Aarhus University Seal / Aarhus Universitets segl

Søren Lykke-Andersen

Making ends meet: Coordination between RNA 3'end processing and transcription initiation

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Making ends meet: Coordination between RNA 3'end processing and transcription initiation. / Andersen, Pia Kjølhede; Jensen, Torben Heick; Lykke-Andersen, Søren.

In: Wiley Interdisciplinary Reviews: RNA, Vol. 4, No. 3, 2013, p. 233-246.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{0ce2dcefbb24443d8f22765508ec36e8,
title = "Making ends meet: Coordination between RNA 3'end processing and transcription initiation",
abstract = "RNA polymerase II (RNAPII)-mediated gene transcription initiates at promoters and ends at terminators. Transcription termination is intimately connected to 3'-end processing of the produced RNA and already when loaded at the promoter, RNAPII starts to become configured for this downstream event. Conversely, RNAPII is 'reset' as part of the 3'-end processing/termination event, thus preparing the enzyme for its next round of transcription--possibly on the same gene. There is both direct and circumstantial evidence for preferential recycling of RNAPII from the gene terminator back to its own promoter, which supposedly increases the efficiency of the transcription process under conditions where RNAPII levels are rate limiting. Here, we review differences and commonalities between initiation and 3'-end processing/termination processes on various types of RNAPII transcribed genes. In doing so, we discuss the requirements for efficient 3'-end processing/termination and how these may relate to proper recycling of RNAPII.",
keywords = "Animals, Humans, RNA 3' End Processing, RNA Polymerase II, Transcription Initiation, Genetic",
author = "Andersen, {Pia Kj{\o}lhede} and Jensen, {Torben Heick} and S{\o}ren Lykke-Andersen",
year = "2013",
doi = "10.1002/wrna.1156",
language = "English",
volume = "4",
pages = "233--246",
journal = "Wiley Interdisciplinary Reviews: RNA",
issn = "1757-7004",
publisher = "JohnWiley & Sons Ltd.",
number = "3",

}

RIS

TY - JOUR

T1 - Making ends meet: Coordination between RNA 3'end processing and transcription initiation

AU - Andersen, Pia Kjølhede

AU - Jensen, Torben Heick

AU - Lykke-Andersen, Søren

PY - 2013

Y1 - 2013

N2 - RNA polymerase II (RNAPII)-mediated gene transcription initiates at promoters and ends at terminators. Transcription termination is intimately connected to 3'-end processing of the produced RNA and already when loaded at the promoter, RNAPII starts to become configured for this downstream event. Conversely, RNAPII is 'reset' as part of the 3'-end processing/termination event, thus preparing the enzyme for its next round of transcription--possibly on the same gene. There is both direct and circumstantial evidence for preferential recycling of RNAPII from the gene terminator back to its own promoter, which supposedly increases the efficiency of the transcription process under conditions where RNAPII levels are rate limiting. Here, we review differences and commonalities between initiation and 3'-end processing/termination processes on various types of RNAPII transcribed genes. In doing so, we discuss the requirements for efficient 3'-end processing/termination and how these may relate to proper recycling of RNAPII.

AB - RNA polymerase II (RNAPII)-mediated gene transcription initiates at promoters and ends at terminators. Transcription termination is intimately connected to 3'-end processing of the produced RNA and already when loaded at the promoter, RNAPII starts to become configured for this downstream event. Conversely, RNAPII is 'reset' as part of the 3'-end processing/termination event, thus preparing the enzyme for its next round of transcription--possibly on the same gene. There is both direct and circumstantial evidence for preferential recycling of RNAPII from the gene terminator back to its own promoter, which supposedly increases the efficiency of the transcription process under conditions where RNAPII levels are rate limiting. Here, we review differences and commonalities between initiation and 3'-end processing/termination processes on various types of RNAPII transcribed genes. In doing so, we discuss the requirements for efficient 3'-end processing/termination and how these may relate to proper recycling of RNAPII.

KW - Animals

KW - Humans

KW - RNA 3' End Processing

KW - RNA Polymerase II

KW - Transcription Initiation, Genetic

U2 - 10.1002/wrna.1156

DO - 10.1002/wrna.1156

M3 - Journal article

VL - 4

SP - 233

EP - 246

JO - Wiley Interdisciplinary Reviews: RNA

JF - Wiley Interdisciplinary Reviews: RNA

SN - 1757-7004

IS - 3

ER -