Aarhus University Seal / Aarhus Universitets segl

Søren Lykke-Andersen

Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Nonsense-mediated mRNA decay : an intricate machinery that shapes transcriptomes. / Lykke-Andersen, Søren; Jensen, Torben Heick.

In: Nature Reviews. Molecular Cell Biology, Vol. 16, 11.2015, p. 665-677.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{b71ffa9e0fcb49f888218eb4e0ffbc25,
title = "Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes",
abstract = "Nonsense-mediated mRNA decay (NMD) is probably the best characterized eukaryotic RNA degradation pathway. Through intricate steps, a set of NMD factors recognize and degrade mRNAs with translation termination codons that are positioned in abnormal contexts. However, NMD is not only part of a general cellular quality control system that prevents the production of aberrant proteins. Mammalian cells also depend on NMD to dynamically adjust their transcriptomes and their proteomes to varying physiological conditions. In this Review, we discuss how NMD targets mRNAs, the types of mRNAs that are targeted, and the roles of NMD in cellular stress, differentiation and maturation processes.",
author = "S{\o}ren Lykke-Andersen and Jensen, {Torben Heick}",
year = "2015",
month = "11",
doi = "10.1038/nrm4063",
language = "English",
volume = "16",
pages = "665--677",
journal = "Nature Reviews. Molecular Cell Biology",
issn = "1471-0072",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Nonsense-mediated mRNA decay

T2 - an intricate machinery that shapes transcriptomes

AU - Lykke-Andersen, Søren

AU - Jensen, Torben Heick

PY - 2015/11

Y1 - 2015/11

N2 - Nonsense-mediated mRNA decay (NMD) is probably the best characterized eukaryotic RNA degradation pathway. Through intricate steps, a set of NMD factors recognize and degrade mRNAs with translation termination codons that are positioned in abnormal contexts. However, NMD is not only part of a general cellular quality control system that prevents the production of aberrant proteins. Mammalian cells also depend on NMD to dynamically adjust their transcriptomes and their proteomes to varying physiological conditions. In this Review, we discuss how NMD targets mRNAs, the types of mRNAs that are targeted, and the roles of NMD in cellular stress, differentiation and maturation processes.

AB - Nonsense-mediated mRNA decay (NMD) is probably the best characterized eukaryotic RNA degradation pathway. Through intricate steps, a set of NMD factors recognize and degrade mRNAs with translation termination codons that are positioned in abnormal contexts. However, NMD is not only part of a general cellular quality control system that prevents the production of aberrant proteins. Mammalian cells also depend on NMD to dynamically adjust their transcriptomes and their proteomes to varying physiological conditions. In this Review, we discuss how NMD targets mRNAs, the types of mRNAs that are targeted, and the roles of NMD in cellular stress, differentiation and maturation processes.

UR - http://biorxiv.org/content/early/2016/05/27/055731

U2 - 10.1038/nrm4063

DO - 10.1038/nrm4063

M3 - Journal article

VL - 16

SP - 665

EP - 677

JO - Nature Reviews. Molecular Cell Biology

JF - Nature Reviews. Molecular Cell Biology

SN - 1471-0072

ER -