Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production. / Reinert, Line S; Rashidi, Ahmad S; Tran, Diana N; Katzilieris-Petras, Georgios; Hvidt, Astrid K; Gohr, Mette; Fruhwürth, Stefanie; Bodda, Chiranjeevi; Thomsen, Martin K; Vendelbo, Mikkel H; Khan, Ahmad R; Hansen, Brian; Bergström, Petra; Agholme, Lotta; Mogensen, Trine H; Christensen, Maria H; Nyengaard, Jens R; Sen, Ganes C; Zetterberg, Henrik; Verjans, Georges Mgm; Paludan, Søren R.
In: Journal of Clinical Investigation, Vol. 131, No. 1, 04.01.2021.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity. / Fougeroux, Cyrielle; Goksøyr, Louise; Idorn, Manja; Soroka, Vladislav; Myeni, Sebenzile K.; Dagil, Robert; Janitzek, Christoph M.; Søgaard, Max; Aves, Kara Lee; Horsted, Emma W.; Erdoğan, Sayit Mahmut; Gustavsson, Tobias; Dorosz, Jerzy; Clemmensen, Stine; Fredsgaard, Laurits; Thrane, Susan; Vidal-Calvo, Elena E.; Khalifé, Paul; Hulen, Thomas M.; Choudhary, Swati; Theisen, Michael; Singh, Susheel K.; Garcia-Senosiain, Asier; Van Oosten, Linda; Pijlman, Gorben; Hierzberger, Bettina; Domeyer, Tanja; Nalewajek, Blanka W.; Strøbæk, Anette; Skrzypczak, Magdalena; Andersson, Laura F.; Buus, Søren; Buus, Anette Stryhn; Christensen, Jan Pravsgaard; Dalebout, Tim J.; Iversen, Kasper; Harritshøj, Lene H.; Mordmüller, Benjamin; Ullum, Henrik; Reinert, Line S.; de Jongh, Willem Adriaan; Kikkert, Marjolein; Paludan, Søren R.; Theander, Thor G.; Nielsen, Morten A.; Salanti, Ali; Sander, Adam F.
In: Nature Communications, Vol. 12, No. 1, 324, 01.2021.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro. / Svenningsen, Esben B; Thyrsted, Jacob; Blay-Cadanet, Julia; Liu, Han; Lin, Shaoquan; Villameriel, Jaime Moyano; Olagnier, David; Idorn, Manja; Paludan, Søren R; Holm, Christian K; Poulsen, Thomas B.
In: Antiviral Research, Vol. 185, 104988, 01.2021.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Letter › peer-review
Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans. / Hait, Alon Schneider; Olagnier, David; Sancho-Shimizu, Vanessa; Skipper, Kristian Alsbjerg; Helleberg, Marie; Larsen, Simon Muller; Bodda, Chiranjeevi; Moldovan, Liviu Ionut; Ren, Fanghui; Brinck Andersen, Nanna-Sophie; Thomsen, Michelle M; Freytag, Mette Ratzer; Darmalinggam, Sathya; Parkes, Isobel; Kadekar, Darshana D; Rahbek, Stine Hess; van der Horst, Demi; Kristensen, Lasse Sommer; Eriksson, Kristina; Kjems, Jørgen; Mostowy, Serge; Christiansen, Mette; Mikkelsen, Jacob Giehm; Brandt, Christian Thomas; Paludan, Søren R; Mogensen, Trine H.
In: Science Immunology, Vol. 5, No. 54, eabc2691, 12.2020.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Author Correction : STEEP mediates STING ER exit and activation of signaling (Nature Immunology, (2020), 21, 8, (868-879), 10.1038/s41590-020-0730-5). / Zhang, Bao-cun; Nandakumar, Ramya; Reinert, Line S.; Huang, Jinrong; Laustsen, Anders; Gao, Zong-liang; Sun, Cheng-long; Jensen, Soren Beck; Troldborg, Anne; Assil, Sonia; Berthelsen, Martin F.; Scavenius, Carsten; Zhang, Yan; Windross, Samuel J.; Olagnier, David; Prabakaran, Thaneas; Bodda, Chiranjeevi; Narita, Ryo; Cai, Yujia; Zhang, Cong-gang; Stenmark, Harald; Doucet, Christine M.; Noda, Takeshi; Guo, Zheng; Goldbach-Mansky, Raphaela; Hartmann, Rune; Chen, Zhijian J.; Enghild, Jan J.; Bak, Rasmus O.; Thomsen, Martin K.; Paludan, Soren R.
In: Nature Immunology, Vol. 21, No. 11, 11.2020, p. 1468-1469.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate › Research › peer-review
Characterization of distinct molecular interactions responsible for IRF3 and IRF7 phosphorylation and subsequent dimerization. / Dalskov, Louise; Narita, Ryo; Andersen, Line L.; Jensen, Nanna; Assil, Sonia; Kristensen, Kennith H.; Mikkelsen, Jacob G.; Fujita, Takashi; Mogensen, Trine H.; Paludan, Søren R.; Hartmann, Rune.
In: Nucleic Acids Research, Vol. 48, No. 20, 11.2020, p. 11421-11433.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Corona's new coat : SARS-CoV-2 in Danish minks and implications for travel medicine. / Larsen, Carsten Schade; Paludan, Søren Riis.
In: Travel Medicine and Infectious Disease, Vol. 38, 101922, 11.2020.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Editorial › peer-review
Author Correction : SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. / Olagnier, David; Farahani, Ensieh; Thyrsted, Jacob; Blay-Cadanet, Julia; Herengt, Angela; Idorn, Manja; Hait, Alon; Hernaez, Bruno; Knudsen, Alice; Iversen, Marie Beck; Schilling, Mirjam; Jørgensen, Sofie E; Thomsen, Michelle; Reinert, Line S; Lappe, Michael; Hoang, Huy-Dung; Gilchrist, Victoria H; Hansen, Anne Louise; Ottosen, Rasmus; Nielsen, Camilla G; Møller, Charlotte; van der Horst, Demi; Peri, Suraj; Balachandran, Siddharth; Huang, Jinrong; Jakobsen, Martin; Svenningsen, Esben B; Poulsen, Thomas B; Bartsch, Lydia; Thielke, Anne L; Luo, Yonglun; Alain, Tommy; Rehwinkel, Jan; Alcamí, Antonio; Hiscott, John; Mogensen, Trine H; Paludan, Søren R; Holm, Christian K.
In: Nature Communications, Vol. 11, No. 1, 5419, 21.10.2020.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate › Research › peer-review
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. / Olagnier, David; Farahani, Ensieh; Thyrsted, Jacob; Blay-Cadanet, Julia; Herengt, Angela; Idorn, Manja; Hait, Alon; Hernaez, Bruno; Knudsen, Alice; Iversen, Marie Beck; Schilling, Mirjam; Jørgensen, Sofie E; Thomsen, Michelle; Reinert, Line S; Lappe, Michael; Hoang, Huy-Dung; Gilchrist, Victoria H; Hansen, Anne Louise; Ottosen, Rasmus; Nielsen, Camilla G; Møller, Charlotte; van der Horst, Demi; Peri, Suraj; Balachandran, Siddharth; Huang, Jinrong; Jakobsen, Martin; Svenningsen, Esben B; Poulsen, Thomas B; Bartsch, Lydia; Thielke, Anne L; Luo, Yonglun; Alain, Tommy; Rehwinkel, Jan; Alcamí, Antonio; Hiscott, John; Mogensen, Trine H.; Paludan, Søren R; Holm, Christian K.
In: Nature Communications, Vol. 11, No. 1, 4938, 10.2020.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
STING Mediates Lupus via the Activation of Conventional Dendritic Cell Maturation and Plasmacytoid Dendritic Cell Differentiation. / Thim-uam, Arthid; Prabakaran, Thaneas; Tansakul, Mookmanee; Makjaroen, Jiradej; Wongkongkathep, Piriya; Chantaravisoot, Naphat; Saethang, Thammakorn; Leelahavanichkul, Asada; Benjachat, Thitima; Paludan, Søren; Pisitkun, Trairak; Pisitkun, Prapaporn.
In: iScience, Vol. 23, No. 9, 101530, 09.2020.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Constitutive immune mechanisms : mediators of host defence and immune regulation. / Paludan, Søren R.; Pradeu, Thomas; Masters, Seth L.; Mogensen, Trine H.
In: Nature Reviews Immunology, 08.2020.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection. / Bodda, Chiranjeevi; Reinert, Line S.; Fruhwürth, Stefanie; Richardo, Timmy; Sun, Chenglong; Zhang, Bao Cun; Kalamvoki, Maria; Pohlmann, Anja; Mogensen, Trine H.; Bergström, Petra; Agholme, Lotta; O'Hare, Peter; Sodeik, Beate; Gyrd-Hansen, Mads; Zetterberg, Henrik; Paludan, Søren R.
In: Journal of Experimental Medicine, Vol. 217, No. 7, e20191422, 07.2020.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation. / Guerra, J.; Valadao, A. L.; Vlachakis, D.; Polak, K.; Vila, I. K.; Taffoni, C.; Prabakaran, T.; Marriott, A. S.; Kaczmarek, R.; Houel, A.; Auzemery, B.; Déjardin, S.; Boudinot, P.; Nawrot, B.; Jones, N. J.; Paludan, S. R.; Kossida, S.; Langevin, C.; Laguette, N.
In: Science Advances, Vol. 6, No. 21, 05.2020, p. eaax3333.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
The cGAS-STING pathway is a therapeutic target in a preclinical model of hepatocellular carcinoma. / Thomsen, Martin K.; Skouboe, Morten K.; Boularan, Cedric; Vernejoul, Fabienne; Lioux, Thierry; Leknes, Siv L.; Berthelsen, Martin F.; Riedel, Maria; Cai, Huiqiang; Joseph, Justin V.; Perouzel, Eric; Tiraby, Michele; Vendelbo, Mikkel H.; Paludan, Søren R.
In: Oncogene, Vol. 39, No. 8, 02.2020, p. 1652-1664.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Essential role of autophagy in restricting poliovirus infection revealed by identification of an ATG7 defect in a poliomyelitis patient. / Brinck Andersen, Nanna Sophie; Jørgensen, Sofie Eg; Skipper, Kristian Alsbjerg; Larsen, Simon Müller; Heinz, Johanna; Thomsen, Michelle Mølgaard; Farahani, Ensieh; Cai, Yujia; Hait, Alon Schneider; Kay, Lise; Giehm Mikkelsen, Jacob; Høgsbjerg Schleimann, Mariane; Thomsen, Martin Kristian; Paludan, Søren R.; Mogensen, Trine H.
In: Autophagy, 2020.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
STEEP mediates STING ER exit and activation of signaling. / Zhang, Bao cun; Nandakumar, Ramya; Reinert, Line S.; Huang, Jinrong; Laustsen, Anders; Gao, Zong liang; Sun, Cheng long; Jensen, Søren Beck; Troldborg, Anne; Assil, Sonia; Berthelsen, Martin F.; Scavenius, Carsten; Zhang, Yan; Windross, Samuel J.; Olagnier, David; Prabakaran, Thaneas; Bodda, Chiranjeevi; Narita, Ryo; Cai, Yujia; Zhang, Cong gang; Stenmark, Harald; Doucet, Christine M.; Noda, Takeshi; Guo, Zheng; Goldbach-Mansky, Raphaela; Hartmann, Rune; Chen, Zhijian J.; Enghild, Jan J.; Bak, Rasmus O.; Thomsen, Martin K.; Paludan, Søren R.
In: Nature Immunology, Vol. 21, No. 8, 2020, p. 868-879.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4. / Juul-Madsen, Kristian; Qvist, Per; Bendtsen, Kirstine L; Langkilde, Annette E; Vestergaard, Bente; Howard, Ken; Dehesa-Etxebeste, Martxel; Paludan, Søren R; Andersen, Gregers Rom; Jensen, Poul Henning; Otzen, Daniel E; Romero-Ramos, Marina; Vorup-Jensen, Thomas.
In: Journal of Immunology, Vol. 204, No. 5, 2020, p. 1345-1361.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis. / Lafaille, Fabien G.; Harschnitz, Oliver; Lee, Yoon Seung; Zhang, Peng; Hasek, Mary L.; Kerner, Gaspard; Itan, Yuval; Ewaleifoh, Osefame; Rapaport, Franck; Carlile, Thomas M.; Carter-Timofte, Madalina E.; Paquet, Dominik; Dobbs, Kerry; Zimmer, Bastian; Gao, Daxing; Rojas-Duran, Maria F.; Kwart, Dylan; Rattina, Vimel; Ciancanelli, Michael J.; McAlpine, Jessica L.; Lorenzo, Lazaro; Boucherit, Soraya; Rozenberg, Flore; Halwani, Rabih; Henry, Benoit; Amenzoui, Naima; Alsum, Zobaida; Marques, Laura; Church, Joseph A.; Al-Muhsen, Saleh; Tardieu, Marc; Bousfiha, Ahmed Aziz; Paludan, Søren R.; Mogensen, Trine Hyrup; Quintana-Murci, Lluis; Tessier-Lavigne, Marc; Smith, Gregory A.; Notarangelo, Luigi D.; Studer, Lorenz; Gilbert, Wendy; Abel, Laurent; Casanova, Jean Laurent; Zhang, Shen Ying.
In: Nature Medicine, Vol. 25, No. 12, 01.12.2019, p. 1873-1884.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Intracellular bacteria engage a STING–TBK1–MVB12b pathway to enable paracrine cGAS–STING signalling. / Nandakumar, Ramya; Tschismarov, Roland; Meissner, Felix; Prabakaran, Thaneas; Krissanaprasit, Abhichart; Farahani, Ensieh; Zhang, Bao cun; Assil, Sonia; Martin, Amandine; Bertrams, Wilhelm; Holm, Christian K.; Ablasser, Andrea; Klause, Tanja; Thomsen, Martin K.; Schmeck, Bernd; Howard, Kenneth A.; Henry, Thomas; Gothelf, Kurt V.; Decker, Thomas; Paludan, Søren R.
In: Nature Microbiology, Vol. 4, 04.2019, p. 701-713.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
DNA-stimulated cell death : implications for host defence, inflammatory diseases and cancer. / Paludan, Søren R.; Reinert, Line S.; Hornung, Veit.
In: Nature Reviews Immunology, Vol. 19, No. 3, 01.03.2019, p. 141-153.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
The herpesviral antagonist m152 reveals differential activation of STING-dependent IRF and NF-κB signaling and STING's dual role during MCMV infection. / Stempel, Markus; Chan, Baca; Juranić Lisnić, Vanda; Krmpotić, Astrid; Hartung, Josephine; Paludan, Søren R.; Füllbrunn, Nadia; Lemmermann, Niels A.W.; Brinkmann, Melanie M.
In: EMBO Journal, Vol. 38, No. 5, e100983, 01.03.2019.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Mutations in RNA Polymerase III genes and defective DNA sensing in adults with varicella-zoster virus CNS infection. / Carter-Timofte, Madalina E; Hansen, Anders F; Christiansen, Mette; Paludan, Søren R; Mogensen, Trine H.
In: Genes and Immunity, Vol. 20, No. 3, 03.2019, p. 214-223.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs. / Frich, Camilla Kaas; Krüger, Franziska; Walther, Raoul; Domar, Cecilie; Andersen, Anna H. F.; Tvilum, Anne ; Dagnæs-Hansen, Frederik; Denton, Paul W.; Tolstrup, Martin; Paludan, Søren Riis; Münch, jJan; Zelikin, Alexander N.
In: Journal of Controlled Release, Vol. 294, 28.01.2019, p. 298-310.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Cellular Requirements for Sensing and Elimination of Incoming HSV-1 DNA and Capsids. / Sun, Chenglong; Luecke, Stefanie; Bodda, Chiranjeevi; Jønsson, Kasper L.; Cai, Yujia; Zhang, Bao Cun; Jensen, Søren B.; Nordentoft, Iver; Jensen, Jacob M.; Jakobsen, Martin R.; Paludan, Sren R.
In: Journal of Interferon and Cytokine Research, Vol. 39, No. 4, 2019, p. 191-204.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0. / Hensel, Niko; Raker, Verena; Förthmann, Benjamin; Detering, Nora Tula; Kubinski, Sabrina; Buch, Anna; Katzilieris-Petras, Georgios; Spanier, Julia; Gudi, Viktoria; Wagenknecht, Sylvia; Kopfnagel, Verena; Werfel, Thomas Andreas; Stangel, Martin; Beineke, Andreas; Kalinke, Ulrich; Paludan, Søren Riis; Sodeik, Beate; Claus, Peter.
In: Journal of Neuroinflammation, Vol. 16, No. 1, 248, 2019.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Intercellular communication in the innate immune system through the cGAS-STING pathway. / Nandakumar, Ramya; Windross, Samuel Joseph; Paludan, Soren R.
DNA Sensors and Inflammasomes. ed. / J Sohn. Elsevier, 2019. p. 1-11 (Methods in Enzymology, Vol. 625).Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins. / Carter-Timofte, Madalina E; Hansen, Anders F; Mardahl, Maibritt; Fribourg, Sébastien; Rapaport, Franck; Zhang, Shen-Ying; Casanova, Jean-Laurent; Paludan, Søren R; Christiansen, Mette; Larsen, Carsten S; Mogensen, Trine H.
In: Neurology(R) neuroimmunology & neuroinflammation, Vol. 5, No. 6, 11.2018, p. e500.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
RNA Polymerase III as a Gatekeeper to Prevent Severe VZV Infections. / Carter-Timofte, Madalina E; Paludan, Søren R; Mogensen, Trine H.
In: Trends in Molecular Medicine, Vol. 24, No. 10, 10.2018, p. 904-915.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Inflammation kinase PKR phosphorylates α-synuclein and causes α-synuclein-dependent cell death. / Reimer, Lasse; Lund, Louise Buur; Betzer, Cristine; Zheng, Jin; Nielsen, Lærke Dalsgaard; Kofoed, Rikke Hahn; Lassen, Louise Berkhoudt; Bølcho, Ulrik; Paludan, Søren Riis; Fog, Karina; Jensen, Poul Henning.
In: Neurobiology of Disease, 01.05.2018.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1. / Prabakaran, Thaneas; Bodda, Chiranjeevi; Krapp, Christian; Zhang, Bao-Cun; Christensen, Maria H; Sun, Chenglong; Reinert, Line; Cai, Yujia; Jensen, Søren B; Skouboe, Morten K; Nyengaard, Jens R; Thompson, Craig B; Lebbink, Robert Jan; Sen, Ganes C; van Loo, Geert; Nielsen, Rikke; Komatsu, Masaaki; Nejsum, Lene N; Jakobsen, Martin R; Gyrd-Hansen, Mads; Paludan, Søren R.
In: E M B O Journal, Vol. 37, No. 8, E97858, 13.04.2018.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
STING agonists enable antiviral cross-talk between human cells and confer protection against genital herpes in mice. / Skouboe, Morten K; Knudsen, Alice; Reinert, Line S; Boularan, Cedric; Lioux, Thierry; Perouzel, Eric; Thomsen, Martin K; Paludan, Søren R.
In: P L o S Pathogens, Vol. 14, No. 4, e1006976, 02.04.2018.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Human B cells fail to secrete type I interferons upon cytoplasmic DNA exposure. / Gram, Anna M.; Sun, Chenglong; Landman, Sanne L.; Oosenbrug, Timo; Koppejan, Hester J.; Kwakkenbos, Mark J.; Hoeben, Rob C.; Paludan, Soren R.; Ressing, Maaike E.
In: Molecular Immunology, Vol. 91, 11.2017, p. 225-237.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Cutting Edge : Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2-Induced IFN-β Expression. / Eriksson, Kristina; Svensson, Alexandra; Hait, Alon S; Schlüter, Kerstin; Tunbäck, Petra; Nordström, Inger; Padyukov, Leonid; Liljeqvist, Jan-Åke; Mogensen, Trine H; Paludan, Søren R.
In: Journal of Immunology, Vol. 199, No. 8, 15.10.2017, p. 2613-2617.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Molecular requirements for sensing of intracellular microbial nucleic acids by the innate immune system. / Luecke, Stefanie; Paludan, Soren R.
In: Cytokine, Vol. 98, 10.2017, p. 4-14.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
cGAS is activated by DNA in a length-dependent manner. / Luecke, Stefanie; Holleufer, Andreas; Christensen, Maria H; Jønsson, Kasper L; Boni, Gerardo A; Sørensen, Lambert K; Johannsen, Mogens; Jakobsen, Martin R; Hartmann, Rune; Paludan, Søren R.
In: E M B O Reports, Vol. 18, No. 10, 10.2017, p. 1707–1715.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections. / Ogunjimi, Benson; Zhang, Shen-Ying; Sørensen, Katrine Biehl; Skipper, Kristian A; Carter-Timofte, Madalina; Kerner, Gaspard; Luecke, Stefanie; Prabakaran, Thaneas; Cai, Yujia; Meester, Josephina; Bartholomeus, Esther; Bolar, Nikhita Ajit; Vandeweyer, Geert; Claes, Charlotte; Sillis, Yasmine; Lorenzo, Lazaro; Fiorenza, Raffaele A; Boucherit, Soraya; Dielman, Charlotte; Heynderickx, Steven; Elias, George; Kurotova, Andrea; Auwera, Ann Vander; Verstraete, Lieve; Lagae, Lieven; Verhelst, Helene; Jansen, Anna; Ramet, Jose; Suls, Arvid; Smits, Evelien; Ceulemans, Berten; Van Laer, Lut; Plat Wilson, Genevieve; Kreth, Jonas; Picard, Capucine; Von Bernuth, Horst; Fluss, Joël; Chabrier, Stephane; Abel, Laurent; Mortier, Geert; Fribourg, Sebastien; Mikkelsen, Jacob Giehm; Casanova, Jean-Laurent; Paludan, Søren R; Mogensen, Trine H.
In: Journal of Clinical Investigation, 01.09.2017.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. / Jønsson, K L; Laustsen, A; Krapp, C; Skipper, K A; Thavachelvam, K; Hotter, D; Egedal, J H; Kjolby, M; Mohammadi, P; Prabakaran, T; Sørensen, L K; Sun, C; Jensen, S B; Holm, C K; Lebbink, Robert Jan; Johannsen, M; Nyegaard, M; Mikkelsen, J G; Kirchhoff, F; Paludan, S R; Jakobsen, M R.
In: Nature Communications, Vol. 8, 14391, 10.02.2017.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Viral evasion of DNA-stimulated innate immune responses. / Christensen, Maria H.; Paludan, Soren R.
In: Cellular & molecular immunology, Vol. 14, No. 1, 01.2017, p. 4-13.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS. / Reinert, Line S; Lopušná, Katarína; Winther, Henriette; Sun, Chenglong; Thomsen, Martin K; Nandakumar, Ramya; Mogensen, Trine H; Meyer, Morten; Vægter, Christian; Nyengaard, Jens R; Fitzgerald, Katherine A; Paludan, Søren R.
In: Nature Communications, Vol. 7, 13348, 10.11.2016.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Gene-environmental interactions between genetic variants in antiviral response genes and prenatal maternal infections in schizophrenia. / Manikandan, Veera; Reinert, Line; Paludan, Søren Riis; Grove, Jakob; Nielsen, Philip Finn Rising; Hougaard, David M.; Nordentoft, Merete; Werge, Thomas; Børglum, Anders; Mortensen, Preben Bo; Demontis, Ditte.
2016. Poster session presented at American Society of Human Genetics 2016, Vancouver, Canada.Research output: Contribution to conference › Poster › Research
HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression. / Christensen, Maria H.; Jensen, Søren B.; Miettinen, Juho J.; Luecke, Stefanie; Prabakaran, Thaneas; Reinert, Line S.; Mettenleiter, Thomas; Chen, Zhijian J.; Knipe, David M.; Sandri-Goldin, Rozanne M.; Enquist, Lynn W.; Hartmann, Rune; Mogensen, Trine H.; Rice, Stephen A.; Nyman, Tuula A.; Matikainen, Sampsa; Paludan, Søren R.
In: The EMBO Journal, Vol. 35, No. 13, 01.07.2016, p. 1385-1399.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection. / Thomsen, Martin K; Nandakumar, Ramya; Stadler, Daniela; Malo, Antje; Valls, Roser Marin; Wang, Fan; Reinert, Line S; Dagnaes-Hansen, Frederik; Hollensen, Anne Kruse; Mikkelsen, Jacob Giehm; Protzer, Ulrike; Paludan, Søren R.
In: Hepatology, Vol. 64, No. 3, 16.06.2016, p. 746-759.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses. / Holm, Christian K; Rahbek, Stine H; Gad, Hans Henrik; Bak, Rasmus O; Jakobsen, Martin R; Jiang, Zhaozaho; Hansen, Anne Louise; Jensen, Simon K; Sun, Chenglong; Thomsen, Martin K; Laustsen, Anders; Nielsen, Camilla G; Severinsen, Kasper; Xiong, Yingluo; Burdette, Dara L; Hornung, Veit; Lebbink, Robert Jan; Duch, Mogens; Fitzgerald, Katherine A; Bahrami, Shervin; Mikkelsen, Jacob Giehm; Hartmann, Rune; Paludan, Søren R.
In: Nature Communications, Vol. 7, 10680, 19.02.2016.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Interleukin 20 regulates dendritic cell migration and expression of co-stimulatory molecules. / Bech, Rikke; Jalilian, Babak; Agger, Ralf; Iversen, Lars; Erlandsen, Mogens; Otkjaer, Kristian; Johansen, Claus; Paludan, Søren R; Rosenberg, Carina A; Kragballe, Knud; Vorup-Jensen, Thomas.
In: Molecular and Cellular Therapies, Vol. 4, No. 1, 2016.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis. / Mørk, N; Kofod-Olsen, E; Sørensen, K B; Bach, E; Ørntoft, T F; Østergaard, Lars Jørgen; Paludan, S R; Christiansen, M; Mogensen, Trine.
In: Genes and Immunity, Vol. 16, No. 8, 12.2015, p. 552-66.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
An innate antiviral pathway acting before interferons at epithelial surfaces. / Iversen, Marie B; Reinert, Line S; Thomsen, Martin K; Bagdonaite, Ieva; Nandakumar, Ramya; Cheshenko, Natalia; Prabakaran, Thaneas; Vakhrushev, Sergey Y; Krzyzowska, Malgosha; Kratholm, Sine K; Ruiz-Perez, Fernando; Petersen, Steen V; Goriely, Stanislas; Bibby, Bo Martin; Eriksson, Kristina; Ruland, Jürgen; Thomsen, Allan R; Herold, Betsy C; Wandall, Hans H; Frische, Sebastian; Holm, Christian K; Paludan, Søren R.
In: Nature Immunology, 30.11.2015.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Activation and regulation of DNA-driven immune responses. / Paludan, Søren R.
In: Microbiology and Molecular Biology Reviews, Vol. 79, No. 2, 06.2015, p. 225-41.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Catching the adaptor-WDFY1, a new player in the TLR-TRIF pathway. / Nandakumar, Ramya; Paludan, Søren R.
In: E M B O Reports, Vol. 16, No. 4, 04.2015, p. 397-8.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection. / Sun, Chenglong; Schattgen, Stefan A; Pisitkun, Prapaporn; Jorgensen, Joan P; Hilterbrand, Adam T; Wang, Lucas J; West, John A; Hansen, Kathrine; Horan, Kristy A; Jakobsen, Martin Roelsgaard; O'Hare, Peter; Adler, Heiko; Sun, Ren; Ploegh, Hidde L; Damania, Blossom; Upton, Jason W; Fitzgerald, Katherine A; Paludan, Søren R.
In: Journal of Immunology, Vol. 194, No. 4, 15.02.2015, p. 1819-31.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Functional IRF3 deficiency in a patient with herpes simplex encephalitis. / Andersen, Line Lykke; Mørk, Nanna; Reinert, Line S; Kofod-Olsen, Emil; Narita, Ryo; Jørgensen, Sofie E; Skipper, Kristian A; Höning, Klara; Gad, Hans Henrik; Østergaard, Lars; Ørntoft, Torben F; Hornung, Veit; Paludan, Søren R; Mikkelsen, Jacob Giehm; Fujita, Takashi; Christiansen, Mette; Hartmann, Rune; Mogensen, Trine H.
In: Journal of Experimental Medicine, Vol. 212, No. 9, 2015, p. 1371-9.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Innate recognition of alphaherpesvirus DNA. / Luecke, Stefanie; Paludan, Søren R.
In: Virus Research, Vol. 92, 2015, p. 63-100.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
TRAM is required for TLR2 endosomal signaling to type I IFN induction. / Stack, Julianne; Doyle, Sarah L; Connolly, Dympna J; Reinert, Line S; O'Keeffe, Kate M; McLoughlin, Rachel M; Paludan, Søren R; Bowie, Andrew G.
In: Journal of Immunology, Vol. 193, No. 12, 15.12.2014, p. 6090-102.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival. / Wang, Hui; Flannery, Sinead M; Dickhöfer, Sabine; Huhn, Stefanie; George, Julie; Kubarenko, Andriy V; Lascorz, Jesus; Bevier, Melanie; Willemsen, Joschka; Pichulik, Tica; Schafmayer, Clemens; Binder, Marco; Manoury, Bénédicte; Paludan, Søren R; Alarcon-Riquelme, Marta; Bowie, Andrew G; Försti, Asta; Weber, Alexander N R.
In: Journal of Biological Chemistry, Vol. 289, No. 33, 15.08.2014, p. 23123-31.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway. / Hansen, Kathrine; Prabakaran, Thaneas; Laustsen, Anders; Jørgensen, Sofie E; Rahbek, Stine Hess; Jensen, Søren B; Nielsen, Rikke; Leber, Jess H; Decker, Thomas; Horan, Kristy A; Jakobsen, Martin R; Paludan, Søren R.
In: E M B O Journal, Vol. 33, No. 15, 01.08.2014, p. 1654-66.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
IFI16 : At the interphase between innate DNA sensing and genome regulation. / Jakobsen, Martin Roelsgaard; Paludan, Søren R.
In: Cytokine & Growth Factor Reviews, 21.06.2014.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Innate DNA sensing is impaired in HIV patients and IFI16 expression correlates to chronic immune activation. / Nissen, Sara K; Højen, Jesper Falkesgaard; Andersen, Karen L D; Kofod-Olsen, Emil; Berg, Randi K; Paludan, Søren R; Ostergaard, Lars; Jakobsen, Martin Roelsgaard; Tolstrup, Martin; Mogensen, Trine H.
In: Clinical and Experimental Immunology, Vol. 177, No. 1, 05.03.2014, p. 295-309.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Innate antiviral signalling in the central nervous system. / Carty, Michael; Reinert, Line; Paludan, Søren R.; Bowie, Andrew G.
In: Trends in Immunology, Vol. 35, No. 2, 01.02.2014, p. 79-87.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Inflammatory Cytokines Break Down Intrinsic Immunological Tolerance of Human Primary Keratinocytes to Cytosolic DNA. / Chiliveru, Srikanth; Rahbek, Stine H; Jensen, Simon K; Jørgensen, Sofie E; Nissen, Sara K; Christiansen, Stig H; Mogensen, Trine H; Jakobsen, Martin R; Iversen, Lars; Johansen, Claus; Paludan, Søren R.
In: Journal of Immunology, 2014.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
T Cells Detect Intracellular DNA but Fail to Induce Type I IFN Responses : Implications for Restriction of HIV Replication. / Berg, Randi K; Rahbek, Stine Hess; Kofod-Olsen, Emil; Holm, Christian K; Melchjorsen, Jesper; Jensen, David G.; Hansen, Anne Louise; Jørgensen, Louise B.; Østergaard, Lars Jørgen; Tolstrup, Martin; Larsen, Carsten S; Paludan, Søren R; Jakobsen, Martin R; Mogensen, Trine H.
In: PLOS ONE, Vol. 9, No. 1, 2014, p. e84513.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication. / Jakobsen, Martin Roelsgaard; Bak, Rasmus O; Andersen, Annika; Berg, Randi K; Jensen, Søren B; Tengchuan, Jin; Laustsen, Anders; Hansen, Kathrine; Ostergaard, Lars; Fitzgerald, Katherine A; Xiao, T Sam; Mikkelsen, Jacob G; Mogensen, Trine H; Paludan, Søren R.
In: Proceedings of the National Academy of Sciences of the United States of America, 23.10.2013.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors. / Horan, Kristy A; Hansen, Kathrine; Jakobsen, Martin Roelsgaard; Holm, Christian K; Søby, Stine; Unterholzner, Leonie; Thompson, Mikayla; West, John A; Iversen, Marie B; Rasmussen, Simon B; Ellermann-Eriksen, Svend; Kurt-Jones, Evelyn; Landolfo, Santo; Damania, Blossom; Melchjorsen, Jesper; Bowie, Andrew G; Fitzgerald, Katherine A; Paludan, Søren R.
In: Journal of Immunology, Vol. 190, No. 5, 01.03.2013, p. 2311-2329.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Interleukin-21 Receptor Signalling Is Important for Innate Immune Protection against HSV-2 Infections. / Kratholm, Sine K; Iversen, Marie B; Reinert, Line; Jensen, Simon K; Hokland, Marianne; Andersen, Thomas; Rankin, Andrew; Young, Deborah; Frische, Sebastian; Paludan, Søren R; Holm, Christian K.
In: PLOS ONE, Vol. 8, No. 12, 2013, p. e81790.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
The crystal structure of the interleukin 21 receptor bound to interleukin 21 reveals that a sugar chain interacting with the WSXWS motif is an integral part of the interleukin 21 receptor. / Hamming, Ole Jensen; Kang, Lishan; Svensson, Anders; Karlsen, Jesper Lykkegaard; Rahbek-Nielsen, Henrik; Paludan, Søren Riis; Hjorth, Siv A; Bondensgaard, Kent; Hartmann, Rune.
In: Journal of Biological Chemistry, Vol. 287, 16.03.2012, p. 9454-9460.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Antiviral and immunological effects of tenofovir microbicide in vaginal herpes simplex virus 2 infection. / Vibholm, Line; Reinert, Line S; Søgaard, Ole S; Paludan, Søren R; Østergaard, Lars Jørgen; Tolstrup, Martin; Melchjorsen, Jesper.
In: AIDS Research and Human Retroviruses, Vol. 28, No. 11, 2012, p. 1404-11.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Caught in translation : innate restriction of HIV mRNA translation by a schlafen family protein. / Jakobsen, Martin Roelsgaard; Mogensen, Trine H; Paludan, Søren R.
In: Cell Research, 2012.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Differential impact of interferon regulatory factor 7 in the initiation of the type I interferon response in the LCMV infected CNS versus the periphery. / Christensen, Jeanette Erbo; Fenger, Christina; Issazadeh-Navikas, Shohreh; Krug, Anna; Liljestrøm, Peter; Goriely, Stanislas; Paludan, Søren Riis; Finsen, Bente; Christensen, Jan Pravsgaard; Thomsen, Allan Randrup.
In: Indian Journal of Virology, 2012.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Genomic HIV RNA Induces Innate Immune Responses through RIG-I-Dependent Sensing of Secondary-Structured RNA. / Berg, Randi K; Melchjorsen, Jesper; Rintahaka, Johanna; Diget, Elisabeth; Søby, Stine; Horan, Kristy A; Gorelick, Robert J; Matikainen, Sampsa; Larsen, Carsten S; Østergaard, Lars Jørgen; Paludan, Søren R; Mogensen, Trine H.
In: P L o S One, Vol. 7, No. 1, 2012, p. e29291.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Mitochondria-derived reactive oxygen species negatively regulates immune innate signaling pathways triggered by a DNA virus, but not by an RNA virus. / Gonzalez-Dosal, Regina; Horan, Kristy A; Paludan, Søren Riis.
In: Biochemical and Biophysical Research Communications, Vol. 418, No. 4, 2012, p. 806-10.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Pattern recognition receptor responses in children with chronic hepatitis B virus infection. / Heiberg, Ida Louise; Winther, Thilde Nordmann; Paludan, Søren Riis; Hogh, Birthe.
In: Journal of Clinical Virology, 2012.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice. / Reinert, Line S; Harder, Louis; Holm, Christian K; Iversen, Marie Beck; Horan, Kristy A; Dagnæs-Hansen, Frederik; Ulhøi, Benedicte P; Holm, Thomas H; Mogensen, Trine H; Owens, Trevor; Nyengaard, Jens R; Thomsen, Allan Randrup; Paludan, Søren Riis.
In: Journal of Clinical Investigation, 2012.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults. / Offersen, Rasmus; Melchjorsen, Jesper; Paludan, Søren R; Østergaard, Lars Jørgen; Tolstrup, Martin; Søgaard, Ole S.
In: Human Vaccines & Immunotherapeutics, Vol. 8, No. 8, 2012, p. 1042-7.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Type III IFNs : new layers of complexity in innate antiviral immunity. / Ank, Nina; Paludan, Søren Riis.
In: BioFactors, Vol. 35, No. 1, 2012, p. 82-7.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING. / Holm, Christian K; Jensen, Søren B; Jakobsen, Martin Roelsgaard; Cheshenko, Natalia; Horan, Kristy A; Moeller, Hanne B; Gonzalez-Dosal, Regina; Rasmussen, Simon B; Christensen, Maria H; Yarovinsky, Timur O; Rixon, Frazer J; Herold, Betsy C; Fitzgerald, Katherine A; Paludan, Søren R.
In: Nature Immunology, Vol. 13, No. 8, 2012, p. 737-43.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Tenofovir selectively regulates production of inflammatory cytokines and shifts the IL-12 / IL-10 balance in human primary cells. / Melchjorsen, Jesper; Risør, Michael W; Søgaard, Ole S; Oʼloughlin, Kieran L; Chow, Sue; Paludan, Søren R; Ellermann-Eriksen, Svend; Hedley, David W; Phd, Hans Minderman; Østergaard, Lars Jørgen; Tolstrup, Martin.
In: J A I D S, Vol. 57, No. 4, 05.04.2011, p. 265-275.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Activation and receptor studies of human mast cells in healthy individuals and patients with asthma and allergy. / Schiøtz, Peter Oluf; Frandsen, Pernille Munk; Paludan, Søren Riis.
2011. Poster session presented at Britishc Society of Immunology Summerschool, Llantwit Major, Wales, United Kingdom.Research output: Contribution to conference › Poster › Research › peer-review
Activation of autophagy by α-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on stimulator of IFN genes. / Rasmussen, Simon B; Horan, Kristy A; Holm, Christian K; Stranks, Amanda J; Mettenleiter, Thomas C; Simon, A Katharina; Jensen, Søren B; Rixon, Frazer J; He, Bin; Paludan, Søren Riis.
In: Journal of Immunology, Vol. 187, No. 10, 2011, p. 5268-76.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6. / Dosal, Regina Gonzalez; Horan, Kristy A; Rahbek, Stine H; Ichijo, Hidenori; Chen, Zhijian J; Mieyal, John J; Hartmann, Rune; Paludan, Søren R.
In: P L o S Pathogens, Vol. 7, No. 9, 2011, p. e1002250.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
IgE in Culture Medium Influences the Activation of Human Mast Cells. / Schiøtz, Peter Oluf; Frandsen, Pernille Munk; Paludan, Søren Riis.
2011. Poster session presented at Dansk Selskab for Allergologi, Årsmøde 2011, Kolding, .Research output: Contribution to conference › Poster › Research › peer-review
Recognition of herpesviruses by the innate immune system. / Paludan, Søren Riis; Bowie, Andrew G; Horan, Kristy A; Fitzgerald, Katherine A.
In: Nature Reviews. Immunology, Vol. 11, No. 2, 2011, p. 143-54.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Toll2011 at Lago di Garda : studying danger sensors by the guard towers at the lake. / Paludan, Søren Riis; Levy, Ofer; Bowie, Andrew G.
In: Nature Immunology, Vol. 12, No. 9, 2011, p. 805-8.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity. / Kristiansen, Helle; Scherer, Christina A; McVean, Maralee; Iadonato, Shawn P; Vends, Susanne; Thavachelvam, Karthiga; Steffensen, Thomas B; Horan, Kristy A; Kuri, Thomas; Weber, Friedemann; Paludan, Søren R; Hartmann, Rune.
In: Journal of Virology, Vol. 84, No. 22, 01.11.2010, p. 11898-904.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
IFI16 is an innate immune sensor for intracellular DNA. / Unterholzner, Leonie; Keating, Sinead E; Baran, Marcin; Horan, Kristy A; Jensen, Søren B; Sharma, Shruti; Sirois, Cherilyn M; Jin, Tengchuan; Latz, Eicke; Xiao, T Sam; Fitzgerald, Katherine A; Paludan, Søren R; Bowie, Andrew G.
In: Nature Immunology, Vol. 11, No. 11, 01.11.2010, p. 997-1004.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Mechanisms of type III interferon expression. / Iversen, Marie Beck; Paludan, Søren R.
In: Journal of Interferon & Cytokine Research, Vol. 30, No. 8, 01.08.2010, p. 573-8.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Expression of type III interferon (IFN) in the vaginal mucosa is mediated primarily by dendritic cells and displays stronger dependence on NF-kappaB than type I IFNs. / Iversen, Marie Beck; Ank, Nina; Melchjorsen, Jesper; Paludan, Søren R.
In: Journal of Virology, Vol. 84, No. 9, 05.2010, p. 4579-86.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Innate immune recognition and activation during HIV infection. / Mogensen, Trine H; Melchjorsen, Jesper; Larsen, Carsten S; Paludan, Søren R.
In: Retrovirology, Vol. 7, 01.01.2010, p. 54.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Early innate recognition of herpes simplex virus in human primary macrophages is mediated via the MDA5/MAVS-dependent and MDA5/MAVS/RNA polymerase III-independent pathways. / Melchjorsen, Jesper; Rintahaka, Johanna; Søby, Stine; Horan, Kristy A; Poltajainen, Alina; Østergaard, Lars; Paludan, Søren R; Matikainen, Sampsa.
In: Journal of Virology, Vol. 84, No. 21, 2010, p. 11350-8.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Induction of interferon-stimulated genes by Chlamydia pneumoniae in fibroblasts is mediated by intracellular nucleotide-sensing receptors. / Chiliveru, Srikanth; Birkelund, Svend; Paludan, Søren R.
In: P L o S One, Vol. 5, No. 4, 2010, p. e10005.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Recognition of Herpes Simplex Virus by Human Macrophages via Non-Toll Recognition Receptors - Impact on both Inflammatory and Interferon Genes. / Melchjorsen, Jesper; Rintakaha, Johanna; Østergaard, Lars Jørgen; Paludan, Søren Riis; Matikainen, Sampsa.
2010. Poster session presented at 26th Annual Meeting of the Scandinavian Society for Antimicrobial Chemotherapy, Tromsø, Norway.Research output: Contribution to conference › Poster › Research
The p38 MAPK regulates IL-24 expression by stabilization of the 3' UTR of IL-24 mRNA. / Otkjaer, Kristian; Holtmann, Helmut; Kragstrup, Tue Wenzel; Paludan, Søren Riis; Johansen, Claus; Gaestel, Matthias; Kragballe, Knud; Iversen, Lars.
In: P L o S One, Vol. 5, No. 1, 2010, p. e8671.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Activation and Evasion of Innate Antiviral Immunity by Herpes Simplex Virus. / Melchjorsen, Jesper; Matikainen, Sampsa; Paludan, Søren Riis.
In: Viruses, 05.11.2009, p. 737-759.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Innate recognition of intracellular pathogens: detection and activation of the first line of defense. / Rasmussen, Simon B; Reinert, Line; Paludan, Søren R.
In: A P M I S Supplementum, Vol. 117, No. 5-6, 01.05.2009, p. 323-37.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Role of mitogen-activated protein kinases, nuclear factor-κB, and interferon regulatory factor 3 in Toll-like receptor 4-mediated activation of HIV long terminal repeat. / Berg, Randi S.; Aggerholm, Anni; Bertelsen, Lone S.; Østergaard, Lars; Paludan, Søren R.
In: APMIS, Vol. 117, No. 2, 02.2009, p. 124-132.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible gene- like receptors, which synergize to induce type I interferon production. / Rasmussen, Simon B; Jensen, Søren B; Nielsen, Christoffer; Quartin, Emanuel; Kato, Hiroki; Chen, Zhijian J; Silverman, Robert H; Akira, Shizuo; Paludan, Søren R.
In: Journal of General Virology, Vol. 90, No. Pt 1, 01.01.2009, p. 74-8.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Activation and evasion of innate antiviral immunity by herpes simplex virus. / Melchjorsen, Jesper; Matikainen, Sampsa; Paludan, Søren Riis.
In: Viruses, Vol. 1, No. 3, 2009, p. 737-59.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Differential Regulation of the OASL and OAS1 Genes in Response to Viral Infections. / Melchjorsen, Jesper; Kristiansen, Helle; Christiansen, Rune; Rintahaka, Johanna; Matikainen, Sampsa; Paludan, Søren R; Hartmann, Rune.
In: Journal of Interferon & Cytokine Research, 2009.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Differential regulation of OASL and OAS1 genes in response to viral infections : Virus induction of OASL. / Kristiansen, Helle; Melchjorsen, Jesper; Christiansen, Rune; Rintahaka, Johanna; Matikainen, Sampsa; Paludan, Søren Riis; Hartmann, Rune.
2009. Poster session presented at Cytokines 2008, Montreal, Canada.Research output: Contribution to conference › Poster › Research
Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice. / Koenen, Rory R; von Hundelshausen, Philipp; Nesmelova, Irina V; Zernecke, Alma; Liehn, Elisa A; Sarabi, Alisina; Kramp, Birgit K; Piccinini, Anna M; Paludan, Søren Riis; Kowalska, M Anna; Kungl, Andreas J; Hackeng, Tilman M; Mayo, Kevin H; Weber, Christian.
In: Nature Medicine, Vol. 15, No. 1, 2009, p. 97-103.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice. / Koenen, RR; Hundelshausen, P; Nesmelova, IV; Zernecke, A; Liehn, EA; Sarabi, A; Kramp, BK; Piccinini, AM; Paludan, Søren Riis; Kowalska, MA; Kungl, A; Hackeng, TM; Mayo, KH; Weber, C.
In: Nature Medicine, Vol. 15, 2009, p. 97-103.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Divergent effects of Tenofovir and Retrovir (AZT) on TLR-mediated cytokine production. / Melchjorsen, Jesper; Tolstrup, Martin; Paludan, Søren Riis; Østergaard, Lars Jørgen.
2009. Poster session presented at The 25th Annual Meeting of the Scandinavian Society for Antimicrobial Chemotherapy, København, Denmark.Research output: Contribution to conference › Poster › Research
Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible gene- like receptors, which synergize to induce type I interferon production. / Rasmussen, Simon Brandtoft; Jensen, Søren B; Nielsen, C; Quartin, E; Kato, H; Chen, ZJ; Silverman, RH; Akira, S; Paludan, Søren Riis.
In: Journal of General Virology, Vol. 90, 2009, p. 74-8.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review