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Søren Vrønning Hoffmann

Radio- and photosensitization of DNA with compounds containing platinum and bromine atoms

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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Radio- and photosensitization of DNA with compounds containing platinum and bromine atoms. / Smialek, Malgorzata A.; Ptasinska, Sylwia; Gow, Jason et al.

In: The European Physical Journal D: Atomic, Molecular, Optical and Plasma Physics, Vol. 69, No. 5, 121, 05.05.2015.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Smialek, MA, Ptasinska, S, Gow, J, Hoffmann, SV & Mason, NJ 2015, 'Radio- and photosensitization of DNA with compounds containing platinum and bromine atoms', The European Physical Journal D: Atomic, Molecular, Optical and Plasma Physics, vol. 69, no. 5, 121. https://doi.org/10.1140/epjd/e2015-60036-5

APA

Smialek, M. A., Ptasinska, S., Gow, J., Hoffmann, S. V., & Mason, N. J. (2015). Radio- and photosensitization of DNA with compounds containing platinum and bromine atoms. The European Physical Journal D: Atomic, Molecular, Optical and Plasma Physics, 69(5), [121]. https://doi.org/10.1140/epjd/e2015-60036-5

CBE

Smialek MA, Ptasinska S, Gow J, Hoffmann SV, Mason NJ. 2015. Radio- and photosensitization of DNA with compounds containing platinum and bromine atoms. The European Physical Journal D: Atomic, Molecular, Optical and Plasma Physics. 69(5):Article 121. https://doi.org/10.1140/epjd/e2015-60036-5

MLA

Smialek, Malgorzata A. et al. "Radio- and photosensitization of DNA with compounds containing platinum and bromine atoms". The European Physical Journal D: Atomic, Molecular, Optical and Plasma Physics. 2015. 69(5). https://doi.org/10.1140/epjd/e2015-60036-5

Vancouver

Smialek MA, Ptasinska S, Gow J, Hoffmann SV, Mason NJ. Radio- and photosensitization of DNA with compounds containing platinum and bromine atoms. The European Physical Journal D: Atomic, Molecular, Optical and Plasma Physics. 2015 May 5;69(5). 121. https://doi.org/10.1140/epjd/e2015-60036-5

Author

Smialek, Malgorzata A. ; Ptasinska, Sylwia ; Gow, Jason et al. / Radio- and photosensitization of DNA with compounds containing platinum and bromine atoms. In: The European Physical Journal D: Atomic, Molecular, Optical and Plasma Physics. 2015 ; Vol. 69, No. 5.

Bibtex

@article{d60405688abf4f909a7162b45180923f,

title = "Radio- and photosensitization of DNA with compounds containing platinum and bromine atoms",

abstract = "Irradiations of plasmid DNA by both X-rays and UV light in the presence and absence of compounds containing platinum and bromine atoms were performed in order to asses the sensitization potential of these compounds. Plasmid DNA pBR322 was incubated with platinum (II) bromide, hydrogen hexabromoplatinate (IV), hydrogen hexahydroxyplatinate (IV) and sodium hexahydroxyplatinate (IV). Incubation was followed by X-ray or UV irradiations. It was found that amongst the sensitizers tested, during irradiations carried out in the presence of platinum (II) bromide, the highest levels of double strand breaks formation upon X-ray treatment were recorded. In contrast much less damage was induced by UV light. Data presented here suggests that this compound may be a promising radiosensitizer for cancer treatment.",

keywords = "STRAND BREAKS, VACUUM CONDITIONS, PHOTOABSORPTION, CISPLATIN, RADIATION, INDUCTION, MOLECULES, ELECTRONS, MECHANISM, THERAPY",

author = "Smialek, {Malgorzata A.} and Sylwia Ptasinska and Jason Gow and Hoffmann, {Soren Vronning} and Mason, {Nigel J.}",

year = "2015",

month = may,

day = "5",

doi = "10.1140/epjd/e2015-60036-5",

language = "English",

volume = "69",

journal = "The European Physical Journal D: Atomic, Molecular, Optical and Plasma Physics",

issn = "1434-6060",

publisher = "Springer",

number = "5",

}

RIS

TY - JOUR

T1 - Radio- and photosensitization of DNA with compounds containing platinum and bromine atoms

AU - Smialek, Malgorzata A.

AU - Ptasinska, Sylwia

AU - Gow, Jason

AU - Hoffmann, Soren Vronning

AU - Mason, Nigel J.

PY - 2015/5/5

Y1 - 2015/5/5

N2 - Irradiations of plasmid DNA by both X-rays and UV light in the presence and absence of compounds containing platinum and bromine atoms were performed in order to asses the sensitization potential of these compounds. Plasmid DNA pBR322 was incubated with platinum (II) bromide, hydrogen hexabromoplatinate (IV), hydrogen hexahydroxyplatinate (IV) and sodium hexahydroxyplatinate (IV). Incubation was followed by X-ray or UV irradiations. It was found that amongst the sensitizers tested, during irradiations carried out in the presence of platinum (II) bromide, the highest levels of double strand breaks formation upon X-ray treatment were recorded. In contrast much less damage was induced by UV light. Data presented here suggests that this compound may be a promising radiosensitizer for cancer treatment.

AB - Irradiations of plasmid DNA by both X-rays and UV light in the presence and absence of compounds containing platinum and bromine atoms were performed in order to asses the sensitization potential of these compounds. Plasmid DNA pBR322 was incubated with platinum (II) bromide, hydrogen hexabromoplatinate (IV), hydrogen hexahydroxyplatinate (IV) and sodium hexahydroxyplatinate (IV). Incubation was followed by X-ray or UV irradiations. It was found that amongst the sensitizers tested, during irradiations carried out in the presence of platinum (II) bromide, the highest levels of double strand breaks formation upon X-ray treatment were recorded. In contrast much less damage was induced by UV light. Data presented here suggests that this compound may be a promising radiosensitizer for cancer treatment.

KW - STRAND BREAKS

KW - VACUUM CONDITIONS

KW - PHOTOABSORPTION

KW - CISPLATIN

KW - RADIATION

KW - INDUCTION

KW - MOLECULES

KW - ELECTRONS

KW - MECHANISM

KW - THERAPY

U2 - 10.1140/epjd/e2015-60036-5

DO - 10.1140/epjd/e2015-60036-5

M3 - Journal article

VL - 69

JO - The European Physical Journal D: Atomic, Molecular, Optical and Plasma Physics

JF - The European Physical Journal D: Atomic, Molecular, Optical and Plasma Physics

SN - 1434-6060

IS - 5

M1 - 121

ER -