [C-11]yohimbine binding yield consistent estimates of non-displaceable volumes of distribution in multiple tests. / Landau, Anne M; Dyve, Suzan; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Doudet, Doris; Gjedde, Albert.

    2012. Abstract from The 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain, Baltimore, United States.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  15. Conference abstract for conference › Research › Not peer-reviewed
  16. Published

    A dose-response study of ecstasy (MDMA) on the porcine serotonin system. / Olsen, Aage Kristian; Jakobsen, Steen; Jensen, Svend Borup; Minuzzi, Luciano; Cumming, Paul.

    2005. Abstract from ScandLAS Symposium, Uppsala, Sweden.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  17. Published

    Acute vagal nerve stimulation promotes noradrenaline release in minipig brain. / Landau, Anne M.; Dyve, Suzan; Alstrup, Aage Kristian Olsen; Jakobsen, Steen; Rodell, Anders; Gjedde, Albert; Doudet, Doris.

    2010. Abstract from 16th World Congress of Basic and Clinical Pharmacology, København, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  18. Published

    Binding of the hallucinogen 5-[11C] Meo-DMT in brain of living pigs. / Pedersen, Kasper; Gjedde, Albert; Olsen, Aage Kristian; Jakobsen, Steen; Cumming, Paul; Jensen, Svend Borup.

    2006. Abstract from NRM Meeting, København, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  19. Published

    Binding of the hallucinogen MeO-DMT in the brain of domestic pig. / Olsen, Aage Kristian; Jensen, Svend Borup; Pedersen, Kasper; Jakobsen, Steen; Cumming, Paul.

    2006. Abstract from ScandLAS Symposium, Helsingør, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  20. Published

    Combined PET/microdialysis studies in minipig for PET tracer validation. / Landau, Anne M.; Alstrup, Aage Kristian Olsen; Wegener, Gregers; Jakobsen, Steen; Schacht, Anna C.; Jacobsen, Jan; Mørk, Arne; Sørensen, Jens Christian Hedemann; Doudet, Doris.

    2013. Abstract from Minipig Research Forum, Rom, Italy.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  21. Published

    Displacement of [11C]yohimbine binding in brain reveals noradrenaline release by vagal nerve stimulation. / Landau, Annie; Dyve, Suzan; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Møller, Arne; Doudet, Doris; Gjedde, Albert.

    2012. Abstract from Mind Lab Symposium, Aarhus, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  22. Published

    Electroconvulsive therapy alters monoamine receptor binding in the brain of Göttingen minipigs : mechanistic clues into antidepressant action. / Landau, Anne M.; Alstrup, Aage Kristian Olsen; Møller, Arne; Simonsen, Mette; Jakobsen, Steen; Videbech, Poul; Wegener, Gregers; Gjedde, Albert; Doudet, Doris.

    2010. Abstract from Society for Neuroscience, .

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  23. Published

    Electroconvulsive therapy induces alterations in monoaminergic receptor binding in the striatum and frontal cortex of healthy minipigs. / Landau, Anne M.; Alstrup, Aage Kristian Olsen; Møller, Arne; Jakobsen, Steen; Wegener, Gregers; Videbech, Poul; Vang, Kim; Gjedde, Albert; Doudet, Doris.

    2009. Abstract from OAK Meeting, Århus, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  24. Published

    Imaging techniques in small and large animals. / Alstrup, Aage Kristian Olsen; Winterdahl, Michael; Simonsen, Mette; Jakobsen, Steen; Møller, Arne; Scheel-Krüger, Jørgen; Landau, Anne M.

    2011. Abstract from Scandlas Symposium, København, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  25. Published

    Long term decrease in alpha 2 receptor distribution volume after acute stimulation of NA release. / Doudet, Doris; Landau, Anne M.; Dyve, Suzan; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Gjedde, Albert.

    2011. Abstract from XXVth International Symposium on Cerebral Blood Flow, Metabolism and Function and the Xth International Conference on Quantification of Brain Function with PET, Barcelona, Spain.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  26. Published

    Mapping of the hallucinogen 5-Meo-DMT in living pig brain. / Pedersen, Kasper; Olsen, Aage Kristian; Jakobsen, Steen; Gjedde, Albert; Cumming, Paul; Jensen, Svend Borup.

    2006. Abstract from Århus Sygehus - Forskningens Dag, Århus, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  27. Published

    Mapping of the hallucinogen 5-Meo-DMT in living porcine brain. / Pedersen, Kasper; olsen, Aage Kristian; Jakobsen, Steen; Gjedde, Albert; Cumming, Paul; Jensen, Svend Borup.

    2006. Abstract from OAK Meeting, Odense, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  28. Published

    Noradrenaline release: a potential antidepressant mechanism of brain stimulation therapies. / Landau, Anne M.; Dyve, Suzan; Alstrup, Aage Kristian Olsen; Møller, Arne; Simonsen, Mette; Jakobsen, Steen; Videbech, Poul; Wegener, Gregers; Doudet, Doris.

    2010. Abstract from OAK Meeting, København, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  29. Published

    Novel synthesis and evaluation of 11C Corynanthine as alpha-1 adrenergic tracer. / Jakobsen, Steen; Olsen, Aage Kristian; Nahimi, Adjmal.

    2008. Abstract from Turku PET Symposium, Turku, Finland.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  30. Published
  31. Published

    Role of monoaminergic innervation in 6-hydroxydopamine unilateral lesioned animal model of Parkinsons Disease and L-DOPA induced dyskinesia. / Nahimi, Adjmal; Olsen, Aage Kristian; Møller, Arne; Jakobsen, Steen; Østergaard, Søren Dinesen; Doudet, Doris.

    2007. Abstract from OAK Meeting, København, Denmark.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  32. Published

    Synthesis, radiolabeling and in vivo evaluation of [11C]RAL-01 as potential phospordiesterase PET radioligand in the pig. / Jakobsen, Steen; Kodahl, Gitte; Cumming, Paul; Olsen, Aage Kristian.

    2005. Abstract from Turku PET Symposium, Turku, Finland.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  33. Published

    The dose-response effect of MDMA ("Ecstasy") treatment on the serotonin system in the porcine brain. / Olsen, Aage Kristian; Jakobsen, Steen; Jensen, Svend Borup; Minuzzi, Luciano; Cumming, Paul.

    2005. Abstract from ScandLAS Symposium, Uppsala, Sweden.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  34. Published

    Tracer kinetic responses to propofol-induced reduction of brain perfusion: Comparison of [11C]Yohimbine and [11C]SCH23390. / Holden, Jim E.; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Doudet, Doris; Landau, Anne M.

    2011. Abstract from XXVth International Symposium on Cerebral Blood Flow, Metabolism and Function and the Xth International Conference on Quantification of Brain Function with PET, Barcelona, Spain.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  35. Poster › Research › Peer-reviewed
  36. Published

    A model of Parkinson’s disease (PD) in pig and primate by repeated ICV administration of an inhibitor of the ubiquitin proteasome system (UPS). / Doudet, Doris; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Møller, Arne; Sørensen, Jens Christian Hedemann; Landau, Anne M.

    2013. Poster session presented at XX World Congress on Parkinson´s Disease and related disorders, Geneva, Switzerland.

    Research output: Contribution to conferencePosterResearchpeer-review

  37. Published

    Amphetamine-induced inhibition of [C-11]yohimbine binding in rat brain. / Phan, Jenny-Ann; Jakobsen, Steen; Landau, Anne M.; Doudet, Doris; Gjedde, Albert.

    2012. Poster session presented at The Ninth International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM2012), Baltimore, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  38. Published

    Carbon-11 labelled cholylsarcosine: a PET-tracer for conjugated bile acids. / Frisch, Kim; Jakobsen, Steen; Sørensen, Michael; Munk, Ole Lajord; Alstrup, Aage Kristian Olsen; Ott, Peter; Hofmann, Alan F. ; Keiding, Susanne.

    2012. Poster session presented at Falk Symposium 184, XXII International Bile Acid Meeting, Wien, Austria.

    Research output: Contribution to conferencePosterResearchpeer-review

  39. Published

    Carbon-11 labelling of cholylsarcosine and in vivo imaging of conjugated bile acids by positron emission tomography. / Frisch, Kim; Jakobsen, Steen; Sørensen, Michael; Munk, Ole Lajord; Alstrup, Aage Kristian Olsen; Ott, Peter; Hofmann, Alan F.; Keiding, Susanne.

    2012. Poster session presented at Danish Chemical Society, Odense, Denmark.

    Research output: Contribution to conferencePosterResearchpeer-review

  40. Published

    Chronic L-DOPA treatment prevents increased binding of [11C] MDL100907 to 5-HT2A receptors in a rat model of Parkinson’s disease. / Nahimi, Adjmal; Landau, Annie; Høltzermann, Mette; Simonsen, Mette; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Gjedde, Albert; Doudet, Doris.

    2012. Poster session presented at The 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain, Baltimore, United States.

    Research output: Contribution to conferencePosterResearchpeer-review

  41. Published

    Combined in vivo PET-microdialysis studies of NA release in minipig. / Doudet, Doris; Landau, Annie; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Mørk, Arne; Sørensen, Jens Christian H.; Wegener, Gregers.

    2012. Poster session presented at 28th World CINP, Stockholm, Sweden.

    Research output: Contribution to conferencePosterResearchpeer-review

  42. Published
  43. Published

    Dose response in the binding of 11C-Yohimbine to alpha 2 adrenergic receptors in response to increasing doses of amphetamine. / Doudet, Doris; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Landau, Anne M.

    2013. Poster session presented at The XXVIth International Symposium on Cerebral Blood Flow, Metabolism and Function & XIth International Conference on Quantification of Brain Function with PET, Shanghai, China.

    Research output: Contribution to conferencePosterResearchpeer-review

  44. Published

    In vivo alpha2 adrenoceptor binding demonstrates a prolonged effect of electroconvulsive therapy on noradrenergic function in Gottingen minipigs. / Landau, Annie; Wegener, Gregers; Alstrup, Aage Kristian Olsen; Jakobsen, Steen; Audrain, Hélène; Møller, Arne; Simonsen, Mette; Gjedde, Albert; Videbech, Poul; Doudet, Doris.

    2012. Poster session presented at 28th World CINP, Stockholm, Sweden.

    Research output: Contribution to conferencePosterResearchpeer-review

  45. Published

    Kombineret in vivo PET-mikrodialyse studier af noradrenalin frisættelse i minigrise. / Landau, Anne M; Wegener, Gregers; Jakobsen, Steen; Schacht, A.C.; Alstrup, Aage Kristian Olsen; Jacobsen, J.; Mørk, Arne; Sørensen, Jens Christian Hedemann; Doudet, Doris.

    2012. Poster session presented at Psykiatriens 7. Forskningsdag, Aarhus, .

    Research output: Contribution to conferencePosterResearchpeer-review

  46. Published

    Longitudinal in vivo imaging in a novel model of Parkinson’s disease in minipig. / Landau, Anne M.; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Schacht, A.C.; Winterdahl, Michael; Møller, Arne; Sørensen, Jens Christian Hedemann; Doudet, Doris.

    2013. Poster session presented at World Parkinson Congress, Montreal, Denmark.

    Research output: Contribution to conferencePosterResearchpeer-review

  47. Published

    Neonatal domoic acid decreases in vivo binding of [11C]yohimbine to α2 adrenoceptors in adult rat brain. / Thomsen, Majken; Lillethorup, Thea Pinholt; Jakobsen, Steen; Nielsen, Erik Holm Toustrup; Simonsen, Mette; Wegener, Gregers; Tasker, Andrew; Landau, Anne M.

    2015. Poster session presented at NeuroConX, Charlottetown, Prince Edward Island, Canada.

    Research output: Contribution to conferencePosterResearchpeer-review

  48. Published

    Neonatal domoic acid decreases in vivo binding of [11C]yohimbine to α2 adrenoceptors in adult rat brain. / Thomsen, Majken; Lillethorup, Thea Pinholt; Jakobsen, Steen; Nielsen, Erik Holm Toustrup; Simonsen, Mette; Wegener, Gregers; Tasker, Andrew; Landau, Anne M.

    2015. Poster session presented at Brain & Brain PET 2015, Vancouver, Canada.

    Research output: Contribution to conferencePosterResearchpeer-review

  49. Published

    PET Imaging Sugar Addiction in Minipigs. / Landau, Anne M.; Møller, Arne; Winterdahl, Michael; Alstrup, Aage Kristian Olsen; Jakobsen, Steen; Schacht, Anna C.; Bender, Dirk; Scheel-Krüger, Jørgen; Kringelbach, Morten L.

    2013. Poster session presented at Scandinavian College of Neuropsychopharmacology, København, Denmark.

    Research output: Contribution to conferencePosterResearchpeer-review

  50. Published

    PET imaging of sugar addiction in minipigs: Effects on the dopamine D2/3 receptor. / Landau, Anne M; Møller, Arne; Winterdahl, Michael; Jakobsen, Steen; Alstrup, Aage Kristian Olsen; Schacht, Anne; Bender, Dirk; Scheel-Krüger, Jørgen; Kringelbach, Morten L.

    2013. Poster session presented at The XXVIth International Symposium on Cerebral Blood Flow, Metabolism and Function & XIth International Conference on Quantification of Brain Function with PET, Shanghai, China.

    Research output: Contribution to conferencePosterResearchpeer-review

  51. Poster › Research › Not peer-reviewed
  52. Published

    Brain Serotonin Transporter Binding In a Minipig Model of Parkinson's Disease. / Lillethorup, Thea Pinholt; Glud, Andreas Nørgaard; Sørensen, Jens Christian Hedemann; Landau, Anne M.; Jakobsen, Steen; Jakobsen, Steen.

    2015. Poster session presented at Brain & Brain PET 2015, Vancouver, Canada.

    Research output: Contribution to conferencePosterResearch

  53. Published

    Elektrochok påvirker hjernens dopamin- og noradrenalin receptor-binding hos Göttingen minigrise. / Alstrup, Aage Kristian Olsen; Landau, Anne M.; Møller, Arne; Simonsen, Mette; Jakobsen, Steen; Audrain, Hélène; Videbech, Poul; Wegener, Gregers; Gjedde, Albert; Doudet, Doris.

    2011. Poster session presented at Psykiatriens Forskningsdag, .

    Research output: Contribution to conferencePosterResearch

  54. Published

    Noradrenaline release explains effects of vagal nerve stimulation in pig brain in vivo. PET study with tracer [11C]yohimbine, an alpha 2 adrenoceptor antagonist. / Dyve, Suzan; Landau, Anne M.; Alstrup, Aage Kristian Olsen; Jakobsen, Steen; Doudet, Doris; Gjedde, Albert.

    2010. Poster session presented at American College of Neurophychopharmacology, Miami, United States.

    Research output: Contribution to conferencePosterResearch

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