1997 – present : Associate professor at Dept. of Molecular Biology and Genetics, Aarhus University.
1993 - 1997: Assistant professor at Dept. of Chemistry, Aarhus University.
1986 – 1993: Post doc at Dept. of Chemistry, Aarhus University.
1984 – 1986: EMBO long-term fellowship at Dept. of Molecular Biology, Uppsala University
A Semester-Long Learning Path Teaching Computational Skills via Molecular Graphics in PyMOL
Kjærgaard, M., Rasmussen, L. S., Vinther, J. N., Andersen, K. R., Andersen, E. S., Lorentzen, E., Thirup, S. S., Otzen, D. & Brodersen, D. E., Dec 2022, In: The Biophysicist. 3, 2, p. 106–114 9 p.Carbamylated sortilin associates with cardiovascular calcification in patients with chronic kidney disease
Jankowski, V., Saritas, T., Kjolby, M., Hermann, J., Speer, T., Himmelsbach, A., Mahr, K., Heuschkel, M. A., Schunk, S. J., Thirup, S., Winther, S., Bottcher, M., Nyegard, M., Nykjaer, A., Kramann, R., Kaesler, N., Jankowski, J., Floege, J., Marx, N. & Goettsch, C., Mar 2022, In: Kidney International. 101, 3, p. 574-584SorCS1 binds the insulin receptor to enhance insulin sensitivity
Kjolby, M.,
Pedersen, K. M.,
Breining, P., Wellner, N.,
Sørensen, K. M. J., Vittrup, D. M., Gjesing, A. M. P., Januliene, D., Manavalan, A., Rotman, M., Thotakura, G.,
Skeldal, S., Madsen, P.,
Thirup, S., Hermey, G.,
Vaegter, C. B., Möller, A., Asplund, O., Prasad, R. B., Parlevliet, E. T.,
& 7 othersRensen, P. C. N., Füchtbauer, E. M., Madsen, A. N., Holst, B., Andersen, O. M., Hansen, T. & Nykjaer, A.,
1 Nov 2020,
bioRxiv.
Crystal and solution structures of fragments of the human leucocyte common antigen-related protein
Vilstrup, J., Simonsen, A., Birkefeldt, T., Strandbygård, D., Lyngsø, J., Pedersen, J. S. & Thirup, S., May 2020, In: Acta crystallographica Section D: Structural biology . 76, p. 406-417 12 p.PAK kinases targets sortilin and modulates its sorting
Pallesen, L. T., Gustafsen, C., Cramer, J., Petersen, S. V., Thirup, S. S., Madsen, P. & Petersen, C. M., Feb 2020, In: Molecular and Cellular Biology. 40, 3, 16 p., e00411-19.A Lotus japonicus cytoplasmic kinase connects Nod factor perception by the NFR5 LysM receptor to nodulation
Wong, J. E. M. M., Nadzieja, M., Madsen, L. H., Bücherl, C. A., Dam, S., Sandal, N. N., Couto, D., Derbyshire, P., Uldum-Berentsen, M., Schroeder, S., Schwämmle, V., Nogueira, F. C. S., Asmussen, M. H., Thirup, S., Radutoiu, S., Blaise, M., Andersen, K. R., Menke, F. L. H., Zipfel, C. & Stougaard, J., 2019, In: Proceedings of the National Academy of Sciences. 116, 28, p. 14339-14348 10 p.E. coli elongation factor Tu bound to a GTP analogue displays an open conformation equivalent to the GDP-bound form
Johansen, J. S., Kavaliauskas, D., Pfeil, S., Blaise, M., Cooperman, B., Goldman, Y., Thirup, S. S. & Knudsen, C. R., 19 Sept 2018, In: Nucleic Acids Research. 46, 16, p. 8641-8650 10 p.Acidic Environment Induces Dimerization and Ligand Binding Site Collapse in the Vps10p Domain of Sortilin
Januliene, D., Andersen, J. L., Nielsen, J. A., Quistgaard, E. M., Hansen, M., Strandbygaard, D., Moeller, A., Petersen, C. M., Madsen, P. & Thirup, S. S., 5 Dec 2017, In: Structure. 25, 12, p. 1809-1819.e3 14 p., 12.Hidden Twins: SorCS Neuroreceptors Form Stable Dimers
Januliene, D., Manavalan, A., Ovesen, P. L., Pedersen, K. M., Thirup, S., Nykjær, A. & Moeller, A., 15 Sept 2017, In: Journal of Molecular Biology. 429, 19, p. 2907-2917 11 p.Heparan sulfate proteoglycans present PCSK9 to the LDL receptor
Gustafsen, C., Olsen, D., Vilstrup, J., Lund, S., Reinhardt, A., Wellner, N., Larsen, T., Andersen, C. B. F., Weyer, K., Li, J-P., Seeberger, P. H., Thirup, S., Madsen, P. & Glerup, S., 11 Sept 2017, In: Nature Communications. 8, 1, p. 503 503.The identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin
Andersen, J. L., Lindberg, S., Langgård, M., Maltas, P. J., Rønn, L. C. B., Bundgaard, C., Strandbygaard, D., Thirup, S. & Watson, S. P., 1 Jun 2017, In: Bioorganic & Medicinal Chemistry Letters. 27, 11, p. 2629-2633 5 p.Receptor-mediated exopolysaccharide perception controls bacterial infection
Kawaharada, Y., Kelly, S., Nielsen, M. W., Hjuler, C. T., Gysel, K., Muszyński, A., Carlson, R. W., Thygesen, M. B., Sandal, N., Asmussen, M. H., Vinther, M., Andersen, S. U., Krusell, L., Thirup, S., Jensen, K. J., Ronson, C. W., Blaise, M., Radutoiu, S. & Stougaard, J., 16 Jul 2015, In: Nature. 523, p. 308-312 5 p.Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu
Thirup, S. S., Van, L. B., Nielsen, T. K. & Knudsen, C. R., 11 Jun 2015, In: Journal of Structural Biology. 191, 1, p. 10-21 12 p.An intermolecular binding mechanism involving multiple LysM domains mediates carbohydrate recognition by an endopeptidase
Wong, J. E. M. M., Midtgaard, S. R., Gysel, K., Thygesen, M. B., Sørensen, K. K., Jensen, K. J., Stougaard, J., Thirup, S. & Blaise, M., Mar 2015, In: Acta crystallographica Section D: Structural biology . 71, Pt 3, p. 592-605 14 p.Revisiting the structure of the Vps10 domain of human sortilin and its interaction with neurotensin
Quistgaard, E. M., Grøftehauge, M. K., Madsen, P., Pallesen, L. T., Christensen, B. S., Sørensen, E. S., Nissen, P., Petersen, C. M. & Thirup, S. S., Sept 2014, In: Protein Science. 23, 9, p. 1291-1300 10 p.Cooperative binding of LysM domains determines the carbohydrate affinity of a bacterial endopeptidase protein
Wong, J. E. M. M., Alsarraf, H. M. A. B., Kaspersen, J. D., Pedersen, J. S., Stougaard, J., Thirup, S. S. & Blaise, M., Feb 2014, In: F E B S Journal. 281, 4, p. 1196-1208 13 p.Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex
Andersen, J. L., Schrøder, T. J., Christensen, S.,
Strandbygård, D. J.,
Pallesen, L. T., Garcia Alai, M. M., Lindberg, S., Langgård, M., Eskildsen, J. C., David, L., Tagmose, L., Simonsen, K. B., Maltas, P. J., Rønn, L. C. B., de Jong, I. E. M., Malik, I. J., Egebjerg, J., Karlsson, J. J., Uppalanchi, S., Sakumudi, D. R.,
& 3 othersEradi, P., Watson, S. P. & Thirup, S.,
Feb 2014,
In: Acta Crystallographica. Section D: Biological Crystallography. 70,
Part 2,
p. 451-460 10 p.The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin
Schrøder, T. J., Christensen, S., Lindberg, S., Langgård, M., David, L., Maltas, P. J., Eskildsen, J., Jacobsen, J., Tagmose, L., Simonsen, K. B., Biilmann Rønn, L. C., de Jong, I. E. M., Malik, I. J., Karlsson, J-J., Bundgaard, C., Egebjerg, J., Stavenhagen, J. B.,
Strandbygård, D.,
Thirup, S. S., Andersen, J. L.,
& 6 othersUppalanchi, S., Pervaram, S., Kasturi, S. P., Eradi, P., Sakumudi, D. R. & Watson, S. P.,
1 Jan 2014,
In: Bioorganic & Medicinal Chemistry Letters. 24,
1,
p. 177-180 4 p.Legume receptors perceive the rhizobial lipochitin oligosaccharide signal molecules by direct binding
Broghammer, A., Krusell, L., Blaise, M., Sauer, J., Sullivan, J. T., Maolanon, N. N., Vinther, M., Lorentzen, A. M., Madsen, E. B., Jensen, K. J., Roepstorff, P., Thirup, S. S., Ronson, C. W., Thygesen, M. B. & Stougaard, J., 21 Aug 2012, In: Proceedings of the National Academy of Sciences. 109, 34, p. 13859-13864 6 p.Crystal structure of the TLDc domain of oxidation resistance protein 2 from zebrafish
Blaise, M., Alsarraf, H. M. A. B., Wong, J., Roi Midtgaard, S., Laroche, F. J. F., Schack, L., Spaink, H., Stougaard, J. & Thirup, S. S., Jun 2012, In: Proteins: Structure, Function, and Bioinformatics. 80, 6, p. 1694-1698 5 p.Up, down, and around: Identifying recurrent interactions within and between super-secondary structures in β-propellers
Thirup, S. S., Gupta, V. & Quistgaard, E. M. H., 2012, Protein Supersecondary Structures. Kister, A. E. (ed.). Humana Press, p. 35-50 16 p. (Methods in Molecular Biology, Vol. 932).Purification, crystallization and preliminary crystallographic studies of the TLDc domain of oxidation resistance protein 2 from zebrafish
Alsarraf, H. M. A. B., Laroche, F. J. F., Spaink, H., Thirup, S. S. & Blaise, M., Oct 2011, In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 67, 10Crystallization of Escherichia coli maltoporin in the trigonal space group R3.
Blaise, M. & Thirup, S. S., 1 Jan 2011, In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 67Crystal structure of a transfer-ribonucleoprotein particle that promotes asparagine formation
Blaise, M., Bailly, M., Frechin, M., Behrens, M. A., Fischer, F., Oliveira, C. L. P., Becker, H. D., Pedersen, J. S., Thirup, S. & Kern, D., 15 Sept 2010, In: The EMBO Journal. 29, 18, p. 3118-29 12 p.Characterization of LysM-receptors and their ligands involved in development and regulation of legume-rhizobium symbiosis
Broghammer, A., Krusell, L., Blaise, M., Thirup, S. S. & Stougaard, J., Sept 2010. 1 p.Design and use of Sortilin specific molecular imaging ligands
Thirup, S. S., Grøftehauge, M. K., Madsen, P. S., Petersen, C. M., Nissen, P., Quistgaard, E. M. H., Andersen, J. L. & Cramer, J. F., 2010, Patent No. PA 2008 00593Design of specific ligands to Sortilin
Thirup, S. S., Petersen, C. M., Quistgaard, E. M. H., Madsen, P. S., Nissen, P., Grøftehauge, M. K., Cramer, J. F. & Andersen, J. L., 2010, Patent No. PA 2008 00592Evolution and regulation of the Lotus japonicus LysM receptor gene family
Lohmann, G. V., Shimoda, Y., Nielsen, M. W., Jørgensen, F. G., Grossmann, C., Sandal, N., Sørensen, K., Thirup, S., Madsen, L. H., Tabata, S., Sato, S., Stougaard, J. & Radutoiu, S., 2010, In: Molecular Plant - Microbe Interactions. 23, 4, p. 510-21 11 p.GGA autoinhibition revisited
Cramer, J. F., Gustafsen, C., Behrens, M. A., Oliveira, C. L. P., Pedersen, J. S., Madsen, P., Petersen, C. M. & Thirup, S. S., 2010, In: Traffic. 11, 2, p. 259-73 14 p.Improved Characterization of Nod Factors and Genetically Based Variation in LysM Receptor Domains Identify Amino Acids Expendable for Nod Factor Recognition in Lotus spp
Bek, A. S., Sauer, J., Thygesen, M. B., Duus, J. Ø., Petersen, B. O., Thirup, S., James, E., Jensen, K. J., Stougaard, J. & Radutoiu, S., 2010, In: Molecular Plant - Microbe Interactions. 23, 1, p. 58-66 8 p.Isolation, crystallization and preliminary X-ray analysis of the transamidosome, a ribonucleoprotein involved in asparagine formation
Bailly, M., Blaise, M., Lorber, B., Thirup, S. S. & Kern, D., 2009, In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 65, Pt 6, p. 577-81 4 p.Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain
Quistgaard, E. M., Madsen, P., Grøftehauge, M. K., Nissen, P., Petersen, C. M. & Thirup, S. S., 2009, In: Nature Structural and Molecular Biology. 16, 1, p. 96-8 3 p.Sequence and structural analysis of the Asp-box motif and Asp-box beta-propellers; a widespread propeller-type characteristic of the Vps10 domain family and several glycoside hydrolase families
Quistgaard, E. M. H. & Thirup, S. S., 2009, In: B M C Structural Biology. 9A unique loop extension in the serine protease domain of haptoglobin is essential for CD163 recognition of the haptoglobin-hemoglobin complex
Nielsen, M. J., Petersen, S. V., Jacobsen, C., Thirup, S. S., Enghild, J. J., Graversen, J. H. & Moestrup, S. K., 2007, In: Journal of Biological Chemistry. 282, 2, p. 1072-1079 8 p.LysM domains mediate lipochitin-oligosaccharide recognition and Nfr genes extend the symbiotic host range.
Radutoiu, S., Madsen, L. H., Madsen, E. B., Jurkiewicz, A., Fukai, E., Quistgaard, E. M. H., Albrektsen, A. S., James, E. K., Thirup, S. & Stougaard, J., 2007, In: E M B O Journal. 26, 17, p. 3923-35 12 p.Functional effects of deleting the coiled-coil motif in Escherichia coli elongation factor Ts
Karring, H., Björnsson, A., Thirup, S., Clark, B. F. C. & Knudsen, C. R., 2003, In: F E B S Journal. 270, p. 4294-4305 12 p.Isolation, crystallisation, and preliminary X-ray analysis of the bovine mitochondrial EF-Tu:GDP and EF-Tu:EF-Ts complexes
Karring, H., Andersen, G. R., Thirup, S. S., Nyborg, J., Spremulli, L. L. & Clark, B. F. C., 2002, In: Biochim. Biophys. Acta.. 1601, 2, p. 172-177 6 p.High resolution crystal structure of bovine mitochondrial EF-Tu in complex with GDP
Andersen, G. R., Thirup, S., Spremulli, L. L. & Nyborg, J., 2000, In: J. Mol. Biol.. 297, p. 421-436 16 p.Ternary complex of EF-Tu and its action on the ribosome
Andersen, G. R., Stepanov, V. G., Kjeldgaard, M., Thirup, S. S., Nyborg, J., Garrett, R. A. (ed.), Douthwaite, S. R. (ed.), Liljas, A. (ed.), Matheson, A. T. (ed.), Moore, P. B. (ed.) & Noller, H. F. (ed.), 2000, The Ribosome: Structure, Function, Antibiotics, and Cellular Interactions. Washington DC: ASM Press, p. 337-345 9 p.Structural information for explaining the molecular mechanism of protein biosynthesis (minireview)
Clark, B. F. C., Thirup, S., Kjeldgaard, M. & Nyborg, J., 1999, In: F E B S Letters. 452, p. 41-46 6 p.The crystal structure of Cys-tRNACys--EF-Tu--GDPNP reveals general and specific features in the ternary complex and in tRNA
Nissen, P., Thirup, S., Kjeldgaard, M. & Nyborg, J., 1999, In: Structure. 7, p. 143-156 14 p.Crystallization of human complement component C5
Discipio, R. G., Jenner, L., Thirup, S., Sottrup-Jensen, L., Nyborg, J. & Stura, E., 1998, In: Acta Crystallographica. Section D: Biological Crystallography. 54, Pt 4, p. 643-6 3 p.Crystal structure of the receptor-binding domain of alpha 2-macroglobulin
Jenner, L., Husted, L., Thirup, S., Sottrup-Jensen, L. & Nyborg, J., 1998, In: Structure. 6, 5, p. 595-604 9 p.Crystallization and preliminary X-ray diffraction studies of psoriasin
Nolsøe, S., Thirup, S., Etzerodt, M., Thøgersen, H. C. & Nyborg, J., 5 Apr 1997, In: Acta Crystallographica Section D: Biological Crystallography. 53, 1, p. 119-121 3 p.Crystallisation and preliminary X-ray diffraction studies of psoriasin
Nolsø, S., Thirup, S. S., Etzerodt, M., Thøgersen, H. C. & Nyborg, J., 1997, In: Acta Crystallogr. D. Biol. Crystallogr.. 53, 1, p. 119-121Macromolecular mimicry in protein biosynthesis
Nyborg, J., Nissen, P., Kjeldgaard, M., Thirup, S., Polekhina, G., Clark, B. F. & Reshetnikova, L., 1997, In: Structure. 2, 3, p. S7-11Helix unwinding in the effector region of elongation factor EF-Tu-GDP
Polekhina, G., Thirup, S., Kjeldgaard, M., Nissen, P., Lippmann, C. & Nyborg, J., 1996, In: Structure. 4, 10, p. 1141-51 10 p.Isolation, crystallization and X-ray analysis of the quaternary complex of Phe-tRNA(Phe), EF-Tu, a GTP analog and kirromycin
Kristensen, O., Reshetnikova, L., Nissen, P., Siboska, G., Thirup, S. & Nyborg, J., 1996, In: F E B S Letters. 399, 1-2, p. 59-62 3 p.Structure of the ternary complex of EF-Tu: macromolecular mimicry in translation
Nyborg, J., Nissen, P., Kjeldgaard, M., Thirup, S., Polekhina, G. & Clark, B. F., 1996, In: Trends in Biochemical Sciences. 21, 3, p. 81-2 1 p.The ternary complex of aminoacylated tRNA and EF-Tu-GTP. Recognition of a bond and a fold
Nissen, P., Kjeldgaard, M., Thirup, S., Clark, B. F. & Nyborg, J., 1996, In: Biochimie. 78, 11-12, p. 921-33 12 p.Analysis and crystallization of a 25 kDa C-terminal fragment of cloned elongation factor Ts from Escherichia coli
Bøgestrand, S., Wiborg, O., Thirup, S. & Nyborg, J., 1995, In: F E B S Letters. 368, 1, p. 49-54 5 p.Crystallisation and preliminary X-ray analysis of the receptor-binding domain of human and bovine alpha 2-macroglobulin
Dolmer, K., Jenner, L. B., Jacobsen, L., Andersen, G. R., Koch, T. J., Thirup, S., Sottrup-Jensen, L. & Nyborg, J., 1995, In: F E B S Letters. 372, 1, p. 93-5 2 p.Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog
Nissen, P., Kjeldgaard, M., Thirup, S., Polekhina, G., Reshetnikova, L., Clark, B. F. & Nyborg, J., 1995, In: Science. 270, 5241, p. 1464-72 8 p.Crystallization of human methylamine-treated complement C3 and C3b
Dolmer, K., Thirup, S., Andersen, G. R., Sottrup-Jensen, L. & Nyborg, J., 1 Jan 1994, In: Acta Crystallographica Section D: Biological Crystallography. 50, 5, p. 786-789 4 p.Low-resolution X-ray diffraction data obtained from hexagonal crystals of methylamine-treated alpha2-macroglobulin
Andersen, G. R., Thirup, S., Nyborg, J., Dolmer, K., Jacobsen, L. & Sottrup-Jensen, L., 1 Jan 1994, In: Acta Crystallographica Section D: Biological Crystallography. 50, 3, p. 298-301 4 p.Crystallization of proteins of the alpha 2-macroglobulin superfamily
Andersen, G. R., Koch, T., Sørensen, A. H., Thirup, S., Nyborg, J., Dolmer, K., Jacobsen, L. & Sottrup-Jensen, L., 1994, In: New York Academy of Sciences. Annals. 737, p. 444-6 2 p.Purification and crystallization of the ternary complex of elongation factor Tu:GTP and Phe-tRNA(Phe)
Nissen, P., Reshetnikova, L., Siboska, G., Polekhina, G., Thirup, S., Kjeldgaard, M., Clark, B. F. & Nyborg, J., 1994, In: F E B S Letters. 356, 2-3, p. 165-8 3 p.The crystal structure of elongation factor EF-Tu from Thermus aquaticus in the GTP conformation
Kjeldgaard, M., Nissen, P., Thirup, S. & Nyborg, J., 1993, In: Structure. 1, 1, p. 35-50 15 p.Crystallization and preliminary X-ray analysis of methylamine-treated alpha 2-macroglobulin and 3 alpha 2-macroglobulin-proteinase complexes
Andersen, G. R., Jacobsen, L., Thirup, S., Nyborg, J. & Sottrup-Jensen, L., 1991, In: F E B S Letters. 292, 1-2, p. 267-70 3 p.ALMA, an editor for large sequence alignments
Thirup, S. & Larsen, N. E., 1990, In: Proteins: Structure, Function, and Bioinformatics. 7, 3, p. 291-5 4 p.Structural determination of the functional sites of E. coli elongation factor Tu
Clark, B. F., Kjeldgaard, M., la Cour, T. F., Thirup, S. & Nyborg, J., 1990, In: BBA General Subjects. 1050, 1-3, p. 203-8 5 p.Using known substructures in protein model building and crystallography
Jones, T. A. & Thirup, S., 1986, In: E M B O Journal. 5, 4, p. 819-22 3 p.Structural details of the binding of guanosine diphosphate to elongation factor Tu from E. coli as studied by X-ray crystallography
la Cour, T. F., Nyborg, J., Thirup, S. & Clark, B. F., 1985, In: E M B O Journal. 4, 9, p. 2385-8 3 p.