Søren Riis Paludan

  1. 2022
  2. Published

    Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic. / Duncan, Christopher J A; Skouboe, Morten K; Howarth, Sophie et al.

    In: The Journal of Experimental Medicine, Vol. 219, No. 6, e20212427, 06.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  3. E-pub ahead of print

    Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screen. / Taha, Zaid; Arulanandam, Rozanne; Maznyi, Glib et al.

    In: Molecular Therapy, 06.05.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  4. Published

    The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from COVID-19. / Hennings, Viktoria; Thörn, Karolina; Albinsson, Sofie et al.

    In: European Journal of Immunology, Vol. 52, No. 5, 05.2022, p. 800-809.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  5. Published

    A Capsid Virus-Like Particle-Based SARS-CoV-2 Vaccine Induces High Levels of Antibodies and Protects Rhesus Macaques. / Volkmann, Ariane; Koopman, Gerrit; Mooij, Petra et al.

    In: Frontiers in Immunology, Vol. 13, 857440, 04.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  6. Published

    Microglia Activate Early Antiviral Responses upon Herpes Simplex Virus 1 Entry into the Brain to Counteract Development of Encephalitis-Like Disease in Mice. / Katzilieris-Petras, Georgios; Lai, Xin; Rashidi, Ahmad S. et al.

    In: Journal of Virology, Vol. 96, No. 6, e01311-21, 03.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  7. Published

    TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection. / van der Sluis, Renée M.; Cham, Lamin B.; Gris-Oliver, Albert et al.

    In: EMBO Journal, 17.02.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  8. Published

    Innate immunological pathways in COVID-19 pathogenesis. / Paludan, Søren R.; Mogensen, Trine H.

    In: Science Immunology, Vol. 7, No. 67, eabm5505, 01.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  9. Published

    STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses. / Vila, Isabelle K.; Chamma, Hanane; Steer, Alizée et al.

    In: Cell Metabolism, Vol. 34, No. 1, 01.2022, p. 125-139.e8.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  10. Published

    Single-Cell Monitoring of Activated Innate Immune Signaling by a d2eGFP-Based Reporter Mimicking Time-Restricted Activation of IFNB1 Expression. / Thomsen, Emil Aagaard; Andersen, Sofie; Marqvorsen, Mikkel Haarslev Schröder et al.

    In: Frontiers in cellular and infection microbiology, Vol. 11, 784762, 01.2022.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  11. 2021
  12. Published

    A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry. / Valero, Julian; Civit, Laia; Dupont, Daniel M. et al.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 50, e2112942118, 12.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  13. Published

    B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation. / Green, Kenneth; Wittenborn, Thomas R.; Fahlquist-Hagert, Cecilia et al.

    In: Frontiers in Immunology, Vol. 12, 782558, 12.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  14. Published

    The alpha/b.1.1.7 sars-cov-2 variant exhibits significantly higher affinity for ace-2 and requires lower inoculation doses to cause disease in k18-hace2 mice. / Bayarri-Olmos, Rafael; Johnsen, Laust Bruun; Idorn, Manja et al.

    In: eLife, Vol. 10, e70002, 11.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  15. Published

    Antiviral Potential of the Antimicrobial Drug Atovaquone against SARS-CoV-2 and Emerging Variants of Concern. / Carter-Timofte, Madalina Elena; Arulanandam, Rozanne; Kurmasheva, Naziia et al.

    In: ACS Infectious Diseases, Vol. 7, No. 11, 10.2021, p. 3034-3051.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  16. Published

    Constitutive and latent immune mechanisms exert ‘silent’ control of virus infections in the central nervous system. / Paludan, Soren R.; Mogensen, Trine H.

    In: Current Opinion in Immunology, Vol. 72, 10.2021, p. 158-166.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  17. Published

    Herpes simplex virus 1 and 2 infections during differentiation of human cortical neurons. / Bergström, Petra; Trybala, Edward; Eriksson, Charlotta E. et al.

    In: Viruses, Vol. 13, No. 10, 2072, 10.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  18. Published

    Essential role of autophagy in restricting poliovirus infection revealed by identification of an ATG7 defect in a poliomyelitis patient. / Brinck Andersen, Nanna Sophie; Jørgensen, Sofie Eg; Skipper, Kristian Alsbjerg et al.

    In: Autophagy, Vol. 17, No. 9, 09.2021, p. 2449-2464.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  19. Published

    SARS-CoV-2 neutralizing antibody responses towards full-length spike protein and the receptor-binding domain. / Bayarri-Olmos, Rafael; Idorn, Manja; Rosbjerg, Anne et al.

    In: Journal of Immunology, Vol. 207, No. 3, 08.2021, p. 878-887.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  20. Published

    Characterization of DNA-protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus. / Juul-Madsen, Kristian; Troldborg, Anne; Wittenborn, Thomas R et al.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 30, e2106647118, 07.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  21. Published

    Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility. / Tomac, Jelena; Mazor, Marija; Lisnić, Berislav et al.

    In: Immunity, Vol. 54, No. 7, 07.2021, p. 1478-1493.e6.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  22. Published

    A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology. / Prabakaran, Thaneas; Troldborg, Anne; Kumpunya, Sarinya et al.

    In: EBioMedicine, Vol. 66, 103314, 06.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  23. Published

    Targeting herpes simplex virus with CRISPR–Cas9 cures herpetic stromal keratitis in mice. / Yin, Di; Ling, Sikai; Wang, Dawei et al.

    In: Nature Biotechnology, Vol. 39, No. 5, 05.2021, p. 567-577.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  24. Published

    In vivo CRISPR inactivation of Fos promotes prostate cancer progression by altering the associated AP-1 subunit Jun. / Riedel, Maria; Berthelsen, Martin F.; Cai, Huiqiang et al.

    In: Oncogene, Vol. 40, No. 13, 04.2021, p. 2437–2447.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  25. Published

    Constitutive immune mechanisms : mediators of host defence and immune regulation. / Paludan, Søren R.; Pradeu, Thomas; Masters, Seth L. et al.

    In: Nature Reviews Immunology, Vol. 21, No. 3, 03.2021, p. 137-150.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  26. Published

    Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice. / Ling, Sikai; Yang, Shiqi; Hu, Xinde et al.

    In: Nature Biomedical Engineering, Vol. 5, No. 2, 02.2021, p. 144-156.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  27. Published

    Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production. / Reinert, Line S; Rashidi, Ahmad S; Tran, Diana N et al.

    In: Journal of Clinical Investigation, Vol. 131, No. 1, e136824, 01.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  28. Published

    Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity. / Fougeroux, Cyrielle; Goksøyr, Louise; Idorn, Manja et al.

    In: Nature Communications, Vol. 12, No. 1, 324, 01.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  29. Published

    Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro. / Svenningsen, Esben B; Thyrsted, Jacob; Blay-Cadanet, Julia et al.

    In: Antiviral Research, Vol. 185, 104988, 01.2021.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperLetterResearchpeer-review

  30. 2020
  31. Published

    Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans. / Hait, Alon Schneider; Olagnier, David; Sancho-Shimizu, Vanessa et al.

    In: Science Immunology, Vol. 5, No. 54, eabc2691, 12.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  32. Published

    Author Correction : STEEP mediates STING ER exit and activation of signaling (Nature Immunology, (2020), 21, 8, (868-879), 10.1038/s41590-020-0730-5). / Zhang, Bao-cun; Nandakumar, Ramya; Reinert, Line S. et al.

    In: Nature Immunology, Vol. 21, No. 11, 11.2020, p. 1468-1469.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperComment/debate/letter to the editorResearchpeer-review

  33. Published

    Characterization of distinct molecular interactions responsible for IRF3 and IRF7 phosphorylation and subsequent dimerization. / Dalskov, Louise; Narita, Ryo; Andersen, Line L. et al.

    In: Nucleic Acids Research, Vol. 48, No. 20, 11.2020, p. 11421-11433.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  34. Published

    Corona's new coat : SARS-CoV-2 in Danish minks and implications for travel medicine. / Larsen, Carsten Schade; Paludan, Søren Riis.

    In: Travel Medicine and Infectious Disease, Vol. 38, 101922, 11.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperEditorialResearchpeer-review

  35. Published

    Author Correction : SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. / Olagnier, David; Farahani, Ensieh; Thyrsted, Jacob et al.

    In: Nature Communications, Vol. 11, No. 1, 5419, 21.10.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperComment/debate/letter to the editorResearchpeer-review

  36. Published

    SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. / Olagnier, David; Farahani, Ensieh; Thyrsted, Jacob et al.

    In: Nature Communications, Vol. 11, No. 1, 4938, 10.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  37. Published

    STING Mediates Lupus via the Activation of Conventional Dendritic Cell Maturation and Plasmacytoid Dendritic Cell Differentiation. / Thim-uam, Arthid; Prabakaran, Thaneas; Tansakul, Mookmanee et al.

    In: iScience, Vol. 23, No. 9, 101530, 09.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  38. Published

    HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection. / Bodda, Chiranjeevi; Reinert, Line S.; Fruhwürth, Stefanie et al.

    In: Journal of Experimental Medicine, Vol. 217, No. 7, e20191422, 07.2020.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  39. Published

    Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation. / Guerra, J.; Valadao, A. L.; Vlachakis, D. et al.

    In: Science Advances, Vol. 6, No. 21, 05.2020, p. eaax3333.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  40. Published

    The cGAS-STING pathway is a therapeutic target in a preclinical model of hepatocellular carcinoma. / Thomsen, Martin K.; Skouboe, Morten K.; Boularan, Cedric et al.

    In: Oncogene, Vol. 39, No. 8, 02.2020, p. 1652-1664.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  41. Published

    STEEP mediates STING ER exit and activation of signaling. / Zhang, Bao cun; Nandakumar, Ramya; Reinert, Line S. et al.

    In: Nature Immunology, Vol. 21, No. 8, 2020, p. 868-879.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  42. Published

    Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4. / Juul-Madsen, Kristian; Qvist, Per; Bendtsen, Kirstine L et al.

    In: Journal of Immunology, Vol. 204, No. 5, 2020, p. 1345-1361.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  43. 2019
  44. Published

    Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis. / Lafaille, Fabien G.; Harschnitz, Oliver; Lee, Yoon Seung et al.

    In: Nature Medicine, Vol. 25, No. 12, 01.12.2019, p. 1873-1884.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  45. Published

    The alternative cap-binding complex is required for antiviral defense in vivo. / Gebhardt, Anna; Bergant, Valter; Schnepf, Daniel et al.

    In: PLOS Pathogens, Vol. 15, No. 12, 1008155, 12.2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  46. Published

    Intracellular bacteria engage a STING–TBK1–MVB12b pathway to enable paracrine cGAS–STING signalling. / Nandakumar, Ramya; Tschismarov, Roland; Meissner, Felix et al.

    In: Nature Microbiology, Vol. 4, 04.2019, p. 701-713.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  47. Published

    DNA-stimulated cell death : implications for host defence, inflammatory diseases and cancer. / Paludan, Søren R.; Reinert, Line S.; Hornung, Veit.

    In: Nature Reviews Immunology, Vol. 19, No. 3, 01.03.2019, p. 141-153.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  48. Published

    The herpesviral antagonist m152 reveals differential activation of STING-dependent IRF and NF-κB signaling and STING's dual role during MCMV infection. / Stempel, Markus; Chan, Baca; Juranić Lisnić, Vanda et al.

    In: EMBO Journal, Vol. 38, No. 5, e100983, 01.03.2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  49. Published

    Mutations in RNA Polymerase III genes and defective DNA sensing in adults with varicella-zoster virus CNS infection. / Carter-Timofte, Madalina E; Hansen, Anders F; Christiansen, Mette et al.

    In: Genes and Immunity, Vol. 20, No. 3, 03.2019, p. 214-223.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  50. Published

    Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs. / Frich, Camilla Kaas; Krüger, Franziska; Walther, Raoul et al.

    In: Journal of Controlled Release, Vol. 294, 28.01.2019, p. 298-310.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  51. Published

    Cellular Requirements for Sensing and Elimination of Incoming HSV-1 DNA and Capsids. / Sun, Chenglong; Luecke, Stefanie; Bodda, Chiranjeevi et al.

    In: Journal of Interferon and Cytokine Research, Vol. 39, No. 4, 2019, p. 191-204.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  52. Published

    HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0. / Hensel, Niko; Raker, Verena; Förthmann, Benjamin et al.

    In: Journal of Neuroinflammation, Vol. 16, No. 1, 248, 2019.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  53. Published

    Intercellular communication in the innate immune system through the cGAS-STING pathway. / Nandakumar, Ramya; Windross, Samuel Joseph; Paludan, Soren R.

    DNA Sensors and Inflammasomes. ed. / J Sohn. Elsevier, 2019. p. 1-11 (Methods in Enzymology, Vol. 625).

    Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  54. 2018
  55. Published

    Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins. / Carter-Timofte, Madalina E; Hansen, Anders F; Mardahl, Maibritt et al.

    In: Neurology(R) neuroimmunology & neuroinflammation, Vol. 5, No. 6, 11.2018, p. e500.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  56. Published

    RNA Polymerase III as a Gatekeeper to Prevent Severe VZV Infections. / Carter-Timofte, Madalina E; Paludan, Søren R; Mogensen, Trine H.

    In: Trends in Molecular Medicine, Vol. 24, No. 10, 10.2018, p. 904-915.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  57. Published

    Inflammation kinase PKR phosphorylates α-synuclein and causes α-synuclein-dependent cell death. / Reimer, Lasse; Lund, Louise Buur; Betzer, Cristine et al.

    In: Neurobiology of Disease, 01.05.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  58. Published

    Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1. / Prabakaran, Thaneas; Bodda, Chiranjeevi; Krapp, Christian et al.

    In: E M B O Journal, Vol. 37, No. 8, E97858, 13.04.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  59. Published

    STING agonists enable antiviral cross-talk between human cells and confer protection against genital herpes in mice. / Skouboe, Morten K; Knudsen, Alice; Reinert, Line S et al.

    In: P L o S Pathogens, Vol. 14, No. 4, e1006976, 02.04.2018.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  60. 2017
  61. Published

    Human B cells fail to secrete type I interferons upon cytoplasmic DNA exposure. / Gram, Anna M.; Sun, Chenglong; Landman, Sanne L. et al.

    In: Molecular Immunology, Vol. 91, 11.2017, p. 225-237.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  62. Published

    Cutting Edge : Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2-Induced IFN-β Expression. / Eriksson, Kristina; Svensson, Alexandra; Hait, Alon S et al.

    In: Journal of Immunology, Vol. 199, No. 8, 15.10.2017, p. 2613-2617.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  63. Published

    Molecular requirements for sensing of intracellular microbial nucleic acids by the innate immune system. / Luecke, Stefanie; Paludan, Soren R.

    In: Cytokine, Vol. 98, 10.2017, p. 4-14.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  64. Published

    cGAS is activated by DNA in a length-dependent manner. / Luecke, Stefanie; Holleufer, Andreas; Christensen, Maria H et al.

    In: E M B O Reports, Vol. 18, No. 10, 10.2017, p. 1707–1715.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  65. Published

    Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections. / Ogunjimi, Benson; Zhang, Shen-Ying; Sørensen, Katrine Biehl et al.

    In: Journal of Clinical Investigation, 01.09.2017.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  66. Published

    IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. / Jønsson, K L; Laustsen, A; Krapp, C et al.

    In: Nature Communications, Vol. 8, 14391, 10.02.2017.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  67. Published

    Viral evasion of DNA-stimulated innate immune responses. / Christensen, Maria H.; Paludan, Soren R.

    In: Cellular & molecular immunology, Vol. 14, No. 1, 01.2017, p. 4-13.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  68. 2016
  69. Published

    Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS. / Reinert, Line S; Lopušná, Katarína; Winther, Henriette et al.

    In: Nature Communications, Vol. 7, 13348, 10.11.2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  70. Published

    Gene-environmental interactions between genetic variants in antiviral response genes and prenatal maternal infections in schizophrenia. / Manikandan, Veera; Reinert, Line; Paludan, Søren Riis et al.

    2016. Poster session presented at American Society of Human Genetics 2016, Vancouver, Canada.

    Research output: Contribution to conferencePosterResearch

  71. Published

    An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication. / Mauthe, Mario; Langereis, Martijn; Jung, Jennifer et al.

    In: The Journal of Cell Biology, Vol. 214, No. 5, 29.08.2016, p. 619-35.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  72. Published

    HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression. / Christensen, Maria H.; Jensen, Søren B.; Miettinen, Juho J. et al.

    In: The EMBO Journal, Vol. 35, No. 13, 01.07.2016, p. 1385-1399.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  73. Published

    Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection. / Thomsen, Martin K; Nandakumar, Ramya; Stadler, Daniela et al.

    In: Hepatology, Vol. 64, No. 3, 16.06.2016, p. 746-759.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  74. Published

    Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses. / Holm, Christian K; Rahbek, Stine H; Gad, Hans Henrik et al.

    In: Nature Communications, Vol. 7, 10680, 19.02.2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  75. Published

    Interleukin 20 regulates dendritic cell migration and expression of co-stimulatory molecules. / Bech, Rikke; Jalilian, Babak; Agger, Ralf et al.

    In: Molecular and Cellular Therapies, Vol. 4, No. 1, 2016.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  76. 2015
  77. Published

    Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis. / Mørk, N; Kofod-Olsen, E; Sørensen, K B et al.

    In: Genes and Immunity, Vol. 16, No. 8, 12.2015, p. 552-66.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  78. Published

    An innate antiviral pathway acting before interferons at epithelial surfaces. / Iversen, Marie B; Reinert, Line S; Thomsen, Martin K et al.

    In: Nature Immunology, 30.11.2015.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  79. Published

    Activation and regulation of DNA-driven immune responses. / Paludan, Søren R.

    In: Microbiology and Molecular Biology Reviews, Vol. 79, No. 2, 06.2015, p. 225-41.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  80. Published

    Catching the adaptor-WDFY1, a new player in the TLR-TRIF pathway. / Nandakumar, Ramya; Paludan, Søren R.

    In: E M B O Reports, Vol. 16, No. 4, 04.2015, p. 397-8.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  81. Published

    Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection. / Sun, Chenglong; Schattgen, Stefan A; Pisitkun, Prapaporn et al.

    In: Journal of Immunology, Vol. 194, No. 4, 15.02.2015, p. 1819-31.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  82. Published

    Functional IRF3 deficiency in a patient with herpes simplex encephalitis. / Andersen, Line Lykke; Mørk, Nanna; Reinert, Line S et al.

    In: Journal of Experimental Medicine, Vol. 212, No. 9, 2015, p. 1371-9.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  83. Published

    Innate recognition of alphaherpesvirus DNA. / Luecke, Stefanie; Paludan, Søren R.

    In: Virus Research, Vol. 92, 2015, p. 63-100.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  84. 2014
  85. Published

    TRAM is required for TLR2 endosomal signaling to type I IFN induction. / Stack, Julianne; Doyle, Sarah L; Connolly, Dympna J et al.

    In: Journal of Immunology, Vol. 193, No. 12, 15.12.2014, p. 6090-102.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  86. Published

    A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival. / Wang, Hui; Flannery, Sinead M; Dickhöfer, Sabine et al.

    In: Journal of Biological Chemistry, Vol. 289, No. 33, 15.08.2014, p. 23123-31.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  87. Published

    Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway. / Hansen, Kathrine; Prabakaran, Thaneas; Laustsen, Anders et al.

    In: E M B O Journal, Vol. 33, No. 15, 01.08.2014, p. 1654-66.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  88. Published

    IFI16 : At the interphase between innate DNA sensing and genome regulation. / Jakobsen, Martin Roelsgaard; Paludan, Søren R.

    In: Cytokine & Growth Factor Reviews, 21.06.2014.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  89. Published

    Innate DNA sensing is impaired in HIV patients and IFI16 expression correlates to chronic immune activation. / Nissen, Sara K; Højen, Jesper Falkesgaard; Andersen, Karen L D et al.

    In: Clinical and Experimental Immunology, Vol. 177, No. 1, 05.03.2014, p. 295-309.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  90. Published

    Innate antiviral signalling in the central nervous system. / Carty, Michael; Reinert, Line; Paludan, Søren R. et al.

    In: Trends in Immunology, Vol. 35, No. 2, 01.02.2014, p. 79-87.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  91. Published

    Inflammatory Cytokines Break Down Intrinsic Immunological Tolerance of Human Primary Keratinocytes to Cytosolic DNA. / Chiliveru, Srikanth; Rahbek, Stine H; Jensen, Simon K et al.

    In: Journal of Immunology, 2014.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  92. Published

    T Cells Detect Intracellular DNA but Fail to Induce Type I IFN Responses : Implications for Restriction of HIV Replication. / Berg, Randi K; Rahbek, Stine Hess; Kofod-Olsen, Emil et al.

    In: PLOS ONE, Vol. 9, No. 1, 2014, p. e84513.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  93. 2013
  94. Published

    IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication. / Jakobsen, Martin Roelsgaard; Bak, Rasmus O; Andersen, Annika et al.

    In: Proceedings of the National Academy of Sciences of the United States of America, 23.10.2013.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  95. Published

    Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors. / Horan, Kristy A; Hansen, Kathrine; Jakobsen, Martin Roelsgaard et al.

    In: Journal of Immunology, Vol. 190, No. 5, 01.03.2013, p. 2311-2329.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  96. Published

    Interleukin-21 Receptor Signalling Is Important for Innate Immune Protection against HSV-2 Infections. / Kratholm, Sine K; Iversen, Marie B; Reinert, Line et al.

    In: PLOS ONE, Vol. 8, No. 12, 2013, p. e81790.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  97. 2012
  98. Published

    The crystal structure of the interleukin 21 receptor bound to interleukin 21 reveals that a sugar chain interacting with the WSXWS motif is an integral part of the interleukin 21 receptor. / Hamming, Ole Jensen; Kang, Lishan; Svensson, Anders et al.

    In: Journal of Biological Chemistry, Vol. 287, 16.03.2012, p. 9454-9460.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  99. Published

    Antiviral and immunological effects of tenofovir microbicide in vaginal herpes simplex virus 2 infection. / Vibholm, Line; Reinert, Line S; Søgaard, Ole S et al.

    In: AIDS Research and Human Retroviruses, Vol. 28, No. 11, 2012, p. 1404-11.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  100. Published

    Caught in translation : innate restriction of HIV mRNA translation by a schlafen family protein. / Jakobsen, Martin Roelsgaard; Mogensen, Trine H; Paludan, Søren R.

    In: Cell Research, 2012.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  101. Published

    Differential impact of interferon regulatory factor 7 in the initiation of the type I interferon response in the LCMV infected CNS versus the periphery. / Christensen, Jeanette Erbo; Fenger, Christina; Issazadeh-Navikas, Shohreh et al.

    In: Indian Journal of Virology, 2012.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  102. Published

    Genomic HIV RNA Induces Innate Immune Responses through RIG-I-Dependent Sensing of Secondary-Structured RNA. / Berg, Randi K; Melchjorsen, Jesper; Rintahaka, Johanna et al.

    In: P L o S One, Vol. 7, No. 1, 2012, p. e29291.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  103. Published

    Mitochondria-derived reactive oxygen species negatively regulates immune innate signaling pathways triggered by a DNA virus, but not by an RNA virus. / Gonzalez-Dosal, Regina; Horan, Kristy A; Paludan, Søren Riis.

    In: Biochemical and Biophysical Research Communications, Vol. 418, No. 4, 2012, p. 806-10.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  104. Published

    Pattern recognition receptor responses in children with chronic hepatitis B virus infection. / Heiberg, Ida Louise; Winther, Thilde Nordmann; Paludan, Søren Riis et al.

    In: Journal of Clinical Virology, 2012.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  105. Published

    TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice. / Reinert, Line S; Harder, Louis; Holm, Christian K et al.

    In: Journal of Clinical Investigation, 2012.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  106. Published

    TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults. / Offersen, Rasmus; Melchjorsen, Jesper; Paludan, Søren R et al.

    In: Human Vaccines & Immunotherapeutics, Vol. 8, No. 8, 2012, p. 1042-7.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  107. Published

    Type III IFNs : new layers of complexity in innate antiviral immunity. / Ank, Nina; Paludan, Søren Riis.

    In: BioFactors, Vol. 35, No. 1, 2012, p. 82-7.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  108. Published

    Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING. / Holm, Christian K; Jensen, Søren B; Jakobsen, Martin Roelsgaard et al.

    In: Nature Immunology, Vol. 13, No. 8, 2012, p. 737-43.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  109. 2011
  110. Published

    Tenofovir selectively regulates production of inflammatory cytokines and shifts the IL-12 / IL-10 balance in human primary cells. / Melchjorsen, Jesper; Risør, Michael W; Søgaard, Ole S et al.

    In: J A I D S, Vol. 57, No. 4, 05.04.2011, p. 265-275.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  111. Published

    Activation and receptor studies of human mast cells in healthy individuals and patients with asthma and allergy. / Schiøtz, Peter Oluf; Frandsen, Pernille Munk; Paludan, Søren Riis.

    2011. Poster session presented at Britishc Society of Immunology Summerschool, Llantwit Major, Wales, United Kingdom.

    Research output: Contribution to conferencePosterResearchpeer-review

  112. Published

    Activation of autophagy by α-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on stimulator of IFN genes. / Rasmussen, Simon B; Horan, Kristy A; Holm, Christian K et al.

    In: Journal of Immunology, Vol. 187, No. 10, 2011, p. 5268-76.

    Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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