Søren Riis Paludan

Professor

Curriculum Vitae

EDUCATION

June 2003.       Doctor of Medical Sciences, Aarhus University (AU), DK
Nov 2000.        PhD, Faculty of Science, AU, DK
June 1998.       Master of Science, Molecular Biology, AU, DK
 
EMPLOYMENT
2013-Pres.       Professor in Molecular virology and immunology, Dept. Biomedicine, AU, DK

2019-pres.       Vice-chairman for Research, Department of Biomedicine, AU, DK

2018-2020.      Guest professor (20%), Sahlgrenska Academy, Gothenborg University, S 
2010-2013.      Professor MSO in Molecular virology, Dept. Biomedicine, AU, DK
2003-2010.      Associate professor, Dept. Medical Microbiol & Immunol, AU, DK
2000-2003.      Assistant prof., Dept. Medical Microbiol & Immunol, AU, DK

STUDIES/RESEARCH AT INSTITUTIONS OUTSIDE DENMARK
2013.              Sabbatical in London/Cambridge. Collaborations with groups at ICL and Cambridge                               Univ.
1998-1999.      Research Fellow, The Cleveland Clinic Foundation, Dept. Immunol, Cleveland, USA
1995-1996.      University of Oxford, Dept. Biochemistry, Oxford, UK

SCIENTIFIC LEADERSHIP ACTIVITIES
2018-2019.      Novo Nordisk Foundation Investigator Leadership Development Program
2016-2020.      Coordinator of EDGE, a H2020-funded ITN Network on herpes virology and immunology
2012-2016.      Leader of AUFF pilot center “Center for Innate Immunology”
2003.               Establishment of my laboratory at AU

MAJOR GRANTS RECEIVED AS PRINCIPLE INVESTIGATOR
I Have obtained more than 15 mio Euros in grants as PI since year 2003 from Danish and Swedish National Research Councils, private funding bodies, and EU programs.
2019-2023.      Lundbeck Foundation. Large program grant (1.5 Mio Euros)

2019-2021.      The Swedish Research Council (0.6 mio Euros)
2018-2023.      ERC Advanced Grant (2.5 Mio Euros)
2018-2023.      Novo Nordisk Foundation Distinguished Investigator (1.5 Mio Euros)
2018-2022.      Lundbeck Foundation. Large program grant (1.5 Mio Euros)
2016-2020.      Lundbeck Foundation. Large program grant (1.5 Mio Euros)
2016-2020.      HORIZON2020. ITN PhD training network (3.9 Mio Euros). PI and coordinator
2013-2017.      Sapere aude – Advanced Grant. The Danish Research Council (1.6 Mio Euros)

SCIENTIFIC HONORS

2011.              EliteForsk Prize.

2011.              Anders Jahre Junior prize.

2012.              DFF -Advanced Grant (Sapere aude Topforsker).

2018.              Guest professorship (Sahlgrenska Academy, Gothenburg University).

2018.              ERC Advanced Grant. 

SUPERVISION AND MENTORING OF GRADUATE STUDENTS, POSTDOCS, AND JUNIOR FACULTY
2003-pres.       Previous students: 15 PhD and 8 Master students. Mentored 8 postdocs (5 now 
                       associate professors at universities. one is Founder and CEO in biotech company).                               Currently supervisor for 5 PhD students and mentor for 5 postdocs.

2015-pres.       AU mentor for 2 associate professors; mentor for 1 Lundbeck Fellow; International                               mentor for junior faculty at Montpellier Uni. (ERC StG awardée)


TEACHING ACTIVITIES
2000-pres.       Virology and immunology at the bachelor and master level for Medical and                                           Molecular medicine students, AU
2000-pres.       Frequent teacher graduate courses at courses outside AU. E.g. Karolinska                                             Institute, Stockholm (2015); Barcelona (2016); University of Copenhagen (2018)
2019.              Summer School of Immunotherapy, Aarhus University (co-organizer)

ORGANISATION OF INTERNATIONAL CONFERENCES
2018.              Symposium on Host-Pathogen Communication (Weizmann Institute of Science, Israel).                        (organizing committee). Keynote speaker: Nobel laureate Bruce Beutler

2020.              34th Annual Meeting of the European Macrophage and Dendritic Cell Society. Aarhus.                          Chairman of organizing committee


OUTREACH TO SOCIETY
Academic mentor for one High school student under the “Research shoot” program. 3 x Participation in the “book a researcher” event. Teaching/information on research for Science students at Egå and Ikast High Schools.

Numerous participations in TV, news paper, and Science website interviews (e.g. DR, Information, Videnskab.dk). More than 10 press releases following key publications.

COMMISSIONS OF TRUST
Scientific journals
2015-pres.  Associate editor, Journal of Immunology
2012-pres.  Editorial boards: Cytokine; Genes & Immunity
2003-pres.  Ad hoc reviewer. Past year: e.g. Nature, Science, Nat Immunol, and Nat.Med
Funding agencies
2014-pres.  ERC StG evaluation panel LS6 “Infection and Immunity” (chairman 2016 and 2018)
2003-pres.  Ad hoc reviewer e.g. ERC CoG, SyG, Welcome Trust, INSERM, and NIH (PO1)
Academic institutions
2016.         MRC IIB Scientific Review of the MRC Human Immunology Unit, University of Oxford
2010-pres  Evaluation for leading institutions. e.g. The Pasteur Institute (2016), Johns Hopkins Univ                       (2018), Ecole Polytechnique Federale de Lausanne (2018)

2003-pres. Examiner on 16 PhD theses (11 in DK; 7 in non-DK Europe)

Biotech Industry
2016-pres.  ISD Immunotech (Chair of scientific advisory board). Focus: STING antagonist
2018-pres.  NoToVir (SAB). Focus: Immuno-targeting of virus infections

CAREER BREAKS
6 months paternity leaves. Two month per child (2005, 2007, 2011)

PATENTS

•  Peptides having immune suppressive domains for transfection (WO 2014/166500A2)
•  Modulation of IFI16 and STING activity (WO/2018/029256)

PUBLICATION SUMMARY
Peer-reviewed articles (since 1997): 132
Citations: 10206 (h-index: 49) (source: Scopus)
Top publications (IF>10): Nature Immunology (x4), Nature Medicine (x1), Nature Microbiology (x1), Nature Reviews Immunology (x2), Immunity (x1), Nature Communications (x3), Journal of Experimental Medicine (x1), Journal of Clinical Investigation (x2), Hepatology (x1), Trends Reviews (x3), The EMBO J (x6).

10 selected publications (past 10 years):

Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, Fitzgerald KA, Paludan SR, Bowie AG. IFI16 is an innate immune sensor for intracellular DNA. Nature Immunology 2010 11:997-1004.

Holm CK, Jensen SB, Jakobsen MR, Cheshenko N, Horan KA, Moeller HB, Gonzalez-Dosal R, Rasmussen SB, Christensen MH, Yarovinsky TO, Rixon FJ, Herold BC, Fitzgerald KA, Paludan SR. Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING. Nature Immunology 2012. 13:737-743.

ReinertLS, Harder L, HolmCK, IversenMB, Horan KA, Dagnæs-Hansen F, Ulhøi BP, Holm T, Mogensen TH, Owens T, Nyengaard JR, Thomsen AR, Paludan SR. TLR3-deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in a mouse model. Journal of Clinical Investigation.2012. 122:1368-76. Journal Cover Image.

Iversen MB, Reinert LS, Thomsen MK, BagdonaiteI, Nandakumar R, Cheshenko N, Prabakaran T, Vakhrushev S, Krzyzowska M, Kratholm SK, Ruiz-PerezF, Petersen SV, Goriely S, Bibby BM, Eriksson K, RulandJ, Thomsen AR, Herold BC, Wandall HH, Frische S, Holm CK, Paludan SR.An innate antiviral pathway acting prior to interferons at epithelial surfaces. Nature Immunology. 2016. 17:150-8.

Holm CK, Rahbek SH, Gad HH, Bak RO, Jakobsen MR, Jiang Z, Hansen AL, Jensen SK, Sun C, Thomsen MK, Severinsen K, Xiong Y, Burdette D, Lebbink RJ, Duch M, Fitzgerald KA, Bahrami S, Mikkelsen JG, Hartmann R,Paludan SR. Influenza A virus targets a cGAS independent pathway for STING, which contributes to control of RNA viruses. Nature Communications. 2016. 7:10680.

Reinert LS, Lopušná K, WintherH, SunC, Thomsen MK, Nandakumar R, Mogensen TH, Meyer M, Vægter C, Nyengaard JR, Fitzgerald KA, Paludan SR. Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defense in the CNS. Nature Communications. 2016. 7:13348.

Ogunjimi B, Zhang SY, (.. 39 authors), Casanova JL, Paludan SR*,#, Mogensen TH#. Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections. Journal of Clinical Investigation.2017. 127:3543. * Corresponding author, # equal contribution.

Prabakaran T, Bodda C, Krapp C, Zhang BC, Christensen MH, Sun C, Reinert L, Cai Y, Jensen SB, Skouboe MK, Nyengaard JR, Thompson CB, Lebbink RJ, Sen GC, van Loo G, Nielsen R, Komatsu M, Nejsum LN, Jakobsen MR, Gyrd-Hansen M, PALUDAN SR. Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1. The EMBO Journal. 2018. 37:e97858. Journal Cover Image.

PALUDAN SR, Reinert LS, Hornung V. DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer. Nature Reviews Immunology. 2019. 19:141-153.

Nandakumar R, Tschismarov R, Meissner F, Prabakaran T, Krissanaprasit A, Farahani E, Zhang BC, Assil S, Martin A, Bertrams W, Holm CK, Ablasser A, Klause T, Thomsen MK, Schemck B, Howard KA, Henry T, Gothelf KV, Decker T, PALUDAN SR Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signaling. Nature Microbiology. 2019. 4:701–713.