Aarhus University Seal / Aarhus Universitets segl

Søren Vrønning Hoffmann

On the delocalization length in RNA single strands of cytosine: how many bases see the light?

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

On the delocalization length in RNA single strands of cytosine: how many bases see the light? / Jones, Nykola C.; Nielsen, Steen Brøndsted; Hoffmann, Søren Vrønning.

In: Physical Chemistry Chemical Physics, Vol. 22, No. 4, 2020, p. 2188-2192.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{777cfc5881ed4d77b74fc490b2325266,
title = "On the delocalization length in RNA single strands of cytosine: how many bases see the light?",
abstract = "The interplay between multiple chromophores in nucleic acids and photosynthetic proteins gives rise to complex electronic phenomena and largely governs the de-excitation dynamics. Electronic coupling between bases in the excited states of single strands of DNA and RNA may extend over several bases and likely protects nucleic acids from harmful UV damage. Here we report on the coupling between bases in single RNA strands of cytosine and find that the excited state is delocalized over up to five bases at neutral pH, where all bases are non-protonated (i.e. neutral). Delocalization is over four bases at 278 nm excitation, while it involves five bases at shorter wavelengths of 188 nm and 201 nm. This is in contrast to only nearest-neighbour interactions for corresponding DNA strands as previously reported. The current results seemingly corroborate earlier findings of larger spatial communication in RNA than in DNA strands of adenine, but there is no obvious link between the overall structure of strands and delocalization lengths. RNA cytosine strands form a tight helix, while comparatively, adenine strands show less tight packing, also compared to their DNA counterparts, and yet exhibit even higher delocalisation.",
keywords = "Cytosine/chemistry, Electromagnetic Phenomena, Nucleic Acid Conformation/radiation effects, RNA/chemistry, Ultraviolet Rays",
author = "Jones, {Nykola C.} and Nielsen, {Steen Br{\o}ndsted} and Hoffmann, {S{\o}ren Vr{\o}nning}",
year = "2020",
doi = "10.1039/c9cp05292e",
language = "English",
volume = "22",
pages = "2188--2192",
journal = "Physical Chemistry Chemical Physics",
issn = "1463-9076",
publisher = "ROYAL SOC CHEMISTRY",
number = "4",

}

RIS

TY - JOUR

T1 - On the delocalization length in RNA single strands of cytosine: how many bases see the light?

AU - Jones, Nykola C.

AU - Nielsen, Steen Brøndsted

AU - Hoffmann, Søren Vrønning

PY - 2020

Y1 - 2020

N2 - The interplay between multiple chromophores in nucleic acids and photosynthetic proteins gives rise to complex electronic phenomena and largely governs the de-excitation dynamics. Electronic coupling between bases in the excited states of single strands of DNA and RNA may extend over several bases and likely protects nucleic acids from harmful UV damage. Here we report on the coupling between bases in single RNA strands of cytosine and find that the excited state is delocalized over up to five bases at neutral pH, where all bases are non-protonated (i.e. neutral). Delocalization is over four bases at 278 nm excitation, while it involves five bases at shorter wavelengths of 188 nm and 201 nm. This is in contrast to only nearest-neighbour interactions for corresponding DNA strands as previously reported. The current results seemingly corroborate earlier findings of larger spatial communication in RNA than in DNA strands of adenine, but there is no obvious link between the overall structure of strands and delocalization lengths. RNA cytosine strands form a tight helix, while comparatively, adenine strands show less tight packing, also compared to their DNA counterparts, and yet exhibit even higher delocalisation.

AB - The interplay between multiple chromophores in nucleic acids and photosynthetic proteins gives rise to complex electronic phenomena and largely governs the de-excitation dynamics. Electronic coupling between bases in the excited states of single strands of DNA and RNA may extend over several bases and likely protects nucleic acids from harmful UV damage. Here we report on the coupling between bases in single RNA strands of cytosine and find that the excited state is delocalized over up to five bases at neutral pH, where all bases are non-protonated (i.e. neutral). Delocalization is over four bases at 278 nm excitation, while it involves five bases at shorter wavelengths of 188 nm and 201 nm. This is in contrast to only nearest-neighbour interactions for corresponding DNA strands as previously reported. The current results seemingly corroborate earlier findings of larger spatial communication in RNA than in DNA strands of adenine, but there is no obvious link between the overall structure of strands and delocalization lengths. RNA cytosine strands form a tight helix, while comparatively, adenine strands show less tight packing, also compared to their DNA counterparts, and yet exhibit even higher delocalisation.

KW - Cytosine/chemistry

KW - Electromagnetic Phenomena

KW - Nucleic Acid Conformation/radiation effects

KW - RNA/chemistry

KW - Ultraviolet Rays

U2 - 10.1039/c9cp05292e

DO - 10.1039/c9cp05292e

M3 - Journal article

C2 - 31912828

VL - 22

SP - 2188

EP - 2192

JO - Physical Chemistry Chemical Physics

JF - Physical Chemistry Chemical Physics

SN - 1463-9076

IS - 4

ER -